Endemic transmission of HTLV type II among Kayapo Indians of Brazil.

abstract：:The majority of AIDS patients will experience some degree of dementia induced by human immunodeficiency virus (HIV-1). In this study, we report that treatment of human brain tissue with envelope gp120 of HIV-1 did not cause neuronal death but did cause astrocyte alterations and/or death. Human astrocyte cultures showe...

journal_title：AIDS research and human retroviruses

authors： Pulliam L,West D,Haigwood N,Swanson RA

更新日期：1993-05-01 00:00:00

abstract：:Differences in emergence of HIV resistance between subtypes B and C in vitro and potential implications on tenofovir alafenamide efficacy in vivo were evaluated. Dose escalation resistance selections showed K65R emerging earlier for subtype C viruses in vitro, as previously reported. Viral breakthrough experiments at ...

journal_title：AIDS research and human retroviruses

authors： Cox S,Margot N,Miller M,Callebaut C

更新日期：2018-05-01 00:00:00

abstract：:HIV-1 group N (HIV-1/N) remains rare and mainly restricted to Cameroon. In this study, we report a new HIV-1/N infected case identified during routine HIV screening activities in Yaounde. The genetic characterization of the near full-length genome of this virus strain revealed that it is genetically distinct to all HI...

journal_title：AIDS research and human retroviruses

authors： Tagnouokam Ngoupo PA,Sadeuh-Mba SA,De Oliveira F,Ngo-Malabo ET,Ngono L,Plantier JC,Kfutwah A,Njouom R

更新日期：2018-07-01 00:00:00

abstract：:Women attending the Queen Elizabeth Central Hospital in Blantyre, Malawi, between November 1989 and October 1993 were studied as part of a longitudinal cohort study of mother-to-infant HIV transmission. 694 HIV-seropositive and 687 HIV-seronegative women were enrolled at delivery. In the follow-up phase, women attende...

journal_title：AIDS research and human retroviruses

authors： Miotti P,Canner J,Chiphangwi J,Liomba G,Saah A,Dallabetta G

更新日期：1994-01-01 00:00:00

abstract：:Thirty years after its beginning, the HIV/AIDS epidemic is still raging around the world. According to UNAIDS, in 2011 alone 1.7M deaths were attributable to AIDS, and 2.5M people were newly infected by the virus. Despite the success in treating HIV-infected people with potent antiretroviral drugs, preventing HIV infe...

journal_title：AIDS research and human retroviruses

authors： Romano J,Kashuba A,Becker S,Cummins J,Turpin J,Veronese F,Antiretroviral Pharmacology In HIV Prevention Think Tank Participants.

更新日期：2013-11-01 00:00:00

abstract：:The prevalence of different HIV-1 subtypes in Spain varies by geographic region. In the present study isolates were collected from 72 newly diagnosed individuals in western Andalucia from 2004 to 2006. Viral sequences were amplified and the subtype diversity and prevalence of resistance mutations in the reverse transc...

journal_title：AIDS research and human retroviruses

authors： McConnell MJ,Docobo-Pérez F,Mata RC,Fernandez-Cuenca F,Viciana P,López-Cortés LF,Trastoy M,Pachón J,Pérez-Romero P

更新日期：2008-06-01 00:00:00

abstract：:HIV-1 Vif, Vpr, and Vpu proteins have a profound effect on efficient viral replication and pathogenesis. This study describes the genotypic characterisation of vif , vpr and vpu from 20 South African HIV-1 subtype C primary isolates, and extensive analysis and comparison of known motifs. All HIV-1 subtype C Vif, Vpr a...

journal_title：AIDS research and human retroviruses

authors： Bell CM,Connell BJ,Capovilla A,Venter WD,Stevens WS,Papathanasopoulos MA

更新日期：2007-02-01 00:00:00

abstract：:Transmitted drug resistance mutations (TDRM) have been a constant threat to treatment efficacy. We evaluated TDRM in plasma RNA of 217 antiretroviral therapy-naive patients from sites in the São Paulo metropolitan area, collected from 2012 to 2014. The partial HIV-1 polymerase region was sequenced using Big Dye termin...

journal_title：AIDS research and human retroviruses

authors： Guimarães PM,Ferreira JL,Coelho LP,Cavalcanti Jde S,Lopes GI,Matsuda EM,Almeida FJ,Almeida VC,Campeas AE,Junior LC,Brígido LF,Sa˜o Paulo Salvage Workgroup.

