Effect of ribavirin on zidovudine efficacy and toxicity in vitro: a concentration-dependent interaction.

abstract：:It has been proposed that HIV-1-neutralizing 2F5 and 4E10 monoclonal antibodies recognize gp41 ectodomain pretransmembrane sequences in the context of the membrane interface. With the aim of evaluating lipid-bilayer surface effects on recognition, we use phospholipid model systems to investigate the ability of 2F5 and...

journal_title：AIDS research and human retroviruses

authors： Sánchez-Martínez S,Lorizate M,Katinger H,Kunert R,Nieva JL

更新日期：2006-10-01 00:00:00

abstract：:We tested human immunodeficiency virus type 1 (HIV-1) antibody-positive human sera and sCD4, alone and in combination, for synergistic, additive, or antagonistic effects on blocking of HIV binding and infectivity. Data were analyzed by an application of the median effect principle derived from the law of mass action. ...

journal_title：AIDS research and human retroviruses

authors： Kennedy MS,Orloff S,Ibegbu CC,Odell CD,Maddon PJ,McDougal JS

更新日期：1991-12-01 00:00:00

abstract：:Recombinant forms of HIV-1 contribute significantly to the ongoing epidemic. In the present study, we characterized the near full-length genome of one candidate HIV-1 CRF25_cpx strain originating in Cameroon, 06CM-BA-040. Viral RNA was extracted from plasma, and the genome was obtained using RT-PCR amplification to ge...

journal_title：AIDS research and human retroviruses

authors： Luk KC,Holzmayer V,Ndembi N,Swanson P,Brennan CA,Ngansop C,Mbanya D,Kaptué L,Gürtler L,Devare SG,Hackett J

更新日期：2008-10-01 00:00:00

abstract：:The presence of clinical manifestations of HIV-1 infection is one measure of immune function failure. We examined the occurrence of clinical manifestations of HIV-1 infection, in particular fever and oral thrush, before and after the initiation of highly active antiretroviral therapy (HAART). Using data collected from...

journal_title：AIDS research and human retroviruses

authors： Skolasky RL,Phair J,Detels R,Riddler S,Margolick J,Jacobson LP

更新日期：2001-09-20 00:00:00

abstract：:Epidemiological studies strongly suggest that a newly discovered herpesvirus, Kaposi's sarcoma associated-herpesvirus (KSHV/HHV8), is the likely infectious cause of Kaposi's sarcoma (KS). Identification of this agent suggests the possibility that existing anti-herpesvirus chemotherapeutics have activity against KSHV. ...

journal_title：AIDS research and human retroviruses

authors： Flore O,Gao SJ

更新日期：1997-09-20 00:00:00

abstract：:Data indicate the presence in the Seychelles Islands of a high level of human T cell leukemia/lymphoma virus type I (HTLV-I) endemicity as well as the presence of tropical spastic paraparesis/HTLV-I-associated myelopathy (TSP/HAM). We present here the results of an hospital survey performed since 1988 in La Réunion Is...

journal_title：AIDS research and human retroviruses

authors： Mahieux R,Gessain A,Truffert A,Vitrac D,Hubert A,Dandelot J,Montchamp-Moreau C,Cnudde F,Tekaia F,De Thé G

更新日期：1994-06-01 00:00:00

abstract：:CRF01_AE and subtype B have dominated the HIV-1 epidemic in Thailand since 1989. We reported a new circulating recombinant form of HIV-1, CRF15_01B, as well as other unique CRF01_AE/B recombinants among prevalent HIV infections in Thailand. We sought to study this challenging molecular picture through assessment of su...

journal_title：AIDS research and human retroviruses

authors： Tovanabutra S,Beyrer C,Sakkhachornphop S,Razak MH,Ramos GL,Vongchak T,Rungruengthanakit K,Saokhieo P,Tejafong K,Kim B,De Souza M,Robb ML,Birx DL,Jittiwutikarn J,Suriyanon V,Celentano DD,McCutchan FE

