Eradication therapies for HIV Infection: time to begin again.


:Despite the success of antiretroviral therapy (ART) in decreasing mortality for HIV-1-infected patients, ART has not cured the disease. A persistent viral reservoir in the T cells of HIV patients receiving potent ART is a significant barrier preventing eradication of HIV infection. We will briefly review what is known about the mechanisms that establish and maintain persistent HIV infection despite ART, to create a framework in which to consider approaches to the clearance or eradication of infection ("cure"), or to allow clinical stability in the absence of ART ("functional cure"). With regard to eradication therapies, it could be said that as a field our position is analogous to that of ART early in the HIV pandemic. As then we must now simultaneously develop and optimize platforms and paradigms for the discovery and testing of eradication therapies, and begin to advance candidate therapies toward human testing.


Margolis DM




Has Abstract


2011-04-01 00:00:00












  • Preparations for AIDS vaccine evaluations. Rate of new HIV infection in a cohort of women of childbearing age in Malawi.

    abstract::Women attending the Queen Elizabeth Central Hospital in Blantyre, Malawi, between November 1989 and October 1993 were studied as part of a longitudinal cohort study of mother-to-infant HIV transmission. 694 HIV-seropositive and 687 HIV-seronegative women were enrolled at delivery. In the follow-up phase, women attende...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Miotti P,Canner J,Chiphangwi J,Liomba G,Saah A,Dallabetta G

    更新日期:1994-01-01 00:00:00

  • HIV-1 reverse transcriptase inhibitor from Phyllanthus niruri.

    abstract::An aqueous extract of Phyllanthus niruri (Euphorbiaceae) inhibited human immunodeficiency virus type-1 reverse transcriptase (HIV-1-RT). The inhibitor against HIV-1-RT in this plant was purified by combination of three column chromatographies, Sephadex LH-20, cellulose, and reverse-phase high-performance liquid chroma...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Ogata T,Higuchi H,Mochida S,Matsumoto H,Kato A,Endo T,Kaji A,Kaji H

    更新日期:1992-11-01 00:00:00

  • Short communication: HIV type 1 phenotype, tropism, and sequence patterns: association and preference.

    abstract::In this study, the relationship between biological phenotypes, coreceptor usages, and sequence patterns of V1V2 or V3 regions on HIV-1 envelope gp 120 was carefully analyzed based on the existing isolates in the Los Alamos National Laboratory sequence database. Obviously, SI/NSI phenotypes were closely linked to the c...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Dong XN,Chen X,Chen Y,Ablimit A,Ye Z,Wu Y,Chen YH

    更新日期:2005-03-01 00:00:00

  • A longitudinal study of the changes in body fat and metabolic parameters in a South African population of HIV-positive patients receiving an antiretroviral therapeutic regimen containing stavudine.

    abstract::The aim of this study was to determine the patterns of change in body fat and metabolic parameters in a South African cohort on a first line ART regimen containing stavudine. Fasting lipogram, blood glucose and insulin levels, CD4 cell count, viral load, BMI, waist-to-hip ratio (WHR), and skinfold thickness at the tri...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: George JA,Venter WD,Van Deventer HE,Crowther NJ

    更新日期:2009-08-01 00:00:00

  • Diversity in HIV-1 envelope V1-V3 sequences early in infection reflects sequence diversity throughout the HIV-1 genome but does not predict the extent of sequence diversity during chronic infection.

    abstract::Differences in the extent of genetic diversity have been observed in human immunodeficiency virus type-1 (HIV-1) envelope sequences early in infection, and this has been linked to gender and to modifiable exogenous factors such as hormonal contraceptive use and genital tract infections. But it is unclear whether envel...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Sagar M,Kirkegaard E,Lavreys L,Overbaugh J

    更新日期:2006-05-01 00:00:00

  • Stable expression of the human immunodeficiency virus type 1 envelope glycoprotein in transfected L cells.

    abstract::An SV40-based expression vector was used to generate CD4-negative murine L cell lines which stably expressed the human immunodeficiency virus envelope glycoprotein (env). Despite the presence of abundant intracellular envelope glycoprotein, the expression of env gp120/41 was not detected on the cell surface. Pulse-cha...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Bird C,Gleeson PA,Ramsay A,Li P,McCluskey J

    更新日期:1992-12-01 00:00:00

  • Genotypic characterization of HIV type 1 in Jamaica.

    abstract::This study seeks to analyze nearly full-length viral genomes for distinct genetic characteristics that are unique to local or regional strains and to identify regions that have high variability or are highly conserved. Nearly full length sequences of seven HIV-1 samples were obtained to ascertain the circulating subty...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Roye ME,Amarakoon II,Hamilton CL,Eyzaguirre LM,Figueroa P,Carr JK

