HTLV type 1 molecular study in Brazilian villages with African characteristics giving support to the post-Columbian introduction hypothesis.

abstract：:Analyses of serum samples and blood cells have revealed a dysregulation of the Fas/Fas ligand (FasL) system during HIV infection, which may be related to disease progression. As Fas and FasL have been suggested to participate in brain injury in a variety of CNS disorders, the aim of this study was to determine (1) whe...

journal_title：AIDS research and human retroviruses

authors： Sporer B,Koedel U,Goebel FD,Pfister HW

更新日期：2000-02-10 00:00:00

abstract：:This study seeks to analyze nearly full-length viral genomes for distinct genetic characteristics that are unique to local or regional strains and to identify regions that have high variability or are highly conserved. Nearly full length sequences of seven HIV-1 samples were obtained to ascertain the circulating subty...

journal_title：AIDS research and human retroviruses

authors： Roye ME,Amarakoon II,Hamilton CL,Eyzaguirre LM,Figueroa P,Carr JK

更新日期：2011-01-01 00:00:00

abstract：:The immunoreactivity of HTLV-III-infected individuals and virus-inoculated chimpanzees with gp120 synthetic peptides of the HTLV-III gp120 envelope principle neutralizing domain (amino acid 301-324 sequences), derived from the HTLV-III isolates 3B, RF, MN, WMJ2, and SC were determined. Sequential bleeds from an infect...

journal_title：AIDS research and human retroviruses

authors： Devash Y,Matthews TJ,Drummond JE,Javaherian K,Waters DJ,Arthur LO,Blattner WA,Rusche JR

更新日期：1990-03-01 00:00:00

abstract：:A total of 110 HIV-1-positive samples obtained in 1997 (n = 44) and 2000 (n = 66) were genetically characterized in the V3-V5 envelope region and the p24 gag region. The majority of the strains were CRF02-AG (54.3%) or CRF06-cpx (18.1%) in env and gag. More than 9% of the samples were recombinants between CRF02 and CR...

journal_title：AIDS research and human retroviruses

authors： Mamadou S,Montavon C,Ben A,Djibo A,Rabiou S,Mboup S,Delaporte E,Peeters M

更新日期：2002-07-01 00:00:00

abstract：:Circulating HIV antigens and HIV specific antibodies in sera of experimentally infected chimpanzees were monitored by ELISA immunoassay, Western blot, and radioimmunoprecipitation procedures. Three of three chimpanzees given plasma from patients with AIDS or ARC tested positive for HIV antigens beginning six to ten we...

journal_title：AIDS research and human retroviruses

authors： Saxinger C,Alter HJ,Eichberg JW,Fauci AS,Robey WG,Gallo RC

更新日期：1987-01-01 00:00:00

abstract：:To investigate the changes of neutralizing antibodies and viruses during simian and human immunodeficiency virus (SHIV) infection, we examined the cross-neutralizing ability of sequential sera from three macaques infected with SHIV, NM-3rN, and analyzed the sensitivity of the reisolate to neutralizing antibodies. Neut...

journal_title：AIDS research and human retroviruses

authors： Miyazaki Y,Kuwata T,Takehisa J,Hayami M

更新日期：2002-04-10 00:00:00

abstract：:Evidence derived from studies concerning brain metabolism and brain electrical activity suggests that temporal lobe functioning is impaired in the course of HIV infection. To test the hypothesis of temporal lobe dysfunction in HIV infection, we utilized computerized electroencephalogram (EEG) analysis to evaluate temp...

journal_title：AIDS research and human retroviruses

authors： Grassi B,Locatelli M,Lazzarin A,Scarone S

更新日期：1996-04-10 00:00:00

abstract：:The emergence of T cell-tropic, syncytium-inducing (T-tropic/SI) HIV-1 variants from the background of macrophage-tropic, non-syncytium-inducing (M-tropic/NSI) strains is associated with disease progression in infected individuals. HIV89.6 is a primary isolate with a transitional phenotype: like M-tropic strains it re...

