Factors Associated with Nonsuppression of HIV Infection in the Spanish VACH Cohort.

abstract：:Thirty years after its beginning, the HIV/AIDS epidemic is still raging around the world. According to UNAIDS, in 2011 alone 1.7M deaths were attributable to AIDS, and 2.5M people were newly infected by the virus. Despite the success in treating HIV-infected people with potent antiretroviral drugs, preventing HIV infe...

journal_title：AIDS research and human retroviruses

authors： Romano J,Kashuba A,Becker S,Cummins J,Turpin J,Veronese F,Antiretroviral Pharmacology In HIV Prevention Think Tank Participants.

更新日期：2013-11-01 00:00:00

abstract：:Am important aspect of human immunodeficiency virus (HIV-1) infection is the regulation of its expression by nuclear factor kappa B (NF-kappa B) by redox-controlled signal transduction pathways. In this study, we demonstrate that selenium supplementation can effectively increase glutathione peroxidase (GPx) activity i...

journal_title：AIDS research and human retroviruses

authors： Sappey C,Legrand-Poels S,Best-Belpomme M,Favier A,Rentier B,Piette J

更新日期：1994-11-01 00:00:00

abstract：:Replacing the Pseudomonas exotoxin A (PE) cell binding domain with the human immunodeficiency virus (HIV) gp120 binding domain from CD4 yields a hybrid toxin (CD4-PE) with potential therapeutic use in treating acquired immunodeficiency syndrome (AIDS). To find the most therapeutically potent combination of CD4 and PE ...

journal_title：AIDS research and human retroviruses

authors： Winkler G,Jakubowski A,Turner S,Liu T,Burrus B,McGray P,Heanue T,Rosa M,Griffiths BA,Wali A

更新日期：1991-04-01 00:00:00

abstract：:Little is known about the consequences of short cycles of structured treatment interruption or definitive interruption of HAART for both T cell subset dynamics and T lymphoproliferative responses (LPR). Immunological follow-up was performed in 45 early chronical HIV-1-infected patients during short STI cycles during t...

journal_title：AIDS research and human retroviruses

authors： Libois A,López A,Garcia F,Castro P,Maleno MJ,García A,Climent N,Arnedo M,Gallart T,Gatell JM,Plana M

更新日期：2006-07-01 00:00:00

abstract：:Susceptibility to HIV infection was examined in macrophages differentiated from human monocytes by macrophage colony-stimulating factor (M-CSF) or granulocyte/macrophage colony-stimulating factor (GM-CSF). The replication of macrophage-tropic human immunodeficiency virus type-1 (HIV-1), which was determined by reverse...

journal_title：AIDS research and human retroviruses

authors： Matsuda S,Akagawa K,Honda M,Yokota Y,Takebe Y,Takemori T

更新日期：1995-09-01 00:00:00

abstract：:Population genotyping (PG) can underestimate resistance if resistance-containing low abundance variants go undetected. PG and clonal analysis (CA) results were compared in virologic failures (VFs) from a 48-week clinical trial that evaluated once-daily fosamprenavir/ritonavir (FPV/r) 1400 mg/100 mg or atazanavir/riton...

journal_title：AIDS research and human retroviruses

authors： Ross LL,Weinberg WG,DeJesus E,Fischl MA,Horton JH,Pappa KA,Lancaster CT,Pakes GE,Smith KY

更新日期：2010-04-01 00:00:00

abstract：:We studied vertical transmission of feline immunodeficiency virus (FIV) to determine whether it might provide a model with which to study intervention strategies for mother-to-offspring transmission of human immunodeficiency virus (HIV). We found that pregnant cats acutely infected with FIV (FIV-CSU-2771) transmitted ...

journal_title：AIDS research and human retroviruses

authors： O'Neil LL,Burkhard MJ,Diehl LJ,Hoover EA

更新日期：1995-01-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) infection represents a major global health problem, with HIV now recognized as the fourth leading cause of death on a worldwide basis. One approach to developing effective anti- HIV interventions is to identify and understand the molecular mechanisms by which natural genetic variatio...

