Membrane glycolipids and human immunodeficiency virus infection of primary macrophages.

abstract：:The cells responsible for the second phase decay of HIV-1 viremia following the initiation of antiretroviral therapy have yet to be identified. A dynamic model that considers where drugs act in the virus life cycle places constraints on candidate cell types. In this regard, the rapid drop in viremia in patients starti...

journal_title：AIDS research and human retroviruses

authors： Spivak AM,Rabi SA,McMahon MA,Shan L,Sedaghat AR,Wilke CO,Siliciano RF

更新日期：2011-07-01 00:00:00

abstract：:To investigate HIV-1-related B cell disorders, the quantity of CD27 positive (CD27+) B cells and their CD38, CD95, and bcl-2 intensities were examined by flow cytometry analysis in 16 drug-naive patients, 27 highly active antiretroviral therapy (HAART)-treated patients, and 20 uninfected controls. CD27+ B cells have b...

journal_title：AIDS research and human retroviruses

authors： Chong Y,Ikematsu H,Kikuchi K,Yamamoto M,Murata M,Nishimura M,Nabeshima S,Kashiwagi S,Hayashi J

更新日期：2004-02-01 00:00:00

abstract：:HIV infection is associated with a state of chronic, generalized immune activation that has been shown in many studies to be a key predictor of progression to AIDS. Consistent with this model, nonpathogenic SIV infections of natural hosts, such as the sooty mangabeys, are characterized by low levels of immune activati...

journal_title：AIDS research and human retroviruses

authors： d'Ettorre G,Paiardini M,Ceccarelli G,Silvestri G,Vullo V

更新日期：2011-04-01 00:00:00

abstract：:A potential strategy to combat the worldwide AIDS epidemic is to develop a vaginal microbicide that prevents the sexual transmission of HIV-1. One approach for preventing vaginal HIV transmission is to block the viral coreceptor CCR5 with naturally occurring chemokine ligands. In this study, we used a cynomolgus macaq...

journal_title：AIDS research and human retroviruses

authors： Kish-Catalone T,Pal R,Parrish J,Rose N,Hocker L,Hudacik L,Reitz M,Gallo R,Devico A

更新日期：2007-01-01 00:00:00

abstract：:In a cross-sectional study of 926 subjects from 10 drug treatment programs conducted in 1984 in New Jersey, the seroprevalence of human immunodeficiency virus (HIV) was 35% overall; 30% in whites, 33% in hispanics, and 46% in blacks (p = 0.01 for comparison of blacks to non-blacks). Univariate analysis showed the sero...

journal_title：AIDS research and human retroviruses

authors： Caussy D,Weiss SH,Blattner WA,French J,Cantor KP,Ginzburg H,Altman R,Goedert JJ

更新日期：1990-12-01 00:00:00

abstract：:Antigenic properties of the V3 region are reflected by HIV-1 serotypes. These may represent biological properties of the virus. We serotyped HIV-1 in 142 serum samples from participants in a rural Uganda cohort who seroconverted between August 1991 and December 2001. Clinical progression was assessed using Cox proport...

journal_title：AIDS research and human retroviruses

authors： Senkaali D,Muwonge R,Morgan D,Yirrell D,Whitworth J,Kaleebu P

更新日期：2004-09-01 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiologic agent of COVID-19, a disease that as of July 10, 2020, has infected >12 million people and killed >500,000. COVID-19 infection leads to acute respiratory distress syndrome in a subset of patients and is a primary driver of acute morbidity in...

journal_title：AIDS research and human retroviruses

authors： Al-Harthi L,Campbell E,Schneider JA,Bennett DA

更新日期：2020-08-10 00:00:00

abstract：:HIV-1 infection is associated with vascular alterations. This is accompanied by an increased risk of cardiovascular diseases and Kaposi's sarcoma, an endothelial cell-derived tumor. We investigated the impact of maternal HIV-1 infection on phenotype and gene expression of endothelial cells in newborns. For this reason...

