Immunoliposomes containing antibodies to costimulatory molecules as adjuvants for HIV subunit vaccines.

abstract：:The genetic diversity of HIV-1 is well documented. Except for the HIV-1 isolate LAV-1BRU, no nucleic acid sequence of a European isolate of HIV-1 has been published to date. To further investigate the extent of the genetic variability and the evolution of HIV-1, we have isolated, cloned, and subsequently sequenced HIV...

journal_title：AIDS research and human retroviruses

authors： Sauermann U,Schneider J,Mous J,Brunckhorst U,Schedel I,Jentsch KD,Hunsmann G

更新日期：1990-06-01 00:00:00

abstract：:Maraviroc (MVC) is an allosteric inhibitor of human immunodeficiency virus type 1 (HIV-1) entry, and is the only CCR5 antagonist licensed for use as an anti-HIV-1 therapeutic. It acts by altering the conformation of the CCR5 extracellular loops, rendering CCR5 unrecognizable by the HIV-1 envelope (Env) glycoproteins. ...

journal_title：AIDS research and human retroviruses

authors： Flynn JK,Ellenberg P,Duncan R,Ellett A,Zhou J,Sterjovski J,Cashin K,Borm K,Gray LR,Lewis M,Jubb B,Westby M,Lee B,Lewin SR,Churchill M,Roche M,Gorry PR

更新日期：2017-12-01 00:00:00

abstract：:In this study, HIV strains circulating among military personnel were characterized, in Malabo, the capital city of Equatorial Guinea. One sample was found to be HIV-2 group A while a high degree of genetic diversity was recorded in the pol region of 41 HIV-1-positive samples. CRF02_AG accounted for 53.7% of the strain...

journal_title：AIDS research and human retroviruses

authors： Djoko CF,Wolfe ND,Vidal N,Tamoufe U,Montavon C,LeBreton M,Pike BL,Fair J,Mbacham WF,Benito A,Rimoin AW,Saylors K,Mpoudi-Ngole E,Grillo MP,Peeters M

更新日期：2010-09-01 00:00:00

abstract：:Acquisition of cellular proteins by HIV-1 virions is known to alter the physiology of the virus in vitro. Reported studies of this aspect have been largely limited to transformed T cell lines. In this study, we investigated the incorporation of major histocompatibility antigens (HLAs) on a primary macrophage-tropic is...

journal_title：AIDS research and human retroviruses

authors： Tsai WP,Kung HF,Nara PL

更新日期：1999-01-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNF-alpha) may be involved in the pathogenesis of metabolic and endocrine changes in HIV infection. Pentoxifylline (PTX) is able to suppress the production of TNF-alpha in vitro. The effect of two dosages of intravenously administered PTX on clinical symptoms and ex vivo LPS-stimulated TNF...

journal_title：AIDS research and human retroviruses

authors： Heijligenberg R,Romijn JA,Ackermans M,Endert E,Timmer JG,Sauerwein HP

更新日期：1998-03-01 00:00:00

abstract：:T epitope mapping in human immunodeficiency virus proteins provides a useful tool for AIDS vaccine design. We have previously shown that four peptides selected from the Gag polyprotein of HIV-1 were able to prime mice for in vitro lymphoproliferative responses. These responses were shown to be MHC restricted, and a po...

journal_title：AIDS research and human retroviruses

authors： Vaslin B,Claverie JM,Benveniste O,Barre-Sinoussi FC,Dormont D

更新日期：1994-10-01 00:00:00

abstract：:HIV-1 subtype C is the prevalent subtype in South Africa, with non-C subtypes being sporadically detected. The accessory genes of subtype C have not been well studied in South Africa. In this study the HIV-1 vpr region of 58 strains was amplified, sequenced, and subtyped. Phylogenetic analysis characterized 54 strains...

journal_title：AIDS research and human retroviruses

authors： Romani B,Glashoff R,Engelbrecht S

更新日期：2009-03-01 00:00:00

abstract：:The HIV-1 subtype distribution in 83 HIV-1-seropositive individuals living in Greece was investigated by using the heteroduplex mobility assay (HMA), DNA sequencing, and phylogenetic analysis. The results revealed that partial HIV-1 gp120 sequences from 71 (86%) patients were subtype B, 5 (6%) were subtype A, 4 were s...