    更新日期:2011-01-01 00:00:00

  • Genetic characterization of HIV type 1 Nef-induced vesicle secretion.

    abstract::The HIV-1 Nef protein is known to be secreted, and our group has shown that Nef is secreted from nef-transfected and HIV-1-infected cells in small exosome-like vesicles (d. 40-100 nm). The role of secreted Nef remains to be fully characterized. Thus, it is important to characterize the nature of and the mechanisms reg...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Ali SA,Huang MB,Campbell PE,Roth WW,Campbell T,Khan M,Newman G,Villinger F,Powell MD,Bond VC

    更新日期:2010-02-01 00:00:00

  • Increased levels of soluble Fas receptor and Fas ligand in the cerebrospinal fluid of HIV-infected patients.

    abstract::Analyses of serum samples and blood cells have revealed a dysregulation of the Fas/Fas ligand (FasL) system during HIV infection, which may be related to disease progression. As Fas and FasL have been suggested to participate in brain injury in a variety of CNS disorders, the aim of this study was to determine (1) whe...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Sporer B,Koedel U,Goebel FD,Pfister HW

    更新日期:2000-02-10 00:00:00

  • Detection of anti-human cell antibodies in sera from macaques immunized with whole inactivated virus.

    abstract::More than 200 sera from macaques immunized with several different vaccine preparations were tested in various assays with cells of human and macaque origin. Only in instances where whole inactivated SIV preparations were used for immunization, were reactivities found with normal human cells, and this was the case in e...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Langlois AJ,Weinhold KJ,Matthews TJ,Greenberg ML,Bolognesi DP

    更新日期:1992-09-01 00:00:00

  • Immune restoration by combination of a cytostatic drug (hydroxyurea) and anti-HIV drugs (didanosine and indinavir).

    abstract::Cell activation is essential for HIV infection. CD4+ T lymphocyte activation allows virus replication and CD8+ T lymphocyte activation may contribute to pathogenesis. We combined hydroxyurea, a cytostatic drug that inhibits cell activation and proliferation, with two drugs that inhibit HIV (didanosine and indinavir), ...

    journal_title:AIDS research and human retroviruses

    pub_type: 临床试验,杂志文章


    authors: Lori F,Jessen H,Lieberman J,Clerici M,Tinelli C,Lisziewicz J

    更新日期:1999-05-01 00:00:00

  • Conserved immunogenic region of a major core protein (p24) of human and simian immunodeficiency viruses.

    abstract::A murine monoclonal antibody (MoAb), VAK 4, has been known to specifically react with a major core protein (p24) as well as with its precursor (p55-57) and intermediate precursor (p40) of human immunodeficiency virus strain IIIB (HTLV-IIIB). Radioimmunoprecipitation assays revealed that VAK 4 MoAb precipitated a major...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Koito A,Hattori T,Matsushita S,Maeda Y,Nozaki C,Sagawa K,Takatsuki K

    更新日期:1988-12-01 00:00:00

  • IL-21 Therapy Controls Immune Activation and Maintains Antiviral CD8+ T Cell Responses in Acute Simian Immunodeficiency Virus Infection.

    abstract::Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) replicate during acute infection in lymphocytes of the gastrointestinal tract, before disseminating systemically. Localized replication and associated loss of gut-resident CD4+ T cells occur regardless of the portal of entry of the virus (e.g.,...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Méndez-Lagares G,Lu D,Merriam D,Baker CA,Villinger F,Van Rompay KKA,McCune JM,Hartigan-O'Connor DJ

    更新日期:2017-11-01 00:00:00

  • Virucidal efficacy of various lens cleaning and disinfecting solutions on HIV-I contaminated contact lenses.

    abstract::The virucidal efficacy of various commercially available contact lens care cleaning regimens on human immunodeficiency virus (HIV-1) contaminated contact lenses using either cursory or meticulous cleaning with a rubber policeman was evaluated. Levels of infectious HIV-1 remaining on individual contact lenses were dete...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Amin RM,Dean MT,Zaumetzer LE,Poiesz BJ

    更新日期:1991-04-01 00:00:00

  • Designing preclinical perceptibility measures to evaluate topical vaginal gel formulations: relating user sensory perceptions and experiences to formulation properties.

    abstract::Abstract The effectiveness of any biomedical prevention technology relies on both biological efficacy and behavioral adherence. Microbicide trials have been hampered by low adherence, limiting the ability to draw meaningful conclusions about product effectiveness. Central to this problem may be an inadequate conceptua...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Morrow KM,Fava JL,Rosen RK,Vargas S,Shaw JG,Kojic EM,Kiser PF,Friend DR,Katz DF,Project Link Study Team.

