Eradication therapies for HIV Infection: time to begin again.


:Despite the success of antiretroviral therapy (ART) in decreasing mortality for HIV-1-infected patients, ART has not cured the disease. A persistent viral reservoir in the T cells of HIV patients receiving potent ART is a significant barrier preventing eradication of HIV infection. We will briefly review what is known about the mechanisms that establish and maintain persistent HIV infection despite ART, to create a framework in which to consider approaches to the clearance or eradication of infection ("cure"), or to allow clinical stability in the absence of ART ("functional cure"). With regard to eradication therapies, it could be said that as a field our position is analogous to that of ART early in the HIV pandemic. As then we must now simultaneously develop and optimize platforms and paradigms for the discovery and testing of eradication therapies, and begin to advance candidate therapies toward human testing.


Margolis DM




Has Abstract


2011-04-01 00:00:00












  • The detection of in vivo and in vitro HIV type 1 B/F profiles in Brazil using a real-time PCR assay for five HIV type 1 genomic regions.

    abstract::We sought to determine the frequency and profile of HIV-1 BF recombinants in vitro and in vivo. Laboratory HIV-1 strains from subtypes B and F were cocultured and evaluated. Clinical samples from the city of Santos, Brazil, where the first HIV-1 B/F circulating recombinant forms (CRF) were described, were also assesse...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Teixeira D,Munerato P,Komninakis SC,Fusuma EE,Janini LM,Sucupira MC,Diaz RS

    更新日期:2010-09-01 00:00:00

  • Immunization with recombinant gp160 prolongs the survival of HIV-1 transgenic mice.

    abstract::A strain of mouse transgenic for the env gene of the HIV-1 virus was used to study the immunogenicity of a gp160-derived vaccine (the protein encoded by the HIV env gene) and its effect on disease progression. Untreated transgenic mice frequently developed a rapidly progressive renal disease similar to that affecting ...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Shirai A,Klinman DM

    更新日期:1993-10-01 00:00:00

  • Covert vertical transmission of feline immunodeficiency virus.

    abstract::Covert vertical transmission of feline immunodeficiency virus (FIV), the feline counterpart of human immunodeficiency virus type 1 (HIV-1), was identified in kittens born to FIV-infected cats. DNA PCR detected FIV gag and env sequences in tissues from kittens nonviable at birth, and in viable kittens monitored postnat...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Allison RW,Hoover EA

    更新日期:2003-05-01 00:00:00

  • Serological and molecular typing of HIV type 1 infection in the Tiriyo tribe, a native Indian community of the Amazon region of Brazil.

    abstract::The seroprevalence and the occurrence of an HIV-1 subtype was assessed in blood samples of the Tiriyo tribe. Antibody was found in 0.6% and the molecular analysis of the pro region detected the emergence of a subtype B for the first time in a native Indian tribe of the Amazon region of Brazil. ...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Machado LF,Vallinoto AC,Souza MI,Azevedo VN,Ishak MO,Ishak R

    更新日期:2006-12-01 00:00:00

  • Mitochondrial oxidative phosphorylation protein levels in peripheral blood mononuclear cells correlate with levels in subcutaneous adipose tissue within samples differing by HIV and lipoatrophy status.

    abstract::Depletion of mitochondrial DNA (mtDNA) and mtDNA-encoded respiratory chain proteins in subcutaneous (SC) fat from patients with HIV lipoatrophy have clearly demonstrated the role of mitochondrial dysfunction in this syndrome. Research in HIV lipoatrophy, however, has been severely hampered by the lack of a suitable su...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Shikuma CM,Gerschenson M,Chow D,Libutti DE,Willis JH,Murray J,Capaldi RA,Marusich M

    更新日期:2008-10-01 00:00:00

  • Value of the HLA-B*5701 allele to predict abacavir hypersensitivity in Spaniards.

    abstract::The use of abacavir (ABC) may be associated with a hypersensitivity reaction (HSR) that requires discontinuation of the drug. The HLA-B*5701 allele has been linked to this HSR. Information on the strength of this association across distinct geographic regions and ethnicities is scarce. We tested HLA-B*5701 in 53 Spani...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Rodríguez-Nóvoa S,García-Gascó P,Blanco F,González-Pardo G,Castellares C,Moreno V,Jiménez-Nácher I,González-Lahoz J,Soriano V

    更新日期:2007-11-01 00:00:00

  • Recent advances in AIDS vaccine research and development.

    abstract::There is an urgent need for a prophylactic vaccine to protect individuals from AIDS and to help abate the growing epidemic. In October 1993, the Conference on Advances in AIDS Vaccine Development reviewed the state-of-the-art in vaccine research and confirmed both the progress that has been made and the challenges tha...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章,评审


    authors: Johnston MI,Noe JS,Killen JY

    更新日期:1994-01-01 00:00:00

  • Molecular epidemiology of HIV type 1 subtypes in Taiwan: outbreak of HIV type 1 CRF07_BC infection in intravenous drug users.

