Treatment response and drug resistance in patients infected with HIV type 1 group O viruses.

abstract：:The aim of this study was to determine the patterns of change in body fat and metabolic parameters in a South African cohort on a first line ART regimen containing stavudine. Fasting lipogram, blood glucose and insulin levels, CD4 cell count, viral load, BMI, waist-to-hip ratio (WHR), and skinfold thickness at the tri...

journal_title：AIDS research and human retroviruses

authors： George JA,Venter WD,Van Deventer HE,Crowther NJ

更新日期：2009-08-01 00:00:00

abstract：:We compared HIV-1 subtype B reverse transcriptase (RT) and protease mutation patterns in isolates from heavily treated persons in Northern California with those from persons described in the published literature predominantly from other parts of the United States and Europe. There were few differences in the prevalenc...

journal_title：AIDS research and human retroviruses

authors： Gonzales MJ,Belitskaya I,Dupnik KM,Rhee SY,Shafer RW

更新日期：2003-10-01 00:00:00

abstract：:DNA of a recently described fifth exogenous retrovirus (HRV-5) has been found in blood samples from patients with autoimmune diseases and lymphoma. We analyzed HRV-5 sequence in DNA extracted from whole blood of 17 patients with T cell non-Hodgkin's lymphoma (NHL) and 186 patients with hematological malignancies other...

journal_title：AIDS research and human retroviruses

authors： Kozireva S,Lejniece S,Blomberg J,Murovska M

更新日期：2001-07-01 00:00:00

abstract：:We studied vertical transmission of feline immunodeficiency virus (FIV) to determine whether it might provide a model with which to study intervention strategies for mother-to-offspring transmission of human immunodeficiency virus (HIV). We found that pregnant cats acutely infected with FIV (FIV-CSU-2771) transmitted ...

journal_title：AIDS research and human retroviruses

authors： O'Neil LL,Burkhard MJ,Diehl LJ,Hoover EA

更新日期：1995-01-01 00:00:00

abstract：:CD8+ lymphocytes (CD8 cells) have been shown to inhibit replication of the human immunodeficiency virus (HIV) in vitro when cocultured with HIV-infected CD4+ lymphocytes (CD4 cells). This suppressive effect on HIV replication in experimentally infected CD4 cells has so far been demonstrated only for CD8 cells from HIV...

journal_title：AIDS research and human retroviruses

authors： Røsok B,Voltersvik P,Larsson BM,Albert J,Brinchmann JE,Asjö B

更新日期：1997-01-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) replicate during acute infection in lymphocytes of the gastrointestinal tract, before disseminating systemically. Localized replication and associated loss of gut-resident CD4+ T cells occur regardless of the portal of entry of the virus (e.g.,...

journal_title：AIDS research and human retroviruses

authors： Méndez-Lagares G,Lu D,Merriam D,Baker CA,Villinger F,Van Rompay KKA,McCune JM,Hartigan-O'Connor DJ

更新日期：2017-11-01 00:00:00

abstract：:We studied the ability of several polyionic compounds, previously shown to have activity in vitro against human immunodeficiency virus (anti-HIV) to block binding of anti-CD4 and recombinant HIV gp120 to the CD4 receptor on human lymphocytes. We found that Evans blue and aurin tricarboxylic acid could completely inhib...

journal_title：AIDS research and human retroviruses

authors： Weaver JL,Gergely P,Pine PS,Patzer E,Aszalos A

更新日期：1990-09-01 00:00:00

abstract：:Interferon-α (IFN-α) plays a vital role in combating viral infections especially in the early control after infection. However, the HIV infection has shown substantial level of suppression of IFN-α secretion during initial phase of infection. The reasons behind this impairment are still obscure. As plasmacytoid dendri...

journal_title：AIDS research and human retroviruses

authors： Dhamanage AS,Thakar MR,Paranjape RS

更新日期：2019-01-01 00:00:00

abstract：:Changes in neutralizing antibody (NA) titers in stored sera collected over 5 years from 10 participants in the Multicenter AIDS Cohort Study (MACS) were evaluated. The participants were HIV-1 infected on enrollment in the MACS, and remained AIDS free during the 5-year study interval. Seven viruses derived from molecul...

journal_title：AIDS research and human retroviruses

authors： Quinnan GV Jr,Zhang PF,Fu DW,Dong M,Margolick JB

更新日期：1998-07-20 00:00:00

abstract：:The chemokine polymorphisms CXCR6-3E/K, In1.1T/C, H7 haplotype, CX(3)CR1-V249I, and CX(3)CR1-T280M have been shown to affect the course of HIV infection. We studied their influence on immunologic and virologic response to HAART in a group of 143 HIV-1 patients. We performed Kaplan-Meier analysis using the following en...

journal_title：AIDS research and human retroviruses

authors： Passam AM,Sourvinos G,Krambovitis E,Miyakis S,Stavrianeas N,Zagoreos I,Spandidos DA

