Aggressive adult T cell leukemia/lymphoma: the tip of the iceberg of the hidden human T cell lymphotropic virus type 1 infection burden in nonendemic countries.

abstract：:This prospective, open-label, multicenter trial evaluated the effects of once-weekly (qw) epoetin alfa on quality of life (QOL) and hemoglobin (Hb) levels in anemic human immunodeficiency virus (HIV)-infected adult receiving antiretroviral therapy. A total of 650 patients with Hb < or = 11 g/dl received epoetin alfa 4...

journal_title：AIDS research and human retroviruses

authors： Saag MS,Bowers P,Leitz GJ,Levine AM,Community HIV Anemia Management Protocol Sites (CHAMPS) Study Group.

更新日期：2004-10-01 00:00:00

abstract：:Epidemic modeling suggests that a major scale-up in HIV treatment could have a dramatic impact on HIV incidence. This has led both researchers and policymakers to set a goal of an "AIDS-Free Generation." One of the greatest obstacles to achieving this objective is the number of people with undiagnosed HIV infection. D...

journal_title：AIDS research and human retroviruses

authors： Burns DN,DeGruttola V,Pilcher CD,Kretzschmar M,Gordon CM,Flanagan EH,Duncombe C,Cohen MS

更新日期：2014-03-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) infection represents a major global health problem, with HIV now recognized as the fourth leading cause of death on a worldwide basis. One approach to developing effective anti- HIV interventions is to identify and understand the molecular mechanisms by which natural genetic variatio...

journal_title：AIDS research and human retroviruses

authors： Donfack J,Buchinsky FJ,Post JC,Ehrlich GD

更新日期：2006-10-01 00:00:00

abstract：:The retroviral integrase protein (IN) is essential for virus replication and, therefore, an attractive target for the development of inhibitors to treat human immunodeficiency virus (HIV) infection. Diverse classes of compounds that are active against this protein have been discovered using in vitro assays. Here we de...

journal_title：AIDS research and human retroviruses

authors： Daniel R,Myers CB,Kulkosky J,Taganov K,Greger JG,Merkel G,Weber IT,Harrison RW,Skalka AM

更新日期：2004-02-01 00:00:00

abstract：:A murine monoclonal antibody (MoAb), VAK 4, has been known to specifically react with a major core protein (p24) as well as with its precursor (p55-57) and intermediate precursor (p40) of human immunodeficiency virus strain IIIB (HTLV-IIIB). Radioimmunoprecipitation assays revealed that VAK 4 MoAb precipitated a major...

journal_title：AIDS research and human retroviruses

authors： Koito A,Hattori T,Matsushita S,Maeda Y,Nozaki C,Sagawa K,Takatsuki K

更新日期：1988-12-01 00:00:00

abstract：:HIV patients beginning antiretroviral therapy (ART) with advanced immunodeficiency often retain low CD4+ T cell counts despite virological control. We examined proliferative responses and upregulation of costimulatory molecules, following anti-CD3 stimulation, in HIV patients with persistent CD4+ T cell deficiency on ...

journal_title：AIDS research and human retroviruses

authors： Tanaskovic S,Price P,French MA,Fernandez S

更新日期：2017-02-01 00:00:00

abstract：:HIV-1 infection causes functional defects in T cells. It also leads to a progressive reduction in numbers of such cells and both CD4+ and CD8+ cells have been reported to undergo apoptosis in culture. A corresponding reduction in B cells has not been described, but these cells are also functionally altered, with repor...

journal_title：AIDS research and human retroviruses

authors： Samuelsson A,Sönnerborg A,Heuts N,Cöster J,Chiodi F

更新日期：1997-08-10 00:00:00

abstract：:HIV-1 infection of tonsils takes place when virus spreads systemically, and may occur when tonsillar tissue serves as the initial portal of HIV-1 entry. The HIV replication cycle includes the production of regulatory and accessory gene mRNAs, produced by splicing of genomic mRNA, that are hallmarks of de novo virus pr...

