Genetic analysis of viral variants selected in transmission of human immunodeficiency viruses to newborns.

abstract：:The predictive value of virological response to lopinavir (LPV)/ritonavir (r) was assessed in 126 HIV-infected patients who failed antiretroviral therapy and had begun a rescue intervention based on LPV/r. At 3 months, subjects with < or =6 protease (PRO) resistance mutations showed a higher rate of virological respon...

journal_title：AIDS research and human retroviruses

authors： González de Requena D,Gallego O,Valer L,Jiménez-Nácher I,Soriano V

更新日期：2004-03-01 00:00:00

abstract：:In recent years, the increase of migration from countries where human immunodeficiency virus type 2 (HIV-2) is endemic to industrialized countries has facilitated the spread of the virus in individuals previously unexposed to this threat. In this report, we performed a phylogenetic analysis on pol and env sequences of...

journal_title：AIDS research and human retroviruses

authors： D'Ettorre G,Lo Presti A,Gori C,Cella E,Bertoli A,Vullo V,Perno CF,Ciotti M,Foley BT,Ciccozzi M,HIV-2 Study Group.

更新日期：2013-09-01 00:00:00

abstract：:The national incidence of epidemic Kaposi sarcoma (KS) has decreased dramatically since the availability of combined antiretroviral therapy. Despite national trends, we continue to see admissions for KS. Electronic medical records were queried to identify patients with HIV who were admitted with active KS between 2010...

journal_title：AIDS research and human retroviruses

authors： Kasturia SE,Gunthel C,Zeng C,Nguyen ML

更新日期：2017-06-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) replicate during acute infection in lymphocytes of the gastrointestinal tract, before disseminating systemically. Localized replication and associated loss of gut-resident CD4+ T cells occur regardless of the portal of entry of the virus (e.g.,...

journal_title：AIDS research and human retroviruses

authors： Méndez-Lagares G,Lu D,Merriam D,Baker CA,Villinger F,Van Rompay KKA,McCune JM,Hartigan-O'Connor DJ

更新日期：2017-11-01 00:00:00

abstract：:HIV-1 protease activity is essential for viral replication. In spite of the high rates of HIV mutation, the active site of protease (residues 24-29) is a conserved site, where mutations have not been previously described. To determine the effect of mutations at positions T26 and A29 of the viral protease and its viabi...

journal_title：AIDS research and human retroviruses

authors： Melón S,Gil-Roda C,de Oña M,Erice A

更新日期：2004-11-01 00:00:00

abstract：:Cytotoxic T lymphocytes that specifically lyse HIV-1-infected cells occur at uncommonly high frequency in the blood of infected individuals. The CTL response is dominated by the recognition of a small number of peptides encoded by HIV-1 structural and regulatory genes. These two facts have enabled us to develop potent...

journal_title：AIDS research and human retroviruses

authors： Lieberman J,Fabry JA,Shankar P,Beckett L,Skolnik PR

更新日期：1995-02-01 00:00:00

abstract：:High-resolution structures have revealed major pockets in the MHC class II peptide binding groove within a region designated Pl-P9. The region can accommodate 9-mer peptides, consistent with the observation that minimal core helper T (Th) cell determinants are usually eight or nine residues in size. Here we describe m...

journal_title：AIDS research and human retroviruses

authors： Lockey TD,Surman S,Brown S,Slobod KS,Coleclough C,Doherty PC,Hurwitz JL

更新日期：2002-10-10 00:00:00

abstract：:To investigate the changes of neutralizing antibodies and viruses during simian and human immunodeficiency virus (SHIV) infection, we examined the cross-neutralizing ability of sequential sera from three macaques infected with SHIV, NM-3rN, and analyzed the sensitivity of the reisolate to neutralizing antibodies. Neut...

