HIV rebound after discontinuation of antiretroviral therapy increases and expands HIV-specific CD8+ responses but has no impact on its functionality.

abstract：:An increasing number of circulating recombinant forms (CRFs) and unique recombinant forms (URFs) all over the world has necessitated being vigilant about new recombinants. Since the first report of a recombinant virus with an A1/C mosaic in 1998 more and more B/C and A/C recombinant viruses are being reported from Ind...

journal_title：AIDS research and human retroviruses

authors： Pandey S,Tripathy S,Paranjape R

更新日期：2013-09-01 00:00:00

abstract：:The domain of HIV-2 Vpx previously shown to be important for virion incorporation has been mapped to residues 73--89. Mutational analysis of this domain was employed to further define the sequences important for incorporation into virus-like particles, using a vaccinia virus expression system. Deletion of residues 73-...

journal_title：AIDS research and human retroviruses

authors： Jin L,Zhou Y,Ratner L

更新日期：2001-01-20 00:00:00

abstract：:In this study diverse areas of the autopsied brain of 12 HIV-infected patients with and without dementia were analyzed. All brain samples were obtained at autopsy through prior consent. Env C2-V5 region was PCR amplified and sequenced and compared between different brain regions within the same patient and also betwee...

journal_title：AIDS research and human retroviruses

authors： Shah M,Smit TK,Morgello S,Tourtellotte W,Gelman B,Brew BJ,Saksena NK

更新日期：2006-02-01 00:00:00

abstract：:A highly purified saponin from Q. saponaria (QS-21) was tested in juvenile rhesus macaques for adjuvant activity and toxicity. The QS-21 was tested alone or as part of an experimental subunit HIV-1 vaccine containing a truncated recombinant HIV-1 envelope protein (gp160D) adsorbed to alum. Antibody responses were meas...

journal_title：AIDS research and human retroviruses

authors： Newman MJ,Wu JY,Coughlin RT,Murphy CI,Seals JR,Wyand MS,Kensil CR

更新日期：1992-08-01 00:00:00

abstract：:DC-SIGN, a C-type lection expressed on dendritic cells, enhances HIV-1 infection in cis and in trans. HIV-1 circulating recombinant form (CRF) 07_BC viruses have been the predominant strain found among injection drug users in southern China and Taiwan. The goal of this study was to map the DC-SIGN-interactive domain o...

journal_title：AIDS research and human retroviruses

authors： Liao CF,Wang SF,Lin YT,Ho DD,Chen YM

更新日期：2011-08-01 00:00:00

abstract：:Monocytes are known as an alternative target for HIV/SIV infection, but the contribution of monocytes to viral spread in a host is unclear. In this study, CD14 monocytes were monitored in 6 macaques until six weeks postinfection (wpi) with SIVmac239 to evaluate their contribution to viral load. The monocyte count in b...

journal_title：AIDS research and human retroviruses

authors： Kuwata T,Kodama M,Sato A,Suzuki H,Miyazaki Y,Miura T,Hayami M

更新日期：2007-03-01 00:00:00

abstract：:We have characterized human foamy virus (HFV) proviral DNA and determined HFV expression in a persistent infection model, the Dami megakaryocytic cell line. Molecular studies were performed on parental persistently infected cells (Dami-P), as well as on derived clones (Dami-Cl). We report that in these nonlytic and no...

journal_title：AIDS research and human retroviruses

authors： Wybier-Franqui J,Tobaly-Tapiero J,Coronel A,Giron ML,Chopin-Robert C,Peries J,Emanoil-Ravier R

更新日期：1995-07-01 00:00:00

abstract：:The proportion of human immunodeficiency virus type 1 (HIV-1) among Vietnamese injecting drug users (IDUs) in Melbourne, Australia exceeds that of the background population. To investigate the molecular epidemiology of HIV-1 among this group, the C2-V4 region of the HIV-1 envelope was directly sequenced from 11 Vietna...

journal_title：AIDS research and human retroviruses

authors： Ryan CE,Elliott JH,Middleton T,Mijch AM,Street AC,Hellard M,Crofts N,Crowe SM,Oelrichs RB

更新日期：2004-12-01 00:00:00

abstract：:Transcriptional regulation is critical for the human immunodeficiency virus 1 (HIV-1) life cycle and is the only step at which the virus amplifies the content of its genetic information. Numerous known and still unknown transcriptional factors, both host and viral, regulate HIV-1 gene expression and latency. This arti...

journal_title：AIDS research and human retroviruses

authors： Victoriano AF,Okamoto T

更新日期：2012-02-01 00:00:00

abstract：:HIV-1 infection evokes a vigorous antiviral response that may participate in resolving the initial peak of plasma viremia and maintenance of the asymptomatic state. CD8+ T lymphocytes of HIV-1-infected individuals play a critical role in the cellular anti-HIV response. In agreement with previous reports, we observed a...