journal_title：AIDS research and human retroviruses

authors： Nasioulas G,Paraskevis D,Paparizos V,Lazanas M,Karafoulidou A,Hatzakis A

更新日期：1998-05-20 00:00:00

abstract：:Data reporting sexually transmitted infection (STI) incidence rates among HIV-negative U.S. men who have sex with men (MSM) are lacking. In addition, it is difficult to analyze the effect of STI on HIV acquisition given that sexual risk behaviors confound the relationship between bacterial STIs and incident HIV. The I...

journal_title：AIDS research and human retroviruses

authors： Kelley CF,Vaughan AS,Luisi N,Sanchez TH,Salazar LF,Frew PM,Cooper HL,Diclemente R,del Rio C,Sullivan PS,Rosenberg ES

更新日期：2015-06-01 00:00:00

abstract：:The prevalence of human immunodeficiency virus type 1 (HIV-1) is highest among men who have sex with men (MSM) in Jamaica but no genotypic data are available on the virus strains that are responsible for the epidemic among this key population. HIV-1 polymerase (pol) genes from 65 MSM were sequenced and used to predict...

journal_title：AIDS research and human retroviruses

authors： Collins-Fairclough AM,Dennis AM,Nelson JA,Weir SS,Figueroa JP

更新日期：2015-08-01 00:00:00

abstract：:In order to shed light on the nature of the persistent reservoir of human immunodeficiency virus type 1 (HIV-1), we investigated signs of recent evolution in the pool of proviral DNA in patients on successful HAART. Pro-viral DNA, corresponding to the C2-V3-C3 region of the HIV-1 env gene, was collected from PBMCs iso...

journal_title：AIDS research and human retroviruses

authors： Mens H,Pedersen AG,Jørgensen LB,Hue S,Yang Y,Gerstoft J,Katzenstein TL

更新日期：2007-01-01 00:00:00

abstract：:Despite the success of antiretroviral therapy (ART) in decreasing mortality for HIV-1-infected patients, ART has not cured the disease. A persistent viral reservoir in the T cells of HIV patients receiving potent ART is a significant barrier preventing eradication of HIV infection. We will briefly review what is known...

journal_title：AIDS research and human retroviruses

authors： Margolis DM

更新日期：2011-04-01 00:00:00

abstract：:CCR5 has preferentially been used by all circulating HIV-1 subtype C viruses for cell entry. Recently, we reported the highest proportion of CXCR4-utilizing primary isolates among a cohort of 20 South African AIDS patients. This study describes and compares the Env genotypic characteristics from these 20 HIV-1 subtype...

journal_title：AIDS research and human retroviruses

authors： Michler K,Connell BJ,Venter WD,Stevens WS,Capovilla A,Papathanasopoulos MA

更新日期：2008-05-01 00:00:00

abstract：:We performed a placebo-controlled study to evaluate the effects of immunomodulatory treatment with thalidomide on HIV levels, TNF-alpha levels, and immune status of 31 HIV-infected individuals, after temporary suppression of viral replication with antiretroviral drugs. Treatment with a combination of zidovudine and la...

journal_title：AIDS research and human retroviruses

authors： Haslett PA,Klausner JD,Makonkawkeyoon S,Moreira A,Metatratip P,Boyle B,Kunachiwa W,Maneekarn N,Vongchan P,Corral LG,Elbeik T,Shen Z,Kaplan G

更新日期：1999-09-01 00:00:00

abstract：:Multiple impairments in HIV-1-specific cytotoxic T cells (CTL) have been reported, but derangements in HIV-1-specific CD8+ T-cell chemotaxis have not been described previously. We assessed migration to SDF-1alpha (stromal cell-derived factor 1-alpha) and CX3CL1 in vitro and expression of cognate receptors, CXCR4 and C...

journal_title：AIDS research and human retroviruses

authors： Meditz AL,Schlichtemeier R,Folkvord JM,Givens M,Lesh KC,Ray MG,McCarter MD,Connick E

