Human immunodeficiency virus replication: modulation by cellular levels of cAMP.

abstract：:In order to shed light on the nature of the persistent reservoir of human immunodeficiency virus type 1 (HIV-1), we investigated signs of recent evolution in the pool of proviral DNA in patients on successful HAART. Pro-viral DNA, corresponding to the C2-V3-C3 region of the HIV-1 env gene, was collected from PBMCs iso...

journal_title：AIDS research and human retroviruses

authors： Mens H,Pedersen AG,Jørgensen LB,Hue S,Yang Y,Gerstoft J,Katzenstein TL

更新日期：2007-01-01 00:00:00

abstract：:HIV-1 viremia has been shown to induce several phenotypic and functional abnormalities in natural killer (NK) cells. To assess immune defects associated with HIV viremia, we examined NK cell function, differentiation status, and phenotypic alterations based on expression of inhibitory and activating receptors on NK ce...

journal_title：AIDS research and human retroviruses

authors： Zulu MZ,Naidoo KK,Mncube Z,Jaggernath M,Goulder PJR,Ndung'u T,Altfeld M,Thobakgale CF

更新日期：2017-12-01 00:00:00

abstract：:Lentivirus infections are characterized by a dramatic loss of mucosal CD4(+) T cells, breakdown of the gut mucosa, and subsequent chronic immune activation. Residual immune activation persists even in patients controlling virus replication and remains a significant source of ongoing disease morbidities, but the causes...

journal_title：AIDS research and human retroviruses

authors： Li H,Goepfert P,Reeves RK

更新日期：2014-12-01 00:00:00

abstract：:The purpose of this study was to investigate the mechanism of acquired cellular resistance to AZT, a mechanism that has been described as a potential source of drug resistance in addition to viral mutations. To study this phenomenon the kinetics parameters of thymidine kinase (TK) activity have been defined in CEMazt,...

journal_title：AIDS research and human retroviruses

authors： Antonelli G,Turriziani O,Verri A,Narciso P,Ferri F,D'Offizi G,Dianzani F

更新日期：1996-02-10 00:00:00

abstract：:HLA is one of the genetic factors that influence the clinical course of HIV-1 infection, and patients with HLA-B35 are prone to rapid disease progression. Nine viral epitopes that are recognized by cytotoxic T lymphocytes (CTLs) in an HLA-B35-restricted manner were determined. To examine how HIV-1 sequences are select...

journal_title：AIDS research and human retroviruses

authors： Kawana A,Tomiyama H,Takiguchi M,Shioda T,Nakamura T,Iwamoto A

更新日期：1999-08-10 00:00:00

abstract：:Neutralizing antibodies (NA) against HIV-1MN and HIV-1IIIB, and antibodies binding to synthetic peptides (BA) derived from the gp120 envelope V3 region principal neutralizing determinants (PND) of the HIV-1MN, HIV-1IIIB, and HIV-1Z3 virus strains were assayed in HIV-1 antibody-positive sera from the United States, Hai...

journal_title：AIDS research and human retroviruses

authors： Carrow EW,Vujcic LK,Glass WL,Seamon KB,Rastogi SC,Hendry RM,Boulos R,Nzila N,Quinnan GV Jr

更新日期：1991-10-01 00:00:00

abstract：:The conditioned medium of a HTLV-I-carrying T cell line HUT-102 showed cytotoxic activity against a mouse fibroblast cell line L-M. We prepared the cDNA library from HUT-102 poly(A)+ RNA and screened it using oligonucleotide probes that correspond to the amino acid sequences conserved in tumor necrosis factor (TNF) an...

journal_title：AIDS research and human retroviruses

authors： Kato S,Miki T,Takahashi N,Ohmori M,Hemmi H,Numao N,Kondo K

更新日期：1989-12-01 00:00:00

abstract：:The main goal of this work was to identify molecular signatures in envelope surface glycoprotein that may be correlated with coreceptor usage by different human immunodeficiency virus (HIV)-2 strains. From inspection of aligned HIV-2 sequences, we verified that V1/V2 region showed the highest degree of amino acid sequ...