journal_title：AIDS research and human retroviruses

authors： Chen CH,Weinhold KJ,Bartlett JA,Bolognesi DP,Greenberg ML

更新日期：1993-11-01 00:00:00

abstract：:HIV-1 CRF07_BC became prevalent in Taiwan after the epidemic among injection drug users (IDUs). We describe a unique recombinant form (URF) consisting of CRF01_AE and CRF07_BC (named URF_0107-H8) genes detected from an IDU. The 8.8 kb near full-length genome of URF_0107-H8 had a CRF01_AE backbone with two CRF07_BC fra...

journal_title：AIDS research and human retroviruses

authors： Lee NY,Wang JC,Lin YC,Wu CJ,Li CW,Li MC,Wang SW,Tseng FC,Ko WC

更新日期：2016-06-01 00:00:00

abstract：:We studied the ability of several polyionic compounds, previously shown to have activity in vitro against human immunodeficiency virus (anti-HIV) to block binding of anti-CD4 and recombinant HIV gp120 to the CD4 receptor on human lymphocytes. We found that Evans blue and aurin tricarboxylic acid could completely inhib...

journal_title：AIDS research and human retroviruses

authors： Weaver JL,Gergely P,Pine PS,Patzer E,Aszalos A

更新日期：1990-09-01 00:00:00

abstract：:HIV subtype characterization is an important tool to monitor the genetic variation of the HIV epidemic. This study investigated the current HIV subtype distribution and recombination among the northern Thai population. An in-house genotypic assay of HIV protease and reverse transcriptase genes was performed on 420 pla...

journal_title：AIDS research and human retroviruses

authors： Praparattanapan J,Tragoolpua Y,Pathom-aree W,Kotarathitithum W,Chaiwarith R,Nuntachit N,Sirisanthana T,Supparatpinyo K

更新日期：2011-11-01 00:00:00

abstract：:DNA vaccines have the potential of giving rise to a potent cell-mediated immune response by inducing intracellular synthesis and subsequent antigenic presentation of encoded antigens. We have tested a DNA vaccine specific for human immunodeficiency virus type 1 (HIV-1) by the injection of animals with expression plasm...

journal_title：AIDS research and human retroviruses

authors： Okuda K,Bukawa H,Hamajima K,Kawamoto S,Sekigawa K,Yamada Y,Tanaka S,Ishi N,Aoki I,Nakamura M

更新日期：1995-08-01 00:00:00

abstract：:Thymulin is a thymic peptide important for the maturation and differentiation of immature thymocytes, which have been found to be depressed in patients with low-level CD4(+) cell recovery despite viral control. Substance use is associated with faster progression of HIV disease, which has been ascribed to poor adherenc...

journal_title：AIDS research and human retroviruses

authors： Rafie C,Campa A,Smith S,Huffman F,Newman F,Baum MK

更新日期：2011-08-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) infection has altered both the epidemiology and outcome of enteric opportunistic parasitic infections. This study was done to determine the prevalence and species/genotypes of intestinal coccidian and microsporidial infections among HIV/AIDS patients with diarrhea and/or a history of...

journal_title：AIDS research and human retroviruses

authors： Agholi M,Hatam GR,Motazedian MH

更新日期：2013-01-01 00:00:00

abstract：:A high incidence of decreased bone mineral density (BMD) has increasingly been associated with HIV infection. In this study mesenchymal stem cell (MSC) and human osteoblast (hOB) cell lines were treated with HIV tat, HIV rev, HIV p55-gag, HIV gp120 and HTLV env (100 ng/ml, 24 h). Cells were then analyzed for calcium d...

journal_title：AIDS research and human retroviruses

authors： Cotter EJ,Malizia AP,Chew N,Powderly WG,Doran PP

更新日期：2007-12-01 00:00:00

abstract：:The HIV-1 reverse transcriptase genes from 37 HIV-1-positive pregnant women attending an antenatal clinical in Soweto, South Africa were sequenced and analyzed for the presence of drug resistance mutations. All women were antiretroviral drug naive, but were being screened as potential participants in clinical trials o...

journal_title：AIDS research and human retroviruses

authors： Pillay C,Bredell H,McIntyre J,Gray G,Morris L

更新日期：2002-05-20 00:00:00

abstract：:In this report we have highlighted only a few examples of the extensive efforts underway to better understand the process of HIV pathogenesis, to develop new therapeutic agents to inhibit virus replication, and to identify strategies to restore damage done to the immune system during HIV disease progression. It is exp...

journal_title：AIDS research and human retroviruses

authors： Miller RH,Turk SR,Black RJ,Bridges S,Sarver N

更新日期：1996-07-01 00:00:00

abstract：:Differences in emergence of HIV resistance between subtypes B and C in vitro and potential implications on tenofovir alafenamide efficacy in vivo were evaluated. Dose escalation resistance selections showed K65R emerging earlier for subtype C viruses in vitro, as previously reported. Viral breakthrough experiments at ...

