Identification and characterization of HLA-A*3303-restricted, HIV type 1 Pol- and Gag-derived cytotoxic T cell epitopes.

abstract：:The genetic diversity of HIV-1 is well documented. Except for the HIV-1 isolate LAV-1BRU, no nucleic acid sequence of a European isolate of HIV-1 has been published to date. To further investigate the extent of the genetic variability and the evolution of HIV-1, we have isolated, cloned, and subsequently sequenced HIV...

journal_title：AIDS research and human retroviruses

authors： Sauermann U,Schneider J,Mous J,Brunckhorst U,Schedel I,Jentsch KD,Hunsmann G

更新日期：1990-06-01 00:00:00

abstract：:It has been proposed that HIV-1-neutralizing 2F5 and 4E10 monoclonal antibodies recognize gp41 ectodomain pretransmembrane sequences in the context of the membrane interface. With the aim of evaluating lipid-bilayer surface effects on recognition, we use phospholipid model systems to investigate the ability of 2F5 and...

journal_title：AIDS research and human retroviruses

authors： Sánchez-Martínez S,Lorizate M,Katinger H,Kunert R,Nieva JL

更新日期：2006-10-01 00:00:00

abstract：:This study seeks to analyze nearly full-length viral genomes for distinct genetic characteristics that are unique to local or regional strains and to identify regions that have high variability or are highly conserved. Nearly full length sequences of seven HIV-1 samples were obtained to ascertain the circulating subty...

journal_title：AIDS research and human retroviruses

authors： Roye ME,Amarakoon II,Hamilton CL,Eyzaguirre LM,Figueroa P,Carr JK

更新日期：2011-01-01 00:00:00

abstract：:Human immunodeficiency virus, type 1 (HIV-1), produces a chronic infection with a long latency before clinical disease. We followed 214 untreated subjects for 12-42 months to study the natural history of HIV infection: 110 were classified as asymptomatic, 11 as AIDS-related complex (ARC), 15 as AIDS with Kaposi's sarc...

journal_title：AIDS research and human retroviruses

authors： Croxson TS,Mathur-Wagh U,Handwerger S,Siroty WE,Kaminisky D,Reagan KJ,Yancovitz SR,Mildvan D

更新日期：1990-04-01 00:00:00

abstract：:The ability to trigger an innate immune response against opportunistic pathogens associated with HIV-1 infection is an important aspect of AIDS pathogenesis. Toll-like receptors (TLRs) play a critical role in innate immunity against pathogens, but in HIV-1 patients coinfected with opportunistic infections, the regulat...

journal_title：AIDS research and human retroviruses

authors： Hernández JC,Arteaga J,Paul S,Kumar A,Latz E,Urcuqui-Inchima S

更新日期：2011-10-01 00:00:00

abstract：:Am important aspect of human immunodeficiency virus (HIV-1) infection is the regulation of its expression by nuclear factor kappa B (NF-kappa B) by redox-controlled signal transduction pathways. In this study, we demonstrate that selenium supplementation can effectively increase glutathione peroxidase (GPx) activity i...

journal_title：AIDS research and human retroviruses

authors： Sappey C,Legrand-Poels S,Best-Belpomme M,Favier A,Rentier B,Piette J

更新日期：1994-11-01 00:00:00

abstract：:Preexposure prophylaxis (PrEP) with antiretroviral drugs constitutes a promising strategy for HIV prevention. Potent PrEP regimens with reverse transcriptase inhibitors can prevent detectable SHIV infection in a repeated low-dose macaque model that resembles human transmission, supporting plans to quickly move this ap...

journal_title：AIDS research and human retroviruses

authors： Kersh EN,Luo W,Adams DR,Mitchell J,Garcia-Lerma JG,Heneine W,Folks TM,Butera S,Otten RA

更新日期：2008-04-01 00:00:00

abstract：:Monocytes are known as an alternative target for HIV/SIV infection, but the contribution of monocytes to viral spread in a host is unclear. In this study, CD14 monocytes were monitored in 6 macaques until six weeks postinfection (wpi) with SIVmac239 to evaluate their contribution to viral load. The monocyte count in b...

