当前位置： SCI文献检索 > AIDS RESEARCH AND HUMAN RETROVIRUSES期刊下所有文献 > CD155 on HIV-Infected Cells Is Not Modulated by HIV-1 Vpu and Nef but Synergizes with NKG2D Ligands to Trigger NK Cell Lysis of Autologous Primary HIV-Infected Cells.

CD155 on HIV-Infected Cells Is Not Modulated by HIV-1 Vpu and Nef but Synergizes with NKG2D Ligands to Trigger NK Cell Lysis of Autologous Primary HIV-Infected Cells.

Abstract：

:Activation of primary CD4+ T cells induces the CD155, but not the CD112 ligands for the natural killer (NK) cell activation receptor (aNKR) CD226 [DNAX accessory molecule-1 (DNAM-1)]. We hypothesize that HIV productively infects activated CD4+ T cells and makes itself vulnerable to NK cell-mediated lysis when CD155 on infected T cells engages DNAM-1. The primary objective of this study is to determine whether CD155 alone or together with NKG2D ligands triggers autologous NK cell lysis of HIV-infected T cells and whether HIV modulates CD155. To determine whether HIV modulates this activation ligand, we infected "activated" CD4+ T cells with HIV in the absence or presence of Nef and/or Vpu and determined by flow cytometry whether they modulated CD155. To determine if CD155 alone, or together with NKG2D ligands, triggered NK cell lysis of autologous HIV-infected T cells, we treated purified NK cells with DNAM-1 and/or NKG2D blocking antibodies before the addition of purified autologous HIV-infected cells in cytolytic assays. Finally, we determined whether DNAM-1 works together with NKG2D as an NK cell coactivation receptor (caNKR) or whether they work independently as aNKRs to induce an NK cell lytic response. We demonstrate that HIV and specifically Nef and/or Vpu do not modulate CD155 on infected primary T cells; and both CD155 and NKG2D ligands synergize as aNKRs to trigger NK cell lysis of the infected cell.

journal_name

AIDS Res Hum Retroviruses

journal_title

AIDS research and human retroviruses

authors

Davis ZB,Sowrirajan B,Cogswell A,Ward JP,Planelles V,Barker E

doi

10.1089/AID.2015.0375

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

93-100

issue

2

eissn

0889-2229

issn

1931-8405

journal_volume

33

pub_type

杂志文章

相关文献

AIDS RESEARCH AND HUMAN RETROVIRUSES文献大全
  • Mapping of Neutralizing Antibody Epitopes on the Envelope of Viruses Obtained from Plasma Samples Exhibiting Broad Cross-Clade Neutralization Potential Against HIV-1.

    abstract：:Several broadly neutralizing antibodies (bNAbs) that can target HIV strains with large degrees of variability have recently been identified. However, efforts to induce synthesis of such bNAbs that can protect against HIV infection have not met with much success. Identification of specific epitopes encoded in the HIV-1...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/AID.2018.0224

    authors： Cheedarla N,Sundaramurthi JC,Hemalatha B,Anangi B,Nesakumar M,Ashokkumar M,Vidya Vijayan KK,Tripathy SP,Swaminathan S,Vaniambadi SK,Ramanathan DV,Hanna LE

    更新日期：2019-02-01 00:00:00

  • HIV type 1 grown on interferon gamma-treated U937 cells shows selective increase in virion-associated intercellular adhesion molecule 1 and HLA-DR and enhanced infectivity for CD4-negative cells.

    abstract：:Cellular adhesion molecules, such as ICAM-1, -2, and -3; LFA-1; and HLA class I and II are incorporated into HIV-1 virions during budding from infected cells. These virion-associated molecules can be involved in the adsorption to susceptible cells displaying the corresponding counterligands. A number of cytokines have...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/aid.1995.11.547

    authors： Castilletti C,Capobianchi MR,Fais S,Abbate I,Ficociello B,Ameglio F,Cordiali Fei P,Santini SM,Dianzani F

    更新日期：1995-05-01 00:00:00

  • Short communication: reversible mitochondrial respiratory chain impairment during symptomatic hyperlactatemia associated with antiretroviral therapy.

    abstract：:Direct evidence confirming the hypothesis that a dysfunction of the mitochondrial respiratory chain (MRC) underlies the pathogenesis of hyperlactatemia associated with highly active antiretroviral therapy (HAART) is scarce. We studied mitochondrial DNA (mtDNA) content and MRC function in the skeletal muscle of an HIV-...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/088922203322588387

    authors： Miró O,López S,Martínez E,Rodríguez-Santiago B,Blanco JL,Milinkovic A,Miró JM,Nunes V,Casademont J,Gatell JM,Cardellach F