journal_title：AIDS research and human retroviruses

authors： Brachtel EF,Mascola JR,Wear DJ,Ehrenberg PK,Dayhoff DE,Sanders-Buell E,Michael NL,Frankel SS

更新日期：2002-07-20 00:00:00

abstract：:Benzylated peptides with a primary amino acid sequence corresponding to either human CD4(81-92) (#18), or chimpanzee CD4(81-92) (#18C), were equipotent inhibitors of human immunodeficiency virus type 1 (HIV-1) infection of CD4+ cells and high-affinity binding of 125I-gp120 to CD4+ cells. The chimpanzee-based CD4(81-92...

journal_title：AIDS research and human retroviruses

authors： Lifson JD,Rausch DM,Kalyanaraman VS,Hwang KM,Eiden LE

更新日期：1991-06-01 00:00:00

abstract：:Membrane-interactive phospholipids (PLs), previously evaluated for activity against HIV-1 in vitro, are known to affect late steps in viral replication. Studies were done to determine the effects of PL analogs on post-translational processing of HIV-1 proteins, binding of viral surface gp160/gp120 to CD4 receptor, and...

journal_title：AIDS research and human retroviruses

authors： Krugner-Higby L,Goff D,Edwards T,Iyer N,Neufeld J,Kute T,Morris-Natschke S,Ishaq K,Piantadosi C,Kucera LS

更新日期：1995-06-01 00:00:00

abstract：:C-C chemokine receptor (CCR) 5 (CCR5) is the main HIV-1 coreceptor involved in virus entry and cell-to-cell spread during acute and chronic infections: such CCR5 and T cell tropic viruses are adapted to and replicate in CD4+ memory T cells. Polymorphisms in CCR5 regulate CCR5 expression, which, in turn, influences HIV...

journal_title：AIDS research and human retroviruses

authors： Mehlotra RK

更新日期：2020-10-01 00:00:00

abstract：:Coadministration of pVecB7, a replication-defective SIV DNA vaccine, with interleukin-12 and GM-CSF expression plasmids, induced markedly enhanced control of viral replication and disease-free survival in macaques challenged intrarectally with pathogenic SIVsmE660. Protective mechanisms correlated with broader cell-me...

journal_title：AIDS research and human retroviruses

authors： O'Neill E,Bostik V,Montefiori DC,Kraiselburd E,Villinger F

更新日期：2003-10-01 00:00:00

abstract：:The feline immunodeficiency virus (FIV) Rev protein and its cognate sequence the Rev response element (RRE) are essential for virus replication. Thus, the inhibition of either Rev or RRE function can significantly inhibit FIV replication. In the present study, we constructed a ribozyme that targets the RRE sequence an...

journal_title：AIDS research and human retroviruses

authors： Mergia A,Blackwell J,Chari S

更新日期：1997-10-10 00:00:00

abstract：:It has been proposed that HIV-1-neutralizing 2F5 and 4E10 monoclonal antibodies recognize gp41 ectodomain pretransmembrane sequences in the context of the membrane interface. With the aim of evaluating lipid-bilayer surface effects on recognition, we use phospholipid model systems to investigate the ability of 2F5 and...

journal_title：AIDS research and human retroviruses

authors： Sánchez-Martínez S,Lorizate M,Katinger H,Kunert R,Nieva JL

更新日期：2006-10-01 00:00:00

abstract：:Immunoliposomes containing monoclonal antibodies (MAbs) to the costimulatory molecules CD28 and CTLA4 and their counterreceptors B7-1 (CD80) and B7-2 (CD86) were evaluated for the ability to increase the immune response to recombinant envelope protein rgp120 of the MN strain of human immunodeficiency virus type 1 (HIV...

journal_title：AIDS research and human retroviruses

authors： Ozpolat B,Rao XM,Powell MF,Lachman LB

更新日期：1998-03-20 00:00:00

abstract：:Both saponin and muramyl dipeptide (MDP) formulated with a squalane-in-water emulsion of large particle size prepared with a vortex mixer were superior to Al(OH)3 as adjuvants for HIV gp120 in mice. All the adjuvants induced IgG1 antibody, but saponin elicited the highest titers of IgG2a. The secretion of interleukin-...

