Thalidomide stimulates T cell responses and interleukin 12 production in HIV-infected patients.

abstract：:SIVsmmFGb is a lentivirus swarm that induces neuropathology in over 90% of infected pigtailed macaques and reliably models central nervous system HIV infection in people. We have previously studied SIVsmmFGb genetic diversity and compartmentalization during acute infection, but little is understood about diversity and...

journal_title：AIDS research and human retroviruses

authors： Reeve AB,Pearce NC,Patel K,Augustus KV,Novembre FJ

更新日期：2010-06-01 00:00:00

abstract：:Little is known about the consequences of short cycles of structured treatment interruption or definitive interruption of HAART for both T cell subset dynamics and T lymphoproliferative responses (LPR). Immunological follow-up was performed in 45 early chronical HIV-1-infected patients during short STI cycles during t...

journal_title：AIDS research and human retroviruses

authors： Libois A,López A,Garcia F,Castro P,Maleno MJ,García A,Climent N,Arnedo M,Gallart T,Gatell JM,Plana M

更新日期：2006-07-01 00:00:00

abstract：:Human immunodeficiency virus type-1 (HIV-1) is a leading cause of mortality and morbidity in the world, with almost 46 million people infected globally. HIV-1 subtype C accounts for 55% of these infections. In Zambia, the majority of HIV-1 infections are subtype C. However, to its north most countries have non-subtype...

journal_title：AIDS research and human retroviruses

authors： Munkanta M,Handema R,Kasai H,Gondwe C,Deng X,Yamashita A,Asagi T,Yamamoto N,Ito M,Kasolo F,Terunuma H

更新日期：2005-10-01 00:00:00

abstract：:Elite controllers or suppressors (ES) are HIV-1-infected patients who maintain viral loads of <50 copies/ml without antiretroviral therapy. While HLA-B*57 and B*5801 alleles are overrepresented in ES, many HLA-B*57/B*5801 patients become chronic progressors (CP). We show here that HIV-1 infection results in similar le...

journal_title：AIDS research and human retroviruses

authors： Sampah ME,Ceccato CM,Blankson JN

更新日期：2011-02-01 00:00:00

abstract：:This study examines the association between presence of drug resistance mutations and phenotypic resistance at baseline to virologic response to salvage therapy in a community setting. The study population consisted of 58 antiretroviral drug-experienced patients with HIV-1 infection who had recently switched therapy b...

journal_title：AIDS research and human retroviruses

authors： Ross L,Liao Q,Gao H,Pham S,Tolson J,Hertogs K,Larder B,Saag MS

更新日期：2001-10-10 00:00:00

abstract：:The objectives of this study were to evaluate the performance of parallel rapid HIV testing and the presence of HIV-associated risk factors in pregnant women with unknown HIV status in Baja California, Mexico. Pregnant women attending the delivery unit or the prenatal clinic at Tijuana General Hospital had blood drawn...

journal_title：AIDS research and human retroviruses

authors： Viani RM,Araneta MR,Spector SA

更新日期：2013-03-01 00:00:00

abstract：:Human T cell leukemia virus type-1 (HTLV-1) is prevalent worldwide with foci of high prevalence. However, to date no effective vaccine or drug against HTLV-1 infection has been developed. In efforts to define the role of antibodies in the control of HTLV-1 infection, we capitalized on the use of our previously defined...

journal_title：AIDS research and human retroviruses

authors： Tanaka Y,Takahashi Y,Tanaka R,Kodama A,Fujii H,Hasegawa A,Kannagi M,Ansari AA,Saito M

更新日期：2014-06-01 00:00:00

abstract：:With improved survival and aging, more persons living with HIV/AIDS (PLWHA) are at risk for colorectal cancer (CRC). This retrospective longitudinal study evaluated patient characteristics associated with CRC screening in our HIV cohort. Patients were followed beginning at age 50 years during a study period from Janua...

journal_title：AIDS research and human retroviruses

authors： Burkholder GA,Tamhane AR,Appell LE,Willig JH,Saag MS,Raper JL,Westfall AO,Mugavero MJ