journal_title：AIDS research and human retroviruses

authors： Donfack J,Buchinsky FJ,Post JC,Ehrlich GD

更新日期：2006-10-01 00:00:00

abstract：:Simian species of Asian and African origin are naturally infected with the simian T cell leukemia virus type I (STLV-I). Like the closely related human T cell leukemia virus type I (HTLV-I), STLV-I is primarily cell associated, and typical infections exhibit low viral burdens. Four macaques experimentally inoculated w...

journal_title：AIDS research and human retroviruses

authors： Liska V,Fultz PN,Su L,Ruprecht RM

更新日期：1997-09-01 00:00:00

abstract：:We have studied a woman with transfusion-acquired HIV who appears to have contained infectious virus to consistently undetectable levels over a 13-year period without antiviral treatment. She received the infected transfusion for intra- and postpartum blood loss immediately after delivery of her second child in 1981. ...

journal_title：AIDS research and human retroviruses

authors： Schwartz D,Sharma U,Busch M,Weinhold K,Matthews T,Lieberman J,Birx D,Farzedagen H,Margolick J,Quinn T

更新日期：1994-12-01 00:00:00

abstract：:Even in the setting of maximally suppressive antiretroviral therapy (ART), HIV persists indefinitely. Several mechanisms might contribute to this persistence, including chronic inflammation and immune dysfunction. In this study, we have explored a preclinical model for the evaluation of potential interventions that mi...

journal_title：AIDS research and human retroviruses

authors： Dunham RM,Gordon SN,Vaccari M,Piatak M,Huang Y,Deeks SG,Lifson J,Franchini G,McCune JM

更新日期：2013-02-01 00:00:00

abstract：:We report the results of an external quality control program, including 17 Italian centers involved in the care of patients infected by HIV, to evaluate CD4 T cell count proficiency and reproducibility. The centers received two commercial stabilized blood preparations, one with "normal" and one with "low" CD4 T cell c...

journal_title：AIDS research and human retroviruses

authors： Martini F,D'Offizi G,Girardi E,Vitale A,Cimini E,Mollicone B,Vlassi C,Aiuti F,Other Members of 2005 Italian CD4 Quality Control Network.

更新日期：2007-06-01 00:00:00

abstract：:The presence of transmitted drug-resistant HIV-1 (TDR) at the time of antiretroviral therapy (ART) initiation is associated with failure to achieve viral load suppression. Rates of TDR in ART-naive patients have been reported from various parts of the world through ongoing national, regional, and global evaluations; h...

journal_title：AIDS research and human retroviruses

authors： MacVeigh MS,Kosmetatos MK,McDonald JE,Reeder JL,Parrish DA,Young TP

更新日期：2013-02-01 00:00:00

abstract：:Evidence derived from studies concerning brain metabolism and brain electrical activity suggests that temporal lobe functioning is impaired in the course of HIV infection. To test the hypothesis of temporal lobe dysfunction in HIV infection, we utilized computerized electroencephalogram (EEG) analysis to evaluate temp...

journal_title：AIDS research and human retroviruses

authors： Grassi B,Locatelli M,Lazzarin A,Scarone S

更新日期：1996-04-10 00:00:00

abstract：:Serum specimens (n = 1899) were assayed for infections with HTLV-I, HTLV-II, and HIV-1 in seven classified groups of normal healthy controls, children, pregnant women, prostitutes, intravenous drug abusers, patients under going hemodialysis, and hemophiliacs in South and North Vietnam. Surprisingly, 125 of 954 samples...

journal_title：AIDS research and human retroviruses

authors： Fukushima Y,Takahashi H,Hall WW,Nakasone T,Nakata S,Song P,Dinh Duc D,Hien B,Nguyen XQ,Ngoc Trinh T

更新日期：1995-05-01 00:00:00

abstract：:We examined risk factors for avascular bone necrosis (AVN) particularly focusing o the question of whether antiretroviral treatment (ART) is associated with the emergence of osteonecrosis. After 11 years of following the entire cohort, 26 patients were found to have AVN. Compared to 260 concurrent HIV-infected control...

journal_title：AIDS research and human retroviruses

authors： Hasse B,Ledergerber B,Egger M,Flepp M,Bachmann S,Bernasconi E,Egger M,Guyot S,Hirschel B,Weber R,Günthard HF,Swiss HIV Cohort Study.

