Immunogenicity and toxicity testing of an experimental HIV-1 vaccine in nonhuman primates.

abstract：:Human immunodeficiency virus type 1 (HIV-1) proviral DNA sequences in the 5' long terminal repeat (LTR) were examined among 28 drug-naive individuals. Twenty-four subjects had highly conserved LTR sequences, however, more significant changes were observed in the remaining four LTR sequences. These included a 9-bp dele...

journal_title：AIDS research and human retroviruses

authors： Copeland KF,Chen Z,Fiebig M,Ni L,Savoy S,Smaill FM,Rosenthal KL,Kim JE

更新日期：2004-09-01 00:00:00

abstract：:Six morphine-dependent and three control macaques were infected with a mixture of SIV/SHIV. Half of the animals in the morphine group developed accelerated disease (rapid progressor) and died within 20 weeks postinfection. The evolution of the envelope gene in the brain of the rapid progressor and morphine-dependent g...

journal_title：AIDS research and human retroviruses

authors： Rivera-Amill V,Noel RJ Jr,Román IR,Flores YG,Buch S,Kumar A

更新日期：2009-05-01 00:00:00

abstract：:The emergence of T cell-tropic, syncytium-inducing (T-tropic/SI) HIV-1 variants from the background of macrophage-tropic, non-syncytium-inducing (M-tropic/NSI) strains is associated with disease progression in infected individuals. HIV89.6 is a primary isolate with a transitional phenotype: like M-tropic strains it re...

journal_title：AIDS research and human retroviruses

authors： Smyth RJ,Yi Y,Kim FM,Collman RG

更新日期：1997-06-10 00:00:00

abstract：:The U.S. military represents a unique population within the human immunodeficiency virus 1 (HIV-1) pandemic. The last comprehensive study of HIV-1 in members of the U.S. Navy and Marine Corps (Sea Services) was completed in 2000, before large-scale combat operations were taking place. Here, we present molecular charac...

journal_title：AIDS research and human retroviruses

authors： Heipertz RA Jr,Sanders-Buell E,Kijak G,Howell S,Lazzaro M,Jagodzinski LL,Eggleston J,Peel S,Malia J,Armstrong A,Michael NL,Kim JH,O'Connell RJ,Scott PT,Brett-Major DM,Tovanabutra S

更新日期：2013-10-01 00:00:00

abstract：:Eosinophils are granulocytic leukocytes that function in both protective and pathological immune responses. They can be infected by HIV-1, but characterization of the infection has been hindered by lack of a productive cell culture model. In the present study, the unique eosinophilic cell line AML14.3D10 was used as a...

journal_title：AIDS research and human retroviruses

authors： Wooley DP,Peterson KT,Taylor RJ,Paul CC,Baumann MA

更新日期：2000-09-20 00:00:00

abstract：:Il28B single nucleotide polymorphisms were found to influence interferon λ expression, resulting in changes in hepatitis C virus (HCV)-RNA serum levels as well as the HIV-RNA set point prior to combined antiretroviral therapy (cART). To date, there is limited information on the influence of this polymorphism on surviv...

journal_title：AIDS research and human retroviruses

authors： Parczewski M,Bander D,Leszczyszyn-Pynka M,Urbańska A,Socha Ł,Boroń-Kaczmarska A

更新日期：2012-12-01 00:00:00

abstract：:Epidemic modeling suggests that a major scale-up in HIV treatment could have a dramatic impact on HIV incidence. This has led both researchers and policymakers to set a goal of an "AIDS-Free Generation." One of the greatest obstacles to achieving this objective is the number of people with undiagnosed HIV infection. D...

journal_title：AIDS research and human retroviruses

authors： Burns DN,DeGruttola V,Pilcher CD,Kretzschmar M,Gordon CM,Flanagan EH,Duncombe C,Cohen MS

