Abstract:
:Tuberculosis (TB) is the major opportunistic infection of HIV-infected patients in developing countries and is associated with activation of the immune system and increased HIV-1 expression. The aim of this study was to explore the biological properties of HIV-1 isolates from patients with active TB. Ten HIV-1 subtype C isolates were analyzed for biological phenotypes, using MT-2 cells, and for coreceptor usage, using coreceptor-transfected cell lines. All isolates were nonsyncytium inducing (NSI) in the MT-2 assay and replicated in CCR5-expressing cells. None of the isolates used CXCR4 or any of the minor coreceptors (CCR1, CCR2b, or CCR3) efficiently. Analysis of the V3 region showed that all isolates contained the GPGQ motif characteristic of subtype C and also had a sequence profile typical of NSI viruses. These data indicate that despite their advanced disease state, patients with TB harbor viruses that use the CCR5 coreceptor. It is possible that activation of monocytes and macrophages during TB infection results in the expansion of macrophage-tropic isolates that preferentially use CCR5.
journal_name
AIDS Res Hum Retrovirusesjournal_title
AIDS research and human retrovirusesauthors
Morris L,Cilliers T,Bredell H,Phoswa M,Martin DJdoi
10.1089/088922201750236979subject
Has Abstractpub_date
2001-05-20 00:00:00pages
697-701issue
8eissn
0889-2229issn
1931-8405journal_volume
17pub_type
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journal_title:AIDS research and human retroviruses
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journal_title:AIDS research and human retroviruses
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journal_title:AIDS research and human retroviruses
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journal_title:AIDS research and human retroviruses
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journal_title:AIDS research and human retroviruses
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journal_title:AIDS research and human retroviruses
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journal_title:AIDS research and human retroviruses
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doi:10.1089/aid.1994.10.181
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journal_title:AIDS research and human retroviruses
pub_type: 杂志文章
doi:10.1089/088922202320886361
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journal_title:AIDS research and human retroviruses
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doi:10.1089/AID.2015.0122
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journal_title:AIDS research and human retroviruses
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doi:10.1089/aid.2004.20.909
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journal_title:AIDS research and human retroviruses
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doi:10.1089/aid.1997.13.235
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journal_title:AIDS research and human retroviruses
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doi:10.1089/08892220151126689
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journal_title:AIDS research and human retroviruses
pub_type: 杂志文章,评审
doi:
更新日期:1994-01-01 00:00:00
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journal_title:AIDS research and human retroviruses
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journal_title:AIDS research and human retroviruses
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journal_title:AIDS research and human retroviruses
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journal_title:AIDS research and human retroviruses
pub_type: 杂志文章,多中心研究
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journal_title:AIDS research and human retroviruses
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journal_title:AIDS research and human retroviruses
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更新日期:2013-02-01 00:00:00
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journal_title:AIDS research and human retroviruses
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journal_title:AIDS research and human retroviruses
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journal_title:AIDS research and human retroviruses
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abstract::Partial sequences of HIV-1 polymerase from 185 patients, 141 ARV experienced and 44 naive, of gag (p24) and env (C2V3) from a subset of naive cases were evaluated in São Paulo, Brazil. Antiretroviral resistance mutations were detected in 4% of 26 recently (<2 years) infected patients. Polymorphisms at the protease gen...
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