Abstract:
:Mycophenolate mofetil (MMF), the bioavailable form of mycophenolic acid (MPA), has been proposed as adjuvant therapy for human immunodeficiency virus type 1 (HIV-1) infection. MPA can inhibit viral replication and might blunt virus-induced immunopathology. However, other effects of this inhibitor might be detrimental in an HIV-infected patient. We therefore studied the effect of MPA on selected cellular processes of relevance to HIV infection. We found that MPA did not alter the expression of the primary HIV coreceptor CCR5 on primary resting lymphocytes, but modestly increased CCR5 expression after activation. Conversely, MPA modestly decreased the secretion of the CCR5 ligand RANTES in resting lymphocytes, but had no effect after activation. It has been suggested that the use of inhibitors of host nucleoside metabolism may enhance clinical toxicities induced by HIV-1 nucleoside reverse transcriptase inhibitors (NRTIs). We found no evidence that MPA induced mitochondrial dysfunction or enhanced dysfunction induced by NRTIs in an HepG2 cell line model of mitochondrial toxicity. Further, MPA did not selectively enhance apoptosis in HIV-1-infected lymphocytes. Our findings support the testing of MMF to augment suppression of viral replication. However, careful study will be required to demonstrate that MMF is beneficial when used without antiretroviral therapy, to inhibit residual replication, or to deplete the pool of latently infected nonactivated cells.
journal_name
AIDS Res Hum Retrovirusesjournal_title
AIDS research and human retrovirusesauthors
Kaur R,Klichko V,Margolis Ddoi
10.1089/aid.2005.21.116subject
Has Abstractpub_date
2005-02-01 00:00:00pages
116-24issue
2eissn
0889-2229issn
1931-8405journal_volume
21pub_type
杂志文章abstract::For a HIV vaccine to be effective, it will be essential that it protect against the virus variants to which individuals are most frequently exposed. HIV-1 is predominantly a sexually acquired virus, thus, variants in genital secretions are a potentially important reservoir of viruses that are transmitted. Because ther...
journal_title:AIDS research and human retroviruses
pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
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journal_title:AIDS research and human retroviruses
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更新日期:2014-02-01 00:00:00
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journal_title:AIDS research and human retroviruses
pub_type: 杂志文章
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更新日期:2008-05-01 00:00:00
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journal_title:AIDS research and human retroviruses
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journal_title:AIDS research and human retroviruses
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journal_title:AIDS research and human retroviruses
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journal_title:AIDS research and human retroviruses
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journal_title:AIDS research and human retroviruses
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2013-10-01 00:00:00
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journal_title:AIDS research and human retroviruses
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:AIDS research and human retroviruses
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:AIDS research and human retroviruses
pub_type: 杂志文章
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更新日期:1992-05-01 00:00:00
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journal_title:AIDS research and human retroviruses
pub_type: 杂志文章
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journal_title:AIDS research and human retroviruses
pub_type: 杂志文章,评审
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