Demonstration of de novo HIV type 1 production by detection of multiply spliced and unspliced HIV type 1 RNA in paraffin-embedded tonsils.

abstract：:DNA vaccines have the potential of giving rise to a potent cell-mediated immune response by inducing intracellular synthesis and subsequent antigenic presentation of encoded antigens. We have tested a DNA vaccine specific for human immunodeficiency virus type 1 (HIV-1) by the injection of animals with expression plasm...

journal_title：AIDS research and human retroviruses

authors： Okuda K,Bukawa H,Hamajima K,Kawamoto S,Sekigawa K,Yamada Y,Tanaka S,Ishi N,Aoki I,Nakamura M

更新日期：1995-08-01 00:00:00

abstract：:The feasibility and effectiveness of a hospital-based exercise-training program followed by a home-based program for improving fitness, strength, and changes in body composition in children and adolescents with HIV were evaluated. Subjects participated in nonrandomized 24-session, hospital supervised exercise training...

journal_title：AIDS research and human retroviruses

authors： Miller TL,Somarriba G,Kinnamon DD,Weinberg GA,Friedman LB,Scott GB

更新日期：2010-03-01 00:00:00

abstract：:Intense research into fundamental processes of human immunodeficiency syndrome type 1 (HIV-1) replication has yielded knowledge that in many aspects equals or exceeds that of the oncogenic retroviruses. The availability of sensitive virus detection methods has allowed a more thorough characterization of the biology of...

journal_title：AIDS research and human retroviruses

authors： Stevenson M,Bukrinsky M,Haggerty S

更新日期：1992-02-01 00:00:00

abstract：:The human foamy virus (HFV) is a complex retrovirus that contains several regulatory and auxiliary bel genes besides the gag, pol, and env genes. In contrast to the gene products of bel 1 and bel 2/bet that were identified previously, the Bel 3 protein has not been described to date. Here we report the identification ...

journal_title：AIDS research and human retroviruses

authors： Weissenberger J,Flügel RM

更新日期：1994-05-01 00:00:00

abstract：:We report here a novel HIV-1 second-generation recombinant form (CRF01_AE/CRF07_BC) composed of CRF01_AE and CRF07_BC, identified among men who have sex with men (MSM) in Jilin, with four breakpoints observed in the pol, vif, and vpr genes. The CRF01_AE regions of the recombinant were clustered with the CRF01_AE linea...

journal_title：AIDS research and human retroviruses

authors： Li X,Ning C,He X,Yang Y,Xing H,Hong K,Shao Y,Yang R

更新日期：2013-12-01 00:00:00

abstract：:In a series of 60 HIV-1-infected individuals, serum electrofocusing analysis disclosed clonally restricted IgG patterns in 9 patients (15%), most with limited disease progression (stages WR1-WR3). These oligoclonal bands had a very heterogeneous light chain pattern, and most showed specificity for HIV-1 in affinity-dr...

journal_title：AIDS research and human retroviruses

authors： Amadori A,Gallo P,Zamarchi R,Veronese ML,De Rossi A,Wolf D,Chieco-Bianchi L

更新日期：1990-05-01 00:00:00

abstract：BACKGROUND:Immune activation, which is accompanied by the production of proinflammatory cytokines, is a strong predictor of disease progression in HIV infection. Inflammation is critical in neuronal damage linked to HIV-associated neurocognitive disorders. METHODS:We examined the relationship between plasma cytokine l...

journal_title：AIDS research and human retroviruses

authors： Ruhanya V,Jacobs GB,Naidoo S,Paul RH,Joska J,Seedat S,Nyandoro G,Engelbrecht S,Glashoff R

更新日期：2021-01-20 00:00:00

abstract：:The domain of HIV-2 Vpx previously shown to be important for virion incorporation has been mapped to residues 73--89. Mutational analysis of this domain was employed to further define the sequences important for incorporation into virus-like particles, using a vaccinia virus expression system. Deletion of residues 73-...

