Near full-length genome characterization of an HIV type 1 CRF25_cpx strain from Cameroon.

abstract：:We performed a placebo-controlled study to evaluate the effects of immunomodulatory treatment with thalidomide on HIV levels, TNF-alpha levels, and immune status of 31 HIV-infected individuals, after temporary suppression of viral replication with antiretroviral drugs. Treatment with a combination of zidovudine and la...

journal_title：AIDS research and human retroviruses

authors： Haslett PA,Klausner JD,Makonkawkeyoon S,Moreira A,Metatratip P,Boyle B,Kunachiwa W,Maneekarn N,Vongchan P,Corral LG,Elbeik T,Shen Z,Kaplan G

更新日期：1999-09-01 00:00:00

abstract：:Studies of HIV molecular evolution and pathogenesis have relied on the polymerase chain reaction (PCR) to provide sequence information from infected tissues. Until recently, studies have been constrained by the limited length of fragments that can be reliably amplified. The addition of a thermostable 3'-exonuclease ac...

journal_title：AIDS research and human retroviruses

authors： Yang YL,Wang G,Dorman K,Kaplan AH

更新日期：1996-03-01 00:00:00

abstract：:DC-SIGN, a C-type lection expressed on dendritic cells, enhances HIV-1 infection in cis and in trans. HIV-1 circulating recombinant form (CRF) 07_BC viruses have been the predominant strain found among injection drug users in southern China and Taiwan. The goal of this study was to map the DC-SIGN-interactive domain o...

journal_title：AIDS research and human retroviruses

authors： Liao CF,Wang SF,Lin YT,Ho DD,Chen YM

更新日期：2011-08-01 00:00:00

abstract：:The national incidence of epidemic Kaposi sarcoma (KS) has decreased dramatically since the availability of combined antiretroviral therapy. Despite national trends, we continue to see admissions for KS. Electronic medical records were queried to identify patients with HIV who were admitted with active KS between 2010...

journal_title：AIDS research and human retroviruses

authors： Kasturia SE,Gunthel C,Zeng C,Nguyen ML

更新日期：2017-06-01 00:00:00

abstract：:HIV patients beginning antiretroviral therapy (ART) with advanced immunodeficiency often retain low CD4+ T cell counts despite virological control. We examined proliferative responses and upregulation of costimulatory molecules, following anti-CD3 stimulation, in HIV patients with persistent CD4+ T cell deficiency on ...

journal_title：AIDS research and human retroviruses

authors： Tanaskovic S,Price P,French MA,Fernandez S

更新日期：2017-02-01 00:00:00

abstract：:In order to investigate how human immunodeficiency virus (HIV) gains entry to the placenta, we have performed in vitro experiments in which highly purified trophoblast cells isolated from term human placentas were examined for their susceptibility to HIV infection. Trophoblast cells were exposed to cell-free HIV-1 for...

journal_title：AIDS research and human retroviruses

authors： Douglas GC,Fry GN,Thirkill T,Holmes E,Hakim H,Jennings M,King BF

更新日期：1991-09-01 00:00:00

abstract：:A new HIV-1 circulating recombinant form (CRF), CRF33_01B, has been identified in Malaysia. Concurrently we found a unique recombinant form (URF), that is, the HIV-1 isolate 06MYKLD46, in Kuala Lumpur, Malaysia. It is composed of B or a Thai variant of the B subtype (B') and CRF01_AE. Here, we determined the near full...

journal_title：AIDS research and human retroviruses

authors： Lau KA,Wang B,Kamarulzaman A,Ng KP,Saksena NK

更新日期：2007-09-01 00:00:00

abstract：:The measurement of antiretroviral concentrations in hair is emerging as an important technology to objectively quantify adherence to combination antiretroviral therapy. Hair levels of antiretrovirals are the strongest independent predictor of virologic success in large prospective cohorts of HIV-infected patients and ...