更新日期：2014-03-01 00:00:00

abstract：:Using blood samples from primary HIV-1 infection (PHI) patients obtained in Lyon, France, we characterized the newly transmitted HIV-1 variants in this area during the 1992-1996 period. As PHI samples allowed the precise timing of the transmission event, we were able to date the introduction of non-B subtypes or recom...

journal_title：AIDS research and human retroviruses

authors： Vachot L,Ataman-Onal Y,Terrat C,Durand PY,Ponceau B,Biron F,Verrier B

更新日期：2004-07-01 00:00:00

abstract：:This study explores whether previous failures on antiretroviral drug regimens preclude the possibility of immune restoration. This was assessed by evaluating T cell subset changes in individuals who received a salvage regimen of highly active antiretroviral therapy (HAART) after initially failing protease inhibitor mo...

journal_title：AIDS research and human retroviruses

authors： Gray CM,Schapiro JM,Winters MA,Merigan TC

更新日期：1998-05-01 00:00:00

abstract：:We analyzed the HIV-1 pol gene from patients in Cape Town to determine the genetic diversity of HIV-1 in the region and to assess the baseline HIV-1 resistance level of treatment-naive patients. Plasma was collected prior to the national antiretroviral therapy (ART) program. RNA was extracted, followed by RT-PCR and a...

journal_title：AIDS research and human retroviruses

authors： Jacobs GB,Laten A,van Rensburg EJ,Bodem J,Weissbrich B,Rethwilm A,Preiser W,Engelbrecht S

更新日期：2008-07-01 00:00:00

abstract：:Mutations within the protease gene associated with reduced susceptibility to protease inhibitors have been well documented for HIV-1 group M subtype B strains. In contrast, limited genotypic and phenotypic information is available for the genetically diverse HIV-1 group O strains. Preexisting resistance-associated pol...

journal_title：AIDS research and human retroviruses

authors： Luk KC,Kaptué L,Zekeng L,Soriano V,Gürtler L,Devare SG,Schochetman G,Hackett J Jr

更新日期：2001-11-01 00:00:00

abstract：:Depletion of mitochondrial DNA (mtDNA) and mtDNA-encoded respiratory chain proteins in subcutaneous (SC) fat from patients with HIV lipoatrophy have clearly demonstrated the role of mitochondrial dysfunction in this syndrome. Research in HIV lipoatrophy, however, has been severely hampered by the lack of a suitable su...

journal_title：AIDS research and human retroviruses

authors： Shikuma CM,Gerschenson M,Chow D,Libutti DE,Willis JH,Murray J,Capaldi RA,Marusich M

更新日期：2008-10-01 00:00:00

abstract：:A sharp increase in the number of people living with HIV has been documented in the Philippines. In response, the government has instituted antiretroviral therapy (ART) nationwide through HIV treatment hubs. However, no data presently exist on the status of ART drug-resistance-associated mutations (DRMs). In this stud...

journal_title：AIDS research and human retroviruses

authors： SahBandar IN,Samonte G,Telan E,Siripong N,Belcaid M,Schanzenbach D,Leano S,Chagan-Yasutan H,Hattori T,Shikuma CM,Ndhlovu LC

更新日期：2017-11-01 00:00:00

abstract：:The recombinant virus assay (RVA) is a method for assessing the susceptibility of human immunodeficiency virus type 1 (HIV-1) plasma isolates to antiretroviral drugs. The RVA involves the production of viable virus in vitro by homologous recombination of RT-PCR products from plasma virus with a noninfectious reverse t...

journal_title：AIDS research and human retroviruses

authors： Robinson LH,Myers RE,Snowden BW,Tisdale M,Blair ED

更新日期：2000-08-10 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) viral genes nef and tat play an important role in disease progression. In this study we characterized the Nef and Tat proteins from a group of HLA-B57 typed pediatric perinatally infected long-term survivors (LTS) with ≥10 years of infection. We identified 19 therapy-naive L...

