Prognostic significance of quantitative levels of HIV p24 binding capacity in HIV infection.

abstract：:Genetic polymorphisms within the MHC encoding region have the strongest impact on HIV disease progression of any in the human genome and provide important clues to the mechanisms of HIV immune control. Few analyses have been undertaken of HLA alleles associated with rapid disease progression. HLA-B*07:02 is an HLA cla...

journal_title：AIDS research and human retroviruses

authors： Kløverpris HN,Adland E,Koyanagi M,Stryhn A,Harndahl M,Matthews PC,Shapiro R,Walker BD,Ndung'u T,Brander C,Takiguchi M,Buus S,Goulder P

更新日期：2014-05-01 00:00:00

abstract：:We partially purified the human immunodeficiency virus (HIV) glycoprotein gp41 from infected H9 cells by immunoaffinity chromatography using a column containing the M25 monoclonal antibody (diMarzo-Veronese et al., 1985). A pH 11.5 buffer worked best for eluting the glycoprotein from this column. The eluted gp41 was u...

journal_title：AIDS research and human retroviruses

authors： Zweig M,Showalter SD,Bladen SV,Gilden RV,Arthur LO,Robey WG,Nara PL,Fischinger PJ

更新日期：1988-02-01 00:00:00

abstract：:We evaluated the effect of drug alternation on human immunodeficiency virus type 1 (HIV-1) suppression and emergence of resistant virus strains in CEM cell cultures. Rapid, that is, twice weekly, alternation of lamivudine and nevirapine (at 0.1 microg/ml) at the time of each subcultivation resulted in a long-term supp...

journal_title：AIDS research and human retroviruses

authors： Balzarini J,De Clercq E

更新日期：2001-11-20 00:00:00

abstract：:HIV type 1 (HIV-1) envelope glycoproteins (Env) mediate virus entry and are the target of neutralizing antibodies. Binding of the metastable HIV-1 Env trimer to the CD4 receptor triggers structural rearrangements that mediate Env conformational transitions from a closed conformation to a more open state through an int...

journal_title：AIDS research and human retroviruses

authors： Flemming J,Wiesen L,Herschhorn A

更新日期：2018-09-01 00:00:00

abstract：:The gene encoding the major envelope glycoprotein of the HIV-SF2 isolate was engineered for the secretion of recombinant gp120 (rgp120SF2) from permanent Chinese hamster ovary (CHO) cell lines. Cellular production methods were scaled up and a method for purification of the secreted glycoprotein was devised. Mild purif...

journal_title：AIDS research and human retroviruses

authors： Scandella CJ,Kilpatrick J,Lidster W,Parker C,Moore JP,Moore GK,Mann KA,Brown P,Coates S,Chapman B

更新日期：1993-12-01 00:00:00

abstract：:We performed an HTLV epidemiological study of 986 individuals from 17 villages from the same state of Salvador, the city with the highest HTLV-1 prevalence in Brazil. The HTLV-1 prevalence was 3.85%, 1.56%, and 1.23% in three villages. Phylogenetic analysis of the LTR region demonstrated that all positive samples anal...

journal_title：AIDS research and human retroviruses

authors： Rego FF,Alcantara LC,Moura Neto JP,Miranda AC,Pereira Ode S,Gonçalves Mde S,Galvão-Castro B

更新日期：2008-05-01 00:00:00

abstract：:To help in the vaccine development, WHO-UNAIDS launched a program for the isolation and characterization of subtype C viruses, the most prevalent HIV-1 subtype in the world. Isolates were obtained from Brazil, China, India, Israel, and South Africa, countries in which these strains are circulating. In this study we ge...

journal_title：AIDS research and human retroviruses

authors： Sánchez-Merino V,Herrero CC,Amorin-Nink A,von Briesen H,López-Galíndez C,World Health Organization-UNAIDS Network for Isolation and Characterization.