journal_title：AIDS research and human retroviruses

authors： Jin L,Zhou Y,Ratner L

更新日期：2001-01-20 00:00:00

abstract：:Tuberculosis (TB) is the major opportunistic infection of HIV-infected patients in developing countries and is associated with activation of the immune system and increased HIV-1 expression. The aim of this study was to explore the biological properties of HIV-1 isolates from patients with active TB. Ten HIV-1 subtype...

journal_title：AIDS research and human retroviruses

authors： Morris L,Cilliers T,Bredell H,Phoswa M,Martin DJ

更新日期：2001-05-20 00:00:00

abstract：:Depletion of mitochondrial DNA (mtDNA) and mtDNA-encoded respiratory chain proteins in subcutaneous (SC) fat from patients with HIV lipoatrophy have clearly demonstrated the role of mitochondrial dysfunction in this syndrome. Research in HIV lipoatrophy, however, has been severely hampered by the lack of a suitable su...

journal_title：AIDS research and human retroviruses

authors： Shikuma CM,Gerschenson M,Chow D,Libutti DE,Willis JH,Murray J,Capaldi RA,Marusich M

更新日期：2008-10-01 00:00:00

abstract：:The human endogenous retrovirus, type K (HERV-K) represents the most biologically active form of known retroelements present in the human genome. Several HERV-K genomes have transcriptionally active open reading frames and encode their own protease (PR). The HERV-K PR has been shown to authentically cleave human immun...

journal_title：AIDS research and human retroviruses

authors： Padow M,Lai L,Fisher RJ,Zhou YC,Wu X,Kappes JC,Towler EM

更新日期：2000-12-10 00:00:00

abstract：:Nucleoside analog-associated sensory neuropathy (NRTI-SN) attributed to stavudine, didanosine, or zalcitabine (the dNRTIs) and distal sensory polyneuropathy (DSP) attributed to HIV are clinically indistinguishable. As inflammatory cytokines are involved in DSP, we addressed a role for inflammation in NRTI-SN by determ...

journal_title：AIDS research and human retroviruses

authors： Cherry CL,Rosenow A,Affandi JS,McArthur JC,Wesselingh SL,Price P

更新日期：2008-02-01 00:00:00

abstract：:We studied plasma samples from 2082 Mataco Indians living in 22 different communities in the western part of Formosa Province, northern Argentina. Samples were screened for HTLV-I/II antibodies by particle agglutination assay. All positive or borderline samples were then tested by an immunofluorescence assay (IFA) on ...

journal_title：AIDS research and human retroviruses

authors： Biglione M,Vidan O,Mahieux R,de Colombo M,de los Angeles de Basualdo M,Bonnet M,Pankow G,De Efron MA,Zorrilla A,Tekaia F,Murphy E,de Thé G,Gessain A

更新日期：1999-03-20 00:00:00

abstract：:We investigated memory cytotoxic T lymphocyte (CTLm) responses to HIV-1 as a determinant of HIV-1 disease progression, in relation to plasma HIV-1 load and T lymphocyte numbers in a longitudinal study of 14 homosexual men with incident HIV-1 infection. Study participants were selected who exhibited failure of T cell h...

journal_title：AIDS research and human retroviruses

authors： Rinaldo CR Jr,Gupta P,Huang XL,Fan Z,Mullins JI,Gange S,Farzadegan H,Shankarappa R,Muñoz A,Margolick JB

更新日期：1998-11-01 00:00:00

abstract：:The efficacy and safety of recombinant human interferon gamma (rIFN-gamma) in the reduction of opportunistic disease in patients with advanced HIV-1 infection are assessed. A 12-month double-blind, placebo-controlled, multicenter, Phase III trial of rIFN-gamma in HIV-positive patients with CD4 < 100 x 10(9)/liter on s...

journal_title：AIDS research and human retroviruses

authors： Riddell LA,Pinching AJ,Hill S,Ng TT,Arbe E,Lapham GP,Ash S,Hillman R,Tchamouroff S,Denning DW,Parkin JM

