HIV-associated immune activation: from bench to bedside.

abstract：:A novel deletion of residue 69 of the HIV-1 reverse transcriptase (RT) gene was detected in combination with mutations V75I/V and F77L/F in a patient with partial virological response to several antiretroviral drug regimens, including stavudine (D4T), didanosine (DDI), lamivudine (3TC), saquinavir (SQV), and nevirapin...

journal_title：AIDS research and human retroviruses

authors： Suzuki K,Kaufmann GR,Mukaide M,Cunningham P,Harris C,Leas L,Kondo M,Imai M,Pett SL,Finlayson R,Zaunders J,Kelleher A,Cooper DA

更新日期：2001-09-01 00:00:00

abstract：:Recombinant forms contribute significantly to the genetic diversity of HIV-1. Here we report a novel HIV-1 recombinant form (CRF01_AE/B'/C) detected from a comprehensive HIV-1 molecular epidemiologic study among heterosexuals in Jilin province of northeastern China. Recombinant analyses of the near full-length genome ...

journal_title：AIDS research and human retroviruses

authors： Li X,Ning C,Chen Y,Feng Y,Wei M,Xing H,Shao Y

更新日期：2014-07-01 00:00:00

abstract：:Current methods to detect intraclade HIV dual infection are poorly suited for determining its prevalence in large cohorts. To investigate the potential of ultra-deep sequencing to screen for dual infection, we compared it to bulk sequence-based synonymous mixture index and the current standard of single genome sequenc...

journal_title：AIDS research and human retroviruses

authors： Pacold M,Smith D,Little S,Cheng PM,Jordan P,Ignacio C,Richman D,Pond SK

更新日期：2010-12-01 00:00:00

abstract：:A primary concern of an antibody-based HIV-1 therapy is the virus' ability to rapidly escape antibody responses. Therefore, we investigated the relationships between antibody neutralization sensitivity, viral phenotype, and infectivity in 13 subtype C viruses using a HeLa transfectant-based assay. We observed that the...

journal_title：AIDS research and human retroviruses

authors： Moyo T,Guleid FH,Schomaker M,Williamson C,Dorfman JR

更新日期：2020-12-01 00:00:00

abstract：:Therapeutic vaccination has the potential to contribute to functional HIV cure strategies. However, to show functional HIV cure, study participants must be taken off combination antiretroviral therapy (cART). The availability of suitable biomarkers that can predict viral load (VL) or CD4 count outcomes following thera...

journal_title：AIDS research and human retroviruses

authors： Huang Y,Zhang L,Jolliffe D,Sanchez B,Stjernholm G,Jelmert Ø,Ökvist M,Sommerfelt MA

更新日期：2018-03-01 00:00:00

abstract：:Most viral vaccines currently in use in humans are live attenuated strains of virus that lack pathogenic potential. In general, such live attenuated vaccines induce the strongest longest-lasting immunity. Live attenuated strains of human immunodeficiency virus type 1 (HIV-1) have not been previously considered as vacc...

journal_title：AIDS research and human retroviruses

authors： Desrosiers RC

更新日期：1992-03-01 00:00:00

abstract：:As the number of women infected with HIV in the United States continues to increase, the medical community is faced with the challenge of providing adequate and appropriate care to them. This paper reviews key questions concerning the state of knowledge on the epidemiology, biology, and clinical care of women living w...

journal_title：AIDS research and human retroviruses

authors： Marlink R,Kao H,Hsieh E,\Giving Voice to a Silent Epidemic\ Working Group.