更新日期：2015-05-01 00:00:00

abstract：:In October of 2019, researchers and community members from around the world met at the NIH for the fifth annual International Workshop on Microbiome in HIV. New research was presented on the role of the microbiome on chronic inflammation and vaccine design, interactions of genetics, environment, sexual practice and HI...

journal_title：AIDS research and human retroviruses

authors： Sherrill-Mix S,Connors K,Aldrovandi GM,Brenchley JM,Boucher C,Bushman FD,Collman RG,Dandekar S,Klatt NR,Lagenaur LA,Paredes R,Tachedjian G,Turpin JA,Landay AL,Ghosh M

更新日期：2020-11-01 00:00:00

abstract：:In this study, HIV strains circulating among military personnel were characterized, in Malabo, the capital city of Equatorial Guinea. One sample was found to be HIV-2 group A while a high degree of genetic diversity was recorded in the pol region of 41 HIV-1-positive samples. CRF02_AG accounted for 53.7% of the strain...

journal_title：AIDS research and human retroviruses

authors： Djoko CF,Wolfe ND,Vidal N,Tamoufe U,Montavon C,LeBreton M,Pike BL,Fair J,Mbacham WF,Benito A,Rimoin AW,Saylors K,Mpoudi-Ngole E,Grillo MP,Peeters M

更新日期：2010-09-01 00:00:00

abstract：:A novel prophylactic AIDS vaccine candidate, consisting of single-stranded DNA for HIV-1 subtype C gag, protease, and part of reverse transcriptase genes, enclosed within a recombinant adeno-associated virus serotype-2 protein capsid (tgAAC09) induced T cell responses and antibodies in nonhuman primates. In this rando...

journal_title：AIDS research and human retroviruses

authors： Mehendale S,van Lunzen J,Clumeck N,Rockstroh J,Vets E,Johnson PR,Anklesaria P,Barin B,Boaz M,Kochhar S,Lehrman J,Schmidt C,Peeters M,Schwarze-Zander C,Kabamba K,Glaunsinger T,Sahay S,Thakar M,Paranjape R,Gilmour J,

更新日期：2008-06-01 00:00:00

abstract：:Signature pattern analysis identifies particular sites in amino acid or nucleic acid alignments of variable sequences that are distinctly representative of a query set of sequences relative to a background set. We explore the merits of using signature patterns for analysis of HIV-1 (human immunodeficiency virus type 1...

journal_title：AIDS research and human retroviruses

authors： Korber B,Myers G

更新日期：1992-09-01 00:00:00

abstract：:Perinatal antiretroviral (ARV) exposure has been related to hyperlactatemia and lactic acidosis in infants born to HIV-infected mothers. Our objective was to determine the incidence of these conditions during the first year of life in uninfected infants born to HIV-infected mothers and compare the data with infants bo...

journal_title：AIDS research and human retroviruses

authors： Soler-Palacín P,Martín-Nalda A,Martínez-Gómez X,Melendo S,Riudor E,Arranz JA,Espiau M,Figueras C

更新日期：2012-08-01 00:00:00

abstract：:A higher functionality of CD8(+) T cells might contribute to low-level HIV replication in long-term nonprogressors (LTNPs). However, the contrary could also be true, being the function of CD8(+) T cells modulated by HIV replication. We tested whether enhanced HIV replication following antiretroviral therapy interrupti...

journal_title：AIDS research and human retroviruses

authors： López M,Rallón N,Soriano V,Rodríguez I,Valencia E,Labarga P,Moreno V,Vispo E,Roncal F,González-Lahoz J,Benito JM

更新日期：2008-09-01 00:00:00

abstract：:HIV-1 Nef (Nef) is a myristoylated protein that contributes to HIV disease pathogenesis. Nef has a modulatory effect on T cell receptor (TCR) signaling, resulting in up-regulation of interleukin-2 (IL-2) production in stimulated T cells. Recent studies have shown that efficient TCR signaling requires enhanced associat...