更新日期：2001-06-10 00:00:00

abstract：:A strain of mouse transgenic for the env gene of the HIV-1 virus was used to study the immunogenicity of a gp160-derived vaccine (the protein encoded by the HIV env gene) and its effect on disease progression. Untreated transgenic mice frequently developed a rapidly progressive renal disease similar to that affecting ...

journal_title：AIDS research and human retroviruses

authors： Shirai A,Klinman DM

更新日期：1993-10-01 00:00:00

abstract：:Our goal has been to develop a safe and effective system that would allow us to explore the functions of the human immunodeficiency virus (HIV) envelope. We have generated a human lymphoid cell line (TF228.1.16) that stably expresses functional HIV envelope proteins on its cell surface, and therefore closely mimics th...

journal_title：AIDS research and human retroviruses

authors： Jonak ZL,Clark RK,Matour D,Trulli S,Craig R,Henri E,Lee EV,Greig R,Debouck C

更新日期：1993-01-01 00:00:00

abstract：:HIV infection is a risk factor for the tumorigenesis including non-AIDS-defining cancers such as those of the gastrointestinal tract. However, the mechanisms underlying such cancer outgrowth are still unknown. Furthermore, combined HIV/cancer studies are difficult to evaluate using primate models or in the clinical pa...

journal_title：AIDS research and human retroviruses

authors： Lu R,Wu S,Zhang Y,Xia Y,Huelsmann EJ,Lacek AT,Nabatiyan A,Richards MH,Narasipura SD,Lutgen V,Chen H,Kaufman HL,Chen D,Al-Harthi L,Zloza A,Sun J

更新日期：2014-07-01 00:00:00

abstract：:Natural polymorphisms of HIV-1, often associated with drug resistance, are widely described in protease and reverse transcriptase regions but data on their presence in the integrase region, especially in non-B subtypes, are still very limited. We aimed to characterize naturally occurring polymorphisms in the integrase...

journal_title：AIDS research and human retroviruses

authors： Avi R,Huik K,Sadam M,Karki T,Krispin T,Ainsalu K,Paap P,Schmidt J,Nikitina N,Lutsar I

更新日期：2010-10-01 00:00:00

abstract：:To better understand the emergence of HIV-1 variants in Barbados and the association with transmission modes, we analyzed phylogenetic relationships and genetic variability among HIV-1 strains collected in 1996 from 36 antiretroviral therapy-naive patients. Only subtype B variants were present in this sampling, based ...

journal_title：AIDS research and human retroviruses

authors： Gittens MV,Roth WW,Roach T,Stringer HG Jr,Pieniazek D,Bond VC,Levett PN

更新日期：2003-04-01 00:00:00

abstract：:The concept that HIV causes AIDS only by directly killing CD4 cells has been questioned by a number of investigators. There has been experimental support for a number of indirect mechanisms such as apoptosis, anergy, superantigen-induced cell proliferation and depletion, defective signaling, molecular mimicry, and aut...

journal_title：AIDS research and human retroviruses

authors： Gougeon ML,Colizzi V,Dalgleish A,Montagnier L

更新日期：1993-03-01 00:00:00

abstract：:HIV-infected individuals are at high risk of developing atherosclerosis and cardiovascular disease, in part, due to HIV-induced impairment of cholesterol metabolism. In vitro studies demonstrated that HIV-1 protein Nef inhibits activity of ABCA1, the main cellular cholesterol transporter, leading to cholesterol accumu...

journal_title：AIDS research and human retroviruses

authors： Pushkarsky T,Shilov E,Kruglova N,Naumann R,Brichacek B,Jennelle L,Sviridov D,Kruglov A,Nedospasov SA,Bukrinsky M

更新日期：2017-01-01 00:00:00

abstract：:Studies have shown a low frequency of HIV-1 protease drug resistance mutations in patients failing protease inhibitor (PI)-based therapy. Recent studies have identified mutations in Gag as an alternate pathway for PI drug resistance in subtype B viruses. We therefore genotyped the Gag and protease genes from 20 HIV-1 ...

