CD8+ T cells from HIV type 1-seronegative individuals suppress virus replication in acutely infected cells.

abstract：:CCR5 has preferentially been used by all circulating HIV-1 subtype C viruses for cell entry. Recently, we reported the highest proportion of CXCR4-utilizing primary isolates among a cohort of 20 South African AIDS patients. This study describes and compares the Env genotypic characteristics from these 20 HIV-1 subtype...

journal_title：AIDS research and human retroviruses

authors： Michler K,Connell BJ,Venter WD,Stevens WS,Capovilla A,Papathanasopoulos MA

更新日期：2008-05-01 00:00:00

abstract：:There is an urgent need for a prophylactic vaccine to protect individuals from AIDS and to help abate the growing epidemic. In October 1993, the Conference on Advances in AIDS Vaccine Development reviewed the state-of-the-art in vaccine research and confirmed both the progress that has been made and the challenges tha...

journal_title：AIDS research and human retroviruses

authors： Johnston MI,Noe JS,Killen JY

更新日期：1994-01-01 00:00:00

abstract：:Previous studies have demonstrated that lopinavir/ritonavir monotherapy maintained plasma HIV-1 RNA suppression in a large proportion of antiretroviral naive subjects. However, more subjects receiving lopinavir/ritonavir monotherapy experienced confirmed virologic rebound >50 copies/ml compared to a standard three-dru...

journal_title：AIDS research and human retroviruses

authors： Campo RE,Da Silva BA,Cotte L,Gathe JC,Gazzard B,Hicks CB,Klein CE,Chiu YL,King MS,Bernstein BM

更新日期：2009-03-01 00:00:00

abstract：:Phylogenetic analysis of partial env sequences of HIV-1 isolates from Cyprus and Greece suggested the existence of a distinct subtype of the virus, designated as I. We examined whether this subtype represents a distinct group, or a mosaic consisting of previously characterized subtypes. The full-length sequences under...

journal_title：AIDS research and human retroviruses

authors： Nasioulas G,Paraskevis D,Magiorkinis E,Theodoridou M,Hatzakis A

更新日期：1999-05-20 00:00:00

abstract：:We generated DNA constructs expressing soluble truncated forms of the envelope of SF162, a neutralization-resistant primary human immunodeficiency virus type 1 isolate, and SF162AV2, a neutralization-susceptible virus derived from SF162 after the deletion of 30 amino acids from the V2 loop. The constructs express the ...

journal_title：AIDS research and human retroviruses

authors： Stamatatos L,Lim M,Cheng-Mayer C

更新日期：2000-07-01 00:00:00

abstract：:Given the rising HIV incidence in men who have sex with men (MSM) despite repeatedly proven effectiveness of oral HIV pre-exposure prophylaxis, behaviorally congruent periodic dosing strategies, such as dosing microbicides as lubricants, are now in demand. Rectal microbicide gel studies largely administer gels using v...

journal_title：AIDS research and human retroviruses

authors： Shieh EC,Weld ED,Fuchs EJ,Hiruy H,Buckheit KW,Buckheit RW Jr,Breakey J,Hendrix CW

更新日期：2017-08-01 00:00:00

abstract：:Eight HIV-2-infected Caucasian men living in the same geographical area in Gipuzkoa (northern Spain) have been identified in the last 5 years. HIV-2 infection in this area is uncommon, and no other cases of HIV-2 infection have been found after extensive testing for HIV-1/2 antibodies. Epidemiological data suggested a...

journal_title：AIDS research and human retroviruses

authors： Cilla G,Rodés B,Pérez-Trallero E,Arrizabalaga J,Soriano V

更新日期：2001-03-20 00:00:00

abstract：:Retroviruses have been suggested as possible pathogenic factors in multiple sclerosis (MS), supported by the observation that endogenous retroviruses are activated in MS patients. Different members of the herpes family of which several are neurotropic have also been suggested as factors in MS pathogenesis. Further, in...

journal_title：AIDS research and human retroviruses

authors： Brudek T,Christensen T,Hansen HJ,Bobecka J,Møller-Larsen A

更新日期：2004-04-01 00:00:00

abstract：:A higher functionality of CD8(+) T cells might contribute to low-level HIV replication in long-term nonprogressors (LTNPs). However, the contrary could also be true, being the function of CD8(+) T cells modulated by HIV replication. We tested whether enhanced HIV replication following antiretroviral therapy interrupti...

journal_title：AIDS research and human retroviruses

authors： López M,Rallón N,Soriano V,Rodríguez I,Valencia E,Labarga P,Moreno V,Vispo E,Roncal F,González-Lahoz J,Benito JM

更新日期：2008-09-01 00:00:00

abstract：:Genotype-based algorithms are valuable tools for the identification of patients eligible for CCR5 inhibitors administration in clinical practice. Among the available methods, geno2pheno[coreceptor] (G2P) is the most used online tool for tropism prediction. This study was conceived to assess if the combination of G2P p...

journal_title：AIDS research and human retroviruses

authors： Montagna C,De Crignis E,Bon I,Re MC,Mezzaroma I,Turriziani O,Graziosi C,Antonelli G