journal_title：AIDS research and human retroviruses

authors： Smyth RJ,Yi Y,Kim FM,Collman RG

更新日期：1997-06-10 00:00:00

abstract：:HLA-A*3303 is one of the common HLA alleles in East and Southeast Asia. Identification of HLA-A*3303-restricted HIV-1 cytotoxic T lymphocyte (CTL) epitopes is therefore required to investigate the immunopathogenesis of AIDS and vaccine development in these areas, where AIDS is rapidly expanding. We attempted to identi...

journal_title：AIDS research and human retroviruses

authors： Hossain MS,Tomiyama H,Inagawa T,Ida S,Oka S,Takiguchi M

更新日期：2003-06-01 00:00:00

abstract：:Vaginal SHIVSF162P3 acquisition in pigtail macaques (Macaca nemestrina) is dependent on time point during the menstrual cycle. Susceptibility is higher around menstruation and lower at ovulation in mid cycle. This complicates the design of repeat low-dose (RLD) SHIV exposure studies because virus challenges given duri...

journal_title：AIDS research and human retroviruses

authors： Kersh EN,Henning TR,Dobard C,Heneine W,McNicholl JM

更新日期：2015-11-01 00:00:00

abstract：:The long-term efficacy of once-daily (qd) fosamprenavir (FPV) 1400 mg boosted by ritonavir 100 mg (FPV/r100) has not been evaluated previously. A 96-week open-label, randomized, multicenter study compared the efficacy/safety of FPV/r100 with FPV 1400 mg boosted by ritonavir 200 mg qd (FPV/r200), plus abacavir/lamivudi...

journal_title：AIDS research and human retroviruses

authors： Hicks CB,DeJesus E,Sloan LM,Sension MG,Wohl DA,Liao Q,Ross LL,Pakes GE,Pappa KA,Lancaster CT,COL100758 Study Team.

更新日期：2009-04-01 00:00:00

abstract：:Previous studies have shown that coinfection of the human T lymphotrophic virus type I (HTLV-I) chronically infected cell line MT4 with human immunodeficiency virus type 1 (HIV-1) results in cells which spontaneously activate complement via the classical pathway. This complement activation was antibody independent, ye...

journal_title：AIDS research and human retroviruses

authors： Spear GT,Jiang HX,Sullivan BL,Gewurz H,Landay AL,Lint TF

更新日期：1991-07-01 00:00:00

abstract：:The prevalence of different HIV-1 subtypes in Spain varies by geographic region. In the present study isolates were collected from 72 newly diagnosed individuals in western Andalucia from 2004 to 2006. Viral sequences were amplified and the subtype diversity and prevalence of resistance mutations in the reverse transc...

journal_title：AIDS research and human retroviruses

authors： McConnell MJ,Docobo-Pérez F,Mata RC,Fernandez-Cuenca F,Viciana P,López-Cortés LF,Trastoy M,Pachón J,Pérez-Romero P

更新日期：2008-06-01 00:00:00

abstract：:Nucleoside analog reverse transcriptase inhibitors (NRTIs) constitute the most commonly used drugs in antiretroviral therapy. NRTIs differ with respect to their host cell toxicity. We compared the in vitro effect of zidovudine (AZT; 2 μg/ml), lamivudine (3TC; 5 μg/ml), stavudine (d4T; 1 μg/ml), and tenofovir (TFV; 1 μ...

journal_title：AIDS research and human retroviruses

authors： Enomoto L,Anderson PL,Li S,Edelstein CL,Weinberg A

更新日期：2011-01-01 00:00:00

abstract：:HIV-1 compartmentalization in the central nervous system (CNS) and its contribution to neurological disease have been well documented. Previous studies were conducted among people infected with subtypes B or C where CNS compartmentalization has been observed when comparing viral sequences in the blood to virus in cere...

journal_title：AIDS research and human retroviruses

authors： Adewumi OM,Dukhovlinova E,Shehu NY,Zhou S,Council OD,Akanbi MO,Taiwo B,Ogunniyi A,Robertson K,Kanyama C,Hosseinipour MC,Swanstrom R