journal_title：AIDS research and human retroviruses

authors： Cerejo P,Santos-Costa Q,Calado M,Espírito-Santo M,Parreira R,Azevedo-Pereira JM

更新日期：2018-02-01 00:00:00

abstract：:Older HIV-positive patients may experience reduced benefit and increased toxicities from combination antiretroviral therapies (cART) due to late diagnosis, weakened immune systems, and other age-related physiological changes. This study investigates the effect of age on time to virologic suppression and CD4 cell count...

journal_title：AIDS research and human retroviruses

authors： Szadkowski L,Tseng A,Walmsley SL,Salit I,Raboud JM

更新日期：2012-12-01 00:00:00

abstract：:Integrase strand transfer inhibitor (InSTI) resistance rates are low. However, genotypic resistance test (GRT) is not routinely performed in many centers. The aim of this study is to evaluate the prevalence of InSTI-related mutations in our large cohort. We examined all integrase GRTs performed as part of routine clin...

journal_title：AIDS research and human retroviruses

authors： De Francesco MA,Izzo I,Properzi M,Gargiulo F,Caccuri F,Quiros-Roldan E,Castelli F,Caruso A,Focà E

更新日期：2018-07-01 00:00:00

abstract：:In cell-mediated immunity T cells recognize peptide fragments of the antigenic protein in association with major histocompatibility complex (MHC) proteins. Synthetic 9- to 16-mer peptides have been widely used to identify the region(s) of a protein that act as T cell epitope. Here, we report antigenic peptides identif...

journal_title：AIDS research and human retroviruses

authors： Blazevic V,Ranki A,Krohn KJ

更新日期：1995-11-01 00:00:00

abstract：:Differences in the extent of genetic diversity have been observed in human immunodeficiency virus type-1 (HIV-1) envelope sequences early in infection, and this has been linked to gender and to modifiable exogenous factors such as hormonal contraceptive use and genital tract infections. But it is unclear whether envel...

journal_title：AIDS research and human retroviruses

authors： Sagar M,Kirkegaard E,Lavreys L,Overbaugh J

更新日期：2006-05-01 00:00:00

abstract：:To evaluate the efficacy, safety and tolerability of switching to a dolutegravir (DTG)-based regimen in a cohort of virological suppressed HIV-infected patients. The dynamics of total HIV-DNA and levels of high-sensitivity c-reactive protein (hsCRP), interleukin-6 (IL-6), soluble-CD14 (sCD14) and D-Dimer were also ana...

journal_title：AIDS research and human retroviruses

authors： Di Carlo D,Falasca F,Palermo E,Mezzaroma I,Fimiani C,Siccardi G,Celani L,Di Campli FM,d'Ettorre G,Antonelli G,Turriziani O

更新日期：2021-01-24 00:00:00

abstract：:Cyanovirin-N (CV-N), an 11-kDa cyanobacterial protein, potently inactivates diverse strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV) and also prevents virus-to-cell fusion, virus entry, and infection of cells in vitro. These properties make CV-N an attractive candidate for use as a topical microbicide ...

journal_title：AIDS research and human retroviruses

authors： Tsai CC,Emau P,Jiang Y,Tian B,Morton WR,Gustafson KR,Boyd MR

更新日期：2003-07-01 00:00:00

abstract：:Studies have shown a low frequency of HIV-1 protease drug resistance mutations in patients failing protease inhibitor (PI)-based therapy. Recent studies have identified mutations in Gag as an alternate pathway for PI drug resistance in subtype B viruses. We therefore genotyped the Gag and protease genes from 20 HIV-1 ...

journal_title：AIDS research and human retroviruses

authors： Giandhari J,Basson AE,Coovadia A,Kuhn L,Abrams EJ,Strehlau R,Morris L,Hunt GM