更新日期：2004-05-01 00:00:00

abstract：:Both saponin and muramyl dipeptide (MDP) formulated with a squalane-in-water emulsion of large particle size prepared with a vortex mixer were superior to Al(OH)3 as adjuvants for HIV gp120 in mice. All the adjuvants induced IgG1 antibody, but saponin elicited the highest titers of IgG2a. The secretion of interleukin-...

journal_title：AIDS research and human retroviruses

authors： Bomford R,Stapleton M,Winsor S,McKnight A,Andronova T

更新日期：1992-10-01 00:00:00

abstract：:We aimed to determine the prevalence of a prolonged QTc interval in HIV-infected patients and its related factors through an observational study of a cohort of asymptomatic HIV-infected outpatients. All patients underwent a standard 12-lead electrocardiogram and a transthoracic echocardiogram. Prolonged QTc was consid...

journal_title：AIDS research and human retroviruses

authors： Moreno T,Pérez I,Isasti G,Cabrera F,Santos J,Palacios R

更新日期：2013-09-01 00:00:00

abstract：:The gag-homologous region of the human endogenous retrovirus K10 (HERV-K10) was amplified by PCR from human genomic DNA and was analyzed by DNA cloning, sequencing, and expression of open reading frames in the prokaryotic pATH expression system. The analysis of genomic DNA of three donors provided evidence that HERV-K...

journal_title：AIDS research and human retroviruses

authors： Mueller-Lantzsch N,Sauter M,Weiskircher A,Kramer K,Best B,Buck M,Grässer F

更新日期：1993-04-01 00:00:00

abstract：:Japan is one of the highest endemic areas of the world for human T cell leukemia-lymphoma virus type I (HTLV-I). To gain new insight as to the origin of this virus in Japan and especially in the southern islands of the archipelago, we investigated the long terminal repeat (LTR) of 67 newly isolated HTLV-I proviral DNA...

journal_title：AIDS research and human retroviruses

authors： Vidal AU,Gessain A,Yoshida M,Mahieux R,Nishioka K,Tekaia F,Rosen L,De Thé G

更新日期：1994-11-01 00:00:00

abstract：:We report one or more HIV resistance mutations in 81.81% of the 33 antiretroviral treatment-experienced study participants with evidence of virologic failure, with M184V being the most commonly observed resistance mutation (69.7%). Two out of four participants with protease inhibitors (PI) experience harbored multiple...

journal_title：AIDS research and human retroviruses

authors： Sen S,Tripathy SP,Patil AA,Chimanpure VM,Paranjape RS

更新日期：2007-10-01 00:00:00

abstract：:In this study, the relationship between biological phenotypes, coreceptor usages, and sequence patterns of V1V2 or V3 regions on HIV-1 envelope gp 120 was carefully analyzed based on the existing isolates in the Los Alamos National Laboratory sequence database. Obviously, SI/NSI phenotypes were closely linked to the c...

journal_title：AIDS research and human retroviruses

authors： Dong XN,Chen X,Chen Y,Ablimit A,Ye Z,Wu Y,Chen YH

更新日期：2005-03-01 00:00:00

abstract：:HIV-1 viremia has been shown to induce several phenotypic and functional abnormalities in natural killer (NK) cells. To assess immune defects associated with HIV viremia, we examined NK cell function, differentiation status, and phenotypic alterations based on expression of inhibitory and activating receptors on NK ce...

journal_title：AIDS research and human retroviruses

authors： Zulu MZ,Naidoo KK,Mncube Z,Jaggernath M,Goulder PJR,Ndung'u T,Altfeld M,Thobakgale CF

更新日期：2017-12-01 00:00:00

abstract：:A murine monoclonal antibody (MoAb), VAK 4, has been known to specifically react with a major core protein (p24) as well as with its precursor (p55-57) and intermediate precursor (p40) of human immunodeficiency virus strain IIIB (HTLV-IIIB). Radioimmunoprecipitation assays revealed that VAK 4 MoAb precipitated a major...