    更新日期：2003-11-01 00:00:00

  • Serological and molecular typing of HIV type 1 infection in the Tiriyo tribe, a native Indian community of the Amazon region of Brazil.

    abstract：:The seroprevalence and the occurrence of an HIV-1 subtype was assessed in blood samples of the Tiriyo tribe. Antibody was found in 0.6% and the molecular analysis of the pro region detected the emergence of a subtype B for the first time in a native Indian tribe of the Amazon region of Brazil. ...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/aid.2006.22.1267

    authors： Machado LF,Vallinoto AC,Souza MI,Azevedo VN,Ishak MO,Ishak R

    更新日期：2006-12-01 00:00:00

  • Lower Frailty Is Associated with Successful Cognitive Aging Among Older Adults with HIV.

    abstract：:Aging with HIV poses unique and complex challenges, including avoidance of neurocognitive disorder. Our objective here is to identify the prevalence and predictors of successful cognitive aging (SCA) in a sample of older adults with HIV. One hundred three HIV-infected individuals aged 50 and older were recruited from ...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/AID.2016.0189

    authors： Wallace LM,Ferrara M,Brothers TD,Garlassi S,Kirkland SA,Theou O,Zona S,Mussini C,Moore D,Rockwood K,Guaraldi G

    更新日期：2017-02-01 00:00:00

  • Cytokine genotype suggests a role for inflammation in nucleoside analog-associated sensory neuropathy (NRTI-SN) and predicts an individual's NRTI-SN risk.

    abstract：:Nucleoside analog-associated sensory neuropathy (NRTI-SN) attributed to stavudine, didanosine, or zalcitabine (the dNRTIs) and distal sensory polyneuropathy (DSP) attributed to HIV are clinically indistinguishable. As inflammatory cytokines are involved in DSP, we addressed a role for inflammation in NRTI-SN by determ...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/aid.2007.0168

    authors： Cherry CL,Rosenow A,Affandi JS,McArthur JC,Wesselingh SL,Price P

    更新日期：2008-02-01 00:00:00

  • Conserved HIV-1 Gag p24 Epitopes Elicit Cellular Immune Responses That Impact Disease Outcome.

    abstract：:Although the breadth of the human immunodeficiency virus type 1 (HIV-1)-specific cellular immune response and its impact on the control of viral replication have already been addressed, reported data have proven controversial. We hypothesize that the nature of targeted epitopes, rather than the simple breadth or magni...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/AID.2016.0168

    authors： Tarosso LF,Vieira VA,Sauer MM,Tomiyama HI,Kalil J,Kallas EG

    更新日期：2017-08-01 00:00:00

  • HIV type 1 Nef increases the association of T cell receptor (TCR)-signaling molecules with T cell rafts and promotes activation-induced raft fusion.

    abstract：:HIV-1 Nef (Nef) is a myristoylated protein that contributes to HIV disease pathogenesis. Nef has a modulatory effect on T cell receptor (TCR) signaling, resulting in up-regulation of interleukin-2 (IL-2) production in stimulated T cells. Recent studies have shown that efficient TCR signaling requires enhanced associat...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/088922204323087804

    authors： Djordjevic JT,Schibeci SD,Stewart GJ,Williamson P

    更新日期：2004-05-01 00:00:00

  • New insights into the origin of the HIV type 1 subtype A epidemic in former Soviet Union's countries derived from sequence analyses of preepidemically transmitted viruses.

    abstract：:The HIV-1 subtype A epidemic affecting injecting drug users (IDU) in former Soviet Union (FSU) countries started dramatically in Odessa, southern Ukraine, in 1995, and is caused by a variant of monophyletic origin, often designated IDU-A. We phylogenetically analyzed one near full-length genome and two partial sequenc...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/aid.2007.0166

    authors： Thomson MM,de Parga EV,Vinogradova A,Sierra M,Yakovlev A,Rakhmanova A,Delgado E,Casado G,Muñoz M,Carmona R,Vega Y,Pérez-Alvarez L,Contreras G,Medrano L,Osmanov S,Nájera R

    更新日期：2007-12-01 00:00:00

  • Short communication: persistence of high blood levels of the chemokines CCL2, CCL19, and CCL20 during the course of HIV infection.

