HIV infection accelerates gastrointestinal tumor outgrowth in NSG-HuPBL mice.


:HIV infection is a risk factor for the tumorigenesis including non-AIDS-defining cancers such as those of the gastrointestinal tract. However, the mechanisms underlying such cancer outgrowth are still unknown. Furthermore, combined HIV/cancer studies are difficult to evaluate using primate models or in the clinical patient setting. To understand the mechanisms of tumor outgrowth in the context of HIV infection, we adopted a humanized mouse model permissive to infection and cancer as well as an in vivo humanized mouse challenge with colon cancer in the context of HIV infection. Immunodeficient NOD SCID IL-2R(-/-) mice were immunologically reconstituted by adoptive transfer of 10(7) HIV-negative donor peripheral blood leukocytes and challenged with 10(6) HCT116 human colon cancer cells. A group of mice was treated with antiretroviral therapy. Tumor microenvironment and epithelial tissues in the context of HIV infection were analyzed using immunohistochemistry. We demonstrate that HIV-infected humanized mice develop significantly larger tumors than uninfected mice (p<0.05). Epithelial cell proliferation in HIV-infected mice is significantly enhanced in comparison to proliferation in uninfected mice (p<0.01). Moreover, the activation of β-catenin, an important step in intestinal epithelial cell proliferation and tumorigenesis, is elevated in the tumors of HIV-infected mice (p<0.0001). Importantly, antiretroviral therapy reverses these pathological processes independently of CD4(+) T cell return. These findings model the ability of HIV infection to result in tumor outgrowth that is evident in HIV-positive patients and lend insight into previously unrecognized mechanisms that may underlie this pathology.


Lu R,Wu S,Zhang Y,Xia Y,Huelsmann EJ,Lacek AT,Nabatiyan A,Richards MH,Narasipura SD,Lutgen V,Chen H,Kaufman HL,Chen D,Al-Harthi L,Zloza A,Sun J




Has Abstract


2014-07-01 00:00:00












  • Intrahost and interhost variability of the HIV type 1 nef gene in Brazilian children.

    abstract::Many aspects of HIV-1 pathogenesis are affected by Nef protein activity, and efforts have been made to study variation in the nef gene and how that variation relates to disease outcome. We studied the genetic diversity of the nef gene in distinct clones obtained from the same patient (intrahost) and in sequences obtai...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Cavalieri E,Florido C,Leal E,Machado DM,Camargo M,Diaz RS,Janini LM

    更新日期:2009-11-01 00:00:00

  • HIV type 1-mediated downregulation of HLA-B*57/B*5801 proteins on elite suppressor CD4+ T cells.

    abstract::Elite controllers or suppressors (ES) are HIV-1-infected patients who maintain viral loads of <50 copies/ml without antiretroviral therapy. While HLA-B*57 and B*5801 alleles are overrepresented in ES, many HLA-B*57/B*5801 patients become chronic progressors (CP). We show here that HIV-1 infection results in similar le...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Sampah ME,Ceccato CM,Blankson JN

    更新日期:2011-02-01 00:00:00

  • Increasing impact of chronic viral hepatitis on hospital admissions and mortality among HIV-infected patients.

    abstract::To assess the impact of chronic viral liver disease (CVLD) on hospital admissions and death in HIV-infected patients since the introduction of highly active antiretroviral therapy, all hospital charts, from January 1996 to December 2000, in a large HIV/AIDS reference center in Madrid were reviewed. Discharge diagnosis...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Martín-Carbonero L,Soriano V,Valencia E,García-Samaniego J,López M,González-Lahoz J

    更新日期:2001-11-01 00:00:00

  • Identification of a complex env subtype E HIV type 1 virus from the democratic republic of congo, recombinant with A, G, H, J, K, and unknown subtypes.

    abstract::Up to now, all known env subtype E viruses (CRF01-AE) have had the same mosaic structure with subtype A, and no other env subtype E HIV-1 viruses with non-A subtypes in their genomes have been described. In this report we describe the full-length genome sequence of an env subtype E isolate with a recombinant genome di...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Vidal N,Mulanga-Kabeya C,Nzilambi N,Delaporte E,Peeters M

