HIV infection accelerates gastrointestinal tumor outgrowth in NSG-HuPBL mice.


:HIV infection is a risk factor for the tumorigenesis including non-AIDS-defining cancers such as those of the gastrointestinal tract. However, the mechanisms underlying such cancer outgrowth are still unknown. Furthermore, combined HIV/cancer studies are difficult to evaluate using primate models or in the clinical patient setting. To understand the mechanisms of tumor outgrowth in the context of HIV infection, we adopted a humanized mouse model permissive to infection and cancer as well as an in vivo humanized mouse challenge with colon cancer in the context of HIV infection. Immunodeficient NOD SCID IL-2R(-/-) mice were immunologically reconstituted by adoptive transfer of 10(7) HIV-negative donor peripheral blood leukocytes and challenged with 10(6) HCT116 human colon cancer cells. A group of mice was treated with antiretroviral therapy. Tumor microenvironment and epithelial tissues in the context of HIV infection were analyzed using immunohistochemistry. We demonstrate that HIV-infected humanized mice develop significantly larger tumors than uninfected mice (p<0.05). Epithelial cell proliferation in HIV-infected mice is significantly enhanced in comparison to proliferation in uninfected mice (p<0.01). Moreover, the activation of β-catenin, an important step in intestinal epithelial cell proliferation and tumorigenesis, is elevated in the tumors of HIV-infected mice (p<0.0001). Importantly, antiretroviral therapy reverses these pathological processes independently of CD4(+) T cell return. These findings model the ability of HIV infection to result in tumor outgrowth that is evident in HIV-positive patients and lend insight into previously unrecognized mechanisms that may underlie this pathology.


Lu R,Wu S,Zhang Y,Xia Y,Huelsmann EJ,Lacek AT,Nabatiyan A,Richards MH,Narasipura SD,Lutgen V,Chen H,Kaufman HL,Chen D,Al-Harthi L,Zloza A,Sun J




Has Abstract


2014-07-01 00:00:00












  • What HIV in the Brain Can Teach Us About SARS-CoV-2 Neurological Complications?

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    journal_title:AIDS research and human retroviruses

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    authors: Al-Harthi L,Campbell E,Schneider JA,Bennett DA

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    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章,评审


    authors: Fang H,Pincus S

    更新日期:1999-10-10 00:00:00

  • HIV-1 Genetic Diversity and High Prevalence of Pretreatment Drug Resistance in Tianjin, China.

    abstract::Diversity of genotypes and prevalence of pretreatment drug resistance (PDR) are challenges for the epidemic control and vaccine development of HIV-1. However, little is known about the situation in Tianjin. Blood samples were collected from newly diagnosed, antiretroviral treatment (ART)-naive HIV/AIDS patients from J...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Zeng R,Ren D,Gong X,Wei M,Gao L,Yu A,Zhang D,Mi Y,Ma P

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  • Association of cervical biopsy with HIV type 1 genital shedding among women on highly active antiretroviral therapy.

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    journal_title:AIDS research and human retroviruses

    pub_type: 临床试验,杂志文章


    authors: Woo VG,Liegler T,Cohen CR,Sawaya GF,Smith-McCune K,Bukusi EA,Huchko MJ

    更新日期:2013-07-01 00:00:00

  • Molecular characterization of the HIV type 1 subtype C accessory genes vif, vpr, and vpu.

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    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Bell CM,Connell BJ,Capovilla A,Venter WD,Stevens WS,Papathanasopoulos MA

    更新日期:2007-02-01 00:00:00

  • Genetic evidence of multiple transmissions of HIV type 1 subtype F within Romania from adult blood donors to children.

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    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Op De Coul E,van den Burg R,Asjö B,Goudsmit J,Cupsa A,Pascu R,Usein C,Cornelissen M

    更新日期:2000-03-01 00:00:00

  • Identification of a complex env subtype E HIV type 1 virus from the democratic republic of congo, recombinant with A, G, H, J, K, and unknown subtypes.

