Prediction of virological response to lopinavir/ritonavir using the genotypic inhibitory quotient.

abstract：:The recombinant virus assay (RVA) is a method for assessing the susceptibility of human immunodeficiency virus type 1 (HIV-1) plasma isolates to antiretroviral drugs. The RVA involves the production of viable virus in vitro by homologous recombination of RT-PCR products from plasma virus with a noninfectious reverse t...

journal_title：AIDS research and human retroviruses

authors： Robinson LH,Myers RE,Snowden BW,Tisdale M,Blair ED

更新日期：2000-08-10 00:00:00

abstract：:T epitope mapping in human immunodeficiency virus proteins provides a useful tool for AIDS vaccine design. We have previously shown that four peptides selected from the Gag polyprotein of HIV-1 were able to prime mice for in vitro lymphoproliferative responses. These responses were shown to be MHC restricted, and a po...

journal_title：AIDS research and human retroviruses

authors： Vaslin B,Claverie JM,Benveniste O,Barre-Sinoussi FC,Dormont D

更新日期：1994-10-01 00:00:00

abstract：:Data indicate the presence in the Seychelles Islands of a high level of human T cell leukemia/lymphoma virus type I (HTLV-I) endemicity as well as the presence of tropical spastic paraparesis/HTLV-I-associated myelopathy (TSP/HAM). We present here the results of an hospital survey performed since 1988 in La Réunion Is...

journal_title：AIDS research and human retroviruses

authors： Mahieux R,Gessain A,Truffert A,Vitrac D,Hubert A,Dandelot J,Montchamp-Moreau C,Cnudde F,Tekaia F,De Thé G

更新日期：1994-06-01 00:00:00

abstract：:Zidovudine (ZDV) is converted to its active triphosphate (ZDVTP) by intracellular kinases. The intermediate ZDV monophosphate (ZDVMP) is believed to play a major role in ZDV toxicity. Manipulation of ZDV phosphorylation is a possible therapeutic strategy for altering the risk-benefit ratio. Here we investigate whether...

journal_title：AIDS research and human retroviruses

authors： Sim SM,Hoggard PG,Sales SD,Phiboonbanakit D,Hart CA,Back DJ

更新日期：1998-12-20 00:00:00

abstract：:Understanding factors that affect heterosexual transmission of HIV in women is of great importance. Lactobacilli in the lower genital tract of women utilize glycogen in vaginal epithelial cells as an energy source and produce lactic acid. The resultant vaginal acidity is believed to provide protection against HIV infe...

journal_title：AIDS research and human retroviruses

authors： Mirmonsef P,Gilbert D,Veazey RS,Wang J,Kendrick SR,Spear GT

更新日期：2012-01-01 00:00:00

abstract：:We evaluated associations of serum 25-hydroxyvitamin D (25[OH]D) and 1,25-dihydroxyvitamin D (1,25[OH]2D) levels in a cohort of HIV-infected and HIV-uninfected men at risk for infection in the United States. Stored samples collected between 1999 and 2008 were tested for vitamin D metabolites between 2014 and 2015. Vit...

journal_title：AIDS research and human retroviruses

authors： Zhang L,Tin A,Brown TT,Margolick JB,Witt MD,Palella FJ Jr,Kingsley LA,Hoofnagle AN,Jacobson LP,Abraham AG

更新日期：2017-03-01 00:00:00

abstract：:Nucleoside analog-associated sensory neuropathy (NRTI-SN) attributed to stavudine, didanosine, or zalcitabine (the dNRTIs) and distal sensory polyneuropathy (DSP) attributed to HIV are clinically indistinguishable. As inflammatory cytokines are involved in DSP, we addressed a role for inflammation in NRTI-SN by determ...

journal_title：AIDS research and human retroviruses

authors： Cherry CL,Rosenow A,Affandi JS,McArthur JC,Wesselingh SL,Price P

更新日期：2008-02-01 00:00:00

abstract：:Extensive studies have been carried out on native Amerindian populations living in French Guiana in an attempt to detect human T cell leukemia virus type 2 (HTLV-2). However, the first strain of this virus identified in this region was not detected in these populations, but in a Brazilian woman of Amerindian origin. C...

