Expression of interleukin-15 and interleukin-15Rα in monocytes of HIV type 1-infected patients with different courses of disease progression.

abstract：:We aim to determine the prevalence of HIV nonsuppression and factors associated with it. This is a cross-sectional multicenter study carried out in January 2016 with data of the VACH Cohort, a registry participated by 23 hospitals from most regions of Spain. The prevalence of HIV nonsuppression, defined as HIV RNA ≥20...

journal_title：AIDS research and human retroviruses

authors： Roca B,Spanish VACH Cohort Group.

更新日期：2020-11-01 00:00:00

abstract：:Perinatal antiretroviral (ARV) exposure has been related to hyperlactatemia and lactic acidosis in infants born to HIV-infected mothers. Our objective was to determine the incidence of these conditions during the first year of life in uninfected infants born to HIV-infected mothers and compare the data with infants bo...

journal_title：AIDS research and human retroviruses

authors： Soler-Palacín P,Martín-Nalda A,Martínez-Gómez X,Melendo S,Riudor E,Arranz JA,Espiau M,Figueras C

更新日期：2012-08-01 00:00:00

abstract：:The feline immunodeficiency virus (FIV) Rev protein and its cognate sequence the Rev response element (RRE) are essential for virus replication. Thus, the inhibition of either Rev or RRE function can significantly inhibit FIV replication. In the present study, we constructed a ribozyme that targets the RRE sequence an...

journal_title：AIDS research and human retroviruses

authors： Mergia A,Blackwell J,Chari S

更新日期：1997-10-10 00:00:00

abstract：:Signature pattern analysis identifies particular sites in amino acid or nucleic acid alignments of variable sequences that are distinctly representative of a query set of sequences relative to a background set. We explore the merits of using signature patterns for analysis of HIV-1 (human immunodeficiency virus type 1...

journal_title：AIDS research and human retroviruses

authors： Korber B,Myers G

更新日期：1992-09-01 00:00:00

abstract：:Two commercially available expression vectors were modified to generate plasmids pGEXcPk and pQ9cPk. Proteins expressed from pGEXcPk and pQ9cPk had a short oligopeptide tag termed Pk at their carboxy termini and either glutathione S-transferase (GST) or a small histidine (His) tag, respectively, at their N termini. GS...

journal_title：AIDS research and human retroviruses

authors： Hanke T,Botting C,Green EA,Szawlowski PW,Rud E,Randall RE

更新日期：1994-06-01 00:00:00

abstract：:Abstract The effectiveness of any biomedical prevention technology relies on both biological efficacy and behavioral adherence. Microbicide trials have been hampered by low adherence, limiting the ability to draw meaningful conclusions about product effectiveness. Central to this problem may be an inadequate conceptua...

journal_title：AIDS research and human retroviruses

authors： Morrow KM,Fava JL,Rosen RK,Vargas S,Shaw JG,Kojic EM,Kiser PF,Friend DR,Katz DF,Project Link Study Team.

更新日期：2014-01-01 00:00:00

abstract：:Interferon-α (IFN-α) plays a vital role in combating viral infections especially in the early control after infection. However, the HIV infection has shown substantial level of suppression of IFN-α secretion during initial phase of infection. The reasons behind this impairment are still obscure. As plasmacytoid dendri...

journal_title：AIDS research and human retroviruses

authors： Dhamanage AS,Thakar MR,Paranjape RS

更新日期：2019-01-01 00:00:00

abstract：:Most HIV-1 transmissions occur at mucosae and involve exposure to semen. Semen contains immunomodulatory factors, which inhibit anti-HIV-1 natural killer cell and T cell responses. We demonstrate high concentrations (1:2 dilution) of seminal plasma (SP) inhibit monocyte phagocytosis and anti-HIV-1 Fc-dependent functio...

journal_title：AIDS research and human retroviruses

authors： Selva KJ,Juno JA,Worley MJ,Chung AW,Tachedjian G,Kent SJ,Parsons MS

更新日期：2019-06-01 00:00:00

abstract：:Multiple impairments in HIV-1-specific cytotoxic T cells (CTL) have been reported, but derangements in HIV-1-specific CD8+ T-cell chemotaxis have not been described previously. We assessed migration to SDF-1alpha (stromal cell-derived factor 1-alpha) and CX3CL1 in vitro and expression of cognate receptors, CXCR4 and C...

journal_title：AIDS research and human retroviruses

authors： Meditz AL,Schlichtemeier R,Folkvord JM,Givens M,Lesh KC,Ray MG,McCarter MD,Connick E

更新日期：2008-07-01 00:00:00

abstract：:T epitope mapping in human immunodeficiency virus proteins provides a useful tool for AIDS vaccine design. We have previously shown that four peptides selected from the Gag polyprotein of HIV-1 were able to prime mice for in vitro lymphoproliferative responses. These responses were shown to be MHC restricted, and a po...

