当前位置： SCI文献检索 > AIDS RESEARCH AND HUMAN RETROVIRUSES期刊下所有文献 > Evaluation of primary resistance to HIV entry inhibitors among brazilian patients failing reverse transcriptase/protease inhibitors treatment reveal high prevalence of maraviroc resistance-related mutations.

Evaluation of primary resistance to HIV entry inhibitors among brazilian patients failing reverse transcriptase/protease inhibitors treatment reveal high prevalence of maraviroc resistance-related mutations.

Abstract：

:Entry inhibitor is a new class of drugs that target the viral envelope protein. This region is variable; hence resistance to these drugs may be present before treatment. The aim of this study was to analyze the frequency of patients failing treatment with transcriptase reverse and protease inhibitors that would respond to the entry inhibitors Enfuvirtide, Maraviroc, and BMS-806. The study included 100 HIV-1 positive patients from one outpatient clinic in the city of Sao Paulo, for whom a genotype test was requested due to treatment failure. Proviral DNA was amplified and sequenced for regions of gp120 and gp41. A total of 80 could be sequenced and from those, 73 (91.3%), 5 (6.3%) and 2 (2.5%) were classified as subtype B, F, and recombinants (B/ F and B/C), respectively. CXCR4 co-receptor use was predicted in 30% of the strains. Primary resistance to Enfuvirtide was found in 1.3%, following the AIDS Society consensus list, and 10% would be considered resistant if a broader criterion was used. Resistance to BMS-806 was higher; 6 (7.5%), and was associated to non-B strains. Strikingly, 27.5% of samples harbored one or more mutation among A316T, I323V, and S405A, which have been related to decreased susceptibility of Maraviroc; 15% of them among viruses predictive to be R5. A more common mutation was A316T, which was associated to the Brazilian B strain harboring the GWGR motif at the tip of V3 loop and their derivative sequences. These results may be impact guidelines for genotype testing and treatment in Brazil.

journal_name

AIDS Res Hum Retroviruses

journal_title

AIDS research and human retroviruses

authors

Alencar CS,Nishiya AS,Ferreira S,Giret MT,Diaz RS,Sabino EC

doi

10.1089/aid.2010.0057

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

1267-71

issue

12

eissn

0889-2229

issn

1931-8405

journal_volume

26

pub_type

杂志文章

相关文献

AIDS RESEARCH AND HUMAN RETROVIRUSES文献大全
  • Cytokine genotype suggests a role for inflammation in nucleoside analog-associated sensory neuropathy (NRTI-SN) and predicts an individual's NRTI-SN risk.

    abstract：:Nucleoside analog-associated sensory neuropathy (NRTI-SN) attributed to stavudine, didanosine, or zalcitabine (the dNRTIs) and distal sensory polyneuropathy (DSP) attributed to HIV are clinically indistinguishable. As inflammatory cytokines are involved in DSP, we addressed a role for inflammation in NRTI-SN by determ...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/aid.2007.0168

    authors： Cherry CL,Rosenow A,Affandi JS,McArthur JC,Wesselingh SL,Price P

    更新日期：2008-02-01 00:00:00

  • Molecular and phylogenetic analysis of HIV type 1 vpr sequences of South African strains.

    abstract：:HIV-1 subtype C is the prevalent subtype in South Africa, with non-C subtypes being sporadically detected. The accessory genes of subtype C have not been well studied in South Africa. In this study the HIV-1 vpr region of 58 strains was amplified, sequenced, and subtyped. Phylogenetic analysis characterized 54 strains...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/aid.2008.0251

    authors： Romani B,Glashoff R,Engelbrecht S

    更新日期：2009-03-01 00:00:00

  • Analysis of reverse transcriptase and protease genes of HIV for antiretroviral drug resistance in treatment-exposed Jamaican pediatrics.

    abstract：:This study reports on the drug resistance profiles for HIV-infected pediatrics in Jamaica who have been exposed to antiretroviral therapy (ART). The genetic diversity of HIV-1 found in these patients was also determined using phylogenetic analysis. The protease-reverse transcriptase (Pro-RT) region of the genome was a...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/AID.2015.0122

    authors： Ramkissoon AP,Amarakoon II,Hamilton CL,Pierre RB,Eyzaguirre LM,Carr JK,Blattner WA,Roye ME