journal_title：AIDS research and human retroviruses

authors： Jörg A,Grubert T,Grimm T,Guenzi E,Naschberger E,Samson E,Oostendorp R,Keller U,Stürzl M

更新日期：2005-11-01 00:00:00

abstract：:The long-term efficacy of once-daily (qd) fosamprenavir (FPV) 1400 mg boosted by ritonavir 100 mg (FPV/r100) has not been evaluated previously. A 96-week open-label, randomized, multicenter study compared the efficacy/safety of FPV/r100 with FPV 1400 mg boosted by ritonavir 200 mg qd (FPV/r200), plus abacavir/lamivudi...

journal_title：AIDS research and human retroviruses

authors： Hicks CB,DeJesus E,Sloan LM,Sension MG,Wohl DA,Liao Q,Ross LL,Pakes GE,Pappa KA,Lancaster CT,COL100758 Study Team.

更新日期：2009-04-01 00:00:00

abstract：:In a set of 42 antiretroviral naive HIV-1 infected persons who were treated with either Zidovudine (AZT) monotherapy, or a combination of AZT + ddC (Zalcitabine) or AZT + ddI (Didanosine), the HIV-1 DNA load was measured by competitive polymerase chain reaction (PCR) and related to the HIV-1 RNA load in plasma, the CD...

journal_title：AIDS research and human retroviruses

authors： Bruisten SM,Reiss P,Loeliger AE,van Swieten P,Schuurman R,Boucher CA,Weverling GJ,Huisman JG

更新日期：1998-08-10 00:00:00

abstract：:The concept that HIV causes AIDS only by directly killing CD4 cells has been questioned by a number of investigators. There has been experimental support for a number of indirect mechanisms such as apoptosis, anergy, superantigen-induced cell proliferation and depletion, defective signaling, molecular mimicry, and aut...

journal_title：AIDS research and human retroviruses

authors： Gougeon ML,Colizzi V,Dalgleish A,Montagnier L

更新日期：1993-03-01 00:00:00

abstract：:In cell-mediated immunity T cells recognize peptide fragments of the antigenic protein in association with major histocompatibility complex (MHC) proteins. Synthetic 9- to 16-mer peptides have been widely used to identify the region(s) of a protein that act as T cell epitope. Here, we report antigenic peptides identif...

journal_title：AIDS research and human retroviruses

authors： Blazevic V,Ranki A,Krohn KJ

更新日期：1995-11-01 00:00:00

abstract：:The HIV-1 subtype distribution in 83 HIV-1-seropositive individuals living in Greece was investigated by using the heteroduplex mobility assay (HMA), DNA sequencing, and phylogenetic analysis. The results revealed that partial HIV-1 gp120 sequences from 71 (86%) patients were subtype B, 5 (6%) were subtype A, 4 were s...

journal_title：AIDS research and human retroviruses

authors： Nasioulas G,Paraskevis D,Paparizos V,Lazanas M,Karafoulidou A,Hatzakis A

更新日期：1998-05-20 00:00:00

abstract：:The proportion of human immunodeficiency virus type 1 (HIV-1) among Vietnamese injecting drug users (IDUs) in Melbourne, Australia exceeds that of the background population. To investigate the molecular epidemiology of HIV-1 among this group, the C2-V4 region of the HIV-1 envelope was directly sequenced from 11 Vietna...

journal_title：AIDS research and human retroviruses

authors： Ryan CE,Elliott JH,Middleton T,Mijch AM,Street AC,Hellard M,Crofts N,Crowe SM,Oelrichs RB

更新日期：2004-12-01 00:00:00

abstract：:This study seeks to analyze nearly full-length viral genomes for distinct genetic characteristics that are unique to local or regional strains and to identify regions that have high variability or are highly conserved. Nearly full length sequences of seven HIV-1 samples were obtained to ascertain the circulating subty...