journal_title：AIDS research and human retroviruses

authors： Bomford R,Stapleton M,Winsor S,McKnight A,Andronova T

更新日期：1992-10-01 00:00:00

abstract：:CCR5 has preferentially been used by all circulating HIV-1 subtype C viruses for cell entry. Recently, we reported the highest proportion of CXCR4-utilizing primary isolates among a cohort of 20 South African AIDS patients. This study describes and compares the Env genotypic characteristics from these 20 HIV-1 subtype...

journal_title：AIDS research and human retroviruses

authors： Michler K,Connell BJ,Venter WD,Stevens WS,Capovilla A,Papathanasopoulos MA

更新日期：2008-05-01 00:00:00

abstract：:We investigate mutations and correlates according to HIV-1 subtype after virological failure (VF) of standard first-line antiretroviral therapy (ART) (non-nucleoside/nucleotide reverse transcriptase inhibitor [NNRTI] +2 nucleoside/nucleotide reverse transcriptase inhibitor [N(t)RTI]). SECOND-LINE study participants we...

journal_title：AIDS research and human retroviruses

authors： Lam EP,Moore CL,Gotuzzo E,Nwizu C,Kamarulzaman A,Chetchotisakd P,van Wyk J,Teppler H,Kumarasamy N,Molina JM,Emery S,Cooper DA,Boyd MA

更新日期：2016-09-01 00:00:00

abstract：:Although the effect of highly active antiretroviral therapy (HAART) on HIV-1 replication has been established, the mechanisms involved in restoration of immune responses and reconstitution remain unknown. This study provides evidence of changes in expression of type 1 and type 2 cytokine-specific mRNA occurring during...

journal_title：AIDS research and human retroviruses

authors： Imami N,Antonopoulos C,Hardy GA,Gazzard B,Gotch FM

更新日期：1999-11-20 00:00:00

abstract：:Data indicate the presence in the Seychelles Islands of a high level of human T cell leukemia/lymphoma virus type I (HTLV-I) endemicity as well as the presence of tropical spastic paraparesis/HTLV-I-associated myelopathy (TSP/HAM). We present here the results of an hospital survey performed since 1988 in La Réunion Is...

journal_title：AIDS research and human retroviruses

authors： Mahieux R,Gessain A,Truffert A,Vitrac D,Hubert A,Dandelot J,Montchamp-Moreau C,Cnudde F,Tekaia F,De Thé G

更新日期：1994-06-01 00:00:00

abstract：:We compared HIV-1 subtype B reverse transcriptase (RT) and protease mutation patterns in isolates from heavily treated persons in Northern California with those from persons described in the published literature predominantly from other parts of the United States and Europe. There were few differences in the prevalenc...

journal_title：AIDS research and human retroviruses

authors： Gonzales MJ,Belitskaya I,Dupnik KM,Rhee SY,Shafer RW

更新日期：2003-10-01 00:00:00

abstract：:We have determined that polymeric IgA in saliva of HIV-1-uninfected individuals binds in varying degrees to components of culture supernatants containing HIV-1 recombinant proteins when ELISA is used for the determination. This finding did not extend to salivary IgG antibodies. Further, such problems were not encounte...

journal_title：AIDS research and human retroviruses

authors： Jackson S,Prince S,Kulhavy R,Mestecky J

更新日期：2000-04-10 00:00:00

abstract：:Cyanovirin-N (CV-N), an 11-kDa cyanobacterial protein, potently inactivates diverse strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV) and also prevents virus-to-cell fusion, virus entry, and infection of cells in vitro. These properties make CV-N an attractive candidate for use as a topical microbicide ...

