Maintaining low HIV type 1 env genetic diversity among injection drug users infected with a B/C recombinant and CRF01_AE HIV type 1 in southern China.

abstract：:To evaluate the efficacy, safety and tolerability of switching to a dolutegravir (DTG)-based regimen in a cohort of virological suppressed HIV-infected patients. The dynamics of total HIV-DNA and levels of high-sensitivity c-reactive protein (hsCRP), interleukin-6 (IL-6), soluble-CD14 (sCD14) and D-Dimer were also ana...

journal_title：AIDS research and human retroviruses

authors： Di Carlo D,Falasca F,Palermo E,Mezzaroma I,Fimiani C,Siccardi G,Celani L,Di Campli FM,d'Ettorre G,Antonelli G,Turriziani O

更新日期：2021-01-24 00:00:00

abstract：:It has been proposed that HIV-1-neutralizing 2F5 and 4E10 monoclonal antibodies recognize gp41 ectodomain pretransmembrane sequences in the context of the membrane interface. With the aim of evaluating lipid-bilayer surface effects on recognition, we use phospholipid model systems to investigate the ability of 2F5 and...

journal_title：AIDS research and human retroviruses

authors： Sánchez-Martínez S,Lorizate M,Katinger H,Kunert R,Nieva JL

更新日期：2006-10-01 00:00:00

abstract：:The HIV-1 subtype distribution in 83 HIV-1-seropositive individuals living in Greece was investigated by using the heteroduplex mobility assay (HMA), DNA sequencing, and phylogenetic analysis. The results revealed that partial HIV-1 gp120 sequences from 71 (86%) patients were subtype B, 5 (6%) were subtype A, 4 were s...

journal_title：AIDS research and human retroviruses

authors： Nasioulas G,Paraskevis D,Paparizos V,Lazanas M,Karafoulidou A,Hatzakis A

更新日期：1998-05-20 00:00:00

abstract：:Antigenic properties of the V3 region are reflected by HIV-1 serotypes. These may represent biological properties of the virus. We serotyped HIV-1 in 142 serum samples from participants in a rural Uganda cohort who seroconverted between August 1991 and December 2001. Clinical progression was assessed using Cox proport...

journal_title：AIDS research and human retroviruses

authors： Senkaali D,Muwonge R,Morgan D,Yirrell D,Whitworth J,Kaleebu P

更新日期：2004-09-01 00:00:00

abstract：:HIV infection is associated with qualitative and functional immune deficiencies. It has been shown that the in vitro infection of CD4+ cells with HIV was associated with sustained elevation of cAMP and cGMP. In the present report the role of cAMP on HIV replication in MT-4 cells was investigated. The MT-4 cells were i...

journal_title：AIDS research and human retroviruses

authors： Nokta MA,Pollard RB

更新日期：1992-07-01 00:00:00

abstract：:Activation of primary CD4+ T cells induces the CD155, but not the CD112 ligands for the natural killer (NK) cell activation receptor (aNKR) CD226 [DNAX accessory molecule-1 (DNAM-1)]. We hypothesize that HIV productively infects activated CD4+ T cells and makes itself vulnerable to NK cell-mediated lysis when CD155 on...

journal_title：AIDS research and human retroviruses

authors： Davis ZB,Sowrirajan B,Cogswell A,Ward JP,Planelles V,Barker E

更新日期：2017-02-01 00:00:00

abstract：:Data indicate the presence in the Seychelles Islands of a high level of human T cell leukemia/lymphoma virus type I (HTLV-I) endemicity as well as the presence of tropical spastic paraparesis/HTLV-I-associated myelopathy (TSP/HAM). We present here the results of an hospital survey performed since 1988 in La Réunion Is...

journal_title：AIDS research and human retroviruses

authors： Mahieux R,Gessain A,Truffert A,Vitrac D,Hubert A,Dandelot J,Montchamp-Moreau C,Cnudde F,Tekaia F,De Thé G