journal_title：AIDS research and human retroviruses

authors： Miyazaki Y,Kuwata T,Takehisa J,Hayami M

更新日期：2002-04-10 00:00:00

abstract：:Depletion of mitochondrial DNA (mtDNA) and mtDNA-encoded respiratory chain proteins in subcutaneous (SC) fat from patients with HIV lipoatrophy have clearly demonstrated the role of mitochondrial dysfunction in this syndrome. Research in HIV lipoatrophy, however, has been severely hampered by the lack of a suitable su...

journal_title：AIDS research and human retroviruses

authors： Shikuma CM,Gerschenson M,Chow D,Libutti DE,Willis JH,Murray J,Capaldi RA,Marusich M

更新日期：2008-10-01 00:00:00

abstract：:Japan is one of the highest endemic areas of the world for human T cell leukemia-lymphoma virus type I (HTLV-I). To gain new insight as to the origin of this virus in Japan and especially in the southern islands of the archipelago, we investigated the long terminal repeat (LTR) of 67 newly isolated HTLV-I proviral DNA...

journal_title：AIDS research and human retroviruses

authors： Vidal AU,Gessain A,Yoshida M,Mahieux R,Nishioka K,Tekaia F,Rosen L,De Thé G

更新日期：1994-11-01 00:00:00

abstract：:The HIV-1 reverse transcriptase genes from 37 HIV-1-positive pregnant women attending an antenatal clinical in Soweto, South Africa were sequenced and analyzed for the presence of drug resistance mutations. All women were antiretroviral drug naive, but were being screened as potential participants in clinical trials o...

journal_title：AIDS research and human retroviruses

authors： Pillay C,Bredell H,McIntyre J,Gray G,Morris L

更新日期：2002-05-20 00:00:00

abstract：:Myeloid dendritic cells (mDCs) are essential for initiation of adaptive immune responses but are depleted in HIV infection. Evidence suggests that apoptosis mediates loss, and to further understand the pathways involved, expression of caspases mediating apoptosis via the extrinsic and intrinsic pathways was analyzed. ...

journal_title：AIDS research and human retroviruses

authors： Chen J,Benlahrech A,Kelleher P,Patterson S

更新日期：2013-04-01 00:00:00

abstract：:Despite repeated exposures to HIV-1, some individuals remain seronegative. This study reports that sera from a fraction of exposed seronegative (ESN) subjects showed HIV-neutralizing activity; 5 of 17 ESN sera and none of 17 controls neutralized two different HIV-1 primary isolates (range of neutralizing titers: 1/20 ...

journal_title：AIDS research and human retroviruses

authors： Lopalco L,Pastori C,Cosma A,Burastero SE,Capiluppi B,Boeri E,Beretta A,Lazzarin A,Siccardi AG

更新日期：2000-01-20 00:00:00

abstract：:Neutralizing antibodies (NA) against HIV-1MN and HIV-1IIIB, and antibodies binding to synthetic peptides (BA) derived from the gp120 envelope V3 region principal neutralizing determinants (PND) of the HIV-1MN, HIV-1IIIB, and HIV-1Z3 virus strains were assayed in HIV-1 antibody-positive sera from the United States, Hai...

journal_title：AIDS research and human retroviruses

authors： Carrow EW,Vujcic LK,Glass WL,Seamon KB,Rastogi SC,Hendry RM,Boulos R,Nzila N,Quinnan GV Jr

更新日期：1991-10-01 00:00:00

abstract：:T epitope mapping in human immunodeficiency virus proteins provides a useful tool for AIDS vaccine design. We have previously shown that four peptides selected from the Gag polyprotein of HIV-1 were able to prime mice for in vitro lymphoproliferative responses. These responses were shown to be MHC restricted, and a po...

journal_title：AIDS research and human retroviruses

authors： Vaslin B,Claverie JM,Benveniste O,Barre-Sinoussi FC,Dormont D

更新日期：1994-10-01 00:00:00

abstract：:HLA-A*3303 is one of the common HLA alleles in East and Southeast Asia. Identification of HLA-A*3303-restricted HIV-1 cytotoxic T lymphocyte (CTL) epitopes is therefore required to investigate the immunopathogenesis of AIDS and vaccine development in these areas, where AIDS is rapidly expanding. We attempted to identi...