journal_title：AIDS research and human retroviruses

authors： Gandhi M,Yang Q,Bacchetti P,Huang Y

更新日期：2014-01-01 00:00:00

abstract：:Women attending the Queen Elizabeth Central Hospital in Blantyre, Malawi, between November 1989 and October 1993 were studied as part of a longitudinal cohort study of mother-to-infant HIV transmission. 694 HIV-seropositive and 687 HIV-seronegative women were enrolled at delivery. In the follow-up phase, women attende...

journal_title：AIDS research and human retroviruses

authors： Miotti P,Canner J,Chiphangwi J,Liomba G,Saah A,Dallabetta G

更新日期：1994-01-01 00:00:00

abstract：:Raltegravir, a novel HIV-1 integrase inhibitor, has superior efficacy with optimized background treatment (OBT) vs. placebo + OBT in treatment-experienced HIV-1 patients. This study assessed the long-term cost effectiveness of raltegravir from a Spanish National Healthcare System perspective. A cohort-state-transition...

journal_title：AIDS research and human retroviruses

authors： Chaudhary MA,Moreno S,Kumar RN,Nocea G,Elbasha E

更新日期：2009-07-01 00:00:00

abstract：:Anti-HIV-1-specific T cell responses in early HIV-1 infection have been found to be important in deciding the course of disease progression. But there are few data concerning nonsubtype B HIV infection. HIV-1 subtype C is the most prevalent subtype in India. HIV-1 Gag-specific T cell responses in 12 Indian subjects wi...

journal_title：AIDS research and human retroviruses

authors： Thakar MR,Patke D,Lakhashe SK,Bhonge L,Kulkarni SV,Tripathy SP,Gupte N,Brookmeyer R,Quinn TC,Paranjape RS,Bollinger RC

更新日期：2002-12-10 00:00:00

abstract：:Phylogenetic analysis of partial env sequences of HIV-1 isolates from Cyprus and Greece suggested the existence of a distinct subtype of the virus, designated as I. We examined whether this subtype represents a distinct group, or a mosaic consisting of previously characterized subtypes. The full-length sequences under...

journal_title：AIDS research and human retroviruses

authors： Nasioulas G,Paraskevis D,Magiorkinis E,Theodoridou M,Hatzakis A

更新日期：1999-05-20 00:00:00

abstract：:Signature pattern analysis identifies particular sites in amino acid or nucleic acid alignments of variable sequences that are distinctly representative of a query set of sequences relative to a background set. We explore the merits of using signature patterns for analysis of HIV-1 (human immunodeficiency virus type 1...

journal_title：AIDS research and human retroviruses

authors： Korber B,Myers G

更新日期：1992-09-01 00:00:00

abstract：:The derivation of ethyl-methanesulfonate (EMS) mutagenized subclones from the CEM T-cell line has been described. These clones expressed CD4 and bound soluble gp120, however, two of the generated clones were markedly reduced in their ability to form syncytia after infection with either gp160-vaccinia vector or cell-fr...

journal_title：AIDS research and human retroviruses

authors： Gruber MF,Hewlett IK,Simms T,Vujcic L,Manischewitz J,Golding H

更新日期：1992-06-01 00:00:00

abstract：:We examined risk factors for avascular bone necrosis (AVN) particularly focusing o the question of whether antiretroviral treatment (ART) is associated with the emergence of osteonecrosis. After 11 years of following the entire cohort, 26 patients were found to have AVN. Compared to 260 concurrent HIV-infected control...

journal_title：AIDS research and human retroviruses

authors： Hasse B,Ledergerber B,Egger M,Flepp M,Bachmann S,Bernasconi E,Egger M,Guyot S,Hirschel B,Weber R,Günthard HF,Swiss HIV Cohort Study.