journal_title：AIDS research and human retroviruses

authors： Roye ME,Amarakoon II,Hamilton CL,Eyzaguirre LM,Figueroa P,Carr JK

更新日期：2011-01-01 00:00:00

abstract：:During HIV-1 infection, distinct biological phenotypes are observed between R5 and X4 HIV-1 strains with respect to pathogenicity and tropism. In this study, temporal changes of the expression levels of the complete human transcriptome, representing 47,000 well-characterized human transcripts, were monitored in the fi...

journal_title：AIDS research and human retroviruses

authors： Sirois M,Robitaille L,Sasik R,Estaquier J,Fortin J,Corbeil J

更新日期：2008-03-01 00:00:00

abstract：:Cross-sectional estimation of HIV incidence could misclassify some established or chronic HIV infections as recent. Usually long-term nonprogressors, elite and viremic controllers, and individuals on ART contribute to misclassification. Local data on the false recent rate (FRR) could minimize misclassification during ...

journal_title：AIDS research and human retroviruses

authors： Moyo S,Kotokwe KP,Mohammed T,Boleo C,Mupfumi L,Chishala S,Tsalaile L,Bussmann H,Gaseitsiwe S,Musonda R,Makhema J,Baum M,Marlink R,Engelbrecht S,Essex M,Novitsky V

更新日期：2017-01-01 00:00:00

abstract：:Serologic reactivities of serum or plasma from 55 HIV-1 subjects in four countries--Brazil, Rwanda, Thailand, and Uganda--were examined by V3 peptide immunoassay. Forty-seven (85.5%) of the 55 specimens tested positive to the homologous peptide. A strong correlation between serotype (i.e., pattern of serologic reactiv...

journal_title：AIDS research and human retroviruses

authors： Pau CP,Kai M,Holloman-Candal DL,Luo CC,Kalish ML,Schochetman G,Byers B,George JR

更新日期：1994-11-01 00:00:00

abstract：:Both HIV and EIAV belong to the retroviridae family and lentivirus genus. Two variable regions (V3 and V4) of equine infectious anemia virus (EIAV) gp90 and two variable regions (V1 and V2) of HIV gp120 possibly adopt the same topology. We have studied the N-glycosylation properties and B cell linear epitope distribut...

journal_title：AIDS research and human retroviruses

authors： Li H,Zhang X,Fan X,Shen T,Tong X,Shen R,Shao Y

更新日期：2005-12-01 00:00:00

abstract：:The dichotomous effects of the protein kinase C (PKC) modulatory compounds 12-myristate 13-acetate (PMA), prostratin, and ingenol 3-angelate (I3A) on HIV-1 infection were investigated. PKC modulatory compounds were shown to be potent activators of cells latently infected with HIV-1 (I3A > prostratin). Conversely, PKC ...

journal_title：AIDS research and human retroviruses

authors： Warrilow D,Gardner J,Darnell GA,Suhrbier A,Harrich D

更新日期：2006-09-01 00:00:00

abstract：:This study explores whether previous failures on antiretroviral drug regimens preclude the possibility of immune restoration. This was assessed by evaluating T cell subset changes in individuals who received a salvage regimen of highly active antiretroviral therapy (HAART) after initially failing protease inhibitor mo...

journal_title：AIDS research and human retroviruses

authors： Gray CM,Schapiro JM,Winters MA,Merigan TC

更新日期：1998-05-01 00:00:00

abstract：:To investigate the changes of neutralizing antibodies and viruses during simian and human immunodeficiency virus (SHIV) infection, we examined the cross-neutralizing ability of sequential sera from three macaques infected with SHIV, NM-3rN, and analyzed the sensitivity of the reisolate to neutralizing antibodies. Neut...

journal_title：AIDS research and human retroviruses

authors： Miyazaki Y,Kuwata T,Takehisa J,Hayami M

更新日期：2002-04-10 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) spends a significant part of its life cycle as latent provirus in nonactivated cells. It induction requires mitogen stimulation. TPA treatment induces HIV-1 transcription by protein kinase C (PKC)-mediated activation of the cellular transcription factor NF-kB. PKC activation...