journal_title：AIDS research and human retroviruses

authors： Hossain MS,Tomiyama H,Inagawa T,Ida S,Oka S,Takiguchi M

更新日期：2003-06-01 00:00:00

abstract：:CRF01_AE is one of the four dominant HIV-1 strains circulating in China. In this study, we performed genetic and phenotypic analyses using a total of 60 full-length envelope gene clones from 14 HIV-1-infected individuals in the Beijing area. Among the 60 sequences analyzed, 32 have a complete open reading frame (ORF),...

journal_title：AIDS research and human retroviruses

authors： Chen D,He X,Ye J,Zhao P,Zeng Y,Feng X

更新日期：2016-10-01 00:00:00

abstract：:Direct evidence confirming the hypothesis that a dysfunction of the mitochondrial respiratory chain (MRC) underlies the pathogenesis of hyperlactatemia associated with highly active antiretroviral therapy (HAART) is scarce. We studied mitochondrial DNA (mtDNA) content and MRC function in the skeletal muscle of an HIV-...

journal_title：AIDS research and human retroviruses

authors： Miró O,López S,Martínez E,Rodríguez-Santiago B,Blanco JL,Milinkovic A,Miró JM,Nunes V,Casademont J,Gatell JM,Cardellach F

更新日期：2003-11-01 00:00:00

abstract：:Previous studies have suggested that the abilities of human immunodeficiency virus type 1 (HIV-1) to infect primary macrophages and transformed T cell lines are mutually exclusive and define an important biological distinction among HIV-1 strains. In a survey of eight macrophage-tropic HIV-1 strains and nine T cell li...

journal_title：AIDS research and human retroviruses

authors： Chowdhury IH,Potash MJ,Volsky DJ

更新日期：1995-12-01 00:00:00

abstract：:Dendritic cells (DCs) are important mediators of the immune response against HIV and yet blood DC numbers fall substantially during HIV infection. Here we report that blood levels of the DC-tissue tropic chemokines monocyte chemotactic protein (MCP-1/CCL2), macrophage inflammatory proteins (MIP-3α/CCL20), and MIP-3β/C...

journal_title：AIDS research and human retroviruses

authors： Fontaine J,Poudrier J,Roger M

更新日期：2011-06-01 00:00:00

abstract：:Epidemiological studies strongly suggest that a newly discovered herpesvirus, Kaposi's sarcoma associated-herpesvirus (KSHV/HHV8), is the likely infectious cause of Kaposi's sarcoma (KS). Identification of this agent suggests the possibility that existing anti-herpesvirus chemotherapeutics have activity against KSHV. ...

journal_title：AIDS research and human retroviruses

authors： Flore O,Gao SJ

更新日期：1997-09-20 00:00:00

abstract：:We set out to investigate whether there are clinically significant consequences when children with perinatal exposure to single-dose nevirapine are initiated on a nonnucleoside reverse transcriptase inhibitor (NNRTI) containing a highly active antiretroviral therapy (HAART) regimen. We carried out a chart and database...

journal_title：AIDS research and human retroviruses

authors： Musiime V,Ssali F,Kayiwa J,Namala W,Kizito H,Kityo C,Mugyenyi P

更新日期：2009-10-01 00:00:00

abstract：:Tuberculosis (TB) is the major opportunistic infection of HIV-infected patients in developing countries and is associated with activation of the immune system and increased HIV-1 expression. The aim of this study was to explore the biological properties of HIV-1 isolates from patients with active TB. Ten HIV-1 subtype...