更新日期：2008-07-01 00:00:00

abstract：:The silent period that follows infection by the human immunodeficiency virus (HIV-1) and precedes seroconversion remains a problem for the screening of blood supply, and knowledge about the mechanism involved in the maintenance of latency is only fragmentary. Using purified nef recombinant protein and six synthetic ne...

journal_title：AIDS research and human retroviruses

authors： Ameisen JC,Guy B,Chamaret S,Loche M,Mouton Y,Neyrinck JL,Khalife J,Leprevost C,Beaucaire G,Boutillon C

更新日期：1989-06-01 00:00:00

abstract：:Replacing the Pseudomonas exotoxin A (PE) cell binding domain with the human immunodeficiency virus (HIV) gp120 binding domain from CD4 yields a hybrid toxin (CD4-PE) with potential therapeutic use in treating acquired immunodeficiency syndrome (AIDS). To find the most therapeutically potent combination of CD4 and PE ...

journal_title：AIDS research and human retroviruses

authors： Winkler G,Jakubowski A,Turner S,Liu T,Burrus B,McGray P,Heanue T,Rosa M,Griffiths BA,Wali A

更新日期：1991-04-01 00:00:00

abstract：:Cross-sectional estimation of HIV incidence could misclassify some established or chronic HIV infections as recent. Usually long-term nonprogressors, elite and viremic controllers, and individuals on ART contribute to misclassification. Local data on the false recent rate (FRR) could minimize misclassification during ...

journal_title：AIDS research and human retroviruses

authors： Moyo S,Kotokwe KP,Mohammed T,Boleo C,Mupfumi L,Chishala S,Tsalaile L,Bussmann H,Gaseitsiwe S,Musonda R,Makhema J,Baum M,Marlink R,Engelbrecht S,Essex M,Novitsky V

更新日期：2017-01-01 00:00:00

abstract：:Deoxyguanylic acids, but not other deoxynucleotides, as short as 3- to 4-mer, were effective in preventing HIV-1-induced cytopathicity. In addition, they prevented giant cell formation of infected Sup-T1 cells, and p24 production in HIV-1 infected H9 cells. Phosphorylation at either the 5'- or 3'-end enhanced these ac...

journal_title：AIDS research and human retroviruses

authors： Fujihashi T,Sakata T,Kaji A,Kaji H

更新日期：1995-04-01 00:00:00

abstract：:Genotype-based algorithms are valuable tools for the identification of patients eligible for CCR5 inhibitors administration in clinical practice. Among the available methods, geno2pheno[coreceptor] (G2P) is the most used online tool for tropism prediction. This study was conceived to assess if the combination of G2P p...

journal_title：AIDS research and human retroviruses

authors： Montagna C,De Crignis E,Bon I,Re MC,Mezzaroma I,Turriziani O,Graziosi C,Antonelli G

更新日期：2014-12-01 00:00:00

abstract：:In Western countries, HTLV-1 infection is recognized mainly among foreigners coming from endemic areas. In contrast, HTLV-2 is found predominantly in native intravenous drug users (IDUs). Spain has experienced a large wave of immigration, which could have influenced the current prevalence and distribution of HTLV-1 an...

journal_title：AIDS research and human retroviruses

authors： Toro C,Aguilera A,Caballero E,Tuset C,Alvarez P,García-Campello M,Rodríguez-Iglesias M,de Lejarazu RO,Eiros J,Rodriguez C,del Romero J,Benito R,Calderón E,Santana O,Amor A,Gómez-Hernando C,García J,Soriano V

更新日期：2007-09-01 00:00:00

abstract：:We report here a novel HIV-1 second-generation recombinant form (CRF01_AE/CRF07_BC) composed of CRF01_AE and CRF07_BC, identified among men who have sex with men (MSM) in Jilin, with four breakpoints observed in the pol, vif, and vpr genes. The CRF01_AE regions of the recombinant were clustered with the CRF01_AE linea...

journal_title：AIDS research and human retroviruses

authors： Li X,Ning C,He X,Yang Y,Xing H,Hong K,Shao Y,Yang R

更新日期：2013-12-01 00:00:00

abstract：:We examined baseline HIV-1 protease and reverse transcriptase sequences and HIV clinical parameters from 1,021 consecutive patients (814 male, 207 female) through the Royal Perth Hospital HIV service to investigate HIV-1 subtype diversity and local phylogenetic networks from 2000 to 2014. HIV-1 subtype B virus sequenc...