journal_title：AIDS research and human retroviruses

authors： Kazanji M,Benoit B,Meddeb M,Meertens L,Marty C,Gessain A,Talarmin A

更新日期：2001-04-10 00:00:00

abstract：:Using blood samples from primary HIV-1 infection (PHI) patients obtained in Lyon, France, we characterized the newly transmitted HIV-1 variants in this area during the 1992-1996 period. As PHI samples allowed the precise timing of the transmission event, we were able to date the introduction of non-B subtypes or recom...

journal_title：AIDS research and human retroviruses

authors： Vachot L,Ataman-Onal Y,Terrat C,Durand PY,Ponceau B,Biron F,Verrier B

更新日期：2004-07-01 00:00:00

abstract：:Identifying and monitoring HIV clusters could be useful in tracking the leading edge of HIV transmission in epidemics. Currently, greater specificity in the definition of HIV clusters is needed to reduce confusion in the interpretation of HIV clustering results. We address sampling density as one of the key aspects of...

journal_title：AIDS research and human retroviruses

authors： Novitsky V,Moyo S,Lei Q,DeGruttola V,Essex M

更新日期：2014-12-01 00:00:00

abstract：:The antiretroviral (ARV) service at Edendale Hospital in Pietermaritzburg, KwaZulu-Natal, South Africa has initiated more than 9,000 adults on therapy since 2004; however, virological outcomes among this patient cohort have not been systematically assessed. We conducted a retrospective chart review of patients initiat...

journal_title：AIDS research and human retroviruses

authors： Costiniuk CT,Sigal A,Jenabian MA,Nijs P,Wilson D

更新日期：2014-06-01 00:00:00

abstract：:HIV-1 RNA dimerization involves at least two key regions, one located upstream from the splice donor (SD) site, and the other located downstream from the SD site. To determine the precise location and the mechanism of action of the downstream region, we constructed a model system using a synthetic HIV-1 RNA fragment (...

journal_title：AIDS research and human retroviruses

authors： Zhang S,Hara H,Kaji H,Kaji A

更新日期：1997-07-01 00:00:00

abstract：:To investigate the HIV-1 molecular epidemiology among young people (18 to 25 years old) in Hangzhou. Plasma samples from 262 newly diagnosed HIV-1-infected patients were collected between 2009 and 2013 from Hangzhou of Zhejiang province. HIV-1 nucleotide sequences of pol gene regions were amplified using a nested poly...

journal_title：AIDS research and human retroviruses

authors： Zhang W,Chen J,Pan X,Zhang J,Guo Z,Luo Y,Yang J,Xia Y,He L,Xu Y,Xu K,Ding X

更新日期：2017-03-01 00:00:00

abstract：:In a polygamous marriage in Senegal, the husband and his two spouses were infected with HIV-1 group O. This study provides new full-length genome sequences for the two spouses (99SE-MP1299 and 99SE-MP1300) and the 3'-end LTR-tat fragment (6084 bp) for the husband (98SE-42HALD). Phylogenetic tree and diversity plot ana...

journal_title：AIDS research and human retroviruses

authors： Kane CT,Montavon C,Toure MA,Faye MA,Ndiaye AG,Diallo AG,Ndoye I,Liegeois F,Delaporte E,Mboup S,Peeters M

更新日期：2001-08-10 00:00:00

abstract：:A high incidence of decreased bone mineral density (BMD) has increasingly been associated with HIV infection. In this study mesenchymal stem cell (MSC) and human osteoblast (hOB) cell lines were treated with HIV tat, HIV rev, HIV p55-gag, HIV gp120 and HTLV env (100 ng/ml, 24 h). Cells were then analyzed for calcium d...