更新日期：2015-12-01 00:00:00

abstract：:Mycophenolate mofetil (MMF), the bioavailable form of mycophenolic acid (MPA), has been proposed as adjuvant therapy for human immunodeficiency virus type 1 (HIV-1) infection. MPA can inhibit viral replication and might blunt virus-induced immunopathology. However, other effects of this inhibitor might be detrimental ...

journal_title：AIDS research and human retroviruses

authors： Kaur R,Klichko V,Margolis D

更新日期：2005-02-01 00:00:00

abstract：:The Human Immunodeficiency Virus (HIV), the causative agent of AIDS, is thought to bind to T4+ (CD4+) target cells through the heavily glycosylated gp120 envelope glycoprotein. Plant lectins bind glycoproteins through noncovalent interaction with specific hexose residues; therefore, lectins were evaluated for their ab...

journal_title：AIDS research and human retroviruses

authors： Robinson WE Jr,Montefiori DC,Mitchell WM

更新日期：1987-10-01 00:00:00

abstract：:The emergence of T cell-tropic, syncytium-inducing (T-tropic/SI) HIV-1 variants from the background of macrophage-tropic, non-syncytium-inducing (M-tropic/NSI) strains is associated with disease progression in infected individuals. HIV89.6 is a primary isolate with a transitional phenotype: like M-tropic strains it re...

journal_title：AIDS research and human retroviruses

authors： Smyth RJ,Yi Y,Kim FM,Collman RG

更新日期：1997-06-10 00:00:00

abstract：:Inhibitory factors to human immunodeficiency virus type 1 (HIV-1) in saliva may be responsible for the infrequent isolation of virus from saliva and also may account for the marked infrequency of salivary and/or oral transmission of HIV-1. Incubation of HIV-1 with human saliva followed by addition of the mixture to su...

journal_title：AIDS research and human retroviruses

authors： Archibald DW,Cole GA

更新日期：1990-12-01 00:00:00

abstract：:We characterized two immune escape viruses (SHIV(KU-1/105w52) and SHIV(KU-1/105w98)) from a macaque immunized with DeltavpuDeltanef SHIV-4 and challenged with pathogenic SHIV(KU-1). This macaque developed neutralizing antibodies as well as virus-specific CTLs against the challenge virus. However, the two new viruses c...

journal_title：AIDS research and human retroviruses

authors： Stipp HL,Kumar A,Narayan O

更新日期：2000-10-10 00:00:00

abstract：:We evaluated the effect of drug alternation on human immunodeficiency virus type 1 (HIV-1) suppression and emergence of resistant virus strains in CEM cell cultures. Rapid, that is, twice weekly, alternation of lamivudine and nevirapine (at 0.1 microg/ml) at the time of each subcultivation resulted in a long-term supp...

journal_title：AIDS research and human retroviruses

authors： Balzarini J,De Clercq E

更新日期：2001-11-20 00:00:00

abstract：:In order to investigate how human immunodeficiency virus (HIV) gains entry to the placenta, we have performed in vitro experiments in which highly purified trophoblast cells isolated from term human placentas were examined for their susceptibility to HIV infection. Trophoblast cells were exposed to cell-free HIV-1 for...

journal_title：AIDS research and human retroviruses

authors： Douglas GC,Fry GN,Thirkill T,Holmes E,Hakim H,Jennings M,King BF

更新日期：1991-09-01 00:00:00

abstract：:Endogenous retroviruses (ERVs) probably originate from ancient germ cell infections by exogenous retroviruses. A high expression of retroviruses in reproductive tissue increases the risk of viral transmission to germ line cells. We therefore investigated the expression of human ERVs (HERVs) in normal endometrium, endo...

journal_title：AIDS research and human retroviruses

authors： Hu L,Hornung D,Kurek R,Ostman H,Blomberg J,Bergqvist A

更新日期：2006-06-01 00:00:00

abstract：:HIV type 1 (HIV-1) envelope glycoproteins (Env) mediate virus entry and are the target of neutralizing antibodies. Binding of the metastable HIV-1 Env trimer to the CD4 receptor triggers structural rearrangements that mediate Env conformational transitions from a closed conformation to a more open state through an int...

journal_title：AIDS research and human retroviruses

authors： Flemming J,Wiesen L,Herschhorn A

更新日期：2018-09-01 00:00:00

abstract：:Dendritic cells (DCs) are important mediators of the immune response against HIV and yet blood DC numbers fall substantially during HIV infection. Here we report that blood levels of the DC-tissue tropic chemokines monocyte chemotactic protein (MCP-1/CCL2), macrophage inflammatory proteins (MIP-3α/CCL20), and MIP-3β/C...

journal_title：AIDS research and human retroviruses

authors： Fontaine J,Poudrier J,Roger M

更新日期：2011-06-01 00:00:00

abstract：:In the context of an emerging aging epidemic affecting people living with HIV (PLWH), we critically discuss existing data regarding two different conceptual models of aging-frailty and intrinsic capacity, respectively, both in a clinical and public health perspective. These constructs have not yet been integrated in t...

journal_title：AIDS research and human retroviruses

authors： Guaraldi G,Milic J

更新日期：2019-11-01 00:00:00

abstract：:We used enzyme-linked immunosorbant assay (ELISA) and Western blotting, with "purified" human T-cell leukemia virus I (HTLV-I), to test for HTLV-I antibodies in 2583 plasma samples from 1053 leukemia/lymphoma patients treated at Roswell Park Memorial Institute, mostly between 1972 and 1984, and in 110 sera samples fro...