journal_title：AIDS research and human retroviruses

authors： Castley AS,Gaudieri S,James I,Gizzarelli LS,Guelfi G,John M,Nolan D

更新日期：2016-03-01 00:00:00

abstract：:The function of the p12(I) protein of human T cell lymphotropic virus type I (HTLV-I) has been under debate. p12K (lysine) and p12R (arginine) variants of this protein at amino acid 88 and a shorter life of p12K had been reported by another group. Because HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/...

journal_title：AIDS research and human retroviruses

authors： Furukawa Y,Usuku K,Izumo S,Osame M

更新日期：2004-10-01 00:00:00

abstract：:This study reports on the drug resistance profiles for HIV-infected pediatrics in Jamaica who have been exposed to antiretroviral therapy (ART). The genetic diversity of HIV-1 found in these patients was also determined using phylogenetic analysis. The protease-reverse transcriptase (Pro-RT) region of the genome was a...

journal_title：AIDS research and human retroviruses

authors： Ramkissoon AP,Amarakoon II,Hamilton CL,Pierre RB,Eyzaguirre LM,Carr JK,Blattner WA,Roye ME

更新日期：2015-09-01 00:00:00

abstract：:We characterized two immune escape viruses (SHIV(KU-1/105w52) and SHIV(KU-1/105w98)) from a macaque immunized with DeltavpuDeltanef SHIV-4 and challenged with pathogenic SHIV(KU-1). This macaque developed neutralizing antibodies as well as virus-specific CTLs against the challenge virus. However, the two new viruses c...

journal_title：AIDS research and human retroviruses

authors： Stipp HL,Kumar A,Narayan O

更新日期：2000-10-10 00:00:00

abstract：:In a set of 42 antiretroviral naive HIV-1 infected persons who were treated with either Zidovudine (AZT) monotherapy, or a combination of AZT + ddC (Zalcitabine) or AZT + ddI (Didanosine), the HIV-1 DNA load was measured by competitive polymerase chain reaction (PCR) and related to the HIV-1 RNA load in plasma, the CD...

journal_title：AIDS research and human retroviruses

authors： Bruisten SM,Reiss P,Loeliger AE,van Swieten P,Schuurman R,Boucher CA,Weverling GJ,Huisman JG

更新日期：1998-08-10 00:00:00

abstract：:The relationship between adherence to highly active antiretroviral therapy (HAART) and RNA-HIV viral load outcomes has been extensively shown. Although there are different procedures for assessing treatment adherence, there is no ideal method. We present the SERAD (Self-Reported Adherence) questionnaire, a qualitative...

journal_title：AIDS research and human retroviruses

authors： Muñoz-Moreno JA,Fumaz CR,Ferrer MJ,Tuldrà A,Rovira T,Viladrich C,Bayés R,Burger DM,Negredo E,Clotet B,SERAD Validation Team.

更新日期：2007-10-01 00:00:00

abstract：:We set out to investigate whether there are clinically significant consequences when children with perinatal exposure to single-dose nevirapine are initiated on a nonnucleoside reverse transcriptase inhibitor (NNRTI) containing a highly active antiretroviral therapy (HAART) regimen. We carried out a chart and database...

journal_title：AIDS research and human retroviruses

authors： Musiime V,Ssali F,Kayiwa J,Namala W,Kizito H,Kityo C,Mugyenyi P

更新日期：2009-10-01 00:00:00

abstract：:Abstract The effectiveness of any biomedical prevention technology relies on both biological efficacy and behavioral adherence. Microbicide trials have been hampered by low adherence, limiting the ability to draw meaningful conclusions about product effectiveness. Central to this problem may be an inadequate conceptua...

journal_title：AIDS research and human retroviruses

authors： Morrow KM,Fava JL,Rosen RK,Vargas S,Shaw JG,Kojic EM,Kiser PF,Friend DR,Katz DF,Project Link Study Team.

更新日期：2014-01-01 00:00:00