    更新日期：2015-09-01 00:00:00

  • The relationship between HIV type 1 disease progression and V3 serotype in a rural Ugandan cohort.

    abstract：:Antigenic properties of the V3 region are reflected by HIV-1 serotypes. These may represent biological properties of the virus. We serotyped HIV-1 in 142 serum samples from participants in a rural Uganda cohort who seroconverted between August 1991 and December 2001. Clinical progression was assessed using Cox proport...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/aid.2004.20.932

    authors： Senkaali D,Muwonge R,Morgan D,Yirrell D,Whitworth J,Kaleebu P

    更新日期：2004-09-01 00:00:00

  • Short communication: reversible mitochondrial respiratory chain impairment during symptomatic hyperlactatemia associated with antiretroviral therapy.

    abstract：:Direct evidence confirming the hypothesis that a dysfunction of the mitochondrial respiratory chain (MRC) underlies the pathogenesis of hyperlactatemia associated with highly active antiretroviral therapy (HAART) is scarce. We studied mitochondrial DNA (mtDNA) content and MRC function in the skeletal muscle of an HIV-...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/088922203322588387

    authors： Miró O,López S,Martínez E,Rodríguez-Santiago B,Blanco JL,Milinkovic A,Miró JM,Nunes V,Casademont J,Gatell JM,Cardellach F

    更新日期：2003-11-01 00:00:00

  • Human susceptibility to viral infection: the search for HIV-protective alleles among Africans by means of genome-wide studies.

    abstract：:Human immunodeficiency virus (HIV) infection represents a major global health problem, with HIV now recognized as the fourth leading cause of death on a worldwide basis. One approach to developing effective anti- HIV interventions is to identify and understand the molecular mechanisms by which natural genetic variatio...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/aid.2006.22.925

    authors： Donfack J,Buchinsky FJ,Post JC,Ehrlich GD

    更新日期：2006-10-01 00:00:00

  • Identification of the DC-SIGN-interactive domains on the envelope glycoprotein of HIV-1 CRF07_BC.

    abstract：:DC-SIGN, a C-type lection expressed on dendritic cells, enhances HIV-1 infection in cis and in trans. HIV-1 circulating recombinant form (CRF) 07_BC viruses have been the predominant strain found among injection drug users in southern China and Taiwan. The goal of this study was to map the DC-SIGN-interactive domain o...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/AID.2010.0215

    authors： Liao CF,Wang SF,Lin YT,Ho DD,Chen YM

    更新日期：2011-08-01 00:00:00

  • Identification of MIP-1 alpha/LD78 as a monocyte chemoattractant released by the HTLV-I-transformed cell line MT4.

    abstract：:It is known that the HTLV-I-transformed cell line MT4 releases chemotactic activity for monocytes spontaneously. The MT4 monocyte chemoattractant was purified to homogeneity and sequencing of 25 amino acids revealed identity with the C-C chemokine macrophage inflammatory protein-1 alpha (MIP-1 alpha/LD78). An anti-MIP...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/aid.1995.11.155

    authors： Bertini R,Luini W,Sozzani S,Bottazzi B,Ruggiero P,Boraschi D,Saggioro D,Chieco-Bianchi L,Proost P,van Damme J

    更新日期：1995-01-01 00:00:00

  • Isolation of potent neutralizing monoclonal antibodies from an SIV-Infected rhesus macaque by phage display.

    abstract：:The humoral immune response is a mechanism that potently suppresses or prevents viral infections. However, genetic diversity and resistance to antibody-mediated neutralization are serious obstacles in controlling HIV-1 infection. In this study, we isolated monoclonal antibodies from an SIV-infected macaque by using th...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/AID.2010.0191

    authors： Kuwata T,Katsumata Y,Takaki K,Miura T,Igarashi T

    更新日期：2011-05-01 00:00:00

  • Naturally occurring sequence polymorphisms within HIV type 1 group O protease.

    abstract：:Mutations within the protease gene associated with reduced susceptibility to protease inhibitors have been well documented for HIV-1 group M subtype B strains. In contrast, limited genotypic and phenotypic information is available for the genetically diverse HIV-1 group O strains. Preexisting resistance-associated pol...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/08892220152644269

    authors： Luk KC,Kaptué L,Zekeng L,Soriano V,Gürtler L,Devare SG,Schochetman G,Hackett J Jr