更新日期：2020-06-01 00:00:00

abstract：:Activation of primary CD4+ T cells induces the CD155, but not the CD112 ligands for the natural killer (NK) cell activation receptor (aNKR) CD226 [DNAX accessory molecule-1 (DNAM-1)]. We hypothesize that HIV productively infects activated CD4+ T cells and makes itself vulnerable to NK cell-mediated lysis when CD155 on...

journal_title：AIDS research and human retroviruses

authors： Davis ZB,Sowrirajan B,Cogswell A,Ward JP,Planelles V,Barker E

更新日期：2017-02-01 00:00:00

abstract：:The human T cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T cell leukemia (ATL), an aggressive and fatal leukemia of CD4(+) T lymphocytes, and is also associated with a neurological demyelinating disease, tropical spastic paraparesis. The oncogenic potential of HTLV-1 resides in the 353-aa, 40-kD...

journal_title：AIDS research and human retroviruses

authors： Sharma S,Mamane Y,Grandvaux N,Bartlett J,Petropoulos L,Lin R,Hiscott J

更新日期：2000-11-01 00:00:00

abstract：:Neutralizing antibodies (NA) against HIV-1MN and HIV-1IIIB, and antibodies binding to synthetic peptides (BA) derived from the gp120 envelope V3 region principal neutralizing determinants (PND) of the HIV-1MN, HIV-1IIIB, and HIV-1Z3 virus strains were assayed in HIV-1 antibody-positive sera from the United States, Hai...

journal_title：AIDS research and human retroviruses

authors： Carrow EW,Vujcic LK,Glass WL,Seamon KB,Rastogi SC,Hendry RM,Boulos R,Nzila N,Quinnan GV Jr

更新日期：1991-10-01 00:00:00

abstract：:HGP-30-KLH vaccine in alum at doses of 10, 25, 50, and 100 micrograms/kg administered intramuscularly at weeks 0, 4, and 10 appear well-tolerated clinically. Local pain at the injection site, appears to be the main clinical toxicity. Laboratory parameters are not affected by administration of the vaccine candidate exc...

journal_title：AIDS research and human retroviruses

authors： Kahn JO,Stites DP,Scillian J,Murcar N,Stryker R,Volberding PA,Naylor PH,Goldstein AL,Sarin PS,Simmon VF

更新日期：1992-08-01 00:00:00

abstract：:Despite the considerable progress that has been made in identifying cellular factors and pathways that contribute to establishment and maintenance of the latent HIV reservoir, it remains the major obstacle to eradicating this virus. Most recently, noncoding genes have been implicated in regulation of HIV expression. I...

journal_title：AIDS research and human retroviruses

authors： Heinson AI,Woo J,Mukim A,White CH,Moesker B,Bosque A,Spina CA,Woelk CH,Macarthur BD,Beliakova-Bethell N

更新日期：2020-11-10 00:00:00

abstract：:Our previous studies have indicated that HIV transmission from infected mothers to infants occurs with viruses showing rapid kinetics of replication, and either resistance to maternal neutralizing antibodies or sensitivity to enhancing antibodies. The genotypic patterns that result in these and other phenotypic viral ...

journal_title：AIDS research and human retroviruses

authors： Kliks S,Contag CH,Corliss H,Learn G,Rodrigo A,Wara D,Mullins JI,Levy JA

更新日期：2000-09-01 00:00:00

abstract：:Peripheral blood mononuclear cell (PBMC) cultures were established from patients with antibody to human immunodeficiency virus (HIV). Asymptomatically infected patients [5 of 19] had significant lymphocyte transformation responses induced in culture by a purified, recombinant envelope glycoprotein (rgp120) from the vi...

