Isolation of potent neutralizing monoclonal antibodies from an SIV-Infected rhesus macaque by phage display.

abstract：:The objectives of this study were to evaluate the performance of parallel rapid HIV testing and the presence of HIV-associated risk factors in pregnant women with unknown HIV status in Baja California, Mexico. Pregnant women attending the delivery unit or the prenatal clinic at Tijuana General Hospital had blood drawn...

journal_title：AIDS research and human retroviruses

authors： Viani RM,Araneta MR,Spector SA

更新日期：2013-03-01 00:00:00

abstract：:Several reports have suggested an increased prevalence of osteopenia and osteoporosis in HIV-infected individuals. Vitamin D deficiency may be a risk factor for osteoporosis and bone fractures. We aimed to determine the prevalence of vitamin D insufficiency in an outpatient HIV clinic in Boston. We collected serum lev...

journal_title：AIDS research and human retroviruses

authors： Rodríguez M,Daniels B,Gunawardene S,Robbins GK

更新日期：2009-01-01 00:00:00

abstract：:GLQ223 is a formulated version of tricosanthin, a single-chain ribosome-inactivating protein that was shown in earlier studies to inhibit human immunodeficiency virus (HIV) replication in T-lymphoblastoid cells and to decrease HIV p24 levels in HIV-infected monocyte-derived macrophages as measured by flow cytometry. T...

journal_title：AIDS research and human retroviruses

authors： McGrath MS,Santulli S,Gaston I

更新日期：1990-08-01 00:00:00

abstract：:In cell-mediated immunity T cells recognize peptide fragments of the antigenic protein in association with major histocompatibility complex (MHC) proteins. Synthetic 9- to 16-mer peptides have been widely used to identify the region(s) of a protein that act as T cell epitope. Here, we report antigenic peptides identif...

journal_title：AIDS research and human retroviruses

authors： Blazevic V,Ranki A,Krohn KJ

更新日期：1995-11-01 00:00:00

abstract：:The majority of early cases of HIV in Russia were among men who have sex with men (MSM). Despite this and the current resurgence of HIV among MSM globally, little systematic work has been done to assess current HIV risks. We conducted a rapid assessment of HIV and associated risk behaviors among MSM in Russia. An anon...

journal_title：AIDS research and human retroviruses

authors： Baral S,Sifakis F,Peryskina A,Mogilnii V,Masenior NF,Sergeyev B,Deobald I,Wirtz AL,Beyrer C

更新日期：2012-08-01 00:00:00

abstract：:Heparin (Hep) and sulfated polysaccharides (SPs) have been reported to inhibit HIV infection in vitro. In vivo, anticoagulant activity and reduced bioavailability were found to limit the antiviral effects of Hep. In this investigation, three nonanticoagulant N-acylated Hep conjugates [OI1:3Hep, Pal1:5Hep, and Pal1:5He...

journal_title：AIDS research and human retroviruses

authors： Clayette P,Moczar E,Mabondzo A,Martin M,Toutain B,Marcé D,Dormont D

更新日期：1996-01-01 00:00:00

abstract：:The genetic diversity of HIV-1 is well documented. Except for the HIV-1 isolate LAV-1BRU, no nucleic acid sequence of a European isolate of HIV-1 has been published to date. To further investigate the extent of the genetic variability and the evolution of HIV-1, we have isolated, cloned, and subsequently sequenced HIV...

journal_title：AIDS research and human retroviruses

authors： Sauermann U,Schneider J,Mous J,Brunckhorst U,Schedel I,Jentsch KD,Hunsmann G

更新日期：1990-06-01 00:00:00

abstract：:Vaginal anti-HIV antibody responses may be beneficial, and possibly required, for vaccine-induced protection against HIV infection acquired through receptive vaginal intercourse. We have previously determined that intranasal immunization with a hybrid HIV peptide and cholera toxin induced vaginal anti-HIV IgA response...

journal_title：AIDS research and human retroviruses

authors： Staats HF,Montgomery SP,Palker TJ

更新日期：1997-07-20 00:00:00

abstract：:We have analyzed amino acid, nucleotide sequence, and RNA secondary structure variability in the env gene of human immunodeficiency virus type (HIV-1). In applying algorithms for computing optimal RNA-folding patterns to a nonredundant data set of 178 env nucleotide sequences, we found a conserved RNA stem-loop struct...

journal_title：AIDS research and human retroviruses

authors： Peleg O,Brunak S,Trifonov EN,Nevo E,Bolshoy A

更新日期：2002-08-10 00:00:00

abstract：:HIV prevalence is the most commonly used measure to prioritize communities for HIV prevention. We show that data on two HIV infection stages (early vs. nonearly and late vs. nonlate) allow estimation of two better measures of prevention need: HIV incidence (for prevention of HIV acquisition) and expected probability o...