更新日期：2003-01-01 00:00:00

abstract：:Integrase strand transfer inhibitor (InSTI) resistance rates are low. However, genotypic resistance test (GRT) is not routinely performed in many centers. The aim of this study is to evaluate the prevalence of InSTI-related mutations in our large cohort. We examined all integrase GRTs performed as part of routine clin...

journal_title：AIDS research and human retroviruses

authors： De Francesco MA,Izzo I,Properzi M,Gargiulo F,Caccuri F,Quiros-Roldan E,Castelli F,Caruso A,Focà E

更新日期：2018-07-01 00:00:00

abstract：:Analysis of reverse transcriptase (RT) sequences of 382 HIV-1 isolates from untreated and treated patients recruited in JJ Hospital (Mumbai, India) between 2002 and 2008 shows that subtype C is largely predominant (98%) and that non-C sequences cluster with A1, B, CRF01_AE, and CRF06_cpx. ...

journal_title：AIDS research and human retroviruses

authors： Deshpande A,Jauvin V,Pinson P,Jeannot AC,Fleury HJ

更新日期：2009-06-01 00:00:00

abstract：:Serum samples collected prospectively between 1982 and 1987 from a cohort of homosexual men were analyzed for HIV-1 neutralizing antibodies. Seven seroconverters who became infected between 1982 and 1984 and 12 seroprevalents who were already seropositive in 1982 remained free of AIDS. During the 6 year period, 1 sero...

journal_title：AIDS research and human retroviruses

authors： Robert-Guroff M,Goedert JJ,Naugle CJ,Jennings AM,Blattner WA,Gallo RC

更新日期：1988-10-01 00:00:00

abstract：:We examined the sera from 14 HIV-1 seroconverters for the presence of autoantibodies against CD4. Anti-CD4 antibodies were detected in the serum of 11 of 13 HIV-1-infected persons at the time of HIV-1 seroconversion. In 6 of 14 persons from whom a serum was obtained prior to HIV-1 seroconversion, anti-CD4 antibodies w...

journal_title：AIDS research and human retroviruses

authors： Keiser P,Keay S,Wasserman S,Wecksler W

更新日期：1992-11-01 00:00:00

abstract：:This retrospective and longitudinal study evaluated the long-term hepatic tolerance of a nelfinavir (NFV)-antiretroviral combined regimen in 82 patients of the HCV-HIV Cohort of CISIH-Sud of Marseilles. Follow-up data (liver enzyme levels, CD4 cell count, HIV viral load, and metabolic parameters) of patients treated w...

journal_title：AIDS research and human retroviruses

authors： Poizot-Martin I,Marimoutou C,Drogoul-Vey MP,Vion-Dury F,Frixon-Marin V,Benhaim S,Poggi P,Gastaut JA

更新日期：2005-10-01 00:00:00

abstract：:We recently reported a novel adhesion pathway in lymphocytes that is mediated by cyclin-dependent kinase (Cdk) 4 activity and mediates lymphocyte interactions with endothelial matrix. We now demonstrate that HIV-infected lymphocytes also use Cdk4 to mediate spontaneous adhesion to fibronectin and endothelial matrix. W...

journal_title：AIDS research and human retroviruses

authors： Chow YH,Liu L,Schwartz B,Harlan JM,Schnapp LM

更新日期：2012-12-01 00:00:00

abstract：:We studied plasma samples from 2082 Mataco Indians living in 22 different communities in the western part of Formosa Province, northern Argentina. Samples were screened for HTLV-I/II antibodies by particle agglutination assay. All positive or borderline samples were then tested by an immunofluorescence assay (IFA) on ...

journal_title：AIDS research and human retroviruses

authors： Biglione M,Vidan O,Mahieux R,de Colombo M,de los Angeles de Basualdo M,Bonnet M,Pankow G,De Efron MA,Zorrilla A,Tekaia F,Murphy E,de Thé G,Gessain A

更新日期：1999-03-20 00:00:00

abstract：:The induction of both neutralizing antibodies and non-neutralizing antibodies with effector functions, for example, antibody-dependent cellular cytotoxicity (ADCC), is desired in the search for effective vaccines against HIV-1. In the pursuit of novel immunogens capable of inducing an efficient antibody response, rabb...