journal_title：AIDS research and human retroviruses

authors： Koito A,Hattori T,Matsushita S,Maeda Y,Nozaki C,Sagawa K,Takatsuki K

更新日期：1988-12-01 00:00:00

abstract：:Evidence derived from studies concerning brain metabolism and brain electrical activity suggests that temporal lobe functioning is impaired in the course of HIV infection. To test the hypothesis of temporal lobe dysfunction in HIV infection, we utilized computerized electroencephalogram (EEG) analysis to evaluate temp...

journal_title：AIDS research and human retroviruses

authors： Grassi B,Locatelli M,Lazzarin A,Scarone S

更新日期：1996-04-10 00:00:00

abstract：:Recombination contributes substantially to the genetic diversity of HIV-1, and mosaic strains arise frequently, especially in populations in which multiple subtypes circulate. Yunnan, which borders the "Golden triangle" region of Southeast Asia in the south, was considered as the epicenter of China. B, CRF01_AE, CRF07...

journal_title：AIDS research and human retroviruses

authors： Li L,Chen L,Yang S,Liu Y,Li H,Bao Z,Wang Z,Zhuang D,Liu S,Li J

更新日期：2010-06-01 00:00:00

abstract：:Cessation of highly active antiretroviral therapy (HAART) in HIV-infected individual leads to a rebound of viral replication due to reactivation of a viral reservoir composed largely of latently infected memory CD4(+) T cells. Efforts to deplete this reservoir have focused on reactivation of transcriptionally silent l...

journal_title：AIDS research and human retroviruses

authors： Jamaluddin MS,Hu PW,Jan Y,Siwak EB,Rice AP

更新日期：2016-02-01 00:00:00

abstract：:HIV-1 outbreaks in Guangxi Province, southern China were initiated from two separate border cities in 1996 and 1997. Drug users in Pingxiang City, which borders Vietnam, were infected with CRF01_AE HIV-1, and drug users in Baise City, which borders Yunan Province, were infected with a novel B/C recombinant HIV-1. Sinc...

journal_title：AIDS research and human retroviruses

authors： Yu XF,Liu W,Chen J,Kong W,Liu B,Zhu Q,Liang F,McCutchan F,Piyasirisilp S,Lai S

更新日期：2002-01-20 00:00:00

abstract：:Data reporting sexually transmitted infection (STI) incidence rates among HIV-negative U.S. men who have sex with men (MSM) are lacking. In addition, it is difficult to analyze the effect of STI on HIV acquisition given that sexual risk behaviors confound the relationship between bacterial STIs and incident HIV. The I...

journal_title：AIDS research and human retroviruses

authors： Kelley CF,Vaughan AS,Luisi N,Sanchez TH,Salazar LF,Frew PM,Cooper HL,Diclemente R,del Rio C,Sullivan PS,Rosenberg ES

更新日期：2015-06-01 00:00:00

abstract：:Lectins with specificity for terminal mannose residues and anti-mannan antibodies neutralize HIV-1 infection in vitro. This is assumed to be caused by binding of the agents to the viral glycoproteins. In this study we show that one such agent, the Galanthus nivalis lectin (GNA), also blocks infection at the target cel...

journal_title：AIDS research and human retroviruses

authors： Hammar L,Hirsch I,Machado AA,De Mareuil J,Baillon JG,Bolmont C,Chermann JC

更新日期：1995-01-01 00:00:00

abstract：:DNA vaccines have the potential of giving rise to a potent cell-mediated immune response by inducing intracellular synthesis and subsequent antigenic presentation of encoded antigens. We have tested a DNA vaccine specific for human immunodeficiency virus type 1 (HIV-1) by the injection of animals with expression plasm...

journal_title：AIDS research and human retroviruses

authors： Okuda K,Bukawa H,Hamajima K,Kawamoto S,Sekigawa K,Yamada Y,Tanaka S,Ishi N,Aoki I,Nakamura M

更新日期：1995-08-01 00:00:00

abstract：:Given the rising HIV incidence in men who have sex with men (MSM) despite repeatedly proven effectiveness of oral HIV pre-exposure prophylaxis, behaviorally congruent periodic dosing strategies, such as dosing microbicides as lubricants, are now in demand. Rectal microbicide gel studies largely administer gels using v...