journal_title：AIDS research and human retroviruses

authors： Djordjevic JT,Schibeci SD,Stewart GJ,Williamson P

更新日期：2004-05-01 00:00:00

abstract：:We evaluated the effect of drug alternation on human immunodeficiency virus type 1 (HIV-1) suppression and emergence of resistant virus strains in CEM cell cultures. Rapid, that is, twice weekly, alternation of lamivudine and nevirapine (at 0.1 microg/ml) at the time of each subcultivation resulted in a long-term supp...

journal_title：AIDS research and human retroviruses

authors： Balzarini J,De Clercq E

更新日期：2001-11-20 00:00:00

abstract：:Previous studies have suggested that the abilities of human immunodeficiency virus type 1 (HIV-1) to infect primary macrophages and transformed T cell lines are mutually exclusive and define an important biological distinction among HIV-1 strains. In a survey of eight macrophage-tropic HIV-1 strains and nine T cell li...

journal_title：AIDS research and human retroviruses

authors： Chowdhury IH,Potash MJ,Volsky DJ

更新日期：1995-12-01 00:00:00

abstract：:We have used a panel of anti-gp160 MAbs to construct anti-HIV immunotoxins by coupling antibodies to ricin A chain (RAC). The ability of the immunotoxins to kill HIV-1-infected cells and halt the spread of infection was tested in tissue culture on persistently and acutely infected cell lines and primary lymphocyte cul...

journal_title：AIDS research and human retroviruses

authors： Pincus SH,Wehrly K,Cole R,Fang H,Lewis GK,McClure J,Conley AJ,Wahren B,Posner MR,Notkins AL,Tilley SA,Pinter A,Eiden L,Teintze M,Dorward D,Tolstikov VV

更新日期：1996-07-20 00:00:00

abstract：:In a polygamous marriage in Senegal, the husband and his two spouses were infected with HIV-1 group O. This study provides new full-length genome sequences for the two spouses (99SE-MP1299 and 99SE-MP1300) and the 3'-end LTR-tat fragment (6084 bp) for the husband (98SE-42HALD). Phylogenetic tree and diversity plot ana...

journal_title：AIDS research and human retroviruses

authors： Kane CT,Montavon C,Toure MA,Faye MA,Ndiaye AG,Diallo AG,Ndoye I,Liegeois F,Delaporte E,Mboup S,Peeters M

更新日期：2001-08-10 00:00:00

abstract：:Cell activation is essential for HIV infection. CD4+ T lymphocyte activation allows virus replication and CD8+ T lymphocyte activation may contribute to pathogenesis. We combined hydroxyurea, a cytostatic drug that inhibits cell activation and proliferation, with two drugs that inhibit HIV (didanosine and indinavir), ...

journal_title：AIDS research and human retroviruses

authors： Lori F,Jessen H,Lieberman J,Clerici M,Tinelli C,Lisziewicz J

更新日期：1999-05-01 00:00:00

abstract：:Eight fragments derived from the HIV-1 pol gene were expressed as recombinant polypeptides in Escherichia coli. The fragments were from the portion of the pol gene that encodes the reverse transcriptase. The expressed peptides were analyzed immunologically with sera from HIV-1-infected individuals. Three distinct immu...

journal_title：AIDS research and human retroviruses

authors： Padberg C,Nowlan S,Mermer B

更新日期：1989-02-01 00:00:00

abstract：:Diversity of genotypes and prevalence of pretreatment drug resistance (PDR) are challenges for the epidemic control and vaccine development of HIV-1. However, little is known about the situation in Tianjin. Blood samples were collected from newly diagnosed, antiretroviral treatment (ART)-naive HIV/AIDS patients from J...

journal_title：AIDS research and human retroviruses

authors： Zeng R,Ren D,Gong X,Wei M,Gao L,Yu A,Zhang D,Mi Y,Ma P

更新日期：2020-10-01 00:00:00

abstract：:Il28B single nucleotide polymorphisms were found to influence interferon λ expression, resulting in changes in hepatitis C virus (HCV)-RNA serum levels as well as the HIV-RNA set point prior to combined antiretroviral therapy (cART). To date, there is limited information on the influence of this polymorphism on surviv...