更新日期：1994-06-01 00:00:00

abstract：:We studied the ability of several polyionic compounds, previously shown to have activity in vitro against human immunodeficiency virus (anti-HIV) to block binding of anti-CD4 and recombinant HIV gp120 to the CD4 receptor on human lymphocytes. We found that Evans blue and aurin tricarboxylic acid could completely inhib...

journal_title：AIDS research and human retroviruses

authors： Weaver JL,Gergely P,Pine PS,Patzer E,Aszalos A

更新日期：1990-09-01 00:00:00

abstract：:We investigated the Th1 protective and regulatory T and B cell (Treg and Breg) responses to pH1N1 monovalent influenza vaccine (IIV1) in HIV-infected pregnant women on combination antiretroviral therapy (cART). Peripheral blood mononuclear cells (PBMCs) from 52 study participants were cryopreserved before and after va...

journal_title：AIDS research and human retroviruses

authors： Weinberg A,Muresan P,Richardson K,Fenton T,Dominguez T,Bloom A,Watts DH,Abzug MJ,Nachman SA,Levin MJ,P1086 Study Team.

更新日期：2015-11-01 00:00:00

abstract：:We identified an HIV-1 variant that belongs to the M group, with limited similarity of short genetic regions (100-200 nt) to subtype K, but the remainder of the genome is unrelated to any established HIV-1 subtype. The isolate was obtained from an HIV-1-positive male, living in the Netherlands, who encountered the vir...

journal_title：AIDS research and human retroviruses

authors： van der Hoek L,Pollakis G,Lukashov VV,Jebbink MF,Jeeninga RE,Bakker M,Dukers N,Jurriaans S,Paxton WA,Back NK,Berkhout B

更新日期：2007-03-01 00:00:00

abstract：:The combination of didanosine (ddI) and lamivudine (3TC) is attractive considering its low cost, potency, tolerability, and convenience (once daily administration), but it is not recommended as first-line therapy for HIV infection. A prospective, multicenter, open, comparative trial was conducted in HIV-infected, anti...

journal_title：AIDS research and human retroviruses

authors： Sánchez-Conde M,Palacios R,Sanz J,Rodríguez-Novoa S,Rivas P,Santos J,Sola J,Asensi V,de Mendoza C,Estrada V,Barreiro P,González-Lahoz J,Jiménez-Nacher I,Soriano V

更新日期：2007-10-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) isolates differ in their use of coreceptors to enter target cells. This has important implications for both viral pathogenicity and susceptibility to entry inhibitors, recently approved or under development. Predicting HIV-1 coreceptor usage on the basis of sequence informat...

journal_title：AIDS research and human retroviruses

authors： Prosperi MC,Fanti I,Ulivi G,Micarelli A,De Luca A,Zazzi M

更新日期：2009-03-01 00:00:00

abstract：:The majority of AIDS patients will experience some degree of dementia induced by human immunodeficiency virus (HIV-1). In this study, we report that treatment of human brain tissue with envelope gp120 of HIV-1 did not cause neuronal death but did cause astrocyte alterations and/or death. Human astrocyte cultures showe...

journal_title：AIDS research and human retroviruses

authors： Pulliam L,West D,Haigwood N,Swanson RA

更新日期：1993-05-01 00:00:00

abstract：:Given the rising HIV incidence in men who have sex with men (MSM) despite repeatedly proven effectiveness of oral HIV pre-exposure prophylaxis, behaviorally congruent periodic dosing strategies, such as dosing microbicides as lubricants, are now in demand. Rectal microbicide gel studies largely administer gels using v...

journal_title：AIDS research and human retroviruses

authors： Shieh EC,Weld ED,Fuchs EJ,Hiruy H,Buckheit KW,Buckheit RW Jr,Breakey J,Hendrix CW

更新日期：2017-08-01 00:00:00

abstract：:Monoclonal antibodies (mAbs) specific for CD4 are potent inhibitors of HIV replication in vitro. These agents may be useful prophylactically or in chronic HIV infection if they can be administered without inducing immunosuppression. In the present study, we explored the safety of a CD4-specific murine mAb in rhesus mo...