journal_title：AIDS research and human retroviruses

authors： Kuwata T,Kodama M,Sato A,Suzuki H,Miyazaki Y,Miura T,Hayami M

更新日期：2007-03-01 00:00:00

abstract：:Studies have demonstrated that HIV-1 isolated from subjects experiencing virologic failure on stavudine (d4T)-containing regimens often contains thymidine analog mutations (TAMs), consisting of reverse transcriptase (RT) mutations M41L, D67N, K70R, L210W, T215Y/F, and K219Q/E, previously associated only with zidovudin...

journal_title：AIDS research and human retroviruses

authors： Ross L,Scarsella A,Raffanti S,Henry K,Becker S,Fisher R,Liao Q,Hirani A,Graham N,St Clair M,Hernandez J,NZT40012 Study Team.

更新日期：2001-08-10 00:00:00

abstract：:With improved survival and aging, more persons living with HIV/AIDS (PLWHA) are at risk for colorectal cancer (CRC). This retrospective longitudinal study evaluated patient characteristics associated with CRC screening in our HIV cohort. Patients were followed beginning at age 50 years during a study period from Janua...

journal_title：AIDS research and human retroviruses

authors： Burkholder GA,Tamhane AR,Appell LE,Willig JH,Saag MS,Raper JL,Westfall AO,Mugavero MJ

更新日期：2015-05-01 00:00:00

abstract：:Cessation of highly active antiretroviral therapy (HAART) in HIV-infected individual leads to a rebound of viral replication due to reactivation of a viral reservoir composed largely of latently infected memory CD4(+) T cells. Efforts to deplete this reservoir have focused on reactivation of transcriptionally silent l...

journal_title：AIDS research and human retroviruses

authors： Jamaluddin MS,Hu PW,Jan Y,Siwak EB,Rice AP

更新日期：2016-02-01 00:00:00

abstract：:It became evident that tenofovir DF (TDF) causes a modest and gradual decline in GFR, however, the impact of long-term use of TDF on tubular function has not been fully evaluated. In 40 patients treated with TDF and 23 patients treated with other NRTIs, urine beta(2)-microglobulin (U-BMG), percentage tubular reabsorpt...

journal_title：AIDS research and human retroviruses

authors： Kinai E,Hanabusa H

更新日期：2009-04-01 00:00:00

abstract：:Retroviruses have been suggested as possible pathogenic factors in multiple sclerosis (MS), supported by the observation that endogenous retroviruses are activated in MS patients. Different members of the herpes family of which several are neurotropic have also been suggested as factors in MS pathogenesis. Further, in...

journal_title：AIDS research and human retroviruses

authors： Brudek T,Christensen T,Hansen HJ,Bobecka J,Møller-Larsen A

更新日期：2004-04-01 00:00:00

abstract：:A high incidence of decreased bone mineral density (BMD) has increasingly been associated with HIV infection. In this study mesenchymal stem cell (MSC) and human osteoblast (hOB) cell lines were treated with HIV tat, HIV rev, HIV p55-gag, HIV gp120 and HTLV env (100 ng/ml, 24 h). Cells were then analyzed for calcium d...

journal_title：AIDS research and human retroviruses

authors： Cotter EJ,Malizia AP,Chew N,Powderly WG,Doran PP

更新日期：2007-12-01 00:00:00

abstract：:To investigate the changes of neutralizing antibodies and viruses during simian and human immunodeficiency virus (SHIV) infection, we examined the cross-neutralizing ability of sequential sera from three macaques infected with SHIV, NM-3rN, and analyzed the sensitivity of the reisolate to neutralizing antibodies. Neut...

journal_title：AIDS research and human retroviruses

authors： Miyazaki Y,Kuwata T,Takehisa J,Hayami M

更新日期：2002-04-10 00:00:00

abstract：:Despite dramatic reduction of the levels of human immunodeficiency virus type I (HIV-1) virions in blood and seminal plasma of infected patients, highly active antiretroviral therapy (HAART) does not eradicate HIV-1. Three patients, with less than 50 copies/ml of plasma viral RNA, were enrolled in this eradication pro...