journal_title：AIDS research and human retroviruses

authors： Karlsson I,Borggren M,Jensen SS,Heyndrickx L,Stewart-Jones G,Scarlatti G,Fomsgaard A

更新日期：2018-02-01 00:00:00

abstract：:Chemokine receptors are molecules involved in the fusion of immunodeficiency viruses after their attachment. As chimpanzees are the animal model for infection by HIV-1, we cloned and sequenced chimpanzee CXCR4 and CCR5 from PBMCs. Chimpanzee CXCR4 was found to be identical to human CXCR4, which provides an explanation...

journal_title：AIDS research and human retroviruses

authors： Prétet JL,Zerbib AC,Girard M,Guillet JG,Butor C

更新日期：1997-12-10 00:00:00

abstract：:The human immunodeficiency virus 1 envelope glycoprotein is synthesized as a precursor, gp160, which is subsequently cleaved to generate the external gp120 and the transmembrane gp41. Both of these cleavage products are known to mediate critical functions of the virus. In order to define the best strategy for the deve...

journal_title：AIDS research and human retroviruses

authors： Pasquali JL,Kieny MP,Kolbe H,Christmann D,Knapp AM

更新日期：1990-09-01 00:00:00

abstract：:Preexposure prophylaxis (PrEP) of HIV infection with tenofovir-containing regimens is effective, but plagued by poor adherence in some studies. Options for safe, effective, and acceptable PrEP products, especially for men and women at risk of HIV via receptive anal intercourse (RAI), are needed. We performed a randomi...

journal_title：AIDS research and human retroviruses

authors： Leyva F,Fuchs EJ,Bakshi R,Carballo-Dieguez A,Ventuneac A,Yue C,Caffo B,Du Y,Torbenson M,Li L,Mullin G,Lee L,Rohan L,Anton PA,Hendrix CW

更新日期：2015-11-01 00:00:00

abstract：:We investigated the Th1 protective and regulatory T and B cell (Treg and Breg) responses to pH1N1 monovalent influenza vaccine (IIV1) in HIV-infected pregnant women on combination antiretroviral therapy (cART). Peripheral blood mononuclear cells (PBMCs) from 52 study participants were cryopreserved before and after va...

journal_title：AIDS research and human retroviruses

authors： Weinberg A,Muresan P,Richardson K,Fenton T,Dominguez T,Bloom A,Watts DH,Abzug MJ,Nachman SA,Levin MJ,P1086 Study Team.

更新日期：2015-11-01 00:00:00

abstract：:We studied the ability of several polyionic compounds, previously shown to have activity in vitro against human immunodeficiency virus (anti-HIV) to block binding of anti-CD4 and recombinant HIV gp120 to the CD4 receptor on human lymphocytes. We found that Evans blue and aurin tricarboxylic acid could completely inhib...

journal_title：AIDS research and human retroviruses

authors： Weaver JL,Gergely P,Pine PS,Patzer E,Aszalos A

更新日期：1990-09-01 00:00:00

abstract：:The advent of antiretroviral treatment (ART) has resulted in a dramatic reduction in AIDS-related morbidity and mortality. However, the emergence and spread of antiretroviral drug resistance (DR) threaten to negatively impact treatment regimens and compromise efforts to control the epidemic. It is recommended that sur...

journal_title：AIDS research and human retroviruses

authors： Cheriro W,Kiptoo M,Kikuvi G,Mining S,Emonyi W,Songok E

更新日期：2015-12-01 00:00:00

abstract：:We analyzed the HIV-1 pol gene from patients in Cape Town to determine the genetic diversity of HIV-1 in the region and to assess the baseline HIV-1 resistance level of treatment-naive patients. Plasma was collected prior to the national antiretroviral therapy (ART) program. RNA was extracted, followed by RT-PCR and a...

journal_title：AIDS research and human retroviruses

authors： Jacobs GB,Laten A,van Rensburg EJ,Bodem J,Weissbrich B,Rethwilm A,Preiser W,Engelbrecht S