更新日期：2004-09-01 00:00:00

abstract：:In the context of an emerging aging epidemic affecting people living with HIV (PLWH), we critically discuss existing data regarding two different conceptual models of aging-frailty and intrinsic capacity, respectively, both in a clinical and public health perspective. These constructs have not yet been integrated in t...

journal_title：AIDS research and human retroviruses

authors： Guaraldi G,Milic J

更新日期：2019-11-01 00:00:00

abstract：:Human T cell leukemia virus protein induces T cells to permanent IL-2-dependent growth. These cells occasionally convert to factor independence. The viral oncoprotein Tax acts as an essential growth factor of transformed lymphocytes and stimulates the cell cycle in the G(1) phase. In T cells and fibroblasts Tax enhanc...

journal_title：AIDS research and human retroviruses

authors： Haller K,Ruckes T,Schmitt I,Saul D,Derow E,Grassmann R

更新日期：2000-11-01 00:00:00

abstract：:Japan is one of the highest endemic areas of the world for human T cell leukemia-lymphoma virus type I (HTLV-I). To gain new insight as to the origin of this virus in Japan and especially in the southern islands of the archipelago, we investigated the long terminal repeat (LTR) of 67 newly isolated HTLV-I proviral DNA...

journal_title：AIDS research and human retroviruses

authors： Vidal AU,Gessain A,Yoshida M,Mahieux R,Nishioka K,Tekaia F,Rosen L,De Thé G

更新日期：1994-11-01 00:00:00

abstract：:In India Kaposi's sarcoma is rarely seen in AIDS patients. Hence the current belief is that the incidence of human herpesvirus-8 (HHV-8) is very low in this subcontinent, most probably due to the heterosexual route of HIV transmission. However, there is a scarcity of data on the prevalence of HHV-8 in India. In India ...

journal_title：AIDS research and human retroviruses

authors： Munawwar A,Sharma SK,Gupta S,Singh S

更新日期：2014-12-01 00:00:00

abstract：:HIV-infected individuals are at high risk of developing atherosclerosis and cardiovascular disease, in part, due to HIV-induced impairment of cholesterol metabolism. In vitro studies demonstrated that HIV-1 protein Nef inhibits activity of ABCA1, the main cellular cholesterol transporter, leading to cholesterol accumu...

journal_title：AIDS research and human retroviruses

authors： Pushkarsky T,Shilov E,Kruglova N,Naumann R,Brichacek B,Jennelle L,Sviridov D,Kruglov A,Nedospasov SA,Bukrinsky M

更新日期：2017-01-01 00:00:00

abstract：:SIVsmmFGb is a lentivirus swarm that induces neuropathology in over 90% of infected pigtailed macaques and reliably models central nervous system HIV infection in people. We have previously studied SIVsmmFGb genetic diversity and compartmentalization during acute infection, but little is understood about diversity and...

journal_title：AIDS research and human retroviruses

authors： Reeve AB,Pearce NC,Patel K,Augustus KV,Novembre FJ

更新日期：2010-06-01 00:00:00

abstract：:Antigenic properties of the V3 region are reflected by HIV-1 serotypes. These may represent biological properties of the virus. We serotyped HIV-1 in 142 serum samples from participants in a rural Uganda cohort who seroconverted between August 1991 and December 2001. Clinical progression was assessed using Cox proport...

journal_title：AIDS research and human retroviruses

authors： Senkaali D,Muwonge R,Morgan D,Yirrell D,Whitworth J,Kaleebu P

更新日期：2004-09-01 00:00:00

abstract：:Infection with the human immunodeficiency virus (HIV) leads to a progressive immunodeficiency characterized by decreasing levels of CD4+ T lymphocytes. VaxSyn, a vaccine based on the recombinant envelope glycoprotein subunit (rgp160) of HIV-1IIIB, was used to immunize HIV-infected patients to determine whether its adm...