    abstract：:Dendritic cells (DCs) are important mediators of the immune response against HIV and yet blood DC numbers fall substantially during HIV infection. Here we report that blood levels of the DC-tissue tropic chemokines monocyte chemotactic protein (MCP-1/CCL2), macrophage inflammatory proteins (MIP-3α/CCL20), and MIP-3β/C...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/aid.2010.0261

    authors： Fontaine J,Poudrier J,Roger M

    更新日期：2011-06-01 00:00:00

  • Mitochondrial oxidative phosphorylation protein levels in peripheral blood mononuclear cells correlate with levels in subcutaneous adipose tissue within samples differing by HIV and lipoatrophy status.

    abstract：:Depletion of mitochondrial DNA (mtDNA) and mtDNA-encoded respiratory chain proteins in subcutaneous (SC) fat from patients with HIV lipoatrophy have clearly demonstrated the role of mitochondrial dysfunction in this syndrome. Research in HIV lipoatrophy, however, has been severely hampered by the lack of a suitable su...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/aid.2007.0262

    authors： Shikuma CM,Gerschenson M,Chow D,Libutti DE,Willis JH,Murray J,Capaldi RA,Marusich M

    更新日期：2008-10-01 00:00:00

  • Identification of a recombinant HTLV-II envelope protein for serological detection of HTLV-II carriers.

    abstract：:To understand the pathogenic potential and the true extent of human T-cell leukemia virus type II (HTLV-II) infection, it is important to develop a specific HTLV-II antigen-based serological test. Plasmid pIIB was constructed and induced in Escherichia coli to express a recombinant protein (RP) containing 140 amino ac...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/aid.1991.7.453

    authors： Chen YM,Essex M

    更新日期：1991-05-01 00:00:00

  • Near full-length genome identification of a novel HIV-1 recombinant form (CRF01_AE/B'/C) among heterosexuals in Jilin, China.

    abstract：:Recombinant forms contribute significantly to the genetic diversity of HIV-1. Here we report a novel HIV-1 recombinant form (CRF01_AE/B'/C) detected from a comprehensive HIV-1 molecular epidemiologic study among heterosexuals in Jilin province of northeastern China. Recombinant analyses of the near full-length genome ...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/aid.2013.0278

    authors： Li X,Ning C,Chen Y,Feng Y,Wei M,Xing H,Shao Y

    更新日期：2014-07-01 00:00:00

  • Simultaneous presence of endogenous retrovirus and herpes virus antigens has profound effect on cell-mediated immune responses: implications for multiple sclerosis.

    abstract：:Retroviruses have been suggested as possible pathogenic factors in multiple sclerosis (MS), supported by the observation that endogenous retroviruses are activated in MS patients. Different members of the herpes family of which several are neurotropic have also been suggested as factors in MS pathogenesis. Further, in...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/088922204323048168

    authors： Brudek T,Christensen T,Hansen HJ,Bobecka J,Møller-Larsen A

    更新日期：2004-04-01 00:00:00

  • Interferon-Free Treatment of Hepatitis C Virus in HIV/Hepatitis C Virus-Coinfected Subjects Results in Increased Serum Low-Density Lipoprotein Concentration.

    abstract：:Chronic hepatitis C virus (HCV) infection is associated with lower serum concentration of low-density lipoprotein (LDL-C), the primary cholesterol metabolite targeted pharmaceutically to modulate cardiovascular risk. Chronic infection with human immunodeficiency virus (HIV) and treatment with antiretrovirals (ARVs) ar...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/AID.2015.0170

    authors： Townsend K,Meissner EG,Sidharthan S,Sampson M,Remaley AT,Tang L,Kohli A,Osinusi A,Masur H,Kottilil S

    更新日期：2016-05-01 00:00:00

  • Tax-dependent stimulation of G1 phase-specific cyclin-dependent kinases and increased expression of signal transduction genes characterize HTLV type 1-transformed T cells.

    abstract：:Human T cell leukemia virus protein induces T cells to permanent IL-2-dependent growth. These cells occasionally convert to factor independence. The viral oncoprotein Tax acts as an essential growth factor of transformed lymphocytes and stimulates the cell cycle in the G(1) phase. In T cells and fibroblasts Tax enhanc...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/08892220050193146

    authors： Haller K,Ruckes T,Schmitt I,Saul D,Derow E,Grassmann R

    更新日期：2000-11-01 00:00:00

  • Isolation, characterization, and sequence analysis of a novel HIV type 1 subtype A1 strain from Russia.