journal_title：AIDS research and human retroviruses

authors： Cox S,Margot N,Miller M,Callebaut C

更新日期：2018-05-01 00:00:00

abstract：:Our previous studies have indicated that HIV transmission from infected mothers to infants occurs with viruses showing rapid kinetics of replication, and either resistance to maternal neutralizing antibodies or sensitivity to enhancing antibodies. The genotypic patterns that result in these and other phenotypic viral ...

journal_title：AIDS research and human retroviruses

authors： Kliks S,Contag CH,Corliss H,Learn G,Rodrigo A,Wara D,Mullins JI,Levy JA

更新日期：2000-09-01 00:00:00

abstract：:To provide a better understanding of the role of placenta in vertical human immunodeficiency virus (HIV) transmission, we have studied the infection of placental trophoblast in a group of 15 mother-neonate pairs. By nested PCR amplification of the C2V3 env gene region, HIV-1 has been found to infect the placenta in fi...

journal_title：AIDS research and human retroviruses

authors： Zachar V,Zacharova V,Fink T,Thomas RA,King BR,Ebbesen P,Jones TB,Goustin AS

更新日期：1999-12-10 00:00:00

abstract：:Sexual transmission of human immunodeficiency virus provides an efficient mode for virus spread and poses unique challenges to vaccine developers. Host and viral factors that affect transmission have been studied by epidemiological approaches in the human population, and some of these factors have been modeled with ex...

journal_title：AIDS research and human retroviruses

authors： Pauza CD,Horejsh D,Wallace M

更新日期：1998-04-01 00:00:00

abstract：:The gene encoding the major envelope glycoprotein of the HIV-SF2 isolate was engineered for the secretion of recombinant gp120 (rgp120SF2) from permanent Chinese hamster ovary (CHO) cell lines. Cellular production methods were scaled up and a method for purification of the secreted glycoprotein was devised. Mild purif...

journal_title：AIDS research and human retroviruses

authors： Scandella CJ,Kilpatrick J,Lidster W,Parker C,Moore JP,Moore GK,Mann KA,Brown P,Coates S,Chapman B

更新日期：1993-12-01 00:00:00

abstract：:Mucosal candidiasis is a common complication of HIV infection and HIV-positive women may develop both oropharyngeal and vaginal disease. Colonization with Candida albicans and related species at either site is a common preceding event in asymptomatic women. To examine the molecular epidemiology of colonizing yeast str...

journal_title：AIDS research and human retroviruses

authors： Dahl KM,Keath EJ,Fraser VJ,Powderly WG

更新日期：1997-04-10 00:00:00

abstract：:We evaluated the performance of T-SPOT.TB (a commercial interferon gamma release assay) and its accuracy for the diagnosis of active tuberculosis (TB) among HIV-infected subjects with advanced immunodeficiency. In a clinical prospective study, we assessed the performance of T-SPOT.TB for the diagnosis of active TB in ...

journal_title：AIDS research and human retroviruses

authors： Chen J,Sun J,Zhang R,Liu L,Zheng Y,Shen Y,Wang Z,Sun F,Li L,Lu H

更新日期：2011-03-01 00:00:00

abstract：:To design a vaccine that will remain potent against HIV-1, the immunogenic regions in the viral envelope that tend to change as well as those that remain constant over time must be identified. To determine the neutralization profiles of sequential viruses over time and study whether neutralization patterns correlate w...

journal_title：AIDS research and human retroviruses

authors： Nyambi P,Burda S,Urbanski M,Heyndrickx L,Janssens W,Vanham G,Nadas A

更新日期：2008-12-01 00:00:00

abstract：:We studied 123 samples from adult chronic HIV patients initiating HAART from various centers around a newly established clinical trial site in Pretoria. Each sample was sequenced in at least one structural gene (pol, gag, and env) or functional gene (vif, vpr, and vpu). A subset of 25 samples was subjected to near ful...

journal_title：AIDS research and human retroviruses

authors： Musyoki A,Mothapo K,Rakgole J,Lukhwareni A,Bessong P,Selabe G,Bredell H,Williamson C,Mphahlele MJ

更新日期：2012-09-01 00:00:00

abstract：:HIV-infected patients are at increased risk of decreased bone mineral density. Some studies have implicated antiretroviral therapy as a contributor to the decreased bone mineral density seen in treated HIV-1 patients. In this study we explore the interactions between protease inhibitors (PI) and primary human osteobla...

journal_title：AIDS research and human retroviruses

authors： Malizia AP,Cotter E,Chew N,Powderly WG,Doran PP

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:Immune activation, which is accompanied by the production of proinflammatory cytokines, is a strong predictor of disease progression in HIV infection. Inflammation is critical in neuronal damage linked to HIV-associated neurocognitive disorders. METHODS:We examined the relationship between plasma cytokine l...

journal_title：AIDS research and human retroviruses

authors： Ruhanya V,Jacobs GB,Naidoo S,Paul RH,Joska J,Seedat S,Nyandoro G,Engelbrecht S,Glashoff R

更新日期：2021-01-20 00:00:00