    abstract::In Taiwan, sexual transmission is responsible for most HIV-1 infections with two dominant subtypes, subtype B and CRF01_AE, distributing among homosexual and heterosexual groups, respectively. Recently, intravenous drug use has become an emerging route of HIV-1 transmission and contributed to a significant increase of...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Chang SY,Sheng WH,Lee CN,Sun HY,Kao CL,Chang SF,Liu WC,Yang JY,Wong WW,Hung CC,Chang SC

    更新日期:2006-11-01 00:00:00

  • CD4-Pseudomonas exotoxin hybrid proteins: modulation of potency and therapeutic window through structural design and characterization of cell internalization.

    abstract::Replacing the Pseudomonas exotoxin A (PE) cell binding domain with the human immunodeficiency virus (HIV) gp120 binding domain from CD4 yields a hybrid toxin (CD4-PE) with potential therapeutic use in treating acquired immunodeficiency syndrome (AIDS). To find the most therapeutically potent combination of CD4 and PE ...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Winkler G,Jakubowski A,Turner S,Liu T,Burrus B,McGray P,Heanue T,Rosa M,Griffiths BA,Wali A

    更新日期:1991-04-01 00:00:00

  • Lymphotoxin cDNA clones from a HTLV-I-carrying T cell line HUT-102.

    abstract::The conditioned medium of a HTLV-I-carrying T cell line HUT-102 showed cytotoxic activity against a mouse fibroblast cell line L-M. We prepared the cDNA library from HUT-102 poly(A)+ RNA and screened it using oligonucleotide probes that correspond to the amino acid sequences conserved in tumor necrosis factor (TNF) an...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Kato S,Miki T,Takahashi N,Ohmori M,Hemmi H,Numao N,Kondo K

    更新日期:1989-12-01 00:00:00

  • HTLV type 1 infection in squirrel monkeys (Saimiri sciureus): a promising animal model for HTLV type 1 human infection.

    abstract::We show that the squirrel monkey Saimiri sciureus is susceptible to experimental infection with either syngeneic or allogeneic HTLV-1-immortalized cells. As in humans, such experimental inoculation leads to chronic infection, and HTLV-1 provirus was detected in PBMCs by PCR. Chronically infected monkeys developed high...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章,评审


    authors: Kazanji M

    更新日期:2000-11-01 00:00:00

  • The relationship between HIV type 1 disease progression and V3 serotype in a rural Ugandan cohort.

    abstract::Antigenic properties of the V3 region are reflected by HIV-1 serotypes. These may represent biological properties of the virus. We serotyped HIV-1 in 142 serum samples from participants in a rural Uganda cohort who seroconverted between August 1991 and December 2001. Clinical progression was assessed using Cox proport...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Senkaali D,Muwonge R,Morgan D,Yirrell D,Whitworth J,Kaleebu P

    更新日期:2004-09-01 00:00:00

  • Anti-CD4 antibodies are associated with HIV-1 seroconversion and may be detectable before anti-HIV-1 antibodies. The Multicenter AIDS Cohort Study.

    abstract::We examined the sera from 14 HIV-1 seroconverters for the presence of autoantibodies against CD4. Anti-CD4 antibodies were detected in the serum of 11 of 13 HIV-1-infected persons at the time of HIV-1 seroconversion. In 6 of 14 persons from whom a serum was obtained prior to HIV-1 seroconversion, anti-CD4 antibodies w...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章,多中心研究


    authors: Keiser P,Keay S,Wasserman S,Wecksler W

    更新日期:1992-11-01 00:00:00

  • Transmitted Drug Resistance Among Recently Diagnosed Adults and Children in São Paulo, Brazil.

    abstract::Transmitted drug resistance mutations (TDRM) have been a constant threat to treatment efficacy. We evaluated TDRM in plasma RNA of 217 antiretroviral therapy-naive patients from sites in the São Paulo metropolitan area, collected from 2012 to 2014. The partial HIV-1 polymerase region was sequenced using Big Dye termin...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Guimarães PM,Ferreira JL,Coelho LP,Cavalcanti Jde S,Lopes GI,Matsuda EM,Almeida FJ,Almeida VC,Campeas AE,Junior LC,Brígido LF,Sa˜o Paulo Salvage Workgroup.

