Isolation, characterization, and sequence analysis of a novel HIV type 1 subtype A1 strain from Russia.

abstract：:Analyses of serum samples and blood cells have revealed a dysregulation of the Fas/Fas ligand (FasL) system during HIV infection, which may be related to disease progression. As Fas and FasL have been suggested to participate in brain injury in a variety of CNS disorders, the aim of this study was to determine (1) whe...

journal_title：AIDS research and human retroviruses

authors： Sporer B,Koedel U,Goebel FD,Pfister HW

更新日期：2000-02-10 00:00:00

abstract：BACKGROUND:Immune activation, which is accompanied by the production of proinflammatory cytokines, is a strong predictor of disease progression in HIV infection. Inflammation is critical in neuronal damage linked to HIV-associated neurocognitive disorders. METHODS:We examined the relationship between plasma cytokine l...

journal_title：AIDS research and human retroviruses

authors： Ruhanya V,Jacobs GB,Naidoo S,Paul RH,Joska J,Seedat S,Nyandoro G,Engelbrecht S,Glashoff R

更新日期：2021-01-20 00:00:00

abstract：:The efficacy, safety, and pharmacokinetics of three doses of tipranavir/ritonavir (TPV/r) in highly treatment-experienced human immunodeficiency virus (HIV)-1-infected patients with protease inhibitor (PI)-resistant isolates were evaluated. A 24-week multicenter, double-blind, randomized, dose-finding trial was conduc...

journal_title：AIDS research and human retroviruses

authors： Gathe JC Jr,Pierone G,Piliero P,Arasteh K,Rubio R,Lalonde RG,Cooper D,Lazzarin A,Kohlbrenner VM,Dohnanyi C,Sabo J,Mayers D

更新日期：2007-02-01 00:00:00

abstract：:The presence of human immunodeficiency virus (HIV)-specific antibodies was examined in plasma and cervicovaginal (mucosal) samples of 24 HIV-exposed uninfected (EU) female sexual partners of HIV-infected men, and compared with findings in 18 HIV-infected and 15 low-risk HIV-uninfected women. Only HIV-infected women ha...

journal_title：AIDS research and human retroviruses

authors： Buchacz K,Parekh BS,Padian NS,van der Straten A,Phillips S,Jonte J,Holmberg SD

更新日期：2001-12-10 00:00:00

abstract：:HIV antigens were detected by immunoelectron microscopy at the surface of human and simian T4 lymphocytes that had been infected in vitro. HIV antigens were detected at the surface of cells exhibiting viral particles but also at the surface of cells before the release of virions. The latter cells may be considered imm...

journal_title：AIDS research and human retroviruses

authors： Desportes I,Bonnet D,Nicol I,Snart R,Sarin P

更新日期：1989-02-01 00:00:00

abstract：:Murine monoclonal antibodies (MAbs) raised against a recombinant nef protein fragment of human immunodeficiency virus type 1 (HIV-1) strain BH10 were characterized by an epitope mapping system using overlapping decapeptides. Four different immunogenic regions were identified. Ten human HIV-1-positive sera were tested ...

journal_title：AIDS research and human retroviruses

authors： Schneider T,Harthus HP,Hildebrandt P,Niedrig M,Bröker M,Weigelt W,Beck A,Pauli G

更新日期：1991-01-01 00:00:00

abstract：:Human immunodeficiency virus, type 1 (HIV-1), produces a chronic infection with a long latency before clinical disease. We followed 214 untreated subjects for 12-42 months to study the natural history of HIV infection: 110 were classified as asymptomatic, 11 as AIDS-related complex (ARC), 15 as AIDS with Kaposi's sarc...

journal_title：AIDS research and human retroviruses

authors： Croxson TS,Mathur-Wagh U,Handwerger S,Siroty WE,Kaminisky D,Reagan KJ,Yancovitz SR,Mildvan D

更新日期：1990-04-01 00:00:00

abstract：:Eight HIV-2-infected Caucasian men living in the same geographical area in Gipuzkoa (northern Spain) have been identified in the last 5 years. HIV-2 infection in this area is uncommon, and no other cases of HIV-2 infection have been found after extensive testing for HIV-1/2 antibodies. Epidemiological data suggested a...