    更新日期:2000-12-10 00:00:00

  • Predictors for Poor Linkage to Care Among Hospitalized Persons Living with HIV and Co-Occurring Substance Use Disorder.

    abstract::Persons living with HIV (PLWH) with substance use disorders (SUD) remain a population difficult to engage in HIV care. Project HOPE (Hospital Visits as an Opportunity for Prevention and Engagement), a randomized controlled trial testing patient navigation with/without contingency management for PLWH with SUD, aimed to...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Summers NA,Colasanti JA,Feaster DJ,Armstrong WS,Rodriguez A,Jain MK,Jacobs P,Metsch LR,Del Rio C

    更新日期:2020-05-01 00:00:00

  • V3 net charge: additional tool in HIV-1 tropism prediction.

    abstract::Genotype-based algorithms are valuable tools for the identification of patients eligible for CCR5 inhibitors administration in clinical practice. Among the available methods, geno2pheno[coreceptor] (G2P) is the most used online tool for tropism prediction. This study was conceived to assess if the combination of G2P p...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Montagna C,De Crignis E,Bon I,Re MC,Mezzaroma I,Turriziani O,Graziosi C,Antonelli G

    更新日期:2014-12-01 00:00:00

  • Amplification of simian retroviral sequences from human recipients of baboon liver transplants.

    abstract::Investigations into the use of baboons as organ donors for human transplant recipients, a procedure called xenotransplantation, have raised the specter of transmitting baboon viruses to humans and possibly establishing new human infectious diseases. Retrospective analysis of tissues from two human transplant recipient...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Allan JS,Broussard SR,Michaels MG,Starzl TE,Leighton KL,Whitehead EM,Comuzzie AG,Lanford RE,Leland MM,Switzer WM,Heneine W

    更新日期:1998-07-01 00:00:00

  • Chromosomal distribution and coding capacity of the human endogenous retrovirus HERV-W family.

    abstract::Some genomic elements of the multicopy HERV-W endogenous retroviral family have been previously identified in databases. One of them, located on chromosome 7, contains a single complete open reading frame (ORF) putatively encoding an envelope protein. We have experimentally investigated the genomic complexity and codi...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Voisset C,Bouton O,Bedin F,Duret L,Mandrand B,Mallet F,Paranhos-Baccala G

    更新日期:2000-05-20 00:00:00

  • Eradication therapies for HIV Infection: time to begin again.

    abstract::Despite the success of antiretroviral therapy (ART) in decreasing mortality for HIV-1-infected patients, ART has not cured the disease. A persistent viral reservoir in the T cells of HIV patients receiving potent ART is a significant barrier preventing eradication of HIV infection. We will briefly review what is known...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章,评审


    authors: Margolis DM

    更新日期:2011-04-01 00:00:00

  • Identification of human immunodeficiency virus type 1 glycoprotein gp120/gp41 interacting sites by the idiotypic mimicry of two monoclonal antibodies.

    abstract::A sequence of four amino acid residues amino-terminal to the only intramolecular disulphide bond of the human immunodeficiency virus type 1 (HIV-1) transmembrane protein gp41 is recognized by an anti-idiotypic antibody (9G5A) raised against another monoclonal antibody (M38), which recognizes the C5 region of gp120. 9G...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Lopalco L,Longhi R,Ciccomascolo F,De Rossi A,Pelagi M,Andronico F,Moore JP,Schulz T,Beretta A,Siccardi AG

    更新日期:1993-01-01 00:00:00

  • Up-regulation of TLR2 and TLR4 in dendritic cells in response to HIV type 1 and coinfection with opportunistic pathogens.

    abstract::The ability to trigger an innate immune response against opportunistic pathogens associated with HIV-1 infection is an important aspect of AIDS pathogenesis. Toll-like receptors (TLRs) play a critical role in innate immunity against pathogens, but in HIV-1 patients coinfected with opportunistic infections, the regulat...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Hernández JC,Arteaga J,Paul S,Kumar A,Latz E,Urcuqui-Inchima S