    更新日期:2015-12-01 00:00:00

  • Distinct populations of human immunodeficiency virus type 1 in blood and cerebrospinal fluid.

    abstract::The nucleotide sequence of the gp41 transmembrane protein coding region of human immunodeficiency virus type 1 (HIV-1) proviral DNA obtained from blood and cerebrospinal fluid (CSF) from 6 individuals was determined by direct sequencing of polymerase chain reaction (PCR)-amplified DNA. The direct sequencing approach w...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Steuler H,Storch-Hagenlocher B,Wildemann B

    更新日期:1992-01-01 00:00:00

  • Going Beyond Giving Antiretroviral Therapy: Multimorbidity in Older People Aging with HIV in Nigeria.

    abstract::"Graying of HIV epidemic" is observed globally, as people living with HIV (PLWH) are aging, due to effectiveness of antiretrovirals. The normal aging processes and HIV-induced immune dysfunction, are potential mechanisms, driving multimorbidity (MM) in PLWH. MM is the concurrent presence of two or more diseases in a s...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Obimakinde AM,Adebusoye L,Achenbach C,Ogunniyi A,Olaleye D

    更新日期:2020-03-01 00:00:00

  • Molecular differences between two immunologically related spumaretroviruses: the human prototype HSRV and the chimpanzee isolate SFV6.

    abstract::A comparative study at the genomic and protein level was performed between two immunologically related spumaretroviruses, the human HSRV and the simian SFV6. Cross immunoprecipitation analysis with specific polyclonal and monoclonal antisera indicates shared antigenic determinants. However, restriction analysis of the...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Tobaly-Tapiero J,Santillana-Hayat M,Giron ML,Guillemin MC,Rozain F,Périès J,Emanoil-Ravier R

    更新日期:1990-07-01 00:00:00

  • Nonaffinity purification of recombinant gp120 for use in AIDS vaccine development.

    abstract::The gene encoding the major envelope glycoprotein of the HIV-SF2 isolate was engineered for the secretion of recombinant gp120 (rgp120SF2) from permanent Chinese hamster ovary (CHO) cell lines. Cellular production methods were scaled up and a method for purification of the secreted glycoprotein was devised. Mild purif...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Scandella CJ,Kilpatrick J,Lidster W,Parker C,Moore JP,Moore GK,Mann KA,Brown P,Coates S,Chapman B

    更新日期:1993-12-01 00:00:00

  • Strain-dependent productive infection of a unique eosinophilic cell line by human immunodeficiency virus type 1.

    abstract::Eosinophils are granulocytic leukocytes that function in both protective and pathological immune responses. They can be infected by HIV-1, but characterization of the infection has been hindered by lack of a productive cell culture model. In the present study, the unique eosinophilic cell line AML14.3D10 was used as a...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Wooley DP,Peterson KT,Taylor RJ,Paul CC,Baumann MA

    更新日期:2000-09-20 00:00:00

  • Oligopeptide inhibitors of HIV-induced syncytium formation.

    abstract::The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein is essential for virus entry and the formation of multinucleated giant cells by cell fusion, one of the major virus-induced cytopathic effects. To study the effects of potential fusion inhibitors, a vaccinia virus recombinant expressing the envelope...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Owens RJ,Tanner CC,Mulligan MJ,Srinivas RV,Compans RW

    更新日期:1990-11-01 00:00:00

  • Efficacy and safety of a once daily regimen with efavirenz, lamivudine, and didanosine, with and without food, as initial therapy for HIV Infection: the ELADI study.

    abstract::The combination of didanosine (ddI) and lamivudine (3TC) is attractive considering its low cost, potency, tolerability, and convenience (once daily administration), but it is not recommended as first-line therapy for HIV infection. A prospective, multicenter, open, comparative trial was conducted in HIV-infected, anti...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章,多中心研究


    authors: Sánchez-Conde M,Palacios R,Sanz J,Rodríguez-Novoa S,Rivas P,Santos J,Sola J,Asensi V,de Mendoza C,Estrada V,Barreiro P,González-Lahoz J,Jiménez-Nacher I,Soriano V

    更新日期:2007-10-01 00:00:00

  • Short Communication: Viral Suppression Is Associated with Increased Likelihood of Colorectal Cancer Screening Among Persons Living with HIV/AIDS.

    abstract::With improved survival and aging, more persons living with HIV/AIDS (PLWHA) are at risk for colorectal cancer (CRC). This retrospective longitudinal study evaluated patient characteristics associated with CRC screening in our HIV cohort. Patients were followed beginning at age 50 years during a study period from Janua...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Burkholder GA,Tamhane AR,Appell LE,Willig JH,Saag MS,Raper JL,Westfall AO,Mugavero MJ

    更新日期:2015-05-01 00:00:00

  • Evaluation of primary resistance to HIV entry inhibitors among brazilian patients failing reverse transcriptase/protease inhibitors treatment reveal high prevalence of maraviroc resistance-related mutations.

    abstract::Entry inhibitor is a new class of drugs that target the viral envelope protein. This region is variable; hence resistance to these drugs may be present before treatment. The aim of this study was to analyze the frequency of patients failing treatment with transcriptase reverse and protease inhibitors that would respon...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Alencar CS,Nishiya AS,Ferreira S,Giret MT,Diaz RS,Sabino EC