journal_title：AIDS research and human retroviruses

authors： Vaslin B,Claverie JM,Benveniste O,Barre-Sinoussi FC,Dormont D

更新日期：1994-10-01 00:00:00

abstract：:Vaginal anti-HIV antibody responses may be beneficial, and possibly required, for vaccine-induced protection against HIV infection acquired through receptive vaginal intercourse. We have previously determined that intranasal immunization with a hybrid HIV peptide and cholera toxin induced vaginal anti-HIV IgA response...

journal_title：AIDS research and human retroviruses

authors： Staats HF,Montgomery SP,Palker TJ

更新日期：1997-07-20 00:00:00

abstract：:Abstract In southern Brazil, CRF31_BC is the major HIV-1 recombinant form and URFs_BC occurs very infrequently. The near full-length genomes of four samples displaying a similar recombination profile in the integrase region and different profiles in the protease/reverse transcriptase regions were analyzed to elucidate...

journal_title：AIDS research and human retroviruses

authors： Passaes CP,Guimarães ML,Bello G,Morgado MG

更新日期：2009-12-01 00:00:00

abstract：:Integrase strand transfer inhibitor (InSTI) resistance rates are low. However, genotypic resistance test (GRT) is not routinely performed in many centers. The aim of this study is to evaluate the prevalence of InSTI-related mutations in our large cohort. We examined all integrase GRTs performed as part of routine clin...

journal_title：AIDS research and human retroviruses

authors： De Francesco MA,Izzo I,Properzi M,Gargiulo F,Caccuri F,Quiros-Roldan E,Castelli F,Caruso A,Focà E

更新日期：2018-07-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) infection has altered both the epidemiology and outcome of enteric opportunistic parasitic infections. This study was done to determine the prevalence and species/genotypes of intestinal coccidian and microsporidial infections among HIV/AIDS patients with diarrhea and/or a history of...

journal_title：AIDS research and human retroviruses

authors： Agholi M,Hatam GR,Motazedian MH

更新日期：2013-01-01 00:00:00

abstract：:A model system was established for studies of humoral and cellular immunity to human immunodeficiency virus (HIV) antigens after vaccination. Macaques (Macaca fascicularis) were immunized with purified HIV, an infected cell extract rich in gp120 or polypeptides of cloned genes representing parts of p24, gp41, and gp12...

journal_title：AIDS research and human retroviruses

authors： Wahren B,Chiodi F,Ljunggren K,Putney S,Kurth R,Gallo RC,Fenyö EM

更新日期：1988-06-01 00:00:00

abstract：:High-resolution structures have revealed major pockets in the MHC class II peptide binding groove within a region designated Pl-P9. The region can accommodate 9-mer peptides, consistent with the observation that minimal core helper T (Th) cell determinants are usually eight or nine residues in size. Here we describe m...

journal_title：AIDS research and human retroviruses

authors： Lockey TD,Surman S,Brown S,Slobod KS,Coleclough C,Doherty PC,Hurwitz JL

更新日期：2002-10-10 00:00:00

abstract：:The proportion of human immunodeficiency virus type 1 (HIV-1) among Vietnamese injecting drug users (IDUs) in Melbourne, Australia exceeds that of the background population. To investigate the molecular epidemiology of HIV-1 among this group, the C2-V4 region of the HIV-1 envelope was directly sequenced from 11 Vietna...

journal_title：AIDS research and human retroviruses

authors： Ryan CE,Elliott JH,Middleton T,Mijch AM,Street AC,Hellard M,Crofts N,Crowe SM,Oelrichs RB

更新日期：2004-12-01 00:00:00

abstract：:HTLV-II-specific antibodies, with patterns similar to those in the Americas, were present in sera collected about 1970 from Bambuti pygmies in Zaire (14/102; 14%) and from pygmies in Cameroon (5/214; 2.3%), and were more prevalent than HTLV-I. In the Central African Republic, 504 pygmies were HTLV negative. After find...

journal_title：AIDS research and human retroviruses

authors： Goubau P,Liu HF,De Lange GG,Vandamme AM,Desmyter J

更新日期：1993-08-01 00:00:00

abstract：:Histone deacetylases (HDACs) act on histones within the nucleosome-bound promoter of human immunodeficiency virus type 1 (HIV-1) to maintain proviral latency. HDAC inhibition leads to promoter expression and the escape of HIV from latency. We evaluated the ability of the potent inhibitor recently licensed for use in o...

journal_title：AIDS research and human retroviruses

authors： Archin NM,Espeseth A,Parker D,Cheema M,Hazuda D,Margolis DM

更新日期：2009-02-01 00:00:00

abstract：:Vaginal SHIVSF162P3 acquisition in pigtail macaques (Macaca nemestrina) is dependent on time point during the menstrual cycle. Susceptibility is higher around menstruation and lower at ovulation in mid cycle. This complicates the design of repeat low-dose (RLD) SHIV exposure studies because virus challenges given duri...