    更新日期:2011-10-01 00:00:00

  • The molecular epidemiology and drug resistance determination of HIV type 1 subtype B infection in Barbados.

    abstract::To better understand the emergence of HIV-1 variants in Barbados and the association with transmission modes, we analyzed phylogenetic relationships and genetic variability among HIV-1 strains collected in 1996 from 36 antiretroviral therapy-naive patients. Only subtype B variants were present in this sampling, based ...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Gittens MV,Roth WW,Roach T,Stringer HG Jr,Pieniazek D,Bond VC,Levett PN

    更新日期:2003-04-01 00:00:00

  • The safety and pharmacokinetics of single-agent and combination therapy with megestrol acetate and dronabinol for the treatment of HIV wasting syndrome. The DATRI 004 Study Group. Division of AIDS Treatment Research Initiative.

    abstract::This randomized, open-labeled, multicenter study was designed to assess safety and pharmacokinetics of dronabinol (Marinol) tablets and megestrol acetate (Megace) micronized tablets, alone and in combination, for treatment of HIV wasting syndrome. Weight and quality of life data were also collected. Fifty-two patients...

    journal_title:AIDS research and human retroviruses

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Timpone JG,Wright DJ,Li N,Egorin MJ,Enama ME,Mayers J,Galetto G

    更新日期:1997-03-01 00:00:00

  • Molecular characteristics of HIV type 1 circulating in São Paulo, Brazil.

    abstract::Partial sequences of HIV-1 polymerase from 185 patients, 141 ARV experienced and 44 naive, of gag (p24) and env (C2V3) from a subset of naive cases were evaluated in São Paulo, Brazil. Antiretroviral resistance mutations were detected in 4% of 26 recently (<2 years) infected patients. Polymorphisms at the protease gen...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Brígido LF,Franco HM,Custódio RM,Oliveira CA,P Ferreira JL,Eira M,Bergel F,Araújo F,Carvalheiro JR,Rodrigues R

    更新日期:2005-07-01 00:00:00

  • Viral dynamics and CD4+ T cell counts in subtype C human immunodeficiency virus type 1-infected individuals from southern Africa.

    abstract::Defining viral dynamics in natural infection is prognostic of disease progression and could prove to be important for vaccine trial design as viremia may be a likely secondary end point in phase III HIV efficacy trials. There are limited data available on the early course of plasma viral load in subtype C HIV-1 infect...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Gray CM,Williamson C,Bredell H,Puren A,Xia X,Filter R,Zijenah L,Cao H,Morris L,Vardas E,Colvin M,Gray G,McIntyre J,Musonda R,Allen S,Katzenstein D,Mbizo M,Kumwenda N,Taha T,Karim SA,Flores J,Sheppard HW

    更新日期:2005-04-01 00:00:00

  • Molecular epidemiology of HTLV type I in Japan: evidence for two distinct ancestral lineages with a particular geographical distribution.

    abstract::Japan is one of the highest endemic areas of the world for human T cell leukemia-lymphoma virus type I (HTLV-I). To gain new insight as to the origin of this virus in Japan and especially in the southern islands of the archipelago, we investigated the long terminal repeat (LTR) of 67 newly isolated HTLV-I proviral DNA...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Vidal AU,Gessain A,Yoshida M,Mahieux R,Nishioka K,Tekaia F,Rosen L,De Thé G

    更新日期:1994-11-01 00:00:00

  • Genome Sequence of a Novel HIV-1 Circulating Recombinant Form (CRF79_0107) Identified from Shanxi, China.

    abstract::We report a novel HIV-1 circulating recombinant form (CRF79_0107) from three epidemiologically unlinked patients through sexual contact in Shanxi province of China. This is the first second-generation circulating recombinant form identified in China. The breakpoint analysis of recombinants showed that CRF79_0107 was c...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Li Y,Feng Y,Li F,Xue Z,Hu J,Xing H,Ruan Y,Shao Y