journal_title：AIDS research and human retroviruses

authors： Neogi U,Palchaudhuri R,Bommana S,Shet A

更新日期：2013-12-01 00:00:00

abstract：:A potential strategy to combat the worldwide AIDS epidemic is to develop a vaginal microbicide that prevents the sexual transmission of HIV-1. One approach for preventing vaginal HIV transmission is to block the viral coreceptor CCR5 with naturally occurring chemokine ligands. In this study, we used a cynomolgus macaq...

journal_title：AIDS research and human retroviruses

authors： Kish-Catalone T,Pal R,Parrish J,Rose N,Hocker L,Hudacik L,Reitz M,Gallo R,Devico A

更新日期：2007-01-01 00:00:00

abstract：:We report a novel HIV-1 circulating recombinant form (CRF79_0107) from three epidemiologically unlinked patients through sexual contact in Shanxi province of China. This is the first second-generation circulating recombinant form identified in China. The breakpoint analysis of recombinants showed that CRF79_0107 was c...

journal_title：AIDS research and human retroviruses

authors： Li Y,Feng Y,Li F,Xue Z,Hu J,Xing H,Ruan Y,Shao Y

更新日期：2017-10-01 00:00:00

abstract：:Enfuvirtide (ENF) is the first of a new class of antiretrovirals (ARVs) known as the HIV fusion inhibitors. Two phase III studies of ENF, TORO 1 and TORO 2, demonstrated that ENF given in combination with optimized background (OB) therapy significantly improved virological response, increased the time to virological f...

journal_title：AIDS research and human retroviruses

authors： Hornberger J,Kilby JM,Wintfeld N,Green J

更新日期：2006-03-01 00:00:00

abstract：:Although the breadth of the human immunodeficiency virus type 1 (HIV-1)-specific cellular immune response and its impact on the control of viral replication have already been addressed, reported data have proven controversial. We hypothesize that the nature of targeted epitopes, rather than the simple breadth or magni...

journal_title：AIDS research and human retroviruses

authors： Tarosso LF,Vieira VA,Sauer MM,Tomiyama HI,Kalil J,Kallas EG

更新日期：2017-08-01 00:00:00

abstract：:High-resolution structures have revealed major pockets in the MHC class II peptide binding groove within a region designated Pl-P9. The region can accommodate 9-mer peptides, consistent with the observation that minimal core helper T (Th) cell determinants are usually eight or nine residues in size. Here we describe m...

journal_title：AIDS research and human retroviruses

authors： Lockey TD,Surman S,Brown S,Slobod KS,Coleclough C,Doherty PC,Hurwitz JL

更新日期：2002-10-10 00:00:00

abstract：:In vitro and in vivo studies have demonstrated that HIV can infect thymocytes at different maturational stages and lead to changes in the thymic microenvironment. To determine the effect of HIV on thymic stromal cells and the production of cytokines important in thymocyte development, three types of adherent thymic cu...

journal_title：AIDS research and human retroviruses

authors： Sandborg CI,Imfeld KL,Zaldivar F Jr,Berman MA

更新日期：1994-10-01 00:00:00

abstract：:HLA-A*3303 is one of the common HLA alleles in East and Southeast Asia. Identification of HLA-A*3303-restricted HIV-1 cytotoxic T lymphocyte (CTL) epitopes is therefore required to investigate the immunopathogenesis of AIDS and vaccine development in these areas, where AIDS is rapidly expanding. We attempted to identi...

journal_title：AIDS research and human retroviruses

authors： Hossain MS,Tomiyama H,Inagawa T,Ida S,Oka S,Takiguchi M

更新日期：2003-06-01 00:00:00

abstract：:Peripheral blood mononuclear cell (PBMC) cultures were established from patients with antibody to human immunodeficiency virus (HIV). Asymptomatically infected patients [5 of 19] had significant lymphocyte transformation responses induced in culture by a purified, recombinant envelope glycoprotein (rgp120) from the vi...