journal_title：AIDS research and human retroviruses

authors： Shieh EC,Weld ED,Fuchs EJ,Hiruy H,Buckheit KW,Buckheit RW Jr,Breakey J,Hendrix CW

更新日期：2017-08-01 00:00:00

abstract：:Acquisition of cellular proteins by HIV-1 virions is known to alter the physiology of the virus in vitro. Reported studies of this aspect have been largely limited to transformed T cell lines. In this study, we investigated the incorporation of major histocompatibility antigens (HLAs) on a primary macrophage-tropic is...

journal_title：AIDS research and human retroviruses

authors： Tsai WP,Kung HF,Nara PL

更新日期：1999-01-01 00:00:00

abstract：:In Taiwan, sexual transmission is responsible for most HIV-1 infections with two dominant subtypes, subtype B and CRF01_AE, distributing among homosexual and heterosexual groups, respectively. Recently, intravenous drug use has become an emerging route of HIV-1 transmission and contributed to a significant increase of...

journal_title：AIDS research and human retroviruses

authors： Chang SY,Sheng WH,Lee CN,Sun HY,Kao CL,Chang SF,Liu WC,Yang JY,Wong WW,Hung CC,Chang SC

更新日期：2006-11-01 00:00:00

abstract：:The derivation of ethyl-methanesulfonate (EMS) mutagenized subclones from the CEM T-cell line has been described. These clones expressed CD4 and bound soluble gp120, however, two of the generated clones were markedly reduced in their ability to form syncytia after infection with either gp160-vaccinia vector or cell-fr...

journal_title：AIDS research and human retroviruses

authors： Gruber MF,Hewlett IK,Simms T,Vujcic L,Manischewitz J,Golding H

更新日期：1992-06-01 00:00:00

abstract：:Thirty years after its beginning, the HIV/AIDS epidemic is still raging around the world. According to UNAIDS, in 2011 alone 1.7M deaths were attributable to AIDS, and 2.5M people were newly infected by the virus. Despite the success in treating HIV-infected people with potent antiretroviral drugs, preventing HIV infe...

journal_title：AIDS research and human retroviruses

authors： Romano J,Kashuba A,Becker S,Cummins J,Turpin J,Veronese F,Antiretroviral Pharmacology In HIV Prevention Think Tank Participants.

更新日期：2013-11-01 00:00:00

abstract：:An EBV-transformed lymphoblastoid B cell clone (A12) derived from peripheral blood lymphocytes of an HIV-1-infected individual is described. The immunoglobulin isotype produced by this clone was IgM, and Southern blot analysis of immunoglobulin gene rearrangement showed a monoclonal pattern. The A12 monoclonal antibod...

journal_title：AIDS research and human retroviruses

authors： Amadori A,Ciminale V,Calabro ML,Tessarollo L,Francavilla E,Chieco-Bianchi L

更新日期：1989-02-01 00:00:00

abstract：:HIV-1 enters immune cells via binding the viral envelope to a host cell CD4 receptor, and then a secondary co-receptor, usually CCR5 (R5) or CXCR4 (X4), and some HIV can utilize both co-receptors (R5X4). Although a small set of amino-acid properties such as charge and sequence length applied to HIV-1 envelope V3 loop ...

journal_title：AIDS research and human retroviruses

authors： Lamers SL,Fogel GB,Liu ES,Salemi M,McGrath MS

更新日期：2016-08-01 00:00:00

abstract：:To understand the evolution of HIV-1, the genetic and biological characteristics of viruses that infect persons living in regions in which the virus has been evolving for several decades must be studied. Thus, we investigated teh genetic subtypes, coreceptor usage, and syncytium-inducing ability of viruses in 47 HIV-1...

journal_title：AIDS research and human retroviruses

authors： Zhong P,BUrda S,Konings F,Urbanski M,Ma L,Zekeng L,Ewane L,Agyingi L,Agwara M,Saa,Afane ZE,Kinge T,Zolla-Pazner S,Nyambi P

更新日期：2003-12-01 00:00:00