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    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Vidal N,Mulanga-Kabeya C,Nzilambi N,Delaporte E,Peeters M

    更新日期:2000-12-10 00:00:00

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    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Weissenberger J,Flügel RM

    更新日期:1994-05-01 00:00:00

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    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Balzarini J,De Clercq E

    更新日期:2001-11-20 00:00:00

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    journal_title:AIDS research and human retroviruses

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    authors: Carrow EW,Vujcic LK,Glass WL,Seamon KB,Rastogi SC,Hendry RM,Boulos R,Nzila N,Quinnan GV Jr

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    journal_title:AIDS research and human retroviruses

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    authors: Ruelle J,Ingels MG,Jnaoui K,Ausselet N,Vincent A,Sasse A,Verhofstede C,Goubau P

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    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章,随机对照试验


    authors: Bedimo R,Kang M,Tebas P,Overton ET,Hollabaugh K,McComsey G,Bhattacharya D,Evans C,Brown TT,Taiwo B

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    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Robert-Guroff M,Goedert JJ,Naugle CJ,Jennings AM,Blattner WA,Gallo RC

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    journal_title:AIDS research and human retroviruses

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    authors: Langlois AJ,Weinhold KJ,Matthews TJ,Greenberg ML,Bolognesi DP

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    abstract::HIV antigens were detected by immunoelectron microscopy at the surface of human and simian T4 lymphocytes that had been infected in vitro. HIV antigens were detected at the surface of cells exhibiting viral particles but also at the surface of cells before the release of virions. The latter cells may be considered imm...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Desportes I,Bonnet D,Nicol I,Snart R,Sarin P

    更新日期:1989-02-01 00:00:00

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    journal_title:AIDS research and human retroviruses

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    authors: Li X,Ning C,He X,Yang Y,Xing H,Hong K,Shao Y,Yang R

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    journal_title:AIDS research and human retroviruses

    pub_type: 临床试验,杂志文章


    authors: Landman R,Diallo MB,Gueye NF,Kane CT,Mboup S,Fall MB,Ndiaye B,Peytavin G,Bennai Y,Benalycherif A,Girard PM,Sow PS

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    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Kazanji M,Benoit B,Meddeb M,Meertens L,Marty C,Gessain A,Talarmin A

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  • Diversity of antibody binding to V3 peptides representing consensus sequences of HIV type 1 genotypes A to E: an approach for HIV type 1 serological subtyping.

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    journal_title:AIDS research and human retroviruses

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    authors: Barin F,Lahbabi Y,Buzelay L,Lejeune B,Baillou-Beaufils A,Denis F,Mathiot C,M'Boup S,Vithayasai V,Dietrich U,Goudeau A

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    abstract::HIV-1 disease is associated with many infectious and neoplastic complications. This is particularly true of the genitourinary tract, where high rates of renal disease, neoplasms, voiding and erectile dysfunction, hematuria, opportunistic genitourinary infections, and epididymo-orchitis are found in HIV-1-infected indi...

    journal_title:AIDS research and human retroviruses

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    authors: Coburn M

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    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Rego FF,Alcantara LC,Moura Neto JP,Miranda AC,Pereira Ode S,Gonçalves Mde S,Galvão-Castro B

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    abstract::The efficacy and safety of recombinant human interferon gamma (rIFN-gamma) in the reduction of opportunistic disease in patients with advanced HIV-1 infection are assessed. A 12-month double-blind, placebo-controlled, multicenter, Phase III trial of rIFN-gamma in HIV-positive patients with CD4 < 100 x 10(9)/liter on s...

    journal_title:AIDS research and human retroviruses

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Riddell LA,Pinching AJ,Hill S,Ng TT,Arbe E,Lapham GP,Ash S,Hillman R,Tchamouroff S,Denning DW,Parkin JM

    更新日期:2001-06-10 00:00:00

  • HIV type 1 Tat protein induces apoptosis and death in Jurkat cells.