    abstract：:A new syncytia-inducing human immunodeficiency virus type 1 (HIV-1) strain designated PokA79 was first isolated from a peripheral blood mononuclear cells (PBMC) pool from 24 HIV-1-infected patients from Russia and adapted to growth in MT2, MT4, and U937 cell cultures. The full-length genome of this isolate was amplifi...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/AID.2011.0302

    authors： Galkin AN,Bychenko AB,Kuznecovs G,Filinova EY

    更新日期：2012-09-01 00:00:00

  • Increased levels of soluble Fas receptor and Fas ligand in the cerebrospinal fluid of HIV-infected patients.

    abstract：:Analyses of serum samples and blood cells have revealed a dysregulation of the Fas/Fas ligand (FasL) system during HIV infection, which may be related to disease progression. As Fas and FasL have been suggested to participate in brain injury in a variety of CNS disorders, the aim of this study was to determine (1) whe...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/088922200309313

    authors： Sporer B,Koedel U,Goebel FD,Pfister HW

    更新日期：2000-02-10 00:00:00

  • Stimulation of glutathione peroxidase activity decreases HIV type 1 activation after oxidative stress.

    abstract：:Am important aspect of human immunodeficiency virus (HIV-1) infection is the regulation of its expression by nuclear factor kappa B (NF-kappa B) by redox-controlled signal transduction pathways. In this study, we demonstrate that selenium supplementation can effectively increase glutathione peroxidase (GPx) activity i...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/aid.1994.10.1451

    authors： Sappey C,Legrand-Poels S,Best-Belpomme M,Favier A,Rentier B,Piette J

    更新日期：1994-11-01 00:00:00

  • Targeting of a CD8 T cell env epitope presented by HLA-B*5802 is associated with markers of HIV disease progression and lack of selection pressure.

    abstract：:In HIV-infected persons, certain HLA class I alleles are associated with effective control of viremia, while others are associated with rapid disease progression. Among the most divergent clinical outcomes are the relatively good prognosis in HLA-B*5801 expressing persons and poor prognosis with HLA-B*5802. These two ...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/aid.2007.0124

    authors： Ngumbela KC,Day CL,Mncube Z,Nair K,Ramduth D,Thobakgale C,Moodley E,Reddy S,de Pierres C,Mkhwanazi N,Bishop K,van der Stok M,Ismail N,Honeyborne I,Crawford H,Kavanagh DG,Rousseau C,Nickle D,Mullins J,Heckerman D,K

    更新日期：2008-01-01 00:00:00

  • Active immunization of patients with HIV infection: a study of the effect of VaxSyn, a recombinant HIV envelope subunit vaccine, on progression of immunodeficiency.

    abstract：:Infection with the human immunodeficiency virus (HIV) leads to a progressive immunodeficiency characterized by decreasing levels of CD4+ T lymphocytes. VaxSyn, a vaccine based on the recombinant envelope glycoprotein subunit (rgp160) of HIV-1IIIB, was used to immunize HIV-infected patients to determine whether its adm...

    journal_title：AIDS research and human retroviruses

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1089/aid.1998.14.483

    authors： Tsoukas CM,Raboud J,Bernard NF,Montaner JS,Gill MJ,Rachlis A,Fong IW,Schlech W,Djurdjev O,Freedman J,Thomas R,Lafrenière R,Wainberg MA,Cassol S,O'Shaughnessy M,Todd J,Volvovitz F,Smith GE

    更新日期：1998-04-10 00:00:00

  • Evolutionary repair of HIV type 1 gp41 with a kink in the N-terminal helix leads to restoration of the six-helix bundle structure.

    abstract：:The HIV-1 envelope glycoprotein complex (Env) can be stabilized by the introduction of a disulfide bond between the gp120 and gp41 subunits. The resulting protein is monomeric, but trimerization can be improved by the introduction of a single helix-breaking residue at the conserved Ile559 site in the N-terminal heptad...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/0889222041524544

    authors： Sanders RW,Busser E,Moore JP,Lu M,Berkhout B

    更新日期：2004-07-01 00:00:00

  • Increasing impact of chronic viral hepatitis on hospital admissions and mortality among HIV-infected patients.

    abstract：:To assess the impact of chronic viral liver disease (CVLD) on hospital admissions and death in HIV-infected patients since the introduction of highly active antiretroviral therapy, all hospital charts, from January 1996 to December 2000, in a large HIV/AIDS reference center in Madrid were reviewed. Discharge diagnosis...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/08892220152644160

    authors： Martín-Carbonero L,Soriano V,Valencia E,García-Samaniego J,López M,González-Lahoz J