更新日期：2014-12-01 00:00:00

abstract：:Information about the efficacy of antiretroviral drugs in HIV-1 group O strains as well on the virus evolution in terms of resistance development in vivo is very limited. We assessed the clinical, immunological, and virological response to antiretroviral therapy as well as the selection of drug resistance in six HIV-1...

journal_title：AIDS research and human retroviruses

authors： Rodes B,de Mendoza C,Rodgers M,Newell A,Jimenez V,Lopez-Brugada RM,Soriano V

更新日期：2005-07-01 00:00:00

abstract：:To investigate the changes of neutralizing antibodies and viruses during simian and human immunodeficiency virus (SHIV) infection, we examined the cross-neutralizing ability of sequential sera from three macaques infected with SHIV, NM-3rN, and analyzed the sensitivity of the reisolate to neutralizing antibodies. Neut...

journal_title：AIDS research and human retroviruses

authors： Miyazaki Y,Kuwata T,Takehisa J,Hayami M

更新日期：2002-04-10 00:00:00

abstract：:Subunit vaccines based on recombinant proteins have proved useful for inducing antibody responses and they are safe for widespread use because they do not contain any live components. Unfortunately, they do not typically induce the types of cell-mediated immune responses required to control viral pathogens; specifical...

journal_title：AIDS research and human retroviruses

authors： Newman MJ,Munroe KJ,Anderson CA,Murphy CI,Panicali DL,Seals JR,Wu JY,Wyand MS,Kensil CR

更新日期：1994-07-01 00:00:00

abstract：:AIDS is inexorably involving all parts of the country and all strata of society, with 10% of the urban and 3% of the rural population infected with HIV. It is increasingly a disease of women and children. The major cofactors for transmission are also sexually transmitted. For most developing countries, in spite of all...

journal_title：AIDS research and human retroviruses

authors： Pape JW,Deschamps MM,Verdier RI,Jean S,Desvarieux M,Taverne G,Gelin C,Hyppolite PR,Denize J,Mellon R

更新日期：1992-08-01 00:00:00

abstract：:The humoral immune response is a mechanism that potently suppresses or prevents viral infections. However, genetic diversity and resistance to antibody-mediated neutralization are serious obstacles in controlling HIV-1 infection. In this study, we isolated monoclonal antibodies from an SIV-infected macaque by using th...

journal_title：AIDS research and human retroviruses

authors： Kuwata T,Katsumata Y,Takaki K,Miura T,Igarashi T

更新日期：2011-05-01 00:00:00

abstract：:Acquisition of cellular proteins by HIV-1 virions is known to alter the physiology of the virus in vitro. Reported studies of this aspect have been largely limited to transformed T cell lines. In this study, we investigated the incorporation of major histocompatibility antigens (HLAs) on a primary macrophage-tropic is...

journal_title：AIDS research and human retroviruses

authors： Tsai WP,Kung HF,Nara PL

更新日期：1999-01-01 00:00:00

abstract：:Coadministration of pVecB7, a replication-defective SIV DNA vaccine, with interleukin-12 and GM-CSF expression plasmids, induced markedly enhanced control of viral replication and disease-free survival in macaques challenged intrarectally with pathogenic SIVsmE660. Protective mechanisms correlated with broader cell-me...

journal_title：AIDS research and human retroviruses

authors： O'Neill E,Bostik V,Montefiori DC,Kraiselburd E,Villinger F

更新日期：2003-10-01 00:00:00

abstract：:In cell-mediated immunity T cells recognize peptide fragments of the antigenic protein in association with major histocompatibility complex (MHC) proteins. Synthetic 9- to 16-mer peptides have been widely used to identify the region(s) of a protein that act as T cell epitope. Here, we report antigenic peptides identif...

journal_title：AIDS research and human retroviruses

authors： Blazevic V,Ranki A,Krohn KJ

更新日期：1995-11-01 00:00:00

abstract：:We tested human immunodeficiency virus type 1 (HIV-1) antibody-positive human sera and sCD4, alone and in combination, for synergistic, additive, or antagonistic effects on blocking of HIV binding and infectivity. Data were analyzed by an application of the median effect principle derived from the law of mass action. ...

journal_title：AIDS research and human retroviruses

authors： Kennedy MS,Orloff S,Ibegbu CC,Odell CD,Maddon PJ,McDougal JS

更新日期：1991-12-01 00:00:00

abstract：:Mucosal candidiasis is a common complication of HIV infection and HIV-positive women may develop both oropharyngeal and vaginal disease. Colonization with Candida albicans and related species at either site is a common preceding event in asymptomatic women. To examine the molecular epidemiology of colonizing yeast str...

journal_title：AIDS research and human retroviruses

authors： Dahl KM,Keath EJ,Fraser VJ,Powderly WG

更新日期：1997-04-10 00:00:00

abstract：:The HIV-1 Nef protein is known to be secreted, and our group has shown that Nef is secreted from nef-transfected and HIV-1-infected cells in small exosome-like vesicles (d. 40-100 nm). The role of secreted Nef remains to be fully characterized. Thus, it is important to characterize the nature of and the mechanisms reg...