journal_title：AIDS research and human retroviruses

authors： Tsai CC,Emau P,Jiang Y,Tian B,Morton WR,Gustafson KR,Boyd MR

更新日期：2003-07-01 00:00:00

abstract：:Infection with human T lymphotropic virus (HTLV), although asymptomatic in most cases, can lead to severe illnesses, such as adult T cell leukemia/lymphoma or myelopathy/tropical spastic paraparesis. HTLV can be transmitted by whole-blood (WB) transfusion. The prevalence of HTLV among blood donor populations has not b...

journal_title：AIDS research and human retroviruses

authors： Pham D,Nguyen D,Nguyen TA,Tran C,Tran L,Devare S,Tran A,Bhatnagar S

更新日期：2019-04-01 00:00:00

abstract：:HIV protease is a virally coded enzyme that cleaves gag as well as gag-pol precursor polyproteins into functional products needed for virus assembly. A pUC plasmid containing an HIV insert starting at the 5' end of the pol gene and ending just inside the intergrase coding sequence was expressed in E. coli. It provided...

journal_title：AIDS research and human retroviruses

authors： Bu M,Oroszlan S,Luftig RB

更新日期：1989-06-01 00:00:00

abstract：:In order to shed light on the nature of the persistent reservoir of human immunodeficiency virus type 1 (HIV-1), we investigated signs of recent evolution in the pool of proviral DNA in patients on successful HAART. Pro-viral DNA, corresponding to the C2-V3-C3 region of the HIV-1 env gene, was collected from PBMCs iso...

journal_title：AIDS research and human retroviruses

authors： Mens H,Pedersen AG,Jørgensen LB,Hue S,Yang Y,Gerstoft J,Katzenstein TL

更新日期：2007-01-01 00:00:00

abstract：:Human immunodeficiency virus, type 1 (HIV-1), produces a chronic infection with a long latency before clinical disease. We followed 214 untreated subjects for 12-42 months to study the natural history of HIV infection: 110 were classified as asymptomatic, 11 as AIDS-related complex (ARC), 15 as AIDS with Kaposi's sarc...

journal_title：AIDS research and human retroviruses

authors： Croxson TS,Mathur-Wagh U,Handwerger S,Siroty WE,Kaminisky D,Reagan KJ,Yancovitz SR,Mildvan D

更新日期：1990-04-01 00:00:00

abstract：:Anti-HIV-1-specific T cell responses in early HIV-1 infection have been found to be important in deciding the course of disease progression. But there are few data concerning nonsubtype B HIV infection. HIV-1 subtype C is the most prevalent subtype in India. HIV-1 Gag-specific T cell responses in 12 Indian subjects wi...

journal_title：AIDS research and human retroviruses

authors： Thakar MR,Patke D,Lakhashe SK,Bhonge L,Kulkarni SV,Tripathy SP,Gupte N,Brookmeyer R,Quinn TC,Paranjape RS,Bollinger RC

更新日期：2002-12-10 00:00:00

abstract：:Maraviroc (MVC) is licensed in clinical practice for patients with R5 virus and virological failure; however, in anecdotal reports, dual/mixed viruses were also inhibited. We retrospectively evaluated the evolution of HIV-1 coreceptor tropism in plasma and peripheral blood mononuclear cells (PBMCs) of an infected adol...

journal_title：AIDS research and human retroviruses

authors： Cavarelli M,Mainetti L,Pignataro AR,Bigoloni A,Tolazzi M,Galli A,Nozza S,Castagna A,Sampaolo M,Boeri E,Scarlatti G

更新日期：2014-12-01 00:00:00

abstract：:We studied the ability of several polyionic compounds, previously shown to have activity in vitro against human immunodeficiency virus (anti-HIV) to block binding of anti-CD4 and recombinant HIV gp120 to the CD4 receptor on human lymphocytes. We found that Evans blue and aurin tricarboxylic acid could completely inhib...

journal_title：AIDS research and human retroviruses

authors： Weaver JL,Gergely P,Pine PS,Patzer E,Aszalos A

更新日期：1990-09-01 00:00:00