更新日期：2008-07-01 00:00:00

abstract：:HIV-1 infection causes functional defects in T cells. It also leads to a progressive reduction in numbers of such cells and both CD4+ and CD8+ cells have been reported to undergo apoptosis in culture. A corresponding reduction in B cells has not been described, but these cells are also functionally altered, with repor...

journal_title：AIDS research and human retroviruses

authors： Samuelsson A,Sönnerborg A,Heuts N,Cöster J,Chiodi F

更新日期：1997-08-10 00:00:00

abstract：:Inhibitory factors to human immunodeficiency virus type 1 (HIV-1) in saliva may be responsible for the infrequent isolation of virus from saliva and also may account for the marked infrequency of salivary and/or oral transmission of HIV-1. Incubation of HIV-1 with human saliva followed by addition of the mixture to su...

journal_title：AIDS research and human retroviruses

authors： Archibald DW,Cole GA

更新日期：1990-12-01 00:00:00

abstract：:This study determined the prevalence of human immunodeficiency virus (HIV) infection and its associated factors in female sex workers (FSWs) from the municipality of Bragança in the state of Pará, Brazil. A cross-sectional study using a respondent-driven sampling method was used to investigate 137 FSWs. They were inte...

journal_title：AIDS research and human retroviruses

authors： da Costa LM,Raiol NC,Lisboa BLA,Frade PCR,Blandtt LDS,Silva-Oliveira GC,Machado LFA,Martins LC,Oliveira-Filho AB

更新日期：2019-09-01 00:00:00

abstract：:CCR5 has preferentially been used by all circulating HIV-1 subtype C viruses for cell entry. Recently, we reported the highest proportion of CXCR4-utilizing primary isolates among a cohort of 20 South African AIDS patients. This study describes and compares the Env genotypic characteristics from these 20 HIV-1 subtype...

journal_title：AIDS research and human retroviruses

authors： Michler K,Connell BJ,Venter WD,Stevens WS,Capovilla A,Papathanasopoulos MA

更新日期：2008-05-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) viral genes nef and tat play an important role in disease progression. In this study we characterized the Nef and Tat proteins from a group of HLA-B57 typed pediatric perinatally infected long-term survivors (LTS) with ≥10 years of infection. We identified 19 therapy-naive L...

journal_title：AIDS research and human retroviruses

authors： Neogi U,Palchaudhuri R,Bommana S,Shet A

更新日期：2013-12-01 00:00:00

abstract：:This prospective, open-label, multicenter trial evaluated the effects of once-weekly (qw) epoetin alfa on quality of life (QOL) and hemoglobin (Hb) levels in anemic human immunodeficiency virus (HIV)-infected adult receiving antiretroviral therapy. A total of 650 patients with Hb < or = 11 g/dl received epoetin alfa 4...

journal_title：AIDS research and human retroviruses

authors： Saag MS,Bowers P,Leitz GJ,Levine AM,Community HIV Anemia Management Protocol Sites (CHAMPS) Study Group.

更新日期：2004-10-01 00:00:00

abstract：:We previously reported that passive transfer of a murine V3-specific monoclonal antibody (BAT123) to hu-PBL-SCID mice challenged with HIV-1LAI confers postexposure protection from infection. The role of the Fc fragment of this antibody as well as the involvement of the complement system in protection were evaluated in...

journal_title：AIDS research and human retroviruses

authors： Gauduin MC,Weir R,Fung MS,Koup RA

更新日期：1998-02-10 00:00:00

abstract：:Investigations into the use of baboons as organ donors for human transplant recipients, a procedure called xenotransplantation, have raised the specter of transmitting baboon viruses to humans and possibly establishing new human infectious diseases. Retrospective analysis of tissues from two human transplant recipient...

journal_title：AIDS research and human retroviruses

authors： Allan JS,Broussard SR,Michaels MG,Starzl TE,Leighton KL,Whitehead EM,Comuzzie AG,Lanford RE,Leland MM,Switzer WM,Heneine W

更新日期：1998-07-01 00:00:00