journal_title：AIDS research and human retroviruses

authors： Bärnighausen T,Tanser F,Hallett T,Newell ML

更新日期：2010-04-01 00:00:00

abstract：:African monkeys can be naturally infected with SIV but do not progress to AIDS. Since mutations in the human CCR5 gene have been shown to influence susceptibility to HIV infection and disease progression, we have now investigated whether mutations in CCR5-coding sequences in African nonhuman primates can explain speci...

journal_title：AIDS research and human retroviruses

authors： Müller-Trutwin MC,Corbet S,Hansen J,Georges-Courbot MC,Diop O,Rigoulet J,Barré-Sinoussi F,Fomsgaard A

更新日期：1999-07-01 00:00:00

abstract：:Epstein-Barr virus (EBV) infection is associated with Burkitt's lymphoma (BL) in normal individuals and immunoblastic B cell lymphomas in immunosuppressed or HIV-infected individuals. SCID mice reconstituted with human peripheral blood leukocytes (hu-PBL-SCID) from EBV-seropositive donors also may develop spontaneous ...

journal_title：AIDS research and human retroviruses

authors： Mosier DE,Picchio GR,Kirven MB,Garnier JL,Torbett BE,Baird SM,Kobayashi R,Kipps TJ

更新日期：1992-05-01 00:00:00

abstract：:This study explores whether previous failures on antiretroviral drug regimens preclude the possibility of immune restoration. This was assessed by evaluating T cell subset changes in individuals who received a salvage regimen of highly active antiretroviral therapy (HAART) after initially failing protease inhibitor mo...

journal_title：AIDS research and human retroviruses

authors： Gray CM,Schapiro JM,Winters MA,Merigan TC

更新日期：1998-05-01 00:00:00

abstract：:Cross-sectional laboratory data were used to model the patterns of total lymphocyte count and lymphocyte subpopulation counts among persons with chronic HIV-1 subtype E (CRF01_AE) infection during the 6.5 years preceding death. The data cover 331 HIV-infected decedents from a heterosexual HIV transmission study of 590...

journal_title：AIDS research and human retroviruses

authors： Kingkeow D,Heilig CM,Costello C,Sennun S,Suriyanon V,Rungruengthanakit K,Taejaroenkul S,Nelson KE,Duerr A

更新日期：2004-06-01 00:00:00

abstract：:The clinical significance of the reduced in vitro susceptibility of HIV to antiretroviral agents has been difficult to elucidate for nucleoside analogs such as zidovudine. However, the virological significance of resistance to nevirapine and other HIV-1-specific reverse transcriptase inhibitors has been established. W...

journal_title：AIDS research and human retroviruses

authors： Richman DD

更新日期：1994-08-01 00:00:00

abstract：:Changes in neutralizing antibody (NA) titers in stored sera collected over 5 years from 10 participants in the Multicenter AIDS Cohort Study (MACS) were evaluated. The participants were HIV-1 infected on enrollment in the MACS, and remained AIDS free during the 5-year study interval. Seven viruses derived from molecul...

journal_title：AIDS research and human retroviruses

authors： Quinnan GV Jr,Zhang PF,Fu DW,Dong M,Margolick JB

更新日期：1998-07-20 00:00:00

abstract：:Abstract We assessed the viral envelope (V3-V5 region) sequence diversity from 13 HIV-1-infected Indian children from north India. All of the 13 children were found to be infected with subtype C viruses. One of the viral sequences exhibited usage of the CXCR4 coreceptor predicted by Web PSSM and Geno2pheno tools. Th...

journal_title：AIDS research and human retroviruses

authors： Prakash SS,Kalra R,Lodha R,Kabra SK,Luthra K

更新日期：2012-05-01 00:00:00

abstract：:We report here the gene for DC-SIGN from Chinese rhesus macaques. DC-SIGN is a C-type lectin expressed by dendritic cells (DCs). It is involved in the interaction of DCs with T cells, and in transmission to T cells of HIV-1 and SIV. Alternative splicing in human DC-SIGN yields A and B isoforms of the protein. The over...

journal_title：AIDS research and human retroviruses

authors： Santos PR,Petitprez K,Butor C

更新日期：2002-09-01 00:00:00

abstract：:To gain more insight into the processes leading to HIV-1 Env-induced cell death, we aim to coexpress stably wild-type and relevant mutant variants of both HIV-1 Env and human CD4 in lymphocyte cell lines. Here we report on the generation and characterization of several cell lines inducibly or constitutively expressing...

journal_title：AIDS research and human retroviruses

authors： Krüger U,Pfeiffer T,Bosch V

更新日期：1996-06-10 00:00:00

abstract：:An increasing number of circulating recombinant forms (CRFs) and unique recombinant forms (URFs) all over the world has necessitated being vigilant about new recombinants. Since the first report of a recombinant virus with an A1/C mosaic in 1998 more and more B/C and A/C recombinant viruses are being reported from Ind...

journal_title：AIDS research and human retroviruses

authors： Pandey S,Tripathy S,Paranjape R

更新日期：2013-09-01 00:00:00

abstract：:We have determined that polymeric IgA in saliva of HIV-1-uninfected individuals binds in varying degrees to components of culture supernatants containing HIV-1 recombinant proteins when ELISA is used for the determination. This finding did not extend to salivary IgG antibodies. Further, such problems were not encounte...