journal_title：AIDS research and human retroviruses

authors： Cotter EJ,Malizia AP,Chew N,Powderly WG,Doran PP

更新日期：2007-12-01 00:00:00

abstract：:The production and characterization of a cell line for quantitative HIV-1 Tat function and T cell activation assays is described. 1G5 is a clonal cell line derived from Jurkat T cells stably transfected with a luciferase gene driven by an HIV-1 long terminal repeat (HIV-LTR). The 1G5 clone was selected for low basal l...

journal_title：AIDS research and human retroviruses

authors： Aguilar-Cordova E,Chinen J,Donehower L,Lewis DE,Belmont JW

更新日期：1994-03-01 00:00:00

abstract：:An increasing number of circulating recombinant forms (CRFs) and unique recombinant forms (URFs) all over the world has necessitated being vigilant about new recombinants. Since the first report of a recombinant virus with an A1/C mosaic in 1998 more and more B/C and A/C recombinant viruses are being reported from Ind...

journal_title：AIDS research and human retroviruses

authors： Pandey S,Tripathy S,Paranjape R

更新日期：2013-09-01 00:00:00

abstract：:Diversity of genotypes and prevalence of pretreatment drug resistance (PDR) are challenges for the epidemic control and vaccine development of HIV-1. However, little is known about the situation in Tianjin. Blood samples were collected from newly diagnosed, antiretroviral treatment (ART)-naive HIV/AIDS patients from J...

journal_title：AIDS research and human retroviruses

authors： Zeng R,Ren D,Gong X,Wei M,Gao L,Yu A,Zhang D,Mi Y,Ma P

更新日期：2020-10-01 00:00:00

abstract：:Monoclonal antibodies (mAbs) specific for CD4 are potent inhibitors of HIV replication in vitro. These agents may be useful prophylactically or in chronic HIV infection if they can be administered without inducing immunosuppression. In the present study, we explored the safety of a CD4-specific murine mAb in rhesus mo...

journal_title：AIDS research and human retroviruses

authors： Reimann KA,Burkly LC,Burrus B,Waite BC,Lord CI,Letvin NL

更新日期：1993-03-01 00:00:00

abstract：:The efficacy and safety of recombinant human interferon gamma (rIFN-gamma) in the reduction of opportunistic disease in patients with advanced HIV-1 infection are assessed. A 12-month double-blind, placebo-controlled, multicenter, Phase III trial of rIFN-gamma in HIV-positive patients with CD4 < 100 x 10(9)/liter on s...

journal_title：AIDS research and human retroviruses

authors： Riddell LA,Pinching AJ,Hill S,Ng TT,Arbe E,Lapham GP,Ash S,Hillman R,Tchamouroff S,Denning DW,Parkin JM

更新日期：2001-06-10 00:00:00

abstract：:Evidence derived from studies concerning brain metabolism and brain electrical activity suggests that temporal lobe functioning is impaired in the course of HIV infection. To test the hypothesis of temporal lobe dysfunction in HIV infection, we utilized computerized electroencephalogram (EEG) analysis to evaluate temp...

journal_title：AIDS research and human retroviruses

authors： Grassi B,Locatelli M,Lazzarin A,Scarone S

更新日期：1996-04-10 00:00:00

abstract：:Antibodies to the carboxy-terminal constant (C5) region 5 of the HIV-1 envelope glycoprotein gp120 have previously been associated with slow disease progression. This is one of the regions on gp120 that interact with the transmembrane glycoprotein, gp41, anchoring it to the viral and infected cell membrane. This study...

journal_title：AIDS research and human retroviruses

authors： Sørensen B,Sommerfelt MA,Stjernholm G,Smith PL,Ökvist M,Hovden AO,Hoddevik G,Redfield R,Ustina V,Jelmert Ø,Zeldis J,Dalgleish A

更新日期：2017-06-01 00:00:00

abstract：:A murine monoclonal antibody (MoAb), VAK 4, has been known to specifically react with a major core protein (p24) as well as with its precursor (p55-57) and intermediate precursor (p40) of human immunodeficiency virus strain IIIB (HTLV-IIIB). Radioimmunoprecipitation assays revealed that VAK 4 MoAb precipitated a major...

