Diversity of HIV type 1 envelope (V3-V5) sequence in HIV type 1-infected Indian children.

Abstract:

:Abstract We assessed the viral envelope (V3-V5 region) sequence diversity from 13 HIV-1-infected Indian children from north India. All of the 13 children were found to be infected with subtype C viruses. One of the viral sequences exhibited usage of the CXCR4 coreceptor predicted by Web PSSM and Geno2pheno tools. This virus also had a longer V3 sequence with 37 amino acids, a GRGQ motif, and a methionine residue before it (AIIMS_307). A unique finding was the complete deletion of the V4 region of another virus (AIIMS_363). High sequence diversity was observed in the envelope of the HIV-1-infected Indian children.

authors

Prakash SS,Kalra R,Lodha R,Kabra SK,Luthra K

doi

10.1089/AID.2011.0206

subject

Has Abstract

pub_date

2012-05-01 00:00:00

pages

505-9

issue

5

eissn

0889-2229

issn

1931-8405

journal_volume

28

pub_type

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