journal_title：AIDS research and human retroviruses

authors： Torseth JW,Berman PW,Merigan TC

更新日期：1988-02-01 00:00:00

abstract：:Bacterial vaginosis (BV) has been linked to an increased risk of human immunodeficiency virus (HIV) acquisition and transmission in observational studies, but the underlying biological mechanisms are unknown. We measured biomarkers of subclinical vaginal inflammation, endogenous antimicrobial activity, and vaginal flo...

journal_title：AIDS research and human retroviruses

authors： Thurman AR,Kimble T,Herold B,Mesquita PM,Fichorova RN,Dawood HY,Fashemi T,Chandra N,Rabe L,Cunningham TD,Anderson S,Schwartz J,Doncel G

更新日期：2015-11-01 00:00:00

abstract：:Identifying and monitoring HIV clusters could be useful in tracking the leading edge of HIV transmission in epidemics. Currently, greater specificity in the definition of HIV clusters is needed to reduce confusion in the interpretation of HIV clustering results. We address sampling density as one of the key aspects of...

journal_title：AIDS research and human retroviruses

authors： Novitsky V,Moyo S,Lei Q,DeGruttola V,Essex M

更新日期：2014-12-01 00:00:00

abstract：:Eosinophils are granulocytic leukocytes that function in both protective and pathological immune responses. They can be infected by HIV-1, but characterization of the infection has been hindered by lack of a productive cell culture model. In the present study, the unique eosinophilic cell line AML14.3D10 was used as a...

journal_title：AIDS research and human retroviruses

authors： Wooley DP,Peterson KT,Taylor RJ,Paul CC,Baumann MA

更新日期：2000-09-20 00:00:00

abstract：:"Graying of HIV epidemic" is observed globally, as people living with HIV (PLWH) are aging, due to effectiveness of antiretrovirals. The normal aging processes and HIV-induced immune dysfunction, are potential mechanisms, driving multimorbidity (MM) in PLWH. MM is the concurrent presence of two or more diseases in a s...

journal_title：AIDS research and human retroviruses

authors： Obimakinde AM,Adebusoye L,Achenbach C,Ogunniyi A,Olaleye D

更新日期：2020-03-01 00:00:00

abstract：:For a HIV vaccine to be effective, it will be essential that it protect against the virus variants to which individuals are most frequently exposed. HIV-1 is predominantly a sexually acquired virus, thus, variants in genital secretions are a potentially important reservoir of viruses that are transmitted. Because ther...

journal_title：AIDS research and human retroviruses

authors： Overbaugh J,Anderson RJ,Ndinya-Achola JO,Kreiss JK

更新日期：1996-01-20 00:00:00

abstract：:HIV-1 from infected subjects has been characterized in order to provide a more accurate view of the strains that are currently found in a given region. In this report, we focused on characterizing the pol gene diversity obtained from newly diagnosed patients in Santos metropolitan area, Brazil. This region is composed...

journal_title：AIDS research and human retroviruses

authors： de Sa-Filho DJ,Ambar RF,Duarte NB,Matias RB,Candido V,Gagliani LH,Caseiro MM

更新日期：2009-09-01 00:00:00

abstract：:HIV-1 infection is characterized by genetic diversity, with multiple subtypes and recombinant variants circulating, particularly in sub-Saharan Africa. During the Rwandan genocide, many women experienced multiple rapes and some became HIV-1 infected. We studied plasma and peripheral blood mononuclear cells (PBMCs) fro...

journal_title：AIDS research and human retroviruses

authors： Kemal KS,Anastos K,Weiser B,Ramirez CM,Shi Q,Burger H

更新日期：2013-06-01 00:00:00

abstract：:Preexposure prophylaxis (PrEP) with antiretroviral drugs constitutes a promising strategy for HIV prevention. Potent PrEP regimens with reverse transcriptase inhibitors can prevent detectable SHIV infection in a repeated low-dose macaque model that resembles human transmission, supporting plans to quickly move this ap...

journal_title：AIDS research and human retroviruses

authors： Kersh EN,Luo W,Adams DR,Mitchell J,Garcia-Lerma JG,Heneine W,Folks TM,Butera S,Otten RA

更新日期：2008-04-01 00:00:00