journal_title：AIDS research and human retroviruses

authors： Tsoukas CM,Raboud J,Bernard NF,Montaner JS,Gill MJ,Rachlis A,Fong IW,Schlech W,Djurdjev O,Freedman J,Thomas R,Lafrenière R,Wainberg MA,Cassol S,O'Shaughnessy M,Todd J,Volvovitz F,Smith GE

更新日期：1998-04-10 00:00:00

abstract：:In Western countries, HTLV-1 infection is recognized mainly among foreigners coming from endemic areas. In contrast, HTLV-2 is found predominantly in native intravenous drug users (IDUs). Spain has experienced a large wave of immigration, which could have influenced the current prevalence and distribution of HTLV-1 an...

journal_title：AIDS research and human retroviruses

authors： Toro C,Aguilera A,Caballero E,Tuset C,Alvarez P,García-Campello M,Rodríguez-Iglesias M,de Lejarazu RO,Eiros J,Rodriguez C,del Romero J,Benito R,Calderón E,Santana O,Amor A,Gómez-Hernando C,García J,Soriano V

更新日期：2007-09-01 00:00:00

abstract：:Sexual transmission of human immunodeficiency virus provides an efficient mode for virus spread and poses unique challenges to vaccine developers. Host and viral factors that affect transmission have been studied by epidemiological approaches in the human population, and some of these factors have been modeled with ex...

journal_title：AIDS research and human retroviruses

authors： Pauza CD,Horejsh D,Wallace M

更新日期：1998-04-01 00:00:00

abstract：:Most HIV-1 transmissions occur at mucosae and involve exposure to semen. Semen contains immunomodulatory factors, which inhibit anti-HIV-1 natural killer cell and T cell responses. We demonstrate high concentrations (1:2 dilution) of seminal plasma (SP) inhibit monocyte phagocytosis and anti-HIV-1 Fc-dependent functio...

journal_title：AIDS research and human retroviruses

authors： Selva KJ,Juno JA,Worley MJ,Chung AW,Tachedjian G,Kent SJ,Parsons MS

更新日期：2019-06-01 00:00:00

abstract：:High-resolution structures have revealed major pockets in the MHC class II peptide binding groove within a region designated Pl-P9. The region can accommodate 9-mer peptides, consistent with the observation that minimal core helper T (Th) cell determinants are usually eight or nine residues in size. Here we describe m...

journal_title：AIDS research and human retroviruses

authors： Lockey TD,Surman S,Brown S,Slobod KS,Coleclough C,Doherty PC,Hurwitz JL

更新日期：2002-10-10 00:00:00

abstract：:The presence of clinical manifestations of HIV-1 infection is one measure of immune function failure. We examined the occurrence of clinical manifestations of HIV-1 infection, in particular fever and oral thrush, before and after the initiation of highly active antiretroviral therapy (HAART). Using data collected from...

journal_title：AIDS research and human retroviruses

authors： Skolasky RL,Phair J,Detels R,Riddler S,Margolick J,Jacobson LP

更新日期：2001-09-20 00:00:00

abstract：:We tested human immunodeficiency virus type 1 (HIV-1) antibody-positive human sera and sCD4, alone and in combination, for synergistic, additive, or antagonistic effects on blocking of HIV binding and infectivity. Data were analyzed by an application of the median effect principle derived from the law of mass action. ...

journal_title：AIDS research and human retroviruses

authors： Kennedy MS,Orloff S,Ibegbu CC,Odell CD,Maddon PJ,McDougal JS

更新日期：1991-12-01 00:00:00

abstract：:CRF01_AE is one of the four dominant HIV-1 strains circulating in China. In this study, we performed genetic and phenotypic analyses using a total of 60 full-length envelope gene clones from 14 HIV-1-infected individuals in the Beijing area. Among the 60 sequences analyzed, 32 have a complete open reading frame (ORF),...

journal_title：AIDS research and human retroviruses

authors： Chen D,He X,Ye J,Zhao P,Zeng Y,Feng X

更新日期：2016-10-01 00:00:00