更新日期：2007-08-01 00:00:00

abstract：:Serological inspection of Simian T-lymphotropic Virus Type 1 was conducted for a wild colony of Macaca fuscata, which was captured in the middle Honshu, Japan. The increase of positive rate after the juvenile stage with the positive rate reaching 100% (or 35/35) in youngster and adult stages, was observed. This findin...

journal_title：AIDS research and human retroviruses

authors： Eguchi K,Ohsawa K,Fuse Kiyono M,Suzuki J,Kurokawa K,Yamamoto T

更新日期：2011-02-01 00:00:00

abstract：:Epidemiological and experimental data suggest that both robust neutralizing antibodies and potent cellular responses play important roles in controlling primary HIV-1 infection. In this study we have investigated the induction of systemic and mucosal immune responses to HIV gp120 monomer immunogen administered intrana...

journal_title：AIDS research and human retroviruses

authors： Bielinska AU,Janczak KW,Landers JJ,Markovitz DM,Montefiori DC,Baker JR Jr

更新日期：2008-02-01 00:00:00

abstract：:We partially purified the human immunodeficiency virus (HIV) glycoprotein gp41 from infected H9 cells by immunoaffinity chromatography using a column containing the M25 monoclonal antibody (diMarzo-Veronese et al., 1985). A pH 11.5 buffer worked best for eluting the glycoprotein from this column. The eluted gp41 was u...

journal_title：AIDS research and human retroviruses

authors： Zweig M,Showalter SD,Bladen SV,Gilden RV,Arthur LO,Robey WG,Nara PL,Fischinger PJ

更新日期：1988-02-01 00:00:00

abstract：:The HIV-1 subtype distribution in 83 HIV-1-seropositive individuals living in Greece was investigated by using the heteroduplex mobility assay (HMA), DNA sequencing, and phylogenetic analysis. The results revealed that partial HIV-1 gp120 sequences from 71 (86%) patients were subtype B, 5 (6%) were subtype A, 4 were s...

journal_title：AIDS research and human retroviruses

authors： Nasioulas G,Paraskevis D,Paparizos V,Lazanas M,Karafoulidou A,Hatzakis A

更新日期：1998-05-20 00:00:00

abstract：:The antiretroviral (ARV) service at Edendale Hospital in Pietermaritzburg, KwaZulu-Natal, South Africa has initiated more than 9,000 adults on therapy since 2004; however, virological outcomes among this patient cohort have not been systematically assessed. We conducted a retrospective chart review of patients initiat...

journal_title：AIDS research and human retroviruses

authors： Costiniuk CT,Sigal A,Jenabian MA,Nijs P,Wilson D

更新日期：2014-06-01 00:00:00

abstract：:We describe four full-length genomic sequences of HIV-1 subtype B isolates from Russia. These full-length HIV-1 genomes were amplified by nested polymerase chain reaction and sequenced. The sequences obtained were subjected to neighbor-joining phylogenetic analysis using a Kimura two-parameter model and to detailed se...

journal_title：AIDS research and human retroviruses

authors： Galkin AN,Gagarina EY,Lukyanova NS,Danilova TV

更新日期：2006-11-01 00:00:00

abstract：:Little is known about the consequences of short cycles of structured treatment interruption or definitive interruption of HAART for both T cell subset dynamics and T lymphoproliferative responses (LPR). Immunological follow-up was performed in 45 early chronical HIV-1-infected patients during short STI cycles during t...

journal_title：AIDS research and human retroviruses

authors： Libois A,López A,Garcia F,Castro P,Maleno MJ,García A,Climent N,Arnedo M,Gallart T,Gatell JM,Plana M

更新日期：2006-07-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) spends a significant part of its life cycle as latent provirus in nonactivated cells. It induction requires mitogen stimulation. TPA treatment induces HIV-1 transcription by protein kinase C (PKC)-mediated activation of the cellular transcription factor NF-kB. PKC activation...

journal_title：AIDS research and human retroviruses

authors： Doppler C,Schalasta G,Amtmann E,Sauer G

更新日期：1992-02-01 00:00:00

abstract：:SIVsmmFGb is a lentivirus swarm that induces neuropathology in over 90% of infected pigtailed macaques and reliably models central nervous system HIV infection in people. We have previously studied SIVsmmFGb genetic diversity and compartmentalization during acute infection, but little is understood about diversity and...

journal_title：AIDS research and human retroviruses

authors： Reeve AB,Pearce NC,Patel K,Augustus KV,Novembre FJ

更新日期：2010-06-01 00:00:00

abstract：:Although the breadth of the human immunodeficiency virus type 1 (HIV-1)-specific cellular immune response and its impact on the control of viral replication have already been addressed, reported data have proven controversial. We hypothesize that the nature of targeted epitopes, rather than the simple breadth or magni...