journal_title：AIDS research and human retroviruses

authors： Morris L,Cilliers T,Bredell H,Phoswa M,Martin DJ

更新日期：2001-05-20 00:00:00

abstract：:Abstract Multiple HIV-1 subtypes and circulating recombinant forms (CRFs) are known to cocirculate in Africa. In West Africa, the high prevalence of CRF02_AG, and cocirculation of subtype A, CRF01_AE, CRF06_cpx, and other complex intersubtype recombinants has been well documented. Mali, situated in the heart of West A...

journal_title：AIDS research and human retroviruses

authors： Imamichi H,Koita O,Dabitao D,Dao S,Ibrah M,Sogoba D,Dewar RL,Berg SC,Jiang MK,Parta M,Washington JA,Polis MA,Lane HC,Tounkara A

更新日期：2009-01-01 00:00:00

abstract：:"Graying of HIV epidemic" is observed globally, as people living with HIV (PLWH) are aging, due to effectiveness of antiretrovirals. The normal aging processes and HIV-induced immune dysfunction, are potential mechanisms, driving multimorbidity (MM) in PLWH. MM is the concurrent presence of two or more diseases in a s...

journal_title：AIDS research and human retroviruses

authors： Obimakinde AM,Adebusoye L,Achenbach C,Ogunniyi A,Olaleye D

更新日期：2020-03-01 00:00:00

abstract：:CD4(+) T cell help is important for the functionality of CD8(+) cytotoxic T-lymphocytes (CTLs) in limiting viral replication and may contribute to mediation of apparent resistance to HIV-1 infection in exposed seronegative (ESN) individuals. Using five HIV-1 antigens in an intracellular cytokine assay, the presence of...

journal_title：AIDS research and human retroviruses

authors： Kebba A,Kaleebu P,Serwanga J,Rowland S,Yirrell D,Downing R,Gilmour J,Imami N,Gotch F,Whitworth J

更新日期：2004-01-01 00:00:00

abstract：:We characterized two immune escape viruses (SHIV(KU-1/105w52) and SHIV(KU-1/105w98)) from a macaque immunized with DeltavpuDeltanef SHIV-4 and challenged with pathogenic SHIV(KU-1). This macaque developed neutralizing antibodies as well as virus-specific CTLs against the challenge virus. However, the two new viruses c...

journal_title：AIDS research and human retroviruses

authors： Stipp HL,Kumar A,Narayan O

更新日期：2000-10-10 00:00:00

abstract：:DNA vaccines have the potential of giving rise to a potent cell-mediated immune response by inducing intracellular synthesis and subsequent antigenic presentation of encoded antigens. We have tested a DNA vaccine specific for human immunodeficiency virus type 1 (HIV-1) by the injection of animals with expression plasm...

journal_title：AIDS research and human retroviruses

authors： Okuda K,Bukawa H,Hamajima K,Kawamoto S,Sekigawa K,Yamada Y,Tanaka S,Ishi N,Aoki I,Nakamura M

更新日期：1995-08-01 00:00:00

abstract：:To eradicate human immunodeficiency virus type 1 (HIV-1) infection, a comprehensive strategy including preventive vaccine development is needed. Envelope glycoproteins (Env) play a central role in viral infection and are the major targets of humoral immune responses. Therefore, Env is a candidate vaccine antigen, and ...

journal_title：AIDS research and human retroviruses

authors： Sasaki M,Kotaki T,Khairunisa SQ,Tachibana S,Ophinni Y,Hayashi Y,Nasronudin,Kameoka M

更新日期：2020-03-01 00:00:00

abstract：:The transmembrane envelope (TM) protein gp41 of HIV-1 is an attractive target when designing a vaccine to induce neutralizing antibodies. A few broadly neutralizing antibodies (2F5, 4E10, and 10E8) that target conserved epitopes in the membrane proximal external region (MPER) of gp41 have been isolated from infected i...

journal_title：AIDS research and human retroviruses

authors： Strasz N,Morozov VA,Kreutzberger J,Keller M,Eschricht M,Denner J

更新日期：2014-05-01 00:00:00