    更新日期：2001-11-01 00:00:00

  • Study of the interaction of HIV-1 and HIV-2 envelope glycoproteins with the CD4 receptor and role of N-glycans.

    abstract：:In order to further characterize the interaction of human immunodeficiency viruses (HIV) with the CD4 receptor at the molecular level, a binding test was performed using iodine-labeled glycoproteins, 125I-gp160 from HIV-1 and 125I-gp140 from HIV-2, to bind to lymphoid cells expressing the CD4 receptor. The inhibition ...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/aid.1992.8.565

    authors： Bahraoui E,Benjouad A,Guetard D,Kolbe H,Gluckman JC,Montagnier L

    更新日期：1992-05-01 00:00:00

  • Tax gene characterization of human T-lymphotropic virus type 1 strains from Brazilian HIV-coinfected patients.

    abstract：:The tax gene of human T-lymphotropic virus type 1 (HTLV-1) diverges among isolates according to geographic regions and has been classified into two genotypes: taxA and taxB. In Brazil, taxA is the most prevalent genotype in symptomatic and asymptomatic carriers. Few studies have been conducted in HIV-infected patients...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/AID.2011.0389

    authors： Magri MC,Brigido LF,Rodrigues R,Morimoto HK,Caterino-de-Araujo A

    更新日期：2012-12-01 00:00:00

  • Longitudinal Trends in Western Australian HIV-1 Sequence Diversity and Viral Transmission Networks and Their Influence on Clinical Parameters: 2000-2014.

    abstract：:We examined baseline HIV-1 protease and reverse transcriptase sequences and HIV clinical parameters from 1,021 consecutive patients (814 male, 207 female) through the Royal Perth Hospital HIV service to investigate HIV-1 subtype diversity and local phylogenetic networks from 2000 to 2014. HIV-1 subtype B virus sequenc...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/AID.2015.0206

    authors： Castley AS,Gaudieri S,James I,Gizzarelli LS,Guelfi G,John M,Nolan D

    更新日期：2016-03-01 00:00:00

  • 9-Nitrocamptothecin inhibits tumor recrosis factor-mediated activation of human immunodeficiency virus type 1 and enhances apoptosis in a latently infected T cell clone.

    abstract：:Transition from latency to active replication is a crucial stage for the process of human immunodeficiency virus type 1 (HIV-1) infection and life cycle. HIV-1 replication in latently infected cells can be strongly induced by the cytokine tumor necrosis factor alpha (TNF-alpha) and the proliferation-arresting chemical...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/aid.1998.14.39

    authors： Moulton S,Pantazis P,Epstein JS,Sadaie MR

    更新日期：1998-01-01 00:00:00

  • Dolutegravir-based regimen for maintenance of viral suppression in people living with HIV: 48-week results in real life setting.

    abstract：:To evaluate the efficacy, safety and tolerability of switching to a dolutegravir (DTG)-based regimen in a cohort of virological suppressed HIV-infected patients. The dynamics of total HIV-DNA and levels of high-sensitivity c-reactive protein (hsCRP), interleukin-6 (IL-6), soluble-CD14 (sCD14) and D-Dimer were also ana...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/AID.2020.0196

    authors： Di Carlo D,Falasca F,Palermo E,Mezzaroma I,Fimiani C,Siccardi G,Celani L,Di Campli FM,d'Ettorre G,Antonelli G,Turriziani O

    更新日期：2021-01-24 00:00:00

  • EBV-induced human B cell lymphomas in hu-PBL-SCID mice.

    abstract：:Epstein-Barr virus (EBV) infection is associated with Burkitt's lymphoma (BL) in normal individuals and immunoblastic B cell lymphomas in immunosuppressed or HIV-infected individuals. SCID mice reconstituted with human peripheral blood leukocytes (hu-PBL-SCID) from EBV-seropositive donors also may develop spontaneous ...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章,评审

    doi：

    authors： Mosier DE,Picchio GR,Kirven MB,Garnier JL,Torbett BE,Baird SM,Kobayashi R,Kipps TJ

    更新日期：1992-05-01 00:00:00

  • Severe Kaposi Sarcoma in an Urban Public Hospital.