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    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Purvis SF,Jacobberger JW,Sramkoski RM,Patki AH,Lederman MM

    更新日期:1995-04-01 00:00:00

  • A sensitive reporter cell line for HIV-1 tat activity, HIV-1 inhibitors, and T cell activation effects.

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    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Aguilar-Cordova E,Chinen J,Donehower L,Lewis DE,Belmont JW

    更新日期:1994-03-01 00:00:00

  • The antiviral activity of the CXCR4 antagonist AMD3100 is independent of the cytokine-induced CXCR4/HIV coreceptor expression level.

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    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Princen K,Hatse S,Vermeire K,Bridger GJ,Skerlj RT,De Clercq E,Schols D

    更新日期:2003-12-01 00:00:00

  • IL28B CC genotype is associated with higher all-cause mortality in antiretroviral-treated HIV-infected patients.

    abstract::Il28B single nucleotide polymorphisms were found to influence interferon λ expression, resulting in changes in hepatitis C virus (HCV)-RNA serum levels as well as the HIV-RNA set point prior to combined antiretroviral therapy (cART). To date, there is limited information on the influence of this polymorphism on surviv...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Parczewski M,Bander D,Leszczyszyn-Pynka M,Urbańska A,Socha Ł,Boroń-Kaczmarska A

    更新日期:2012-12-01 00:00:00

  • Regulatory T cells (Treg) and HIV/AIDS: summary of the September 7-8, 2006 workshop.

    abstract::A workshop entitled "Regulatory T cells (T(reg)) and HIV/AIDS" was held in Cincinnati, OH, September 7-8, 2006. This workshop was the first completely dedicated to T(reg) in HIV infection, and gathered investigators working on different aspects of T(reg) biology, and on HIV pathogenesis. We report here the major topic...

    journal_title:AIDS research and human retroviruses



    authors: Chougnet CA,Shearer GM

    更新日期:2007-07-01 00:00:00

  • Safety and immunovirologic outcomes with maraviroc combination regimens in patients with a history of past treatment failures and virologic resistance in Brazil: an open-label, multicenter phase 3b study.

    abstract::Maraviroc is a first-in-class chemokine coreceptor type-5 (CCR5) antagonist with demonstrated immunovirologic activity in treatment-experienced (TE) patients with CCR5 (R5)-tropic HIV-1; however, experience in regimens containing newer antiretroviral agents is limited. The primary objective of this 96-week open-label,...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章,多中心研究


    authors: Furtado J,Madruga JV,Bicudo EL,da Eira M,Lopes MI,Netto EM,Santini-Oliveira M,Leite OH,Machado AA,Tupinambas U,de Andrade Neto JL,Lima MP,Pedro Rde J,Miranda AF,Lewi DS,Santos BR,Portsmouth S,Wajsbrot DB,Cassoli LM

    更新日期:2013-09-01 00:00:00

  • Diversity of HIV type 1 envelope (V3-V5) sequence in HIV type 1-infected Indian children.

    abstract::Abstract We assessed the viral envelope (V3-V5 region) sequence diversity from 13 HIV-1-infected Indian children from north India. All of the 13 children were found to be infected with subtype C viruses. One of the viral sequences exhibited usage of the CXCR4 coreceptor predicted by Web PSSM and Geno2pheno tools. Th...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Prakash SS,Kalra R,Lodha R,Kabra SK,Luthra K

    更新日期:2012-05-01 00:00:00

  • Genetic and Phenotypic Analysis of CRF01_AE HIV-1 env Clones from Patients Residing in Beijing, China.

    abstract::CRF01_AE is one of the four dominant HIV-1 strains circulating in China. In this study, we performed genetic and phenotypic analyses using a total of 60 full-length envelope gene clones from 14 HIV-1-infected individuals in the Beijing area. Among the 60 sequences analyzed, 32 have a complete open reading frame (ORF),...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Chen D,He X,Ye J,Zhao P,Zeng Y,Feng X

    更新日期:2016-10-01 00:00:00