journal_title：AIDS research and human retroviruses

authors： Cilla G,Rodés B,Pérez-Trallero E,Arrizabalaga J,Soriano V

更新日期：2001-03-20 00:00:00

abstract：:Maraviroc is a first-in-class chemokine coreceptor type-5 (CCR5) antagonist with demonstrated immunovirologic activity in treatment-experienced (TE) patients with CCR5 (R5)-tropic HIV-1; however, experience in regimens containing newer antiretroviral agents is limited. The primary objective of this 96-week open-label,...

journal_title：AIDS research and human retroviruses

authors： Furtado J,Madruga JV,Bicudo EL,da Eira M,Lopes MI,Netto EM,Santini-Oliveira M,Leite OH,Machado AA,Tupinambas U,de Andrade Neto JL,Lima MP,Pedro Rde J,Miranda AF,Lewi DS,Santos BR,Portsmouth S,Wajsbrot DB,Cassoli LM

更新日期：2013-09-01 00:00:00

abstract：:There is little evidence comparing treatment outcomes between adolescents and other age groups, particularly in resource-limited settings. A retrospective analysis of data from seven HIV clinics across urban Gauteng (n=5) and rural Mpumalanga (n=2), South Africa was conducted. The analysis compared HIV-positive antire...

journal_title：AIDS research and human retroviruses

authors： Evans D,Menezes C,Mahomed K,Macdonald P,Untiedt S,Levin L,Jaffray I,Bhana N,Firnhaber C,Maskew M

更新日期：2013-06-01 00:00:00

abstract：:We have shown that HIV budding occurs at cholesterol-rich membrane microdomains called lipid rafts (Nguyen and Hildreth, J Virol 2000;74:3264-3272). This observation prompted us to examine the role in HIV entry of cholesterol in the membrane of cells. We recently reported that host cell cholesterol is required for HIV...

journal_title：AIDS research and human retroviruses

authors： Liao Z,Graham DR,Hildreth JE

更新日期：2003-08-01 00:00:00

abstract：:Extensive studies have been carried out on native Amerindian populations living in French Guiana in an attempt to detect human T cell leukemia virus type 2 (HTLV-2). However, the first strain of this virus identified in this region was not detected in these populations, but in a Brazilian woman of Amerindian origin. C...

journal_title：AIDS research and human retroviruses

authors： Kazanji M,Benoit B,Meddeb M,Meertens L,Marty C,Gessain A,Talarmin A

更新日期：2001-04-10 00:00:00

abstract：:HIV prevalence in the Limpopo Province has increased rapidly within the past 10 years, as in other parts of South Africa. Little is known about the genetic and biological properties of HIV circulating in this region including the baseline drug resistance profiles. We therefore collected blood samples from 42 HIV-1-inf...

journal_title：AIDS research and human retroviruses

authors： Bessong PO,Larry Obi C,Cilliers T,Choge I,Phoswa M,Pillay C,Papathanasopoulos M,Morris L

更新日期：2005-01-01 00:00:00

abstract：:The induction of both neutralizing antibodies and non-neutralizing antibodies with effector functions, for example, antibody-dependent cellular cytotoxicity (ADCC), is desired in the search for effective vaccines against HIV-1. In the pursuit of novel immunogens capable of inducing an efficient antibody response, rabb...

journal_title：AIDS research and human retroviruses

authors： Karlsson I,Borggren M,Jensen SS,Heyndrickx L,Stewart-Jones G,Scarlatti G,Fomsgaard A

更新日期：2018-02-01 00:00:00

abstract：:In an attempt to develop an immunization strategy to induce mucosal and circulatory antibodies against SIV antigens, we have investigated the potential of attenuated recombinant vaccinia virus to deliver SIV antigens (gp160 of SIVmac239) to mucosal surfaces of mice. After systemic or mucosal (intragastric, intranasal,...