journal_title：AIDS research and human retroviruses

authors： Nunnari G,Leto D,Sullivan J,Xu Y,Mehlman KE,Kulkosky J,Pomerantz RJ

更新日期：2005-09-01 00:00:00

abstract：:The first open reading frame of the HIV genome has been identified as the gag gene. The proteins encoded by this gene are p17 as the amino-terminal protein, p24 as the middle peptide, and p15 as the carboxyl-terminal end. A monoclonal antibody recognizing an antigenic determinant on a fragment of p15 has been develope...

journal_title：AIDS research and human retroviruses

authors： Veronese FD,Rahman R,Copeland TD,Oroszlan S,Gallo RC,Sarngadharan MG

更新日期：1987-10-01 00:00:00

abstract：:The U.S. military represents a unique population within the human immunodeficiency virus 1 (HIV-1) pandemic. The last comprehensive study of HIV-1 in members of the U.S. Navy and Marine Corps (Sea Services) was completed in 2000, before large-scale combat operations were taking place. Here, we present molecular charac...

journal_title：AIDS research and human retroviruses

authors： Heipertz RA Jr,Sanders-Buell E,Kijak G,Howell S,Lazzaro M,Jagodzinski LL,Eggleston J,Peel S,Malia J,Armstrong A,Michael NL,Kim JH,O'Connell RJ,Scott PT,Brett-Major DM,Tovanabutra S

更新日期：2013-10-01 00:00:00

abstract：:In the context of an emerging aging epidemic affecting people living with HIV (PLWH), we critically discuss existing data regarding two different conceptual models of aging-frailty and intrinsic capacity, respectively, both in a clinical and public health perspective. These constructs have not yet been integrated in t...

journal_title：AIDS research and human retroviruses

authors： Guaraldi G,Milic J

更新日期：2019-11-01 00:00:00

abstract：:Membrane-interactive phospholipids (PLs), previously evaluated for activity against HIV-1 in vitro, are known to affect late steps in viral replication. Studies were done to determine the effects of PL analogs on post-translational processing of HIV-1 proteins, binding of viral surface gp160/gp120 to CD4 receptor, and...

journal_title：AIDS research and human retroviruses

authors： Krugner-Higby L,Goff D,Edwards T,Iyer N,Neufeld J,Kute T,Morris-Natschke S,Ishaq K,Piantadosi C,Kucera LS

更新日期：1995-06-01 00:00:00

abstract：:Evidence derived from studies concerning brain metabolism and brain electrical activity suggests that temporal lobe functioning is impaired in the course of HIV infection. To test the hypothesis of temporal lobe dysfunction in HIV infection, we utilized computerized electroencephalogram (EEG) analysis to evaluate temp...

journal_title：AIDS research and human retroviruses

authors： Grassi B,Locatelli M,Lazzarin A,Scarone S

更新日期：1996-04-10 00:00:00

abstract：:Simian immunodeficiency virus (SIV) variant SIVsmmPBj14 is unique in producing an acutely lethal enteropathic syndrome in pigtail macaques. To determine whether the nature of the PBj14 disease would be attenuated by decreasing virus input and to relate tissue virus burden to the severity of disease, we infected pigtai...

journal_title：AIDS research and human retroviruses

authors： O'Neil SP,Mossman SP,Maul DH,Hoover EA

更新日期：1999-01-20 00:00:00

abstract：:In a cross-sectional study of 926 subjects from 10 drug treatment programs conducted in 1984 in New Jersey, the seroprevalence of human immunodeficiency virus (HIV) was 35% overall; 30% in whites, 33% in hispanics, and 46% in blacks (p = 0.01 for comparison of blacks to non-blacks). Univariate analysis showed the sero...

journal_title：AIDS research and human retroviruses

authors： Caussy D,Weiss SH,Blattner WA,French J,Cantor KP,Ginzburg H,Altman R,Goedert JJ