更新日期：2004-09-01 00:00:00

abstract：:The development of HIV vaccines is an urgent priority and there is need to generate reagents representing multiple subtypes that can be used to screen HIV-1-specific responses. We used Aldrithiol-2 (AT-2), a mild oxidizing reagent, to eliminate the infectivity of HIV while maintaining its structure and ability to be p...

journal_title：AIDS research and human retroviruses

authors： Rutebemberwa A,Bess JW Jr,Brown B,Arroyo M,Eller M,Slike B,Polonis V,McCutchan F,Currier JR,Birx D,Robb M,Marovich M,Lifson JD,Cox JH

更新日期：2007-04-01 00:00:00

abstract：:A sequence of four amino acid residues amino-terminal to the only intramolecular disulphide bond of the human immunodeficiency virus type 1 (HIV-1) transmembrane protein gp41 is recognized by an anti-idiotypic antibody (9G5A) raised against another monoclonal antibody (M38), which recognizes the C5 region of gp120. 9G...

journal_title：AIDS research and human retroviruses

authors： Lopalco L,Longhi R,Ciccomascolo F,De Rossi A,Pelagi M,Andronico F,Moore JP,Schulz T,Beretta A,Siccardi AG

更新日期：1993-01-01 00:00:00

abstract：:The chemokine receptor CXCR4 is the main coreceptor used by T-tropic X4 HIV-1 strains to infect its target T cells. It has been proven that the CXCR4 expression level in T cells is strongly up-regulated by interleukin (IL)-4, a Th2-type cytokine that is secreted preferentially in HIV-infected patients in a later stage...

journal_title：AIDS research and human retroviruses

authors： Princen K,Hatse S,Vermeire K,Bridger GJ,Skerlj RT,De Clercq E,Schols D

更新日期：2003-12-01 00:00:00

abstract：:Extensive studies have been carried out on native Amerindian populations living in French Guiana in an attempt to detect human T cell leukemia virus type 2 (HTLV-2). However, the first strain of this virus identified in this region was not detected in these populations, but in a Brazilian woman of Amerindian origin. C...

journal_title：AIDS research and human retroviruses

authors： Kazanji M,Benoit B,Meddeb M,Meertens L,Marty C,Gessain A,Talarmin A

更新日期：2001-04-10 00:00:00

abstract：:To assess the impact of chronic viral liver disease (CVLD) on hospital admissions and death in HIV-infected patients since the introduction of highly active antiretroviral therapy, all hospital charts, from January 1996 to December 2000, in a large HIV/AIDS reference center in Madrid were reviewed. Discharge diagnosis...

journal_title：AIDS research and human retroviruses

authors： Martín-Carbonero L,Soriano V,Valencia E,García-Samaniego J,López M,González-Lahoz J

更新日期：2001-11-01 00:00:00

abstract：:We investigated memory cytotoxic T lymphocyte (CTLm) responses to HIV-1 as a determinant of HIV-1 disease progression, in relation to plasma HIV-1 load and T lymphocyte numbers in a longitudinal study of 14 homosexual men with incident HIV-1 infection. Study participants were selected who exhibited failure of T cell h...

journal_title：AIDS research and human retroviruses

authors： Rinaldo CR Jr,Gupta P,Huang XL,Fan Z,Mullins JI,Gange S,Farzadegan H,Shankarappa R,Muñoz A,Margolick JB