journal_title：AIDS research and human retroviruses

authors： Torseth JW,Berman PW,Merigan TC

更新日期：1988-02-01 00:00:00

abstract：:This study seeks to analyze nearly full-length viral genomes for distinct genetic characteristics that are unique to local or regional strains and to identify regions that have high variability or are highly conserved. Nearly full length sequences of seven HIV-1 samples were obtained to ascertain the circulating subty...

journal_title：AIDS research and human retroviruses

authors： Roye ME,Amarakoon II,Hamilton CL,Eyzaguirre LM,Figueroa P,Carr JK

更新日期：2011-01-01 00:00:00

abstract：:The development of HIV vaccines is an urgent priority and there is need to generate reagents representing multiple subtypes that can be used to screen HIV-1-specific responses. We used Aldrithiol-2 (AT-2), a mild oxidizing reagent, to eliminate the infectivity of HIV while maintaining its structure and ability to be p...

journal_title：AIDS research and human retroviruses

authors： Rutebemberwa A,Bess JW Jr,Brown B,Arroyo M,Eller M,Slike B,Polonis V,McCutchan F,Currier JR,Birx D,Robb M,Marovich M,Lifson JD,Cox JH

更新日期：2007-04-01 00:00:00

abstract：:While it is known that selection for specific HIV-1 drug resistance-associated mutations (DRM) occurs following ART failure, the patterns of resistance mutations, reduced susceptibility (RS), and replicative capacity (RC) that appear as the number of major NRTI mutations increases have been less well-studied. These ch...

journal_title：AIDS research and human retroviruses

authors： Ross L,Parkin N,Lanier R

更新日期：2008-04-01 00:00:00

abstract：:The transmembrane envelope (TM) protein gp41 of HIV-1 is an attractive target when designing a vaccine to induce neutralizing antibodies. A few broadly neutralizing antibodies (2F5, 4E10, and 10E8) that target conserved epitopes in the membrane proximal external region (MPER) of gp41 have been isolated from infected i...

journal_title：AIDS research and human retroviruses

authors： Strasz N,Morozov VA,Kreutzberger J,Keller M,Eschricht M,Denner J

更新日期：2014-05-01 00:00:00

abstract：:HIV-1 is capable of mimicking the ligand of integrin α(4)β(7) by displaying a tripeptide mimotope on the V2 region. Through this mimicry HIV can bind the α(4)β(7) integrin and get carried through the lymphocyte proliferation signaling pathway, cell-to-cell adhesion and can migrate to gut-associated lymphoid tissues. T...

journal_title：AIDS research and human retroviruses

authors： He X,Mokili JL,Hong K,Chen J,Wei J,Xin R,Song YH,Feng Y,Jia M,Xing H,Shao Y

更新日期：2011-10-01 00:00:00

abstract：:Diversity of genotypes and prevalence of pretreatment drug resistance (PDR) are challenges for the epidemic control and vaccine development of HIV-1. However, little is known about the situation in Tianjin. Blood samples were collected from newly diagnosed, antiretroviral treatment (ART)-naive HIV/AIDS patients from J...

journal_title：AIDS research and human retroviruses

authors： Zeng R,Ren D,Gong X,Wei M,Gao L,Yu A,Zhang D,Mi Y,Ma P

更新日期：2020-10-01 00:00:00

abstract：:The silent period that follows infection by the human immunodeficiency virus (HIV-1) and precedes seroconversion remains a problem for the screening of blood supply, and knowledge about the mechanism involved in the maintenance of latency is only fragmentary. Using purified nef recombinant protein and six synthetic ne...

journal_title：AIDS research and human retroviruses

authors： Ameisen JC,Guy B,Chamaret S,Loche M,Mouton Y,Neyrinck JL,Khalife J,Leprevost C,Beaucaire G,Boutillon C

更新日期：1989-06-01 00:00:00