    更新日期:2017-10-01 00:00:00

  • Transmission of resistant HIV type 1 variants and epidemiological chains in Italian newly diagnosed individuals.

    abstract::Transmission of HIV-1 and drug resistance continue to occur at a considerable level in Italy, influenced mainly by changes in modality of infection. However, the long period of infectivity makes difficult the interpretation of epidemiological networks, based on epidemiological data only. We studied 510 naive HIV-1-inf...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Lai A,Violin M,Ebranati E,Franzetti M,Micheli V,Gismondo MR,Capetti A,Meraviglia P,Simonetti FR,Bozzi G,Ciccozzi M,Galli M,Zehender G,Balotta C

    更新日期:2012-08-01 00:00:00

  • HIV type 1 diversity in northern Paris, France.

    abstract::During a 6-month period, we studied the diversity of HIV-1 subtypes in 392 adult patients seen in Bichat-Claude Bernard Hospital, northern Paris, France. All the samples were serotyped and a subset was genotyped by means of HMA. Serotyping was performed with a new peptide subtype-specific EIA (SSEIA), based on in vitr...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Simon F,Loussert-Ajaka I,Damond F,Saragosti S,Barin F,Brun-Vézinet F

    更新日期:1996-10-10 00:00:00

  • Opportunistic intestinal infections and risk of colorectal cancer among people with AIDS.

    abstract::Because mucosal inflammation contributes to colorectal carcinogenesis, we studied the impact of intestinal infections on risk of this malignancy among people with AIDS (PWA). Using the population-based HIV/AIDS Cancer Match, which includes approximately half of all PWA in the United States, the cancer registries ascer...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章,多中心研究


    authors: Shebl FM,Engels EA,Goedert JJ

    更新日期:2012-09-01 00:00:00

  • Conservancy of the α4β7 integrin mimotope in the V2 domain of HIV type 1 CRF07_BC compared to subtype B' strains in China.

    abstract::HIV-1 is capable of mimicking the ligand of integrin α(4)β(7) by displaying a tripeptide mimotope on the V2 region. Through this mimicry HIV can bind the α(4)β(7) integrin and get carried through the lymphocyte proliferation signaling pathway, cell-to-cell adhesion and can migrate to gut-associated lymphoid tissues. T...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: He X,Mokili JL,Hong K,Chen J,Wei J,Xin R,Song YH,Feng Y,Jia M,Xing H,Shao Y

    更新日期:2011-10-01 00:00:00

  • HIV type 1 subtypes B and C from new regions of India and Indian and Ethiopian expatriates in Kuwait.

    abstract::HIV-1 subtype B isolates have previously been described in India only in the state of Andhra Pradesh, while subtype C isolates have been reported as widespread in the Bombay and Goa regions of India. Gag subtype was determined in HIV-1 isolates from six Indians and one Ethiopian. One Indian was a native of Goa resid...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Voevodin A,Crandall KA,Seth P,al Mufti S

    更新日期:1996-05-01 00:00:00

  • Diversity of HIV type 1 envelope (V3-V5) sequence in HIV type 1-infected Indian children.

    abstract::Abstract We assessed the viral envelope (V3-V5 region) sequence diversity from 13 HIV-1-infected Indian children from north India. All of the 13 children were found to be infected with subtype C viruses. One of the viral sequences exhibited usage of the CXCR4 coreceptor predicted by Web PSSM and Geno2pheno tools. Th...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Prakash SS,Kalra R,Lodha R,Kabra SK,Luthra K

    更新日期:2012-05-01 00:00:00

  • Tax-dependent stimulation of G1 phase-specific cyclin-dependent kinases and increased expression of signal transduction genes characterize HTLV type 1-transformed T cells.

    abstract::Human T cell leukemia virus protein induces T cells to permanent IL-2-dependent growth. These cells occasionally convert to factor independence. The viral oncoprotein Tax acts as an essential growth factor of transformed lymphocytes and stimulates the cell cycle in the G(1) phase. In T cells and fibroblasts Tax enhanc...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Haller K,Ruckes T,Schmitt I,Saul D,Derow E,Grassmann R