journal_title：AIDS research and human retroviruses

authors： Reimann KA,Burkly LC,Burrus B,Waite BC,Lord CI,Letvin NL

更新日期：1993-03-01 00:00:00

abstract：:The derivation of ethyl-methanesulfonate (EMS) mutagenized subclones from the CEM T-cell line has been described. These clones expressed CD4 and bound soluble gp120, however, two of the generated clones were markedly reduced in their ability to form syncytia after infection with either gp160-vaccinia vector or cell-fr...

journal_title：AIDS research and human retroviruses

authors： Gruber MF,Hewlett IK,Simms T,Vujcic L,Manischewitz J,Golding H

更新日期：1992-06-01 00:00:00

abstract：:For a HIV vaccine to be effective, it will be essential that it protect against the virus variants to which individuals are most frequently exposed. HIV-1 is predominantly a sexually acquired virus, thus, variants in genital secretions are a potentially important reservoir of viruses that are transmitted. Because ther...

journal_title：AIDS research and human retroviruses

authors： Overbaugh J,Anderson RJ,Ndinya-Achola JO,Kreiss JK

更新日期：1996-01-20 00:00:00

abstract：:Raltegravir, a novel HIV-1 integrase inhibitor, has superior efficacy with optimized background treatment (OBT) vs. placebo + OBT in treatment-experienced HIV-1 patients. This study assessed the long-term cost effectiveness of raltegravir from a Spanish National Healthcare System perspective. A cohort-state-transition...

journal_title：AIDS research and human retroviruses

authors： Chaudhary MA,Moreno S,Kumar RN,Nocea G,Elbasha E

更新日期：2009-07-01 00:00:00

abstract：:We have previously used immunotoxins to select for HIV-1 variant cells that transcribe HIV at extremely low levels and fail to produce HIV proteins. Further observation of one of these variants (E9) demonstrated spontaneous in vitro activation of HIV production. The mechanism of activation is different from that of U1...

journal_title：AIDS research and human retroviruses

authors： Fang H,Pincus S

更新日期：1999-10-10 00:00:00

abstract：:Serological studies on 926 blood samples from 703 Brazilian Kayapo (Cayapo) Indians showed, by conventional definition of HTLV seropositivity, a 28% prevalence of human T lymphotropic virus (HTLV) infection, the highest yet reported. Immunoblot (WB) and SYNTH-EIA patterns indicate that the predominant infecting agent ...

journal_title：AIDS research and human retroviruses

authors： Black FL,Biggar RJ,Neel JV,Maloney EM,Waters DJ

更新日期：1994-09-01 00:00:00

abstract：:Despite the availability of antiretroviral therapy (ART), HIV-infected drug users, particularly crack cocaine users, continue to have high HIV-related morbidity and mortality. We conducted a cross-sectional analysis of the baseline data for hospitalized HIV-infected crack cocaine users recruited for Project HOPE (Hosp...

journal_title：AIDS research and human retroviruses

authors： Doshi RK,Vogenthaler NS,Lewis S,Rodriguez A,Metsch L,del Rio C

更新日期：2012-09-01 00:00:00

abstract：:Studies have demonstrated that HIV-1 isolated from subjects experiencing virologic failure on stavudine (d4T)-containing regimens often contains thymidine analog mutations (TAMs), consisting of reverse transcriptase (RT) mutations M41L, D67N, K70R, L210W, T215Y/F, and K219Q/E, previously associated only with zidovudin...

journal_title：AIDS research and human retroviruses

authors： Ross L,Scarsella A,Raffanti S,Henry K,Becker S,Fisher R,Liao Q,Hirani A,Graham N,St Clair M,Hernandez J,NZT40012 Study Team.