journal_title：AIDS research and human retroviruses

authors： Doppler C,Schalasta G,Amtmann E,Sauer G

更新日期：1992-02-01 00:00:00

abstract：:A model system was established for studies of humoral and cellular immunity to human immunodeficiency virus (HIV) antigens after vaccination. Macaques (Macaca fascicularis) were immunized with purified HIV, an infected cell extract rich in gp120 or polypeptides of cloned genes representing parts of p24, gp41, and gp12...

journal_title：AIDS research and human retroviruses

authors： Wahren B,Chiodi F,Ljunggren K,Putney S,Kurth R,Gallo RC,Fenyö EM

更新日期：1988-06-01 00:00:00

abstract：:Nucleotide sequences for long terminal repeat (LTR), gag, the protease gene, and pol of a human T-lymphotropic virus type 1 (HTLV-1) isolate of probable Caribbean origin (HTLV-1CH) and a Zairian isolate (HTLV-1EL) were determined providing complete proviral sequences for these isolates. These sequences were compared w...

journal_title：AIDS research and human retroviruses

authors： Ratner L,Philpott T,Trowbridge DB

更新日期：1991-11-01 00:00:00

abstract：:There is little evidence comparing treatment outcomes between adolescents and other age groups, particularly in resource-limited settings. A retrospective analysis of data from seven HIV clinics across urban Gauteng (n=5) and rural Mpumalanga (n=2), South Africa was conducted. The analysis compared HIV-positive antire...

journal_title：AIDS research and human retroviruses

authors： Evans D,Menezes C,Mahomed K,Macdonald P,Untiedt S,Levin L,Jaffray I,Bhana N,Firnhaber C,Maskew M

更新日期：2013-06-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) infection represents a major global health problem, with HIV now recognized as the fourth leading cause of death on a worldwide basis. One approach to developing effective anti- HIV interventions is to identify and understand the molecular mechanisms by which natural genetic variatio...

journal_title：AIDS research and human retroviruses

authors： Donfack J,Buchinsky FJ,Post JC,Ehrlich GD

更新日期：2006-10-01 00:00:00

abstract：:New HIV infections among younger men who have sex with men (MSM) in the United States are escalating. Data on HIV infections in college students are limited. In 2010, three MSM college students presented to our clinic with primary HIV infection (PHI) in a single month. To determine the number of college students among...

journal_title：AIDS research and human retroviruses

authors： Chan PA,Kazi S,Rana A,Blazar I,Dejong CC,Mayer KH,Huard TK,Carleton K,Gillani F,Alexander N,Parillo Z,Flanigan TP,Kantor R

更新日期：2013-01-01 00:00:00

abstract：:We evaluated associations of serum 25-hydroxyvitamin D (25[OH]D) and 1,25-dihydroxyvitamin D (1,25[OH]2D) levels in a cohort of HIV-infected and HIV-uninfected men at risk for infection in the United States. Stored samples collected between 1999 and 2008 were tested for vitamin D metabolites between 2014 and 2015. Vit...

journal_title：AIDS research and human retroviruses

authors： Zhang L,Tin A,Brown TT,Margolick JB,Witt MD,Palella FJ Jr,Kingsley LA,Hoofnagle AN,Jacobson LP,Abraham AG

更新日期：2017-03-01 00:00:00

abstract：:Anti-HIV-1-specific T cell responses in early HIV-1 infection have been found to be important in deciding the course of disease progression. But there are few data concerning nonsubtype B HIV infection. HIV-1 subtype C is the most prevalent subtype in India. HIV-1 Gag-specific T cell responses in 12 Indian subjects wi...

journal_title：AIDS research and human retroviruses

authors： Thakar MR,Patke D,Lakhashe SK,Bhonge L,Kulkarni SV,Tripathy SP,Gupte N,Brookmeyer R,Quinn TC,Paranjape RS,Bollinger RC

更新日期：2002-12-10 00:00:00