    更新日期:2010-12-01 00:00:00

  • Prevalence of HIV-1 Subtypes and Drug Resistance-Associated Mutations in HIV-1-Positive Treatment-Naive Pregnant Women in Pointe Noire, Republic of the Congo (Kento-Mwana Project).

    abstract::The Kento-Mwana project was carried out in Pointe Noire, Republic of the Congo, to prevent mother-to-child HIV-1 transmission. To determine the prevalence of different subtypes and transmitted drug resistance-associated mutations, 95 plasma samples were collected at baseline from HIV-1-positive naive pregnant women en...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Bruzzone B,Saladini F,Sticchi L,Mayinda Mboungou FA,Barresi R,Caligiuri P,Calzi A,Zazzi M,Icardi G,Viscoli C,Bisio F

    更新日期:2015-08-01 00:00:00

  • Analysis of the V1V2 region of the SIV envelope in the brains of morphine-dependent and control SIV/SHIV-infected macaques.

    abstract::Six morphine-dependent and three control macaques were infected with a mixture of SIV/SHIV. Half of the animals in the morphine group developed accelerated disease (rapid progressor) and died within 20 weeks postinfection. The evolution of the envelope gene in the brain of the rapid progressor and morphine-dependent g...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Rivera-Amill V,Noel RJ Jr,Román IR,Flores YG,Buch S,Kumar A

    更新日期:2009-05-01 00:00:00

  • On the Physicochemical and Structural Modifications Associated with HIV-1 Subtype B Tropism Transition.

    abstract::HIV-1 enters immune cells via binding the viral envelope to a host cell CD4 receptor, and then a secondary co-receptor, usually CCR5 (R5) or CXCR4 (X4), and some HIV can utilize both co-receptors (R5X4). Although a small set of amino-acid properties such as charge and sequence length applied to HIV-1 envelope V3 loop ...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Lamers SL,Fogel GB,Liu ES,Salemi M,McGrath MS

    更新日期:2016-08-01 00:00:00

  • RNA secondary structure and squence conservation in C1 region of human immunodeficiency virus type 1 env gene.

    abstract::We have analyzed amino acid, nucleotide sequence, and RNA secondary structure variability in the env gene of human immunodeficiency virus type (HIV-1). In applying algorithms for computing optimal RNA-folding patterns to a nonredundant data set of 178 env nucleotide sequences, we found a conserved RNA stem-loop struct...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Peleg O,Brunak S,Trifonov EN,Nevo E,Bolshoy A

    更新日期:2002-08-10 00:00:00

  • Interferon-Free Treatment of Hepatitis C Virus in HIV/Hepatitis C Virus-Coinfected Subjects Results in Increased Serum Low-Density Lipoprotein Concentration.

    abstract::Chronic hepatitis C virus (HCV) infection is associated with lower serum concentration of low-density lipoprotein (LDL-C), the primary cholesterol metabolite targeted pharmaceutically to modulate cardiovascular risk. Chronic infection with human immunodeficiency virus (HIV) and treatment with antiretrovirals (ARVs) ar...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Townsend K,Meissner EG,Sidharthan S,Sampson M,Remaley AT,Tang L,Kohli A,Osinusi A,Masur H,Kottilil S

    更新日期:2016-05-01 00:00:00

  • Characterization of integrase region polymorphisms in HIV type 1 CRF06_cpx viruses in treatment-naive patients in Estonia.

    abstract::Natural polymorphisms of HIV-1, often associated with drug resistance, are widely described in protease and reverse transcriptase regions but data on their presence in the integrase region, especially in non-B subtypes, are still very limited. We aimed to characterize naturally occurring polymorphisms in the integrase...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Avi R,Huik K,Sadam M,Karki T,Krispin T,Ainsalu K,Paap P,Schmidt J,Nikitina N,Lutsar I

    更新日期:2010-10-01 00:00:00

  • Susceptibility to antiretroviral drugs of CRF01_AE, CRF02_AG, and subtype C viruses from untreated patients of Africa and Asia: comparative genotypic and phenotypic data.

    abstract::Non-B HIV-1 viruses are predominant in developing countries where access to antiretroviral drugs (ARVs) is progressively being intensified. It is important to obtain more data on the susceptibility of these viruses to available ARVs. CRF01_AE, CRF02_AG, and subtype C strains of HIV-1 obtained from untreated patients f...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Fleury HJ,Toni T,Lan NT,Hung PV,Deshpande A,Recordon-Pinson P,Boucher S,Lazaro E,Jauvin V,Lavignolle-Aurillac V,Lebel-Binay S,Cheret A,Masquelier B

    更新日期:2006-04-01 00:00:00