journal_title：AIDS research and human retroviruses

authors： Jackson S,Prince S,Kulhavy R,Mestecky J

更新日期：2000-04-10 00:00:00

abstract：:The immunoreactivity of HTLV-III-infected individuals and virus-inoculated chimpanzees with gp120 synthetic peptides of the HTLV-III gp120 envelope principle neutralizing domain (amino acid 301-324 sequences), derived from the HTLV-III isolates 3B, RF, MN, WMJ2, and SC were determined. Sequential bleeds from an infect...

journal_title：AIDS research and human retroviruses

authors： Devash Y,Matthews TJ,Drummond JE,Javaherian K,Waters DJ,Arthur LO,Blattner WA,Rusche JR

更新日期：1990-03-01 00:00:00

abstract：:HIV-1 and HTLV-1 infect CD4(+) T lymphocyte but little is known about the impact of coinfection on patient's immune response. In this study we have evaluated the spontaneous production of interleukin (IL)-2, IL-4, IL-6, and IL-10 and interferon (IFN)-γ by unstimulated peripheral blood mononuclear cell (PBMC) cultures ...

journal_title：AIDS research and human retroviruses

authors： Abrahão MH,Lima RG,Netto E,Brites C

更新日期：2012-08-01 00:00:00

abstract：:A strain of mouse transgenic for the env gene of the HIV-1 virus was used to study the immunogenicity of a gp160-derived vaccine (the protein encoded by the HIV env gene) and its effect on disease progression. Untreated transgenic mice frequently developed a rapidly progressive renal disease similar to that affecting ...

journal_title：AIDS research and human retroviruses

authors： Shirai A,Klinman DM

更新日期：1993-10-01 00:00:00

abstract：:The mechanisms responsible for the hematopoietic failure in human immunodeficiency virus type 1 (HIV-1)-infected patients are still unknown. Several findings indicate that the in vitro proliferative potential of precursor cells from AIDS patients is reduced. The changes seen in bone marrow (BM) morphology and the defe...

journal_title：AIDS research and human retroviruses

authors： Isgrò A,Mezzaroma I,Aiuti A,De Vita L,Franchi F,Pandolfi F,Alario C,Ficara F,Riva E,Antonelli G,Aiuti F

更新日期：2000-10-10 00:00:00

abstract：:Both chronic hepatitis C and nevirapine (NVP) use are risk factors for transaminase elevation under highly active antiretroviral therapy. NVP is metabolized in the liver and its clearance could be altered in the presence of chronic hepatitis C virus (HCV) infection, enhancing the risk of liver toxicity. We examined NV...

journal_title：AIDS research and human retroviruses

authors： Núñez M,González-Requena D,González-Lahoz J,Soriano V

更新日期：2003-03-01 00:00:00

abstract：:We studied plasma samples from 2082 Mataco Indians living in 22 different communities in the western part of Formosa Province, northern Argentina. Samples were screened for HTLV-I/II antibodies by particle agglutination assay. All positive or borderline samples were then tested by an immunofluorescence assay (IFA) on ...

journal_title：AIDS research and human retroviruses

authors： Biglione M,Vidan O,Mahieux R,de Colombo M,de los Angeles de Basualdo M,Bonnet M,Pankow G,De Efron MA,Zorrilla A,Tekaia F,Murphy E,de Thé G,Gessain A

更新日期：1999-03-20 00:00:00

abstract：:A new model system is delineated that will enable study of CD4 cofactors and gp120 binding proteins other than CD4. We have previously described a nontransformed rat fibroblast cell line that can efficiently produce HIV-1 upon transfection with an HIV-1 infectious clone, in contrast to other nonhuman mammalian cell li...

journal_title：AIDS research and human retroviruses

authors： Mizrachi Y,Rubinstein A,Golodner M,Sakai K,Volsky DJ

更新日期：1996-09-20 00:00:00

abstract：:To investigate how human immunodeficiency virus type 1 (HIV-1) escapes from antibodies directed against the neutralization domain in the third variable region (V3) of gp120, we examined precisely which amino acid contributed to antibody binding. From six HIV-1-infected individuals, sequential sera were tested for anti...

journal_title：AIDS research and human retroviruses

authors： Langedijk JP,Zwart G,Goudsmit J,Meloen RH

更新日期：1995-10-01 00:00:00

abstract：:The Kento-Mwana project was carried out in Pointe Noire, Republic of the Congo, to prevent mother-to-child HIV-1 transmission. To determine the prevalence of different subtypes and transmitted drug resistance-associated mutations, 95 plasma samples were collected at baseline from HIV-1-positive naive pregnant women en...

journal_title：AIDS research and human retroviruses

authors： Bruzzone B,Saladini F,Sticchi L,Mayinda Mboungou FA,Barresi R,Caligiuri P,Calzi A,Zazzi M,Icardi G,Viscoli C,Bisio F

更新日期：2015-08-01 00:00:00