    更新日期:2014-01-01 00:00:00

  • Human foamy virus DNA forms and expression in persistently infected Dami megakaryocytic cells.

    abstract::We have characterized human foamy virus (HFV) proviral DNA and determined HFV expression in a persistent infection model, the Dami megakaryocytic cell line. Molecular studies were performed on parental persistently infected cells (Dami-P), as well as on derived clones (Dami-Cl). We report that in these nonlytic and no...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Wybier-Franqui J,Tobaly-Tapiero J,Coronel A,Giron ML,Chopin-Robert C,Peries J,Emanoil-Ravier R

    更新日期:1995-07-01 00:00:00

  • Genetic architecture of HIV type 1 Nef and Tat from HLA-B57-typed long-term survivors in an Indian cohort of perinatally HIV-infected children.

    abstract::Human immunodeficiency virus type 1 (HIV-1) viral genes nef and tat play an important role in disease progression. In this study we characterized the Nef and Tat proteins from a group of HLA-B57 typed pediatric perinatally infected long-term survivors (LTS) with ≥10 years of infection. We identified 19 therapy-naive L...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Neogi U,Palchaudhuri R,Bommana S,Shet A

    更新日期:2013-12-01 00:00:00

  • Genome Sequence of a Novel HIV-1 Circulating Recombinant Form (CRF79_0107) Identified from Shanxi, China.

    abstract::We report a novel HIV-1 circulating recombinant form (CRF79_0107) from three epidemiologically unlinked patients through sexual contact in Shanxi province of China. This is the first second-generation circulating recombinant form identified in China. The breakpoint analysis of recombinants showed that CRF79_0107 was c...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Li Y,Feng Y,Li F,Xue Z,Hu J,Xing H,Ruan Y,Shao Y

    更新日期:2017-10-01 00:00:00

  • A high frequency of defective vif genes in peripheral blood mononuclear cells from HIV type 1-infected individuals.

    abstract::We studied the heterogeneity and intactness of the vif gene in six HIV-1-infected individuals at various clinical stages. The proviral vif sequences in peripheral blood mononuclear cells were amplified by PCR, followed by cloning and sequencing of 45 vif clones. The intraindividual diversity of the vif genes ranged fr...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Tominaga K,Kato S,Negishi M,Takano T

    更新日期:1996-11-01 00:00:00

  • Pharmacokinetics and pharmacodynamics in HIV prevention; current status and future directions: a summary of the DAIDS and BMGF sponsored think tank on pharmacokinetics (PK)/pharmacodynamics (PD) in HIV prevention.

    abstract::Thirty years after its beginning, the HIV/AIDS epidemic is still raging around the world. According to UNAIDS, in 2011 alone 1.7M deaths were attributable to AIDS, and 2.5M people were newly infected by the virus. Despite the success in treating HIV-infected people with potent antiretroviral drugs, preventing HIV infe...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章,评审


    authors: Romano J,Kashuba A,Becker S,Cummins J,Turpin J,Veronese F,Antiretroviral Pharmacology In HIV Prevention Think Tank Participants.

    更新日期:2013-11-01 00:00:00

  • Progressive impairment of monocytic function in HIV-1-infected human macrophage hybridomas.

    abstract::Using human macrophage hybridomas infected with HIV-1, we investigated monocyte function over a 5-week period after HIV-1 infection. Two clones, 63 and 30, were infected with HIV-1IIIB. Infection was documented by RT activity (15 x 10(6) cpm/ml), intracytoplasmic staining with an anti-p24 antibody, in situ hybridizati...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Sperber K,Hamrang G,Louie MJ,Kalb T,Banerjee R,Choi HS,Paronetto F,Mayer L

    更新日期:1993-07-01 00:00:00

  • In vitro effects of anti-HIV immunotoxins directed against multiple epitopes on HIV type 1 envelope glycoprotein 160.

    abstract::We have used a panel of anti-gp160 MAbs to construct anti-HIV immunotoxins by coupling antibodies to ricin A chain (RAC). The ability of the immunotoxins to kill HIV-1-infected cells and halt the spread of infection was tested in tissue culture on persistently and acutely infected cell lines and primary lymphocyte cul...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Pincus SH,Wehrly K,Cole R,Fang H,Lewis GK,McClure J,Conley AJ,Wahren B,Posner MR,Notkins AL,Tilley SA,Pinter A,Eiden L,Teintze M,Dorward D,Tolstikov VV

    更新日期:1996-07-20 00:00:00

  • HIV type 1-mediated downregulation of HLA-B*57/B*5801 proteins on elite suppressor CD4+ T cells.