更新日期：1990-12-01 00:00:00

abstract：:Two cynomolgus macaques were infected with a genetically complex challenge stock of simian immunodeficiency virus (SIVmac251-32H). The polymerase chain reaction (PCR) was used to amplify the env gp41, rev, and nef overlapping coding sequences from provirus present in the blood of both animals at 1, 6, and 15 months po...

journal_title：AIDS research and human retroviruses

authors： Slade A,Jones S,Almond N,Kitchin P

更新日期：1993-02-01 00:00:00

abstract：:Combinations of drugs targeting viral proteins have been used to limit or control drug resistance, which is the most important cause of treatment failure in HIV-1-infected individuals. We suggest an alternative approach, namely to target cellular proteins, which are less prone to mutations than viral proteins. Here we...

journal_title：AIDS research and human retroviruses

authors： Lori F,Malykh AG,Foli A,Maserati R,De Antoni A,Minoli L,Padrini D,Degli Antoni A,Barchi E,Jessen H,Wainberg MA,Gallo RC,Lisziewicz J

更新日期：1997-11-01 00:00:00

abstract：:To investigate HIV-1-related B cell disorders, the quantity of CD27 positive (CD27+) B cells and their CD38, CD95, and bcl-2 intensities were examined by flow cytometry analysis in 16 drug-naive patients, 27 highly active antiretroviral therapy (HAART)-treated patients, and 20 uninfected controls. CD27+ B cells have b...

journal_title：AIDS research and human retroviruses

authors： Chong Y,Ikematsu H,Kikuchi K,Yamamoto M,Murata M,Nishimura M,Nabeshima S,Kashiwagi S,Hayashi J

更新日期：2004-02-01 00:00:00

abstract：:Activation of primary CD4+ T cells induces the CD155, but not the CD112 ligands for the natural killer (NK) cell activation receptor (aNKR) CD226 [DNAX accessory molecule-1 (DNAM-1)]. We hypothesize that HIV productively infects activated CD4+ T cells and makes itself vulnerable to NK cell-mediated lysis when CD155 on...

journal_title：AIDS research and human retroviruses

authors： Davis ZB,Sowrirajan B,Cogswell A,Ward JP,Planelles V,Barker E

更新日期：2017-02-01 00:00:00

abstract：:It is known that transmitted drug resistance (TDR) will most likely emerge in regions where antiretroviral therapy (ART) has been widely available for years. However, after a decade of rapid scale-up of ART in China, there are few data regarding TDR among HIV-infected patients prior to initiating first-line ART in Chi...

journal_title：AIDS research and human retroviruses

authors： Wang X,He C,Xing H,Liao L,Xu X,He J,Liu Y,Ling H,Liang S,Hsi JH,Ruan Y,Shao Y

更新日期：2012-12-01 00:00:00

abstract：:Partial sequences of HIV-1 polymerase from 185 patients, 141 ARV experienced and 44 naive, of gag (p24) and env (C2V3) from a subset of naive cases were evaluated in São Paulo, Brazil. Antiretroviral resistance mutations were detected in 4% of 26 recently (<2 years) infected patients. Polymorphisms at the protease gen...

journal_title：AIDS research and human retroviruses

authors： Brígido LF,Franco HM,Custódio RM,Oliveira CA,P Ferreira JL,Eira M,Bergel F,Araújo F,Carvalheiro JR,Rodrigues R

更新日期：2005-07-01 00:00:00

abstract：:To better understand the emergence of HIV-1 variants in Barbados and the association with transmission modes, we analyzed phylogenetic relationships and genetic variability among HIV-1 strains collected in 1996 from 36 antiretroviral therapy-naive patients. Only subtype B variants were present in this sampling, based ...

journal_title：AIDS research and human retroviruses

authors： Gittens MV,Roth WW,Roach T,Stringer HG Jr,Pieniazek D,Bond VC,Levett PN

更新日期：2003-04-01 00:00:00