High frequency of vitamin D deficiency in ambulatory HIV-Positive patients.

abstract：:The incidence of anal cancer is increased in HIV-infected patients compared with the general population. Risk factors associated with the anal cancer precursor, high-grade squamous intraepithelial lesion (HSIL), have not been extensively studied in an urban black population with late-stage HIV disease. We performed a ...

journal_title：AIDS research and human retroviruses

authors： Frank M,Lahiri CD,Nguyen ML,Mehta CC,Mosunjac M,Flowers L

更新日期：2018-07-01 00:00:00

abstract：:Nucleoside analog reverse transcriptase inhibitors (NRTIs) constitute the most commonly used drugs in antiretroviral therapy. NRTIs differ with respect to their host cell toxicity. We compared the in vitro effect of zidovudine (AZT; 2 μg/ml), lamivudine (3TC; 5 μg/ml), stavudine (d4T; 1 μg/ml), and tenofovir (TFV; 1 μ...

journal_title：AIDS research and human retroviruses

authors： Enomoto L,Anderson PL,Li S,Edelstein CL,Weinberg A

更新日期：2011-01-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) isolates from six infected individuals less then 4 years of age were phenotyped for their syncytium-inducing (SI) ability in MT-2 cells. Three viral isolates that induced syncytia were detected. One SI isolate was from an individual who was in disease stage P2A,B,C and two S...

journal_title：AIDS research and human retroviruses

authors： Forte SE,Byron KS,Sullivan JL,Somasundaran M

更新日期：1994-12-01 00:00:00

abstract：:Identifying and monitoring HIV clusters could be useful in tracking the leading edge of HIV transmission in epidemics. Currently, greater specificity in the definition of HIV clusters is needed to reduce confusion in the interpretation of HIV clustering results. We address sampling density as one of the key aspects of...

journal_title：AIDS research and human retroviruses

authors： Novitsky V,Moyo S,Lei Q,DeGruttola V,Essex M

更新日期：2014-12-01 00:00:00

abstract：:Analysis of reverse transcriptase (RT) sequences of 382 HIV-1 isolates from untreated and treated patients recruited in JJ Hospital (Mumbai, India) between 2002 and 2008 shows that subtype C is largely predominant (98%) and that non-C sequences cluster with A1, B, CRF01_AE, and CRF06_cpx. ...

journal_title：AIDS research and human retroviruses

authors： Deshpande A,Jauvin V,Pinson P,Jeannot AC,Fleury HJ

更新日期：2009-06-01 00:00:00

abstract：:Lymphoid tissues are the focus of critical events in HIV pathogenesis. Persistent and high levels of virus production, extensive trapping of virus particles in germinal centers, and progressive degenerative changes in lymph node architecture are characteristics of progressive HIV-1 infection. Infiltrates of granzyme B...

journal_title：AIDS research and human retroviruses

authors： Koopman G,Haaksma AG,ten Velden J,Hack CE,Heeney JL

更新日期：1999-03-01 00:00:00

abstract：:HIV-1 compartmentalization in the central nervous system (CNS) and its contribution to neurological disease have been well documented. Previous studies were conducted among people infected with subtypes B or C where CNS compartmentalization has been observed when comparing viral sequences in the blood to virus in cere...

journal_title：AIDS research and human retroviruses

authors： Adewumi OM,Dukhovlinova E,Shehu NY,Zhou S,Council OD,Akanbi MO,Taiwo B,Ogunniyi A,Robertson K,Kanyama C,Hosseinipour MC,Swanstrom R

更新日期：2020-06-01 00:00:00

abstract：:We studied the heterogeneity and intactness of the vif gene in six HIV-1-infected individuals at various clinical stages. The proviral vif sequences in peripheral blood mononuclear cells were amplified by PCR, followed by cloning and sequencing of 45 vif clones. The intraindividual diversity of the vif genes ranged fr...

journal_title：AIDS research and human retroviruses

authors： Tominaga K,Kato S,Negishi M,Takano T

更新日期：1996-11-01 00:00:00

abstract：:Cellular adhesion molecules, such as ICAM-1, -2, and -3; LFA-1; and HLA class I and II are incorporated into HIV-1 virions during budding from infected cells. These virion-associated molecules can be involved in the adsorption to susceptible cells displaying the corresponding counterligands. A number of cytokines have...

journal_title：AIDS research and human retroviruses

authors： Castilletti C,Capobianchi MR,Fais S,Abbate I,Ficociello B,Ameglio F,Cordiali Fei P,Santini SM,Dianzani F

更新日期：1995-05-01 00:00:00

abstract：:India has experienced multiple introductions of diverse HIV-1 subtypes A, B, C, and E, along with subtype B of HIV-2 between the 1980s and early 1990s. In this study, we have carried out a molecular investigation of 21 heterosexually and vertically acquired HIV-infected individuals from the New Bombay area, who tested...