更新日期：2001-01-01 00:00:00

abstract：:Myeloid dendritic cells (mDCs) are essential for initiation of adaptive immune responses but are depleted in HIV infection. Evidence suggests that apoptosis mediates loss, and to further understand the pathways involved, expression of caspases mediating apoptosis via the extrinsic and intrinsic pathways was analyzed. ...

journal_title：AIDS research and human retroviruses

authors： Chen J,Benlahrech A,Kelleher P,Patterson S

更新日期：2013-04-01 00:00:00

abstract：:Cytotoxic T lymphocytes that specifically lyse HIV-1-infected cells occur at uncommonly high frequency in the blood of infected individuals. The CTL response is dominated by the recognition of a small number of peptides encoded by HIV-1 structural and regulatory genes. These two facts have enabled us to develop potent...

journal_title：AIDS research and human retroviruses

authors： Lieberman J,Fabry JA,Shankar P,Beckett L,Skolnik PR

更新日期：1995-02-01 00:00:00

abstract：:Population genotyping (PG) can underestimate resistance if resistance-containing low abundance variants go undetected. PG and clonal analysis (CA) results were compared in virologic failures (VFs) from a 48-week clinical trial that evaluated once-daily fosamprenavir/ritonavir (FPV/r) 1400 mg/100 mg or atazanavir/riton...

journal_title：AIDS research and human retroviruses

authors： Ross LL,Weinberg WG,DeJesus E,Fischl MA,Horton JH,Pappa KA,Lancaster CT,Pakes GE,Smith KY

更新日期：2010-04-01 00:00:00

abstract：:To understand the pathogenic potential and the true extent of human T-cell leukemia virus type II (HTLV-II) infection, it is important to develop a specific HTLV-II antigen-based serological test. Plasmid pIIB was constructed and induced in Escherichia coli to express a recombinant protein (RP) containing 140 amino ac...

journal_title：AIDS research and human retroviruses

authors： Chen YM,Essex M

更新日期：1991-05-01 00:00:00

abstract：:It is known that the HTLV-I-transformed cell line MT4 releases chemotactic activity for monocytes spontaneously. The MT4 monocyte chemoattractant was purified to homogeneity and sequencing of 25 amino acids revealed identity with the C-C chemokine macrophage inflammatory protein-1 alpha (MIP-1 alpha/LD78). An anti-MIP...

journal_title：AIDS research and human retroviruses

authors： Bertini R,Luini W,Sozzani S,Bottazzi B,Ruggiero P,Boraschi D,Saggioro D,Chieco-Bianchi L,Proost P,van Damme J

更新日期：1995-01-01 00:00:00

abstract：:The silent period that follows infection by the human immunodeficiency virus (HIV-1) and precedes seroconversion remains a problem for the screening of blood supply, and knowledge about the mechanism involved in the maintenance of latency is only fragmentary. Using purified nef recombinant protein and six synthetic ne...

journal_title：AIDS research and human retroviruses

authors： Ameisen JC,Guy B,Chamaret S,Loche M,Mouton Y,Neyrinck JL,Khalife J,Leprevost C,Beaucaire G,Boutillon C

更新日期：1989-06-01 00:00:00

abstract：:We recently reported a novel adhesion pathway in lymphocytes that is mediated by cyclin-dependent kinase (Cdk) 4 activity and mediates lymphocyte interactions with endothelial matrix. We now demonstrate that HIV-infected lymphocytes also use Cdk4 to mediate spontaneous adhesion to fibronectin and endothelial matrix. W...

journal_title：AIDS research and human retroviruses

authors： Chow YH,Liu L,Schwartz B,Harlan JM,Schnapp LM

更新日期：2012-12-01 00:00:00

abstract：:Vaginal anti-HIV antibody responses may be beneficial, and possibly required, for vaccine-induced protection against HIV infection acquired through receptive vaginal intercourse. We have previously determined that intranasal immunization with a hybrid HIV peptide and cholera toxin induced vaginal anti-HIV IgA response...

journal_title：AIDS research and human retroviruses

authors： Staats HF,Montgomery SP,Palker TJ

更新日期：1997-07-20 00:00:00

abstract：:Serum specimens (n = 1899) were assayed for infections with HTLV-I, HTLV-II, and HIV-1 in seven classified groups of normal healthy controls, children, pregnant women, prostitutes, intravenous drug abusers, patients under going hemodialysis, and hemophiliacs in South and North Vietnam. Surprisingly, 125 of 954 samples...