更新日期：2015-08-01 00:00:00

abstract：:Am important aspect of human immunodeficiency virus (HIV-1) infection is the regulation of its expression by nuclear factor kappa B (NF-kappa B) by redox-controlled signal transduction pathways. In this study, we demonstrate that selenium supplementation can effectively increase glutathione peroxidase (GPx) activity i...

journal_title：AIDS research and human retroviruses

authors： Sappey C,Legrand-Poels S,Best-Belpomme M,Favier A,Rentier B,Piette J

更新日期：1994-11-01 00:00:00

abstract：:Mycophenolate mofetil (MMF), the bioavailable form of mycophenolic acid (MPA), has been proposed as adjuvant therapy for human immunodeficiency virus type 1 (HIV-1) infection. MPA can inhibit viral replication and might blunt virus-induced immunopathology. However, other effects of this inhibitor might be detrimental ...

journal_title：AIDS research and human retroviruses

authors： Kaur R,Klichko V,Margolis D

更新日期：2005-02-01 00:00:00

abstract：:Elite controllers or suppressors (ES) are HIV-1-infected patients who maintain viral loads of <50 copies/ml without antiretroviral therapy. While HLA-B*57 and B*5801 alleles are overrepresented in ES, many HLA-B*57/B*5801 patients become chronic progressors (CP). We show here that HIV-1 infection results in similar le...

journal_title：AIDS research and human retroviruses

authors： Sampah ME,Ceccato CM,Blankson JN

更新日期：2011-02-01 00:00:00

abstract：:HIV-1 infection of tonsils takes place when virus spreads systemically, and may occur when tonsillar tissue serves as the initial portal of HIV-1 entry. The HIV replication cycle includes the production of regulatory and accessory gene mRNAs, produced by splicing of genomic mRNA, that are hallmarks of de novo virus pr...

journal_title：AIDS research and human retroviruses

authors： Brachtel EF,Mascola JR,Wear DJ,Ehrenberg PK,Dayhoff DE,Sanders-Buell E,Michael NL,Frankel SS

更新日期：2002-07-20 00:00:00

abstract：:Maraviroc (MVC) is an allosteric inhibitor of human immunodeficiency virus type 1 (HIV-1) entry, and is the only CCR5 antagonist licensed for use as an anti-HIV-1 therapeutic. It acts by altering the conformation of the CCR5 extracellular loops, rendering CCR5 unrecognizable by the HIV-1 envelope (Env) glycoproteins. ...

journal_title：AIDS research and human retroviruses

authors： Flynn JK,Ellenberg P,Duncan R,Ellett A,Zhou J,Sterjovski J,Cashin K,Borm K,Gray LR,Lewis M,Jubb B,Westby M,Lee B,Lewin SR,Churchill M,Roche M,Gorry PR

更新日期：2017-12-01 00:00:00

abstract：:The production and characterization of a cell line for quantitative HIV-1 Tat function and T cell activation assays is described. 1G5 is a clonal cell line derived from Jurkat T cells stably transfected with a luciferase gene driven by an HIV-1 long terminal repeat (HIV-LTR). The 1G5 clone was selected for low basal l...

journal_title：AIDS research and human retroviruses

authors： Aguilar-Cordova E,Chinen J,Donehower L,Lewis DE,Belmont JW

更新日期：1994-03-01 00:00:00

abstract：:Simian immunodeficiency virus (SIV) variant SIVsmmPBj14 is unique in producing an acutely lethal enteropathic syndrome in pigtail macaques. To determine whether the nature of the PBj14 disease would be attenuated by decreasing virus input and to relate tissue virus burden to the severity of disease, we infected pigtai...

journal_title：AIDS research and human retroviruses

authors： O'Neil SP,Mossman SP,Maul DH,Hoover EA

更新日期：1999-01-20 00:00:00

abstract：:DC-SIGN, a C-type lection expressed on dendritic cells, enhances HIV-1 infection in cis and in trans. HIV-1 circulating recombinant form (CRF) 07_BC viruses have been the predominant strain found among injection drug users in southern China and Taiwan. The goal of this study was to map the DC-SIGN-interactive domain o...