journal_title：AIDS research and human retroviruses

authors： Halani N,Wang B,Ge YC,Gharpure H,Hira S,Saksena NK

更新日期：2001-05-01 00:00:00

abstract：:Despite dramatic reduction of the levels of human immunodeficiency virus type I (HIV-1) virions in blood and seminal plasma of infected patients, highly active antiretroviral therapy (HAART) does not eradicate HIV-1. Three patients, with less than 50 copies/ml of plasma viral RNA, were enrolled in this eradication pro...

journal_title：AIDS research and human retroviruses

authors： Nunnari G,Leto D,Sullivan J,Xu Y,Mehlman KE,Kulkosky J,Pomerantz RJ

更新日期：2005-09-01 00:00:00

abstract：:Direct evidence confirming the hypothesis that a dysfunction of the mitochondrial respiratory chain (MRC) underlies the pathogenesis of hyperlactatemia associated with highly active antiretroviral therapy (HAART) is scarce. We studied mitochondrial DNA (mtDNA) content and MRC function in the skeletal muscle of an HIV-...

journal_title：AIDS research and human retroviruses

authors： Miró O,López S,Martínez E,Rodríguez-Santiago B,Blanco JL,Milinkovic A,Miró JM,Nunes V,Casademont J,Gatell JM,Cardellach F

更新日期：2003-11-01 00:00:00

abstract：:Nucleotide sequences for long terminal repeat (LTR), gag, the protease gene, and pol of a human T-lymphotropic virus type 1 (HTLV-1) isolate of probable Caribbean origin (HTLV-1CH) and a Zairian isolate (HTLV-1EL) were determined providing complete proviral sequences for these isolates. These sequences were compared w...

journal_title：AIDS research and human retroviruses

authors： Ratner L,Philpott T,Trowbridge DB

更新日期：1991-11-01 00:00:00

abstract：:In a cross-sectional study of 926 subjects from 10 drug treatment programs conducted in 1984 in New Jersey, the seroprevalence of human immunodeficiency virus (HIV) was 35% overall; 30% in whites, 33% in hispanics, and 46% in blacks (p = 0.01 for comparison of blacks to non-blacks). Univariate analysis showed the sero...

journal_title：AIDS research and human retroviruses

authors： Caussy D,Weiss SH,Blattner WA,French J,Cantor KP,Ginzburg H,Altman R,Goedert JJ

更新日期：1990-12-01 00:00:00

abstract：:This retrospective and longitudinal study evaluated the long-term hepatic tolerance of a nelfinavir (NFV)-antiretroviral combined regimen in 82 patients of the HCV-HIV Cohort of CISIH-Sud of Marseilles. Follow-up data (liver enzyme levels, CD4 cell count, HIV viral load, and metabolic parameters) of patients treated w...

journal_title：AIDS research and human retroviruses

authors： Poizot-Martin I,Marimoutou C,Drogoul-Vey MP,Vion-Dury F,Frixon-Marin V,Benhaim S,Poggi P,Gastaut JA

更新日期：2005-10-01 00:00:00

abstract：:HLA is one of the genetic factors that influence the clinical course of HIV-1 infection, and patients with HLA-B35 are prone to rapid disease progression. Nine viral epitopes that are recognized by cytotoxic T lymphocytes (CTLs) in an HLA-B35-restricted manner were determined. To examine how HIV-1 sequences are select...

journal_title：AIDS research and human retroviruses

authors： Kawana A,Tomiyama H,Takiguchi M,Shioda T,Nakamura T,Iwamoto A

更新日期：1999-08-10 00:00:00

abstract：:Human immunodeficiency virus (HIV) infection represents a major global health problem, with HIV now recognized as the fourth leading cause of death on a worldwide basis. One approach to developing effective anti- HIV interventions is to identify and understand the molecular mechanisms by which natural genetic variatio...

journal_title：AIDS research and human retroviruses

authors： Donfack J,Buchinsky FJ,Post JC,Ehrlich GD

更新日期：2006-10-01 00:00:00

abstract：:We recently reported a novel adhesion pathway in lymphocytes that is mediated by cyclin-dependent kinase (Cdk) 4 activity and mediates lymphocyte interactions with endothelial matrix. We now demonstrate that HIV-infected lymphocytes also use Cdk4 to mediate spontaneous adhesion to fibronectin and endothelial matrix. W...

journal_title：AIDS research and human retroviruses

authors： Chow YH,Liu L,Schwartz B,Harlan JM,Schnapp LM

更新日期：2012-12-01 00:00:00

abstract：:We have determined that polymeric IgA in saliva of HIV-1-uninfected individuals binds in varying degrees to components of culture supernatants containing HIV-1 recombinant proteins when ELISA is used for the determination. This finding did not extend to salivary IgG antibodies. Further, such problems were not encounte...

journal_title：AIDS research and human retroviruses

authors： Jackson S,Prince S,Kulhavy R,Mestecky J

更新日期：2000-04-10 00:00:00

abstract：:Immunoliposomes containing monoclonal antibodies (MAbs) to the costimulatory molecules CD28 and CTLA4 and their counterreceptors B7-1 (CD80) and B7-2 (CD86) were evaluated for the ability to increase the immune response to recombinant envelope protein rgp120 of the MN strain of human immunodeficiency virus type 1 (HIV...