journal_title：AIDS research and human retroviruses

authors： Fukushima Y,Takahashi H,Hall WW,Nakasone T,Nakata S,Song P,Dinh Duc D,Hien B,Nguyen XQ,Ngoc Trinh T

更新日期：1995-05-01 00:00:00

abstract：:Maraviroc (MVC) is licensed in clinical practice for patients with R5 virus and virological failure; however, in anecdotal reports, dual/mixed viruses were also inhibited. We retrospectively evaluated the evolution of HIV-1 coreceptor tropism in plasma and peripheral blood mononuclear cells (PBMCs) of an infected adol...

journal_title：AIDS research and human retroviruses

authors： Cavarelli M,Mainetti L,Pignataro AR,Bigoloni A,Tolazzi M,Galli A,Nozza S,Castagna A,Sampaolo M,Boeri E,Scarlatti G

更新日期：2014-12-01 00:00:00

abstract：:Genotype-based algorithms are valuable tools for the identification of patients eligible for CCR5 inhibitors administration in clinical practice. Among the available methods, geno2pheno[coreceptor] (G2P) is the most used online tool for tropism prediction. This study was conceived to assess if the combination of G2P p...

journal_title：AIDS research and human retroviruses

authors： Montagna C,De Crignis E,Bon I,Re MC,Mezzaroma I,Turriziani O,Graziosi C,Antonelli G

更新日期：2014-12-01 00:00:00

abstract：:HLA-A*3303 is one of the common HLA alleles in East and Southeast Asia. Identification of HLA-A*3303-restricted HIV-1 cytotoxic T lymphocyte (CTL) epitopes is therefore required to investigate the immunopathogenesis of AIDS and vaccine development in these areas, where AIDS is rapidly expanding. We attempted to identi...

journal_title：AIDS research and human retroviruses

authors： Hossain MS,Tomiyama H,Inagawa T,Ida S,Oka S,Takiguchi M

更新日期：2003-06-01 00:00:00

abstract：:HIV-1 Vif, Vpr, and Vpu proteins have a profound effect on efficient viral replication and pathogenesis. This study describes the genotypic characterisation of vif , vpr and vpu from 20 South African HIV-1 subtype C primary isolates, and extensive analysis and comparison of known motifs. All HIV-1 subtype C Vif, Vpr a...

journal_title：AIDS research and human retroviruses

authors： Bell CM,Connell BJ,Capovilla A,Venter WD,Stevens WS,Papathanasopoulos MA

更新日期：2007-02-01 00:00:00

abstract：:The advent of antiretroviral treatment (ART) has resulted in a dramatic reduction in AIDS-related morbidity and mortality. However, the emergence and spread of antiretroviral drug resistance (DR) threaten to negatively impact treatment regimens and compromise efforts to control the epidemic. It is recommended that sur...

journal_title：AIDS research and human retroviruses

authors： Cheriro W,Kiptoo M,Kikuvi G,Mining S,Emonyi W,Songok E

更新日期：2015-12-01 00:00:00

abstract：:Studies have shown a low frequency of HIV-1 protease drug resistance mutations in patients failing protease inhibitor (PI)-based therapy. Recent studies have identified mutations in Gag as an alternate pathway for PI drug resistance in subtype B viruses. We therefore genotyped the Gag and protease genes from 20 HIV-1 ...

journal_title：AIDS research and human retroviruses

authors： Giandhari J,Basson AE,Coovadia A,Kuhn L,Abrams EJ,Strehlau R,Morris L,Hunt GM

更新日期：2015-08-01 00:00:00

abstract：:The cells responsible for the second phase decay of HIV-1 viremia following the initiation of antiretroviral therapy have yet to be identified. A dynamic model that considers where drugs act in the virus life cycle places constraints on candidate cell types. In this regard, the rapid drop in viremia in patients starti...