journal_title：AIDS research and human retroviruses

authors： Srivastava BI,Gonzales C,Loftus R,Fitzpatrick JE,Saxinger CW

更新日期：1990-05-01 00:00:00

abstract：:The ability to trigger an innate immune response against opportunistic pathogens associated with HIV-1 infection is an important aspect of AIDS pathogenesis. Toll-like receptors (TLRs) play a critical role in innate immunity against pathogens, but in HIV-1 patients coinfected with opportunistic infections, the regulat...

journal_title：AIDS research and human retroviruses

authors： Hernández JC,Arteaga J,Paul S,Kumar A,Latz E,Urcuqui-Inchima S

更新日期：2011-10-01 00:00:00

abstract：:Six morphine-dependent and three control macaques were infected with a mixture of SIV/SHIV. Half of the animals in the morphine group developed accelerated disease (rapid progressor) and died within 20 weeks postinfection. The evolution of the envelope gene in the brain of the rapid progressor and morphine-dependent g...

journal_title：AIDS research and human retroviruses

authors： Rivera-Amill V,Noel RJ Jr,Román IR,Flores YG,Buch S,Kumar A

更新日期：2009-05-01 00:00:00

abstract：:We studied vertical transmission of feline immunodeficiency virus (FIV) to determine whether it might provide a model with which to study intervention strategies for mother-to-offspring transmission of human immunodeficiency virus (HIV). We found that pregnant cats acutely infected with FIV (FIV-CSU-2771) transmitted ...

journal_title：AIDS research and human retroviruses

authors： O'Neil LL,Burkhard MJ,Diehl LJ,Hoover EA

更新日期：1995-01-01 00:00:00

abstract：:The antiretroviral (ARV) service at Edendale Hospital in Pietermaritzburg, KwaZulu-Natal, South Africa has initiated more than 9,000 adults on therapy since 2004; however, virological outcomes among this patient cohort have not been systematically assessed. We conducted a retrospective chart review of patients initiat...

journal_title：AIDS research and human retroviruses

authors： Costiniuk CT,Sigal A,Jenabian MA,Nijs P,Wilson D

更新日期：2014-06-01 00:00:00

abstract：:Abstract We assessed the viral envelope (V3-V5 region) sequence diversity from 13 HIV-1-infected Indian children from north India. All of the 13 children were found to be infected with subtype C viruses. One of the viral sequences exhibited usage of the CXCR4 coreceptor predicted by Web PSSM and Geno2pheno tools. Th...

journal_title：AIDS research and human retroviruses

authors： Prakash SS,Kalra R,Lodha R,Kabra SK,Luthra K

更新日期：2012-05-01 00:00:00

abstract：:Elite controllers or suppressors (ES) are HIV-1-infected patients who maintain viral loads of <50 copies/ml without antiretroviral therapy. While HLA-B*57 and B*5801 alleles are overrepresented in ES, many HLA-B*57/B*5801 patients become chronic progressors (CP). We show here that HIV-1 infection results in similar le...

journal_title：AIDS research and human retroviruses

authors： Sampah ME,Ceccato CM,Blankson JN

更新日期：2011-02-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) isolates differ in their use of coreceptors to enter target cells. This has important implications for both viral pathogenicity and susceptibility to entry inhibitors, recently approved or under development. Predicting HIV-1 coreceptor usage on the basis of sequence informat...

journal_title：AIDS research and human retroviruses

authors： Prosperi MC,Fanti I,Ulivi G,Micarelli A,De Luca A,Zazzi M

更新日期：2009-03-01 00:00:00

abstract：:A comparative study at the genomic and protein level was performed between two immunologically related spumaretroviruses, the human HSRV and the simian SFV6. Cross immunoprecipitation analysis with specific polyclonal and monoclonal antisera indicates shared antigenic determinants. However, restriction analysis of the...

journal_title：AIDS research and human retroviruses

authors： Tobaly-Tapiero J,Santillana-Hayat M,Giron ML,Guillemin MC,Rozain F,Périès J,Emanoil-Ravier R

更新日期：1990-07-01 00:00:00

abstract：:Given the rising HIV incidence in men who have sex with men (MSM) despite repeatedly proven effectiveness of oral HIV pre-exposure prophylaxis, behaviorally congruent periodic dosing strategies, such as dosing microbicides as lubricants, are now in demand. Rectal microbicide gel studies largely administer gels using v...

journal_title：AIDS research and human retroviruses

authors： Shieh EC,Weld ED,Fuchs EJ,Hiruy H,Buckheit KW,Buckheit RW Jr,Breakey J,Hendrix CW

更新日期：2017-08-01 00:00:00

abstract：:The relationship between adherence to highly active antiretroviral therapy (HAART) and RNA-HIV viral load outcomes has been extensively shown. Although there are different procedures for assessing treatment adherence, there is no ideal method. We present the SERAD (Self-Reported Adherence) questionnaire, a qualitative...

journal_title：AIDS research and human retroviruses

authors： Muñoz-Moreno JA,Fumaz CR,Ferrer MJ,Tuldrà A,Rovira T,Viladrich C,Bayés R,Burger DM,Negredo E,Clotet B,SERAD Validation Team.

更新日期：2007-10-01 00:00:00