journal_title：AIDS research and human retroviruses

authors： Moldoveanu Z,Vzorov AN,Huang WQ,Mestecky J,Compans RW

更新日期：1999-11-01 00:00:00

abstract：:DNA vaccines have the potential of giving rise to a potent cell-mediated immune response by inducing intracellular synthesis and subsequent antigenic presentation of encoded antigens. We have tested a DNA vaccine specific for human immunodeficiency virus type 1 (HIV-1) by the injection of animals with expression plasm...

journal_title：AIDS research and human retroviruses

authors： Okuda K,Bukawa H,Hamajima K,Kawamoto S,Sekigawa K,Yamada Y,Tanaka S,Ishi N,Aoki I,Nakamura M

更新日期：1995-08-01 00:00:00

abstract：:A potential strategy to combat the worldwide AIDS epidemic is to develop a vaginal microbicide that prevents the sexual transmission of HIV-1. One approach for preventing vaginal HIV transmission is to block the viral coreceptor CCR5 with naturally occurring chemokine ligands. In this study, we used a cynomolgus macaq...

journal_title：AIDS research and human retroviruses

authors： Kish-Catalone T,Pal R,Parrish J,Rose N,Hocker L,Hudacik L,Reitz M,Gallo R,Devico A

更新日期：2007-01-01 00:00:00

abstract：:HIV patients beginning antiretroviral therapy (ART) with advanced immunodeficiency often retain low CD4+ T cell counts despite virological control. We examined proliferative responses and upregulation of costimulatory molecules, following anti-CD3 stimulation, in HIV patients with persistent CD4+ T cell deficiency on ...

journal_title：AIDS research and human retroviruses

authors： Tanaskovic S,Price P,French MA,Fernandez S

更新日期：2017-02-01 00:00:00

abstract：:Activation of primary CD4+ T cells induces the CD155, but not the CD112 ligands for the natural killer (NK) cell activation receptor (aNKR) CD226 [DNAX accessory molecule-1 (DNAM-1)]. We hypothesize that HIV productively infects activated CD4+ T cells and makes itself vulnerable to NK cell-mediated lysis when CD155 on...

journal_title：AIDS research and human retroviruses

authors： Davis ZB,Sowrirajan B,Cogswell A,Ward JP,Planelles V,Barker E

更新日期：2017-02-01 00:00:00

abstract：:Evidence derived from studies concerning brain metabolism and brain electrical activity suggests that temporal lobe functioning is impaired in the course of HIV infection. To test the hypothesis of temporal lobe dysfunction in HIV infection, we utilized computerized electroencephalogram (EEG) analysis to evaluate temp...

journal_title：AIDS research and human retroviruses

authors： Grassi B,Locatelli M,Lazzarin A,Scarone S

更新日期：1996-04-10 00:00:00

abstract：:The genetic diversity of HIV-1 is well documented. Except for the HIV-1 isolate LAV-1BRU, no nucleic acid sequence of a European isolate of HIV-1 has been published to date. To further investigate the extent of the genetic variability and the evolution of HIV-1, we have isolated, cloned, and subsequently sequenced HIV...

journal_title：AIDS research and human retroviruses

authors： Sauermann U,Schneider J,Mous J,Brunckhorst U,Schedel I,Jentsch KD,Hunsmann G

更新日期：1990-06-01 00:00:00

abstract：:Multiple impairments in HIV-1-specific cytotoxic T cells (CTL) have been reported, but derangements in HIV-1-specific CD8+ T-cell chemotaxis have not been described previously. We assessed migration to SDF-1alpha (stromal cell-derived factor 1-alpha) and CX3CL1 in vitro and expression of cognate receptors, CXCR4 and C...

journal_title：AIDS research and human retroviruses

authors： Meditz AL,Schlichtemeier R,Folkvord JM,Givens M,Lesh KC,Ray MG,McCarter MD,Connick E

更新日期：2008-07-01 00:00:00

abstract：:Human T cell leukemia virus type-1 (HTLV-1) is prevalent worldwide with foci of high prevalence. However, to date no effective vaccine or drug against HTLV-1 infection has been developed. In efforts to define the role of antibodies in the control of HTLV-1 infection, we capitalized on the use of our previously defined...