journal_title：AIDS research and human retroviruses

authors： Spivak AM,Rabi SA,McMahon MA,Shan L,Sedaghat AR,Wilke CO,Siliciano RF

更新日期：2011-07-01 00:00:00

abstract：:Acquisition of cellular proteins by HIV-1 virions is known to alter the physiology of the virus in vitro. Reported studies of this aspect have been largely limited to transformed T cell lines. In this study, we investigated the incorporation of major histocompatibility antigens (HLAs) on a primary macrophage-tropic is...

journal_title：AIDS research and human retroviruses

authors： Tsai WP,Kung HF,Nara PL

更新日期：1999-01-01 00:00:00

abstract：:To understand the evolution of HIV-1, the genetic and biological characteristics of viruses that infect persons living in regions in which the virus has been evolving for several decades must be studied. Thus, we investigated teh genetic subtypes, coreceptor usage, and syncytium-inducing ability of viruses in 47 HIV-1...

journal_title：AIDS research and human retroviruses

authors： Zhong P,BUrda S,Konings F,Urbanski M,Ma L,Zekeng L,Ewane L,Agyingi L,Agwara M,Saa,Afane ZE,Kinge T,Zolla-Pazner S,Nyambi P

更新日期：2003-12-01 00:00:00

abstract：:A new HIV-1 circulating recombinant form (CRF), CRF33_01B, has been identified in Malaysia. Concurrently we found a unique recombinant form (URF), that is, the HIV-1 isolate 06MYKLD46, in Kuala Lumpur, Malaysia. It is composed of B or a Thai variant of the B subtype (B') and CRF01_AE. Here, we determined the near full...

journal_title：AIDS research and human retroviruses

authors： Lau KA,Wang B,Kamarulzaman A,Ng KP,Saksena NK

更新日期：2007-09-01 00:00:00

abstract：:Epidemiological and experimental data suggest that both robust neutralizing antibodies and potent cellular responses play important roles in controlling primary HIV-1 infection. In this study we have investigated the induction of systemic and mucosal immune responses to HIV gp120 monomer immunogen administered intrana...

journal_title：AIDS research and human retroviruses

authors： Bielinska AU,Janczak KW,Landers JJ,Markovitz DM,Montefiori DC,Baker JR Jr

更新日期：2008-02-01 00:00:00

abstract：:We investigate mutations and correlates according to HIV-1 subtype after virological failure (VF) of standard first-line antiretroviral therapy (ART) (non-nucleoside/nucleotide reverse transcriptase inhibitor [NNRTI] +2 nucleoside/nucleotide reverse transcriptase inhibitor [N(t)RTI]). SECOND-LINE study participants we...

journal_title：AIDS research and human retroviruses

authors： Lam EP,Moore CL,Gotuzzo E,Nwizu C,Kamarulzaman A,Chetchotisakd P,van Wyk J,Teppler H,Kumarasamy N,Molina JM,Emery S,Cooper DA,Boyd MA

更新日期：2016-09-01 00:00:00

abstract：:HIV-1 disease is associated with many infectious and neoplastic complications. This is particularly true of the genitourinary tract, where high rates of renal disease, neoplasms, voiding and erectile dysfunction, hematuria, opportunistic genitourinary infections, and epididymo-orchitis are found in HIV-1-infected indi...

journal_title：AIDS research and human retroviruses

authors： Coburn M

更新日期：1998-04-01 00:00:00

abstract：:Human T cell leukemia virus protein induces T cells to permanent IL-2-dependent growth. These cells occasionally convert to factor independence. The viral oncoprotein Tax acts as an essential growth factor of transformed lymphocytes and stimulates the cell cycle in the G(1) phase. In T cells and fibroblasts Tax enhanc...

journal_title：AIDS research and human retroviruses

authors： Haller K,Ruckes T,Schmitt I,Saul D,Derow E,Grassmann R

更新日期：2000-11-01 00:00:00