journal_title：AIDS research and human retroviruses

authors： Ali SA,Huang MB,Campbell PE,Roth WW,Campbell T,Khan M,Newman G,Villinger F,Powell MD,Bond VC

更新日期：2010-02-01 00:00:00

abstract：:Recombination contributes substantially to the genetic diversity of HIV-1, and mosaic strains arise frequently, especially in populations in which multiple subtypes circulate. Yunnan, which borders the "Golden triangle" region of Southeast Asia in the south, was considered as the epicenter of China. B, CRF01_AE, CRF07...

journal_title：AIDS research and human retroviruses

authors： Li L,Chen L,Yang S,Liu Y,Li H,Bao Z,Wang Z,Zhuang D,Liu S,Li J

更新日期：2010-06-01 00:00:00

abstract：:Covert vertical transmission of feline immunodeficiency virus (FIV), the feline counterpart of human immunodeficiency virus type 1 (HIV-1), was identified in kittens born to FIV-infected cats. DNA PCR detected FIV gag and env sequences in tissues from kittens nonviable at birth, and in viable kittens monitored postnat...

journal_title：AIDS research and human retroviruses

authors： Allison RW,Hoover EA

更新日期：2003-05-01 00:00:00

abstract：:Analysis of reverse transcriptase (RT) sequences of 382 HIV-1 isolates from untreated and treated patients recruited in JJ Hospital (Mumbai, India) between 2002 and 2008 shows that subtype C is largely predominant (98%) and that non-C sequences cluster with A1, B, CRF01_AE, and CRF06_cpx. ...

journal_title：AIDS research and human retroviruses

authors： Deshpande A,Jauvin V,Pinson P,Jeannot AC,Fleury HJ

更新日期：2009-06-01 00:00:00

abstract：:To investigate the HIV-1 molecular epidemiology among young people (18 to 25 years old) in Hangzhou. Plasma samples from 262 newly diagnosed HIV-1-infected patients were collected between 2009 and 2013 from Hangzhou of Zhejiang province. HIV-1 nucleotide sequences of pol gene regions were amplified using a nested poly...

journal_title：AIDS research and human retroviruses

authors： Zhang W,Chen J,Pan X,Zhang J,Guo Z,Luo Y,Yang J,Xia Y,He L,Xu Y,Xu K,Ding X

更新日期：2017-03-01 00:00:00

abstract：:HIV prevalence in the Limpopo Province has increased rapidly within the past 10 years, as in other parts of South Africa. Little is known about the genetic and biological properties of HIV circulating in this region including the baseline drug resistance profiles. We therefore collected blood samples from 42 HIV-1-inf...

journal_title：AIDS research and human retroviruses

authors： Bessong PO,Larry Obi C,Cilliers T,Choge I,Phoswa M,Pillay C,Papathanasopoulos M,Morris L

更新日期：2005-01-01 00:00:00

abstract：:A comparative study at the genomic and protein level was performed between two immunologically related spumaretroviruses, the human HSRV and the simian SFV6. Cross immunoprecipitation analysis with specific polyclonal and monoclonal antisera indicates shared antigenic determinants. However, restriction analysis of the...

journal_title：AIDS research and human retroviruses

authors： Tobaly-Tapiero J,Santillana-Hayat M,Giron ML,Guillemin MC,Rozain F,Périès J,Emanoil-Ravier R

更新日期：1990-07-01 00:00:00

abstract：:The capacity to neutralize the human immunodeficiency virus (HIV) in vitro was examined in 52 sera obtained from 23 seropositive individuals in addition to 7 negative control sera. Neutralization was measured as the activity of a serum to protect MT-4 cells against the cytopathic effect of HTLV-IIIB. Virus neutralizat...

journal_title：AIDS research and human retroviruses

authors： Wendler I,Bienzle U,Hunsmann G

更新日期：1987-07-01 00:00:00

abstract：:To understand the evolution of HIV-1, the genetic and biological characteristics of viruses that infect persons living in regions in which the virus has been evolving for several decades must be studied. Thus, we investigated teh genetic subtypes, coreceptor usage, and syncytium-inducing ability of viruses in 47 HIV-1...

journal_title：AIDS research and human retroviruses

authors： Zhong P,BUrda S,Konings F,Urbanski M,Ma L,Zekeng L,Ewane L,Agyingi L,Agwara M,Saa,Afane ZE,Kinge T,Zolla-Pazner S,Nyambi P

更新日期：2003-12-01 00:00:00

abstract：:The conditioned medium of a HTLV-I-carrying T cell line HUT-102 showed cytotoxic activity against a mouse fibroblast cell line L-M. We prepared the cDNA library from HUT-102 poly(A)+ RNA and screened it using oligonucleotide probes that correspond to the amino acid sequences conserved in tumor necrosis factor (TNF) an...

journal_title：AIDS research and human retroviruses

authors： Kato S,Miki T,Takahashi N,Ohmori M,Hemmi H,Numao N,Kondo K

更新日期：1989-12-01 00:00:00