    abstract::Elite controllers or suppressors (ES) are HIV-1-infected patients who maintain viral loads of <50 copies/ml without antiretroviral therapy. While HLA-B*57 and B*5801 alleles are overrepresented in ES, many HLA-B*57/B*5801 patients become chronic progressors (CP). We show here that HIV-1 infection results in similar le...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Sampah ME,Ceccato CM,Blankson JN

    更新日期:2011-02-01 00:00:00

  • Effects of GLQ223 on HIV replication in human monocyte/macrophages chronically infected in vitro with HIV.

    abstract::GLQ223 is a formulated version of tricosanthin, a single-chain ribosome-inactivating protein that was shown in earlier studies to inhibit human immunodeficiency virus (HIV) replication in T-lymphoblastoid cells and to decrease HIV p24 levels in HIV-infected monocyte-derived macrophages as measured by flow cytometry. T...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: McGrath MS,Santulli S,Gaston I

    更新日期:1990-08-01 00:00:00

  • Bacterial Vaginosis and Subclinical Markers of Genital Tract Inflammation and Mucosal Immunity.

    abstract::Bacterial vaginosis (BV) has been linked to an increased risk of human immunodeficiency virus (HIV) acquisition and transmission in observational studies, but the underlying biological mechanisms are unknown. We measured biomarkers of subclinical vaginal inflammation, endogenous antimicrobial activity, and vaginal flo...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Thurman AR,Kimble T,Herold B,Mesquita PM,Fichorova RN,Dawood HY,Fashemi T,Chandra N,Rabe L,Cunningham TD,Anderson S,Schwartz J,Doncel G

    更新日期:2015-11-01 00:00:00

  • Value of the HLA-B*5701 allele to predict abacavir hypersensitivity in Spaniards.

    abstract::The use of abacavir (ABC) may be associated with a hypersensitivity reaction (HSR) that requires discontinuation of the drug. The HLA-B*5701 allele has been linked to this HSR. Information on the strength of this association across distinct geographic regions and ethnicities is scarce. We tested HLA-B*5701 in 53 Spani...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Rodríguez-Nóvoa S,García-Gascó P,Blanco F,González-Pardo G,Castellares C,Moreno V,Jiménez-Nácher I,González-Lahoz J,Soriano V

    更新日期:2007-11-01 00:00:00

  • The detection of in vivo and in vitro HIV type 1 B/F profiles in Brazil using a real-time PCR assay for five HIV type 1 genomic regions.

    abstract::We sought to determine the frequency and profile of HIV-1 BF recombinants in vitro and in vivo. Laboratory HIV-1 strains from subtypes B and F were cocultured and evaluated. Clinical samples from the city of Santos, Brazil, where the first HIV-1 B/F circulating recombinant forms (CRF) were described, were also assesse...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Teixeira D,Munerato P,Komninakis SC,Fusuma EE,Janini LM,Sucupira MC,Diaz RS

    更新日期:2010-09-01 00:00:00

  • Isolation, characterization, and sequence analysis of a novel HIV type 1 subtype A1 strain from Russia.

    abstract::A new syncytia-inducing human immunodeficiency virus type 1 (HIV-1) strain designated PokA79 was first isolated from a peripheral blood mononuclear cells (PBMC) pool from 24 HIV-1-infected patients from Russia and adapted to growth in MT2, MT4, and U937 cell cultures. The full-length genome of this isolate was amplifi...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Galkin AN,Bychenko AB,Kuznecovs G,Filinova EY

    更新日期:2012-09-01 00:00:00

  • Coordinate induction of interferon alpha and gamma by recombinant HIV-1 glycoprotein 120.

    abstract::Similarly to HIV-infected cells, recombinant HIV-1 glycoprotein 120 induces acid-labile interferon production in peripheral blood mononuclear cells from healthy donors. Acid lability of this interferon is due to the presence of both IFN-alpha and -gamma molecules. In fact, although not revealed by neutralization of an...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Capobianchi MR,Ameglio F,Cordiali Fei P,Castilletti C,Mercuri F,Fais S,Dianzani F

    更新日期:1993-10-01 00:00:00

  • The safety and pharmacokinetics of single-agent and combination therapy with megestrol acetate and dronabinol for the treatment of HIV wasting syndrome. The DATRI 004 Study Group. Division of AIDS Treatment Research Initiative.

    abstract::This randomized, open-labeled, multicenter study was designed to assess safety and pharmacokinetics of dronabinol (Marinol) tablets and megestrol acetate (Megace) micronized tablets, alone and in combination, for treatment of HIV wasting syndrome. Weight and quality of life data were also collected. Fifty-two patients...

    journal_title:AIDS research and human retroviruses

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Timpone JG,Wright DJ,Li N,Egorin MJ,Enama ME,Mayers J,Galetto G

    更新日期:1997-03-01 00:00:00