journal_title：AIDS research and human retroviruses

authors： Liao CF,Wang SF,Lin YT,Ho DD,Chen YM

更新日期：2011-08-01 00:00:00

abstract：:Sexual transmission of human immunodeficiency virus provides an efficient mode for virus spread and poses unique challenges to vaccine developers. Host and viral factors that affect transmission have been studied by epidemiological approaches in the human population, and some of these factors have been modeled with ex...

journal_title：AIDS research and human retroviruses

authors： Pauza CD,Horejsh D,Wallace M

更新日期：1998-04-01 00:00:00

abstract：:A potential strategy to combat the worldwide AIDS epidemic is to develop a vaginal microbicide that prevents the sexual transmission of HIV-1. One approach for preventing vaginal HIV transmission is to block the viral coreceptor CCR5 with naturally occurring chemokine ligands. In this study, we used a cynomolgus macaq...

journal_title：AIDS research and human retroviruses

authors： Kish-Catalone T,Pal R,Parrish J,Rose N,Hocker L,Hudacik L,Reitz M,Gallo R,Devico A

更新日期：2007-01-01 00:00:00

abstract：:The membrane glycolipids galactosylceramide (GalCer) and sulfatide (SGalCer) have been reported to act as receptors of human immunodeficiency virus (HIV) on CD4- cell lines. We show here that these glycolipids are present on CD4+ cells purified from human blood and on in vitro-differentiated monocyte-derived macrophag...

journal_title：AIDS research and human retroviruses

authors： Seddiki N,Ben Younes-Chennoufi A,Benjouad A,Saffar L,Baumann N,Gluckman JC,Gattegno L

更新日期：1996-05-20 00:00:00

abstract：:Previous studies have shown that coinfection of the human T lymphotrophic virus type I (HTLV-I) chronically infected cell line MT4 with human immunodeficiency virus type 1 (HIV-1) results in cells which spontaneously activate complement via the classical pathway. This complement activation was antibody independent, ye...

journal_title：AIDS research and human retroviruses

authors： Spear GT,Jiang HX,Sullivan BL,Gewurz H,Landay AL,Lint TF

更新日期：1991-07-01 00:00:00

abstract：:The mechanisms responsible for the hematopoietic failure in human immunodeficiency virus type 1 (HIV-1)-infected patients are still unknown. Several findings indicate that the in vitro proliferative potential of precursor cells from AIDS patients is reduced. The changes seen in bone marrow (BM) morphology and the defe...

journal_title：AIDS research and human retroviruses

authors： Isgrò A,Mezzaroma I,Aiuti A,De Vita L,Franchi F,Pandolfi F,Alario C,Ficara F,Riva E,Antonelli G,Aiuti F

更新日期：2000-10-10 00:00:00

abstract：:To investigate HIV-1-related B cell disorders, the quantity of CD27 positive (CD27+) B cells and their CD38, CD95, and bcl-2 intensities were examined by flow cytometry analysis in 16 drug-naive patients, 27 highly active antiretroviral therapy (HAART)-treated patients, and 20 uninfected controls. CD27+ B cells have b...

journal_title：AIDS research and human retroviruses

authors： Chong Y,Ikematsu H,Kikuchi K,Yamamoto M,Murata M,Nishimura M,Nabeshima S,Kashiwagi S,Hayashi J

更新日期：2004-02-01 00:00:00

abstract：:We investigated the Th1 protective and regulatory T and B cell (Treg and Breg) responses to pH1N1 monovalent influenza vaccine (IIV1) in HIV-infected pregnant women on combination antiretroviral therapy (cART). Peripheral blood mononuclear cells (PBMCs) from 52 study participants were cryopreserved before and after va...

journal_title：AIDS research and human retroviruses

authors： Weinberg A,Muresan P,Richardson K,Fenton T,Dominguez T,Bloom A,Watts DH,Abzug MJ,Nachman SA,Levin MJ,P1086 Study Team.

更新日期：2015-11-01 00:00:00