    abstract：:The national incidence of epidemic Kaposi sarcoma (KS) has decreased dramatically since the availability of combined antiretroviral therapy. Despite national trends, we continue to see admissions for KS. Electronic medical records were queried to identify patients with HIV who were admitted with active KS between 2010...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/AID.2016.0141

    authors： Kasturia SE,Gunthel C,Zeng C,Nguyen ML

    更新日期：2017-06-01 00:00:00

  • Evidence for Altered Glutamine Metabolism in Human Immunodeficiency Virus Type 1 Infected Primary Human CD4+ T Cells.

    abstract：:Glutamine is a conditionally essential amino acid that is an important metabolic resource for proliferating tissues by acting as a proteinogenic amino acid, a nitrogen donor for biosynthetic reactions and as a substrate for the citric acid or tricarboxylic acid cycle. The human immunodeficiency virus type 1 (HIV-1) pr...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/AID.2017.0165

    authors： Hegedus A,Kavanagh Williamson M,Khan MB,Dias Zeidler J,Da Poian AT,El-Bacha T,Struys EA,Huthoff H

    更新日期：2017-12-01 00:00:00

  • Efficacy of epoetin alfa administered every 2 weeks to maintain hemoglobin and quality of life in anemic HIV-infected patients.

    abstract：:Anemia, a common hematological abnormality in HIV, contributes to decreased quality of life (QOL). This study assessed once-every-2-week epoetin alfa on maintaining QOL and hemoglobin (Hb) in anemic HIV-infected patients in a 24-week, open-label, multicenter study. HIV-infected patients (Hb < or =12 g/dl) received epo...

    journal_title：AIDS research and human retroviruses

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1089/aid.2006.0200

    authors： Levine AM,Salvato P,Leitz GJ,Champs 2 Study Group.

    更新日期：2008-02-01 00:00:00

  • Elimination of human T cell leukemia virus type-1-infected cells by neutralizing and antibody-dependent cellular cytotoxicity-inducing antibodies against human t cell leukemia virus type-1 envelope gp46.

    abstract：:Human T cell leukemia virus type-1 (HTLV-1) is prevalent worldwide with foci of high prevalence. However, to date no effective vaccine or drug against HTLV-1 infection has been developed. In efforts to define the role of antibodies in the control of HTLV-1 infection, we capitalized on the use of our previously defined...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/aid.2013.0214

    authors： Tanaka Y,Takahashi Y,Tanaka R,Kodama A,Fujii H,Hasegawa A,Kannagi M,Ansari AA,Saito M

    更新日期：2014-06-01 00:00:00

  • R5 and X4 HIV viruses differentially modulate host gene expression in resting CD4+ T cells.

    abstract：:During HIV-1 infection, distinct biological phenotypes are observed between R5 and X4 HIV-1 strains with respect to pathogenicity and tropism. In this study, temporal changes of the expression levels of the complete human transcriptome, representing 47,000 well-characterized human transcripts, were monitored in the fi...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/aid.2007.0120

    authors： Sirois M,Robitaille L,Sasik R,Estaquier J,Fortin J,Corbeil J

    更新日期：2008-03-01 00:00:00

  • Human monoclonal antibody against a gag-coded protein of human immunodeficiency virus produced by a stable EBV-transformed cell clone.

    abstract：:An EBV-transformed lymphoblastoid B cell clone (A12) derived from peripheral blood lymphocytes of an HIV-1-infected individual is described. The immunoglobulin isotype produced by this clone was IgM, and Southern blot analysis of immunoglobulin gene rearrangement showed a monoclonal pattern. The A12 monoclonal antibod...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/aid.1989.5.73

    authors： Amadori A,Ciminale V,Calabro ML,Tessarollo L,Francavilla E,Chieco-Bianchi L

    更新日期：1989-02-01 00:00:00

  • Primary antiretroviral drug resistance among HIV type 1-infected individuals in Brazil.

    abstract：:Infection with drug-resistant human immunodeficiency virus type 1 (HIV-1) has been documented in all countries that have surveyed for it and may result in an unfavorable response to therapy. The prevalence and characteristics of individuals with transmitted resistance to antiretroviral drugs have been scarcely describ...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/aid.2009.0012

    authors： Sprinz E,Netto EM,Patelli M,Lima JS,Furtado JJ,da Eira M,Zajdenverg R,Madruga JV,Lewi DS,Machado AA,Pedro RJ,Soares MA

    更新日期：2009-09-01 00:00:00

  • Expression of interleukin-15 and interleukin-15Rα in monocytes of HIV type 1-infected patients with different courses of disease progression.

    abstract：:Interleukin-15 (IL-15) enhances the effector mechanisms of anti-HIV immune responses and thus is considered a potential adjuvant of HIV-1 vaccine. However, there are a lack of data concerning the relationships between IL-15 expression and regulation in HIV-1-infected patients and the course of disease progression. We ...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/AID.2010.0317

    authors： Tarkowski M,Ferraris L,Martone S,Strambio de Castillia F,Misciagna D,Mazzucchelli RI,Lattuada E,Paraninfo G,Galli M,Riva A,Elvis Study Group.