journal_title：AIDS research and human retroviruses

authors： Tanaka Y,Takahashi Y,Tanaka R,Kodama A,Fujii H,Hasegawa A,Kannagi M,Ansari AA,Saito M

更新日期：2014-06-01 00:00:00

abstract：:Regression of feline immunodeficiency virus (FIV) infection was observed in seven of nine vertically infected kittens born to two chronically infected mother cats. Both provirus and nonmaternal FIV antibody were detected in all kittens by 4 weeks of age but only three of the seven kittens were positive by blood mononu...

journal_title：AIDS research and human retroviruses

authors： O'Neil LL,Burkhard MJ,Obert LA,Hoover EA

更新日期：1997-05-20 00:00:00

abstract：:Recombinant forms contribute significantly to the genetic diversity of HIV-1. Here we report a novel HIV-1 recombinant form (CRF01_AE/B'/C) detected from a comprehensive HIV-1 molecular epidemiologic study among heterosexuals in Jilin province of northeastern China. Recombinant analyses of the near full-length genome ...

journal_title：AIDS research and human retroviruses

authors： Li X,Ning C,Chen Y,Feng Y,Wei M,Xing H,Shao Y

更新日期：2014-07-01 00:00:00

abstract：:Vaccines based on live attenuated viruses are highly effective immunogens in the simian immunodeficiency virus (SIV)/rhesus macaque animal model and offer the possibility of studying correlates of protection against infection with virulent virus. We utilized a tether system for studying, in naive macaques and animals ...

journal_title：AIDS research and human retroviruses

authors： Hodara VL,Parodi LM,Keckler MS,Giavedoni LD

更新日期：2016-10-01 00:00:00

abstract：:The HIV-1 subtype A epidemic affecting injecting drug users (IDU) in former Soviet Union (FSU) countries started dramatically in Odessa, southern Ukraine, in 1995, and is caused by a variant of monophyletic origin, often designated IDU-A. We phylogenetically analyzed one near full-length genome and two partial sequenc...

journal_title：AIDS research and human retroviruses

authors： Thomson MM,de Parga EV,Vinogradova A,Sierra M,Yakovlev A,Rakhmanova A,Delgado E,Casado G,Muñoz M,Carmona R,Vega Y,Pérez-Alvarez L,Contreras G,Medrano L,Osmanov S,Nájera R

更新日期：2007-12-01 00:00:00

abstract：:Simian immunodeficiency virus (SIV) variant SIVsmmPBj14 is unique in producing an acutely lethal enteropathic syndrome in pigtail macaques. To determine whether the nature of the PBj14 disease would be attenuated by decreasing virus input and to relate tissue virus burden to the severity of disease, we infected pigtai...

journal_title：AIDS research and human retroviruses

authors： O'Neil SP,Mossman SP,Maul DH,Hoover EA

更新日期：1999-01-20 00:00:00

abstract：:India has experienced multiple introductions of diverse HIV-1 subtypes A, B, C, and E, along with subtype B of HIV-2 between the 1980s and early 1990s. In this study, we have carried out a molecular investigation of 21 heterosexually and vertically acquired HIV-infected individuals from the New Bombay area, who tested...

journal_title：AIDS research and human retroviruses

authors： Halani N,Wang B,Ge YC,Gharpure H,Hira S,Saksena NK

更新日期：2001-05-01 00:00:00

abstract：:Given the rising HIV incidence in men who have sex with men (MSM) despite repeatedly proven effectiveness of oral HIV pre-exposure prophylaxis, behaviorally congruent periodic dosing strategies, such as dosing microbicides as lubricants, are now in demand. Rectal microbicide gel studies largely administer gels using v...

journal_title：AIDS research and human retroviruses

authors： Shieh EC,Weld ED,Fuchs EJ,Hiruy H,Buckheit KW,Buckheit RW Jr,Breakey J,Hendrix CW

更新日期：2017-08-01 00:00:00