更新日期：2001-08-10 00:00:00

abstract：:The measurement of antiretroviral concentrations in hair is emerging as an important technology to objectively quantify adherence to combination antiretroviral therapy. Hair levels of antiretrovirals are the strongest independent predictor of virologic success in large prospective cohorts of HIV-infected patients and ...

journal_title：AIDS research and human retroviruses

authors： Gandhi M,Yang Q,Bacchetti P,Huang Y

更新日期：2014-01-01 00:00:00

abstract：:In order to shed light on the nature of the persistent reservoir of human immunodeficiency virus type 1 (HIV-1), we investigated signs of recent evolution in the pool of proviral DNA in patients on successful HAART. Pro-viral DNA, corresponding to the C2-V3-C3 region of the HIV-1 env gene, was collected from PBMCs iso...

journal_title：AIDS research and human retroviruses

authors： Mens H,Pedersen AG,Jørgensen LB,Hue S,Yang Y,Gerstoft J,Katzenstein TL

更新日期：2007-01-01 00:00:00

abstract：:Cessation of highly active antiretroviral therapy (HAART) in HIV-infected individual leads to a rebound of viral replication due to reactivation of a viral reservoir composed largely of latently infected memory CD4(+) T cells. Efforts to deplete this reservoir have focused on reactivation of transcriptionally silent l...

journal_title：AIDS research and human retroviruses

authors： Jamaluddin MS,Hu PW,Jan Y,Siwak EB,Rice AP

更新日期：2016-02-01 00:00:00

abstract：:In October of 2019, researchers and community members from around the world met at the NIH for the fifth annual International Workshop on Microbiome in HIV. New research was presented on the role of the microbiome on chronic inflammation and vaccine design, interactions of genetics, environment, sexual practice and HI...

journal_title：AIDS research and human retroviruses

authors： Sherrill-Mix S,Connors K,Aldrovandi GM,Brenchley JM,Boucher C,Bushman FD,Collman RG,Dandekar S,Klatt NR,Lagenaur LA,Paredes R,Tachedjian G,Turpin JA,Landay AL,Ghosh M

更新日期：2020-11-01 00:00:00

abstract：:Low albumin levels have been associated with HIV progression. The objective of this analysis was to confirm this association and to further examine the effect of albumin before and after HIV seroconversion on disease progression. The association was first examined among individuals already infected with HIV at entry i...

journal_title：AIDS research and human retroviruses

authors： Mehta SH,Astemborski J,Sterling TR,Thomas DL,Vlahov D

更新日期：2006-01-01 00:00:00

abstract：:The membrane glycolipids galactosylceramide (GalCer) and sulfatide (SGalCer) have been reported to act as receptors of human immunodeficiency virus (HIV) on CD4- cell lines. We show here that these glycolipids are present on CD4+ cells purified from human blood and on in vitro-differentiated monocyte-derived macrophag...

journal_title：AIDS research and human retroviruses

authors： Seddiki N,Ben Younes-Chennoufi A,Benjouad A,Saffar L,Baumann N,Gluckman JC,Gattegno L

更新日期：1996-05-20 00:00:00

abstract：:HIV inhibitors targeted at the virus-associated reverse transcriptase (RT) can be divided into two groups, depending on whether they are targeted at the substrate or nonsubstrate binding site. To the first group belong the 2',3'-dideoxynucleosides (i.e., DDC, DDI), 3'-azido-2',3'-dideoxynucleosides (i.e., AZT), 3'-flu...

journal_title：AIDS research and human retroviruses

authors： De Clercq E

更新日期：1992-02-01 00:00:00

abstract：:Human T cell leukemia virus type-1 (HTLV-1) is prevalent worldwide with foci of high prevalence. However, to date no effective vaccine or drug against HTLV-1 infection has been developed. In efforts to define the role of antibodies in the control of HTLV-1 infection, we capitalized on the use of our previously defined...

journal_title：AIDS research and human retroviruses

authors： Tanaka Y,Takahashi Y,Tanaka R,Kodama A,Fujii H,Hasegawa A,Kannagi M,Ansari AA,Saito M

更新日期：2014-06-01 00:00:00