journal_title：AIDS research and human retroviruses

authors： Koito A,Hattori T,Matsushita S,Maeda Y,Nozaki C,Sagawa K,Takatsuki K

更新日期：1988-12-01 00:00:00

abstract：:Il28B single nucleotide polymorphisms were found to influence interferon λ expression, resulting in changes in hepatitis C virus (HCV)-RNA serum levels as well as the HIV-RNA set point prior to combined antiretroviral therapy (cART). To date, there is limited information on the influence of this polymorphism on surviv...

journal_title：AIDS research and human retroviruses

authors： Parczewski M,Bander D,Leszczyszyn-Pynka M,Urbańska A,Socha Ł,Boroń-Kaczmarska A

更新日期：2012-12-01 00:00:00

abstract：:Cytotoxic T cell determinants should be an important component of an anti-human immunodeficiency virus (HIV) vaccine. The epitopes of proteins can be defined with short synthetic peptides for class I-restricted CTLs. An immunodominant CTL epitope from the HIV-1 IIIB envelope protein gp160 comprising 15 amino acids (re...

journal_title：AIDS research and human retroviruses

authors： Achour A,Lemhammedi S,Picard O,M'Bika JP,Zagury JF,Moukrim Z,Willer A,Beix F,Burny A,Zagury D

更新日期：1994-01-01 00:00:00

abstract：:We have determined that polymeric IgA in saliva of HIV-1-uninfected individuals binds in varying degrees to components of culture supernatants containing HIV-1 recombinant proteins when ELISA is used for the determination. This finding did not extend to salivary IgG antibodies. Further, such problems were not encounte...

journal_title：AIDS research and human retroviruses

authors： Jackson S,Prince S,Kulhavy R,Mestecky J

更新日期：2000-04-10 00:00:00

abstract：:Eight HIV-2-infected Caucasian men living in the same geographical area in Gipuzkoa (northern Spain) have been identified in the last 5 years. HIV-2 infection in this area is uncommon, and no other cases of HIV-2 infection have been found after extensive testing for HIV-1/2 antibodies. Epidemiological data suggested a...

journal_title：AIDS research and human retroviruses

authors： Cilla G,Rodés B,Pérez-Trallero E,Arrizabalaga J,Soriano V

更新日期：2001-03-20 00:00:00

abstract：:It is known that the HTLV-I-transformed cell line MT4 releases chemotactic activity for monocytes spontaneously. The MT4 monocyte chemoattractant was purified to homogeneity and sequencing of 25 amino acids revealed identity with the C-C chemokine macrophage inflammatory protein-1 alpha (MIP-1 alpha/LD78). An anti-MIP...

journal_title：AIDS research and human retroviruses

authors： Bertini R,Luini W,Sozzani S,Bottazzi B,Ruggiero P,Boraschi D,Saggioro D,Chieco-Bianchi L,Proost P,van Damme J

更新日期：1995-01-01 00:00:00

abstract：:Phylogenetic analysis of partial env sequences of HIV-1 isolates from Cyprus and Greece suggested the existence of a distinct subtype of the virus, designated as I. We examined whether this subtype represents a distinct group, or a mosaic consisting of previously characterized subtypes. The full-length sequences under...

journal_title：AIDS research and human retroviruses

authors： Nasioulas G,Paraskevis D,Magiorkinis E,Theodoridou M,Hatzakis A

更新日期：1999-05-20 00:00:00

abstract：:Gag-specific immune responses and changes in HIV-1 RNA levels were evaluated in eight HIV-1-infected persons, in order to assess the immunotherapeutic potential HIV-1 p17/p24: Ty virus-like particles (p24-VLP). All treated subjects showed transient and dose-dependent proliferative responses to the Ty-VLP carrier (stim...

journal_title：AIDS research and human retroviruses

authors： Klein MR,Veenstra J,Holwerda AM,Roos MT,Gow I,Patou G,Coutinho RA,De Wolf F,Miedema F

更新日期：1997-03-20 00:00:00