    更新日期：2012-07-01 00:00:00

  • Once-weekly epoetin alfa improves quality of life and increases hemoglobin in anemic HIV+ patients.

    abstract：:This prospective, open-label, multicenter trial evaluated the effects of once-weekly (qw) epoetin alfa on quality of life (QOL) and hemoglobin (Hb) levels in anemic human immunodeficiency virus (HIV)-infected adult receiving antiretroviral therapy. A total of 650 patients with Hb < or = 11 g/dl received epoetin alfa 4...

    journal_title：AIDS research and human retroviruses

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1089/aid.2004.20.1037

    authors： Saag MS,Bowers P,Leitz GJ,Levine AM,Community HIV Anemia Management Protocol Sites (CHAMPS) Study Group.

    更新日期：2004-10-01 00:00:00

  • HIV/AIDS-associated opportunistic protozoal diarrhea.

    abstract：:Human immunodeficiency virus (HIV) infection has altered both the epidemiology and outcome of enteric opportunistic parasitic infections. This study was done to determine the prevalence and species/genotypes of intestinal coccidian and microsporidial infections among HIV/AIDS patients with diarrhea and/or a history of...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/AID.2012.0119

    authors： Agholi M,Hatam GR,Motazedian MH

    更新日期：2013-01-01 00:00:00

  • Genotypic characterization of human immunodeficiency virus type 1 in Greece. Multicentre Study on HIV-1 Heterogeneity.

    abstract：:The HIV-1 subtype distribution in 83 HIV-1-seropositive individuals living in Greece was investigated by using the heteroduplex mobility assay (HMA), DNA sequencing, and phylogenetic analysis. The results revealed that partial HIV-1 gp120 sequences from 71 (86%) patients were subtype B, 5 (6%) were subtype A, 4 were s...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章,多中心研究

    doi：10.1089/aid.1998.14.685

    authors： Nasioulas G,Paraskevis D,Paparizos V,Lazanas M,Karafoulidou A,Hatzakis A

    更新日期：1998-05-20 00:00:00

  • Molecular cloning and characterization of a German HIV-1 isolate.

    abstract：:The genetic diversity of HIV-1 is well documented. Except for the HIV-1 isolate LAV-1BRU, no nucleic acid sequence of a European isolate of HIV-1 has been published to date. To further investigate the extent of the genetic variability and the evolution of HIV-1, we have isolated, cloned, and subsequently sequenced HIV...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/aid.1990.6.813

    authors： Sauermann U,Schneider J,Mous J,Brunckhorst U,Schedel I,Jentsch KD,Hunsmann G

    更新日期：1990-06-01 00:00:00

  • Analysis of west African hunters for foamy virus infections.

    abstract：:Foamy viruses are a genus of complex retroviruses that infect a wide variety of mammals. However, a clear association with any disease process has yet to be proven for these viruses. A higher human seroprevalence was reported in African populations, perhaps due to exposure to simian foamy viruses (SFV) endemic in prim...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/aid.1996.12.1725

    authors： Goepfert PA,Ritter GD Jr,Peng X,Gbakima AA,Zhang Y,Mulligan MJ

    更新日期：1996-12-10 00:00:00

  • Modulation of osteoclastogenesis induced by nucleoside reverse transcriptase inhibitors.

    abstract：:Osteopenia is a common and debilitating side-effect of HAART, yet little is known concerning the effects of HAART on bone metabolism. We reported previously that zidovudine (AZT) stimulates osteoclastogenesis in vitro and causes osteopenia in mice. Here, we confirmed that the AZT-induced osteoclastogenesis is dependen...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/aid.2006.22.1131

    authors： Pan G,Kilby M,McDonald JM

    更新日期：2006-11-01 00:00:00