journal_title：AIDS research and human retroviruses

authors： Tarosso LF,Vieira VA,Sauer MM,Tomiyama HI,Kalil J,Kallas EG

更新日期：2017-08-01 00:00:00

abstract：:Genotropism was determined in 608 Brazilian samples collected in dried blood spots using Polyethersulfone collection cards. Patients were infected by subtype B (88.8%), F (5.6%), C (3.3%), A (1.8%), and G (0.5%). All patients were exposed to three classes of antiretrovirals, and 59.8% of the samples harbored R5 viruse...

journal_title：AIDS research and human retroviruses

authors： Lavigne S,Santos C,Arif MS,Reis A,Samer S,Dos Santos CV,Diaz RS

更新日期：2014-02-01 00:00:00

abstract：:The seroprevalence and the occurrence of an HIV-1 subtype was assessed in blood samples of the Tiriyo tribe. Antibody was found in 0.6% and the molecular analysis of the pro region detected the emergence of a subtype B for the first time in a native Indian tribe of the Amazon region of Brazil. ...

journal_title：AIDS research and human retroviruses

authors： Machado LF,Vallinoto AC,Souza MI,Azevedo VN,Ishak MO,Ishak R

更新日期：2006-12-01 00:00:00

abstract：:Human T lymphotropic virus type I trans-activator Tax protein regulates expression of several cellular genes that are involved in cellular activation, proliferation, and transformation. Tax mediates its regulatory activity through interaction with cellular transcription factors such as members of the cAMP-responsive e...

journal_title：AIDS research and human retroviruses

authors： Moriuchi M,Moriuchi H,Fauci AS

更新日期：1999-06-10 00:00:00

abstract：:Many human immunodeficiency virus (HIV) proteins including Tat are produced by HIV-infected astrocytes and secreted into the brain resulting in extensive neuronal damage that contributes to the pathogenesis of HIV dementia. The neuroprotective hormone 17beta-estradiol (E2) is known to negatively regulate the HIV trans...

journal_title：AIDS research and human retroviruses

authors： Heron PM,Turchan-Cholewo J,Bruce-Keller AJ,Wilson ME

更新日期：2009-11-01 00:00:00

abstract：:The presence of human immunodeficiency virus (HIV)-specific antibodies was examined in plasma and cervicovaginal (mucosal) samples of 24 HIV-exposed uninfected (EU) female sexual partners of HIV-infected men, and compared with findings in 18 HIV-infected and 15 low-risk HIV-uninfected women. Only HIV-infected women ha...

journal_title：AIDS research and human retroviruses

authors： Buchacz K,Parekh BS,Padian NS,van der Straten A,Phillips S,Jonte J,Holmberg SD

更新日期：2001-12-10 00:00:00

abstract：:To understand the pathogenic potential and the true extent of human T-cell leukemia virus type II (HTLV-II) infection, it is important to develop a specific HTLV-II antigen-based serological test. Plasmid pIIB was constructed and induced in Escherichia coli to express a recombinant protein (RP) containing 140 amino ac...

journal_title：AIDS research and human retroviruses

authors： Chen YM,Essex M

更新日期：1991-05-01 00:00:00

abstract：:HIV type 1 (HIV-1) envelope glycoproteins (Env) mediate virus entry and are the target of neutralizing antibodies. Binding of the metastable HIV-1 Env trimer to the CD4 receptor triggers structural rearrangements that mediate Env conformational transitions from a closed conformation to a more open state through an int...

journal_title：AIDS research and human retroviruses

authors： Flemming J,Wiesen L,Herschhorn A

更新日期：2018-09-01 00:00:00

abstract：:Mutant HIV virions, encoding C-terminally truncated Env proteins, exhibit a cell-specific replication defect, i.e., they can replicate in a few T cell lines (termed permissive cells) but not in the majority of T cell lines (termed nonpermissive cells). We have studied the properties of two mutant virions (pNL-Tr712 an...

journal_title：AIDS research and human retroviruses

authors： Holtkotte D,Pfeiffer T,Bosch V

更新日期：2007-05-01 00:00:00

abstract：:The aim of this study was to evaluate the impact of HIV-1 very low-level viremia (<50 copies/ml) on the 2-year risk of virological failure. A retrospective analysis including HIV-positive patients presenting two consecutive HIV RNA below 50 copies/ml (outpatient clinic in Italy, first semester of 2010) was performed. ...

journal_title：AIDS research and human retroviruses

authors： Calcagno A,Motta I,Ghisetti V,Lo Re S,Allice T,Marinaro L,Milia MG,Tettoni MC,Trentini L,Orofino G,Salassa B,Di Perri G,Bonora S

更新日期：2015-10-01 00:00:00

abstract：:Studies have shown a low frequency of HIV-1 protease drug resistance mutations in patients failing protease inhibitor (PI)-based therapy. Recent studies have identified mutations in Gag as an alternate pathway for PI drug resistance in subtype B viruses. We therefore genotyped the Gag and protease genes from 20 HIV-1 ...

journal_title：AIDS research and human retroviruses

authors： Giandhari J,Basson AE,Coovadia A,Kuhn L,Abrams EJ,Strehlau R,Morris L,Hunt GM

更新日期：2015-08-01 00:00:00