    更新日期：2001-11-01 00:00:00

  • Amplification of simian retroviral sequences from human recipients of baboon liver transplants.

    abstract：:Investigations into the use of baboons as organ donors for human transplant recipients, a procedure called xenotransplantation, have raised the specter of transmitting baboon viruses to humans and possibly establishing new human infectious diseases. Retrospective analysis of tissues from two human transplant recipient...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/aid.1998.14.821

    authors： Allan JS,Broussard SR,Michaels MG,Starzl TE,Leighton KL,Whitehead EM,Comuzzie AG,Lanford RE,Leland MM,Switzer WM,Heneine W

    更新日期：1998-07-01 00:00:00

  • Human retrovirus type 5 sequences in non-Hodgkin's lymphoma of T cell origin.

    abstract：:DNA of a recently described fifth exogenous retrovirus (HRV-5) has been found in blood samples from patients with autoimmune diseases and lymphoma. We analyzed HRV-5 sequence in DNA extracted from whole blood of 17 patients with T cell non-Hodgkin's lymphoma (NHL) and 186 patients with hematological malignancies other...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/088922201750290069

    authors： Kozireva S,Lejniece S,Blomberg J,Murovska M

    更新日期：2001-07-01 00:00:00

  • HIV-1 reverse transcriptase inhibitor from Phyllanthus niruri.

    abstract：:An aqueous extract of Phyllanthus niruri (Euphorbiaceae) inhibited human immunodeficiency virus type-1 reverse transcriptase (HIV-1-RT). The inhibitor against HIV-1-RT in this plant was purified by combination of three column chromatographies, Sephadex LH-20, cellulose, and reverse-phase high-performance liquid chroma...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/aid.1992.8.1937

    authors： Ogata T,Higuchi H,Mochida S,Matsumoto H,Kato A,Endo T,Kaji A,Kaji H

    更新日期：1992-11-01 00:00:00

  • Aggressive adult T cell leukemia/lymphoma: the tip of the iceberg of the hidden human T cell lymphotropic virus type 1 infection burden in nonendemic countries.

    abstract：:Adult T cell leukemia/lymphoma has only rarely been reported in Europe. We aimed to determine the clinical characteristics and outcome of adult T cell leukemia/lymphoma patients in a nonendemic country. Cases of adult T cell leukemia/lymphoma managed at Hospital Universitari Vall d'Hebron, Barcelona, Spain were review...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/AID.2012.0185

    authors： Lopez-Lerma I,Caballero E,Palacio C,Garcia-Patos V

    更新日期：2013-04-01 00:00:00

  • Identification of unusual and novel HIV type 1 spliced transcripts generated in vivo.

    abstract：:HIV-1 transcripts are generated through a complex alternative splicing mechanism, resulting in the production of multiple RNAs coding for each viral protein. HIV-1 RNA splicing has been analyzed mostly in in vitro assays, and in vivo data are scarce. Here we analyze HIV-1 transcripts generated in peripheral blood mono...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/aid.2010.0011

    authors： Carrera C,Pinilla M,Pérez-Alvarez L,Thomson MM

    更新日期：2010-07-01 00:00:00

  • Short communication: human lymphotropic virus type 1 coinfection modulates the synthesis of cytokines by peripheral blood mononuclear cells from HIV type 1-infected individuals.

    abstract：:HIV-1 and HTLV-1 infect CD4(+) T lymphocyte but little is known about the impact of coinfection on patient's immune response. In this study we have evaluated the spontaneous production of interleukin (IL)-2, IL-4, IL-6, and IL-10 and interferon (IFN)-γ by unstimulated peripheral blood mononuclear cell (PBMC) cultures ...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/AID.2011.0192

    authors： Abrahão MH,Lima RG,Netto E,Brites C

    更新日期：2012-08-01 00:00:00

  • Mutations in CCR5-coding sequences are not associated with SIV carrier status in African nonhuman primates.

    abstract：:African monkeys can be naturally infected with SIV but do not progress to AIDS. Since mutations in the human CCR5 gene have been shown to influence susceptibility to HIV infection and disease progression, we have now investigated whether mutations in CCR5-coding sequences in African nonhuman primates can explain speci...

    journal_title：AIDS research and human retroviruses

    pub_type： 杂志文章

    doi：10.1089/088922299310647

    authors： Müller-Trutwin MC,Corbet S,Hansen J,Georges-Courbot MC,Diop O,Rigoulet J,Barré-Sinoussi F,Fomsgaard A

    更新日期：1999-07-01 00:00:00