journal_title：AIDS research and human retroviruses

authors： Parczewski M,Bander D,Leszczyszyn-Pynka M,Urbańska A,Socha Ł,Boroń-Kaczmarska A

更新日期：2012-12-01 00:00:00

abstract：:A total of 110 HIV-1-positive samples obtained in 1997 (n = 44) and 2000 (n = 66) were genetically characterized in the V3-V5 envelope region and the p24 gag region. The majority of the strains were CRF02-AG (54.3%) or CRF06-cpx (18.1%) in env and gag. More than 9% of the samples were recombinants between CRF02 and CR...

journal_title：AIDS research and human retroviruses

authors： Mamadou S,Montavon C,Ben A,Djibo A,Rabiou S,Mboup S,Delaporte E,Peeters M

更新日期：2002-07-01 00:00:00

abstract：:Genotropism was determined in 608 Brazilian samples collected in dried blood spots using Polyethersulfone collection cards. Patients were infected by subtype B (88.8%), F (5.6%), C (3.3%), A (1.8%), and G (0.5%). All patients were exposed to three classes of antiretrovirals, and 59.8% of the samples harbored R5 viruse...

journal_title：AIDS research and human retroviruses

authors： Lavigne S,Santos C,Arif MS,Reis A,Samer S,Dos Santos CV,Diaz RS

更新日期：2014-02-01 00:00:00

abstract：:We evaluated the performance of T-SPOT.TB (a commercial interferon gamma release assay) and its accuracy for the diagnosis of active tuberculosis (TB) among HIV-infected subjects with advanced immunodeficiency. In a clinical prospective study, we assessed the performance of T-SPOT.TB for the diagnosis of active TB in ...

journal_title：AIDS research and human retroviruses

authors： Chen J,Sun J,Zhang R,Liu L,Zheng Y,Shen Y,Wang Z,Sun F,Li L,Lu H

更新日期：2011-03-01 00:00:00

abstract：:Our previous studies have indicated that HIV transmission from infected mothers to infants occurs with viruses showing rapid kinetics of replication, and either resistance to maternal neutralizing antibodies or sensitivity to enhancing antibodies. The genotypic patterns that result in these and other phenotypic viral ...

journal_title：AIDS research and human retroviruses

authors： Kliks S,Contag CH,Corliss H,Learn G,Rodrigo A,Wara D,Mullins JI,Levy JA

更新日期：2000-09-01 00:00:00

abstract：:A new model system is delineated that will enable study of CD4 cofactors and gp120 binding proteins other than CD4. We have previously described a nontransformed rat fibroblast cell line that can efficiently produce HIV-1 upon transfection with an HIV-1 infectious clone, in contrast to other nonhuman mammalian cell li...

journal_title：AIDS research and human retroviruses

authors： Mizrachi Y,Rubinstein A,Golodner M,Sakai K,Volsky DJ

更新日期：1996-09-20 00:00:00

abstract：:HIV inhibitors targeted at the virus-associated reverse transcriptase (RT) can be divided into two groups, depending on whether they are targeted at the substrate or nonsubstrate binding site. To the first group belong the 2',3'-dideoxynucleosides (i.e., DDC, DDI), 3'-azido-2',3'-dideoxynucleosides (i.e., AZT), 3'-flu...

journal_title：AIDS research and human retroviruses

authors： De Clercq E

更新日期：1992-02-01 00:00:00

abstract：:Dendritic cells (DCs) are important mediators of the immune response against HIV and yet blood DC numbers fall substantially during HIV infection. Here we report that blood levels of the DC-tissue tropic chemokines monocyte chemotactic protein (MCP-1/CCL2), macrophage inflammatory proteins (MIP-3α/CCL20), and MIP-3β/C...

journal_title：AIDS research and human retroviruses

authors： Fontaine J,Poudrier J,Roger M

更新日期：2011-06-01 00:00:00