更新日期：1998-11-01 00:00:00

abstract：:CD8+ lymphocytes (CD8 cells) have been shown to inhibit replication of the human immunodeficiency virus (HIV) in vitro when cocultured with HIV-infected CD4+ lymphocytes (CD4 cells). This suppressive effect on HIV replication in experimentally infected CD4 cells has so far been demonstrated only for CD8 cells from HIV...

journal_title：AIDS research and human retroviruses

authors： Røsok B,Voltersvik P,Larsson BM,Albert J,Brinchmann JE,Asjö B

更新日期：1997-01-01 00:00:00

abstract：:DNA vaccines have the potential of giving rise to a potent cell-mediated immune response by inducing intracellular synthesis and subsequent antigenic presentation of encoded antigens. We have tested a DNA vaccine specific for human immunodeficiency virus type 1 (HIV-1) by the injection of animals with expression plasm...

journal_title：AIDS research and human retroviruses

authors： Okuda K,Bukawa H,Hamajima K,Kawamoto S,Sekigawa K,Yamada Y,Tanaka S,Ishi N,Aoki I,Nakamura M

更新日期：1995-08-01 00:00:00

abstract：:Six morphine-dependent and three control macaques were infected with a mixture of SIV/SHIV. Half of the animals in the morphine group developed accelerated disease (rapid progressor) and died within 20 weeks postinfection. The evolution of the envelope gene in the brain of the rapid progressor and morphine-dependent g...

journal_title：AIDS research and human retroviruses

authors： Rivera-Amill V,Noel RJ Jr,Román IR,Flores YG,Buch S,Kumar A

更新日期：2009-05-01 00:00:00

abstract：:A total of 110 HIV-1-positive samples obtained in 1997 (n = 44) and 2000 (n = 66) were genetically characterized in the V3-V5 envelope region and the p24 gag region. The majority of the strains were CRF02-AG (54.3%) or CRF06-cpx (18.1%) in env and gag. More than 9% of the samples were recombinants between CRF02 and CR...

journal_title：AIDS research and human retroviruses

authors： Mamadou S,Montavon C,Ben A,Djibo A,Rabiou S,Mboup S,Delaporte E,Peeters M

更新日期：2002-07-01 00:00:00

abstract：:We tested human immunodeficiency virus type 1 (HIV-1) antibody-positive human sera and sCD4, alone and in combination, for synergistic, additive, or antagonistic effects on blocking of HIV binding and infectivity. Data were analyzed by an application of the median effect principle derived from the law of mass action. ...

journal_title：AIDS research and human retroviruses

authors： Kennedy MS,Orloff S,Ibegbu CC,Odell CD,Maddon PJ,McDougal JS

更新日期：1991-12-01 00:00:00

abstract：:Osteopenia is a common and debilitating side-effect of HAART, yet little is known concerning the effects of HAART on bone metabolism. We reported previously that zidovudine (AZT) stimulates osteoclastogenesis in vitro and causes osteopenia in mice. Here, we confirmed that the AZT-induced osteoclastogenesis is dependen...

journal_title：AIDS research and human retroviruses

authors： Pan G,Kilby M,McDonald JM

更新日期：2006-11-01 00:00:00

abstract：:High-resolution structures have revealed major pockets in the MHC class II peptide binding groove within a region designated Pl-P9. The region can accommodate 9-mer peptides, consistent with the observation that minimal core helper T (Th) cell determinants are usually eight or nine residues in size. Here we describe m...

journal_title：AIDS research and human retroviruses

authors： Lockey TD,Surman S,Brown S,Slobod KS,Coleclough C,Doherty PC,Hurwitz JL

更新日期：2002-10-10 00:00:00

abstract：:Nucleotide sequences for long terminal repeat (LTR), gag, the protease gene, and pol of a human T-lymphotropic virus type 1 (HTLV-1) isolate of probable Caribbean origin (HTLV-1CH) and a Zairian isolate (HTLV-1EL) were determined providing complete proviral sequences for these isolates. These sequences were compared w...

journal_title：AIDS research and human retroviruses

authors： Ratner L,Philpott T,Trowbridge DB

更新日期：1991-11-01 00:00:00