journal_title：AIDS research and human retroviruses

authors： Giandhari J,Basson AE,Coovadia A,Kuhn L,Abrams EJ,Strehlau R,Morris L,Hunt GM

更新日期：2015-08-01 00:00:00

abstract：:Lentivirus infections are characterized by a dramatic loss of mucosal CD4(+) T cells, breakdown of the gut mucosa, and subsequent chronic immune activation. Residual immune activation persists even in patients controlling virus replication and remains a significant source of ongoing disease morbidities, but the causes...

journal_title：AIDS research and human retroviruses

authors： Li H,Goepfert P,Reeves RK

更新日期：2014-12-01 00:00:00

abstract：:An EBV-transformed lymphoblastoid B cell clone (A12) derived from peripheral blood lymphocytes of an HIV-1-infected individual is described. The immunoglobulin isotype produced by this clone was IgM, and Southern blot analysis of immunoglobulin gene rearrangement showed a monoclonal pattern. The A12 monoclonal antibod...

journal_title：AIDS research and human retroviruses

authors： Amadori A,Ciminale V,Calabro ML,Tessarollo L,Francavilla E,Chieco-Bianchi L

更新日期：1989-02-01 00:00:00

abstract：:To evaluate the efficacy, safety and tolerability of switching to a dolutegravir (DTG)-based regimen in a cohort of virological suppressed HIV-infected patients. The dynamics of total HIV-DNA and levels of high-sensitivity c-reactive protein (hsCRP), interleukin-6 (IL-6), soluble-CD14 (sCD14) and D-Dimer were also ana...

journal_title：AIDS research and human retroviruses

authors： Di Carlo D,Falasca F,Palermo E,Mezzaroma I,Fimiani C,Siccardi G,Celani L,Di Campli FM,d'Ettorre G,Antonelli G,Turriziani O

更新日期：2021-01-24 00:00:00

abstract：:The silent period that follows infection by the human immunodeficiency virus (HIV-1) and precedes seroconversion remains a problem for the screening of blood supply, and knowledge about the mechanism involved in the maintenance of latency is only fragmentary. Using purified nef recombinant protein and six synthetic ne...

journal_title：AIDS research and human retroviruses

authors： Ameisen JC,Guy B,Chamaret S,Loche M,Mouton Y,Neyrinck JL,Khalife J,Leprevost C,Beaucaire G,Boutillon C

更新日期：1989-06-01 00:00:00

abstract：:The prevalence of different HIV-1 subtypes in Spain varies by geographic region. In the present study isolates were collected from 72 newly diagnosed individuals in western Andalucia from 2004 to 2006. Viral sequences were amplified and the subtype diversity and prevalence of resistance mutations in the reverse transc...

journal_title：AIDS research and human retroviruses

authors： McConnell MJ,Docobo-Pérez F,Mata RC,Fernandez-Cuenca F,Viciana P,López-Cortés LF,Trastoy M,Pachón J,Pérez-Romero P

更新日期：2008-06-01 00:00:00

abstract：:In a set of 42 antiretroviral naive HIV-1 infected persons who were treated with either Zidovudine (AZT) monotherapy, or a combination of AZT + ddC (Zalcitabine) or AZT + ddI (Didanosine), the HIV-1 DNA load was measured by competitive polymerase chain reaction (PCR) and related to the HIV-1 RNA load in plasma, the CD...

journal_title：AIDS research and human retroviruses

authors： Bruisten SM,Reiss P,Loeliger AE,van Swieten P,Schuurman R,Boucher CA,Weverling GJ,Huisman JG

更新日期：1998-08-10 00:00:00

abstract：:The production and characterization of a cell line for quantitative HIV-1 Tat function and T cell activation assays is described. 1G5 is a clonal cell line derived from Jurkat T cells stably transfected with a luciferase gene driven by an HIV-1 long terminal repeat (HIV-LTR). The 1G5 clone was selected for low basal l...

journal_title：AIDS research and human retroviruses

authors： Aguilar-Cordova E,Chinen J,Donehower L,Lewis DE,Belmont JW

更新日期：1994-03-01 00:00:00