journal_title：AIDS research and human retroviruses

authors： Kersh EN,Henning TR,Dobard C,Heneine W,McNicholl JM

更新日期：2015-11-01 00:00:00

abstract：:Cross-sectional laboratory data were used to model the patterns of total lymphocyte count and lymphocyte subpopulation counts among persons with chronic HIV-1 subtype E (CRF01_AE) infection during the 6.5 years preceding death. The data cover 331 HIV-infected decedents from a heterosexual HIV transmission study of 590...

journal_title：AIDS research and human retroviruses

authors： Kingkeow D,Heilig CM,Costello C,Sennun S,Suriyanon V,Rungruengthanakit K,Taejaroenkul S,Nelson KE,Duerr A

更新日期：2004-06-01 00:00:00

abstract：:The HIV epidemic in Russia, one of the world's fastest growing, has been concentrated mostly among people who inject drugs (PWID). We sought to explore the epidemiology of the epidemic in St. Petersburg by sampling from the highest risk groups of PWID and men who have sex with men (MSM) and use viral sequencing data t...

journal_title：AIDS research and human retroviruses

authors： Dukhovlinova E,Masharsky A,Toussova O,Verevochkin S,Solovyeva T,Meringof M,Paintsil E,White E,Barbour R,Heimer R,Kozlov A

更新日期：2015-06-01 00:00:00

abstract：:Previous studies have shown that coinfection of the human T lymphotrophic virus type I (HTLV-I) chronically infected cell line MT4 with human immunodeficiency virus type 1 (HIV-1) results in cells which spontaneously activate complement via the classical pathway. This complement activation was antibody independent, ye...

journal_title：AIDS research and human retroviruses

authors： Spear GT,Jiang HX,Sullivan BL,Gewurz H,Landay AL,Lint TF

更新日期：1991-07-01 00:00:00

abstract：:Two cynomolgus macaques were infected with a genetically complex challenge stock of simian immunodeficiency virus (SIVmac251-32H). The polymerase chain reaction (PCR) was used to amplify the env gp41, rev, and nef overlapping coding sequences from provirus present in the blood of both animals at 1, 6, and 15 months po...

journal_title：AIDS research and human retroviruses

authors： Slade A,Jones S,Almond N,Kitchin P

更新日期：1993-02-01 00:00:00

abstract：:Circulating HIV antigens and HIV specific antibodies in sera of experimentally infected chimpanzees were monitored by ELISA immunoassay, Western blot, and radioimmunoprecipitation procedures. Three of three chimpanzees given plasma from patients with AIDS or ARC tested positive for HIV antigens beginning six to ten we...

journal_title：AIDS research and human retroviruses

authors： Saxinger C,Alter HJ,Eichberg JW,Fauci AS,Robey WG,Gallo RC

更新日期：1987-01-01 00:00:00

abstract：:Monocytes are known as an alternative target for HIV/SIV infection, but the contribution of monocytes to viral spread in a host is unclear. In this study, CD14 monocytes were monitored in 6 macaques until six weeks postinfection (wpi) with SIVmac239 to evaluate their contribution to viral load. The monocyte count in b...

journal_title：AIDS research and human retroviruses

authors： Kuwata T,Kodama M,Sato A,Suzuki H,Miyazaki Y,Miura T,Hayami M

更新日期：2007-03-01 00:00:00

abstract：:Mutant HIV virions, encoding C-terminally truncated Env proteins, exhibit a cell-specific replication defect, i.e., they can replicate in a few T cell lines (termed permissive cells) but not in the majority of T cell lines (termed nonpermissive cells). We have studied the properties of two mutant virions (pNL-Tr712 an...

journal_title：AIDS research and human retroviruses

authors： Holtkotte D,Pfeiffer T,Bosch V

更新日期：2007-05-01 00:00:00

abstract：:To better understand the emergence of HIV-1 variants in Barbados and the association with transmission modes, we analyzed phylogenetic relationships and genetic variability among HIV-1 strains collected in 1996 from 36 antiretroviral therapy-naive patients. Only subtype B variants were present in this sampling, based ...

journal_title：AIDS research and human retroviruses

authors： Gittens MV,Roth WW,Roach T,Stringer HG Jr,Pieniazek D,Bond VC,Levett PN

更新日期：2003-04-01 00:00:00

abstract：:All-trans-retinoic acid (RA) has been shown either to activate or repress human immunodeficiency virus type 1 (HIV-1) replication in primary monocyte-derived-macrophages (MDMs). We systematically investigated the contribution that cell donor and virus differences make to this variability. We found that the effect of R...

journal_title：AIDS research and human retroviruses

authors： Brown XQ,Hanley TM,Viglianti GA

更新日期：2002-06-10 00:00:00

abstract：:Human T cell leukemia virus protein induces T cells to permanent IL-2-dependent growth. These cells occasionally convert to factor independence. The viral oncoprotein Tax acts as an essential growth factor of transformed lymphocytes and stimulates the cell cycle in the G(1) phase. In T cells and fibroblasts Tax enhanc...

journal_title：AIDS research and human retroviruses

authors： Haller K,Ruckes T,Schmitt I,Saul D,Derow E,Grassmann R

更新日期：2000-11-01 00:00:00