    更新日期:2000-11-01 00:00:00

  • Risks for HIV infection among gay, bisexual, and other men who have sex with men in Moscow and St. Petersburg, Russia.

    abstract::The majority of early cases of HIV in Russia were among men who have sex with men (MSM). Despite this and the current resurgence of HIV among MSM globally, little systematic work has been done to assess current HIV risks. We conducted a rapid assessment of HIV and associated risk behaviors among MSM in Russia. An anon...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Baral S,Sifakis F,Peryskina A,Mogilnii V,Masenior NF,Sergeyev B,Deobald I,Wirtz AL,Beyrer C

    更新日期:2012-08-01 00:00:00

  • Cell-mediated infection of human placental trophoblast with HIV in vitro.

    abstract::In order to investigate how human immunodeficiency virus (HIV) gains entry to the placenta, we have performed in vitro experiments in which highly purified trophoblast cells isolated from term human placentas were examined for their susceptibility to HIV infection. Trophoblast cells were exposed to cell-free HIV-1 for...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Douglas GC,Fry GN,Thirkill T,Holmes E,Hakim H,Jennings M,King BF

    更新日期:1991-09-01 00:00:00

  • SDF-1alpha is a potent inducer of HIV-1-Specific CD8+ T-cell chemotaxis, but migration of CD8+ T cells is impaired at high viral loads.

    abstract::Multiple impairments in HIV-1-specific cytotoxic T cells (CTL) have been reported, but derangements in HIV-1-specific CD8+ T-cell chemotaxis have not been described previously. We assessed migration to SDF-1alpha (stromal cell-derived factor 1-alpha) and CX3CL1 in vitro and expression of cognate receptors, CXCR4 and C...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Meditz AL,Schlichtemeier R,Folkvord JM,Givens M,Lesh KC,Ray MG,McCarter MD,Connick E

    更新日期:2008-07-01 00:00:00

  • Simultaneous Evaluation of Safety, Acceptability, Pericoital Kinetics, and Ex Vivo Pharmacodynamics Comparing Four Rectal Microbicide Vehicle Candidates.

    abstract::Preexposure prophylaxis (PrEP) of HIV infection with tenofovir-containing regimens is effective, but plagued by poor adherence in some studies. Options for safe, effective, and acceptable PrEP products, especially for men and women at risk of HIV via receptive anal intercourse (RAI), are needed. We performed a randomi...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章,随机对照试验


    authors: Leyva F,Fuchs EJ,Bakshi R,Carballo-Dieguez A,Ventuneac A,Yue C,Caffo B,Du Y,Torbenson M,Li L,Mullin G,Lee L,Rohan L,Anton PA,Hendrix CW

    更新日期:2015-11-01 00:00:00

  • Immunization with Clinical HIV-1 Env Proteins Induces Broad Antibody Dependent Cellular Cytotoxicity-Mediating Antibodies in a Rabbit Vaccination Model.

    abstract::The induction of both neutralizing antibodies and non-neutralizing antibodies with effector functions, for example, antibody-dependent cellular cytotoxicity (ADCC), is desired in the search for effective vaccines against HIV-1. In the pursuit of novel immunogens capable of inducing an efficient antibody response, rabb...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Karlsson I,Borggren M,Jensen SS,Heyndrickx L,Stewart-Jones G,Scarlatti G,Fomsgaard A

    更新日期:2018-02-01 00:00:00

  • Molecular epidemiology of HIV type 1 subtypes in Taiwan: outbreak of HIV type 1 CRF07_BC infection in intravenous drug users.

    abstract::In Taiwan, sexual transmission is responsible for most HIV-1 infections with two dominant subtypes, subtype B and CRF01_AE, distributing among homosexual and heterosexual groups, respectively. Recently, intravenous drug use has become an emerging route of HIV-1 transmission and contributed to a significant increase of...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Chang SY,Sheng WH,Lee CN,Sun HY,Kao CL,Chang SF,Liu WC,Yang JY,Wong WW,Hung CC,Chang SC

    更新日期:2006-11-01 00:00:00