journal_title：AIDS research and human retroviruses

authors： Ozpolat B,Rao XM,Powell MF,Lachman LB

更新日期：1998-03-20 00:00:00

abstract：:HIV-1 Nef has been demonstrated to be integral for viral persistence, infectivity, and the acceleration of disease pathogenesis (AIDS) in humans. Nef has also been detected in the plasma of HIV-infected individuals and is released from infected cells. The form in which Nef is released from infected cells is unknown. H...

journal_title：AIDS research and human retroviruses

authors： Raymond AD,Campbell-Sims TC,Khan M,Lang M,Huang MB,Bond VC,Powell MD

更新日期：2011-02-01 00:00:00

abstract：:Data reporting sexually transmitted infection (STI) incidence rates among HIV-negative U.S. men who have sex with men (MSM) are lacking. In addition, it is difficult to analyze the effect of STI on HIV acquisition given that sexual risk behaviors confound the relationship between bacterial STIs and incident HIV. The I...

journal_title：AIDS research and human retroviruses

authors： Kelley CF,Vaughan AS,Luisi N,Sanchez TH,Salazar LF,Frew PM,Cooper HL,Diclemente R,del Rio C,Sullivan PS,Rosenberg ES

更新日期：2015-06-01 00:00:00

abstract：:We have characterized human foamy virus (HFV) proviral DNA and determined HFV expression in a persistent infection model, the Dami megakaryocytic cell line. Molecular studies were performed on parental persistently infected cells (Dami-P), as well as on derived clones (Dami-Cl). We report that in these nonlytic and no...

journal_title：AIDS research and human retroviruses

authors： Wybier-Franqui J,Tobaly-Tapiero J,Coronel A,Giron ML,Chopin-Robert C,Peries J,Emanoil-Ravier R

更新日期：1995-07-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) replicate during acute infection in lymphocytes of the gastrointestinal tract, before disseminating systemically. Localized replication and associated loss of gut-resident CD4+ T cells occur regardless of the portal of entry of the virus (e.g.,...

journal_title：AIDS research and human retroviruses

authors： Méndez-Lagares G,Lu D,Merriam D,Baker CA,Villinger F,Van Rompay KKA,McCune JM,Hartigan-O'Connor DJ

更新日期：2017-11-01 00:00:00

abstract：:Because mucosal inflammation contributes to colorectal carcinogenesis, we studied the impact of intestinal infections on risk of this malignancy among people with AIDS (PWA). Using the population-based HIV/AIDS Cancer Match, which includes approximately half of all PWA in the United States, the cancer registries ascer...

journal_title：AIDS research and human retroviruses

authors： Shebl FM,Engels EA,Goedert JJ

更新日期：2012-09-01 00:00:00

abstract：:Eight fragments derived from the HIV-1 pol gene were expressed as recombinant polypeptides in Escherichia coli. The fragments were from the portion of the pol gene that encodes the reverse transcriptase. The expressed peptides were analyzed immunologically with sera from HIV-1-infected individuals. Three distinct immu...

journal_title：AIDS research and human retroviruses

authors： Padberg C,Nowlan S,Mermer B

更新日期：1989-02-01 00:00:00

abstract：:Osteopenia is a common and debilitating side-effect of HAART, yet little is known concerning the effects of HAART on bone metabolism. We reported previously that zidovudine (AZT) stimulates osteoclastogenesis in vitro and causes osteopenia in mice. Here, we confirmed that the AZT-induced osteoclastogenesis is dependen...

journal_title：AIDS research and human retroviruses

authors： Pan G,Kilby M,McDonald JM

更新日期：2006-11-01 00:00:00

abstract：:Entry inhibitor is a new class of drugs that target the viral envelope protein. This region is variable; hence resistance to these drugs may be present before treatment. The aim of this study was to analyze the frequency of patients failing treatment with transcriptase reverse and protease inhibitors that would respon...

journal_title：AIDS research and human retroviruses

authors： Alencar CS,Nishiya AS,Ferreira S,Giret MT,Diaz RS,Sabino EC

更新日期：2010-12-01 00:00:00

abstract：:This study seeks to analyze nearly full-length viral genomes for distinct genetic characteristics that are unique to local or regional strains and to identify regions that have high variability or are highly conserved. Nearly full length sequences of seven HIV-1 samples were obtained to ascertain the circulating subty...

journal_title：AIDS research and human retroviruses

authors： Roye ME,Amarakoon II,Hamilton CL,Eyzaguirre LM,Figueroa P,Carr JK

更新日期：2011-01-01 00:00:00

abstract：:Cell activation is essential for HIV infection. CD4+ T lymphocyte activation allows virus replication and CD8+ T lymphocyte activation may contribute to pathogenesis. We combined hydroxyurea, a cytostatic drug that inhibits cell activation and proliferation, with two drugs that inhibit HIV (didanosine and indinavir), ...

journal_title：AIDS research and human retroviruses

authors： Lori F,Jessen H,Lieberman J,Clerici M,Tinelli C,Lisziewicz J

更新日期：1999-05-01 00:00:00