Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis.

abstract：:A new syncytia-inducing human immunodeficiency virus type 1 (HIV-1) strain designated PokA79 was first isolated from a peripheral blood mononuclear cells (PBMC) pool from 24 HIV-1-infected patients from Russia and adapted to growth in MT2, MT4, and U937 cell cultures. The full-length genome of this isolate was amplifi...

journal_title：AIDS research and human retroviruses

authors： Galkin AN,Bychenko AB,Kuznecovs G,Filinova EY

更新日期：2012-09-01 00:00:00

abstract：:Laboratory tests that can distinguish recent from long-term HIV infection are used to estimate HIV incidence in a population, but can potentially misclassify a proportion of long-term HIV infections as recent. Correct application of an assay requires determination of the proportion false recents (PFRs) as part of the ...

journal_title：AIDS research and human retroviruses

authors： Shah NS,Duong YT,Le LV,Tuan NA,Parekh BS,Ha HTT,Pham QD,Cuc CTT,Dobbs T,Tram TH,Lien TTX,Wagar N,Yang C,Martin A,Wolfe M,Hien NT,Kim AA

更新日期：2017-06-01 00:00:00

abstract：:Monoclonal antibodies (mAbs) specific for CD4 are potent inhibitors of HIV replication in vitro. These agents may be useful prophylactically or in chronic HIV infection if they can be administered without inducing immunosuppression. In the present study, we explored the safety of a CD4-specific murine mAb in rhesus mo...

journal_title：AIDS research and human retroviruses

authors： Reimann KA,Burkly LC,Burrus B,Waite BC,Lord CI,Letvin NL

更新日期：1993-03-01 00:00:00

abstract：:Studies have shown a low frequency of HIV-1 protease drug resistance mutations in patients failing protease inhibitor (PI)-based therapy. Recent studies have identified mutations in Gag as an alternate pathway for PI drug resistance in subtype B viruses. We therefore genotyped the Gag and protease genes from 20 HIV-1 ...

journal_title：AIDS research and human retroviruses

authors： Giandhari J,Basson AE,Coovadia A,Kuhn L,Abrams EJ,Strehlau R,Morris L,Hunt GM

更新日期：2015-08-01 00:00:00

abstract：:The majority of early cases of HIV in Russia were among men who have sex with men (MSM). Despite this and the current resurgence of HIV among MSM globally, little systematic work has been done to assess current HIV risks. We conducted a rapid assessment of HIV and associated risk behaviors among MSM in Russia. An anon...

journal_title：AIDS research and human retroviruses

authors： Baral S,Sifakis F,Peryskina A,Mogilnii V,Masenior NF,Sergeyev B,Deobald I,Wirtz AL,Beyrer C

更新日期：2012-08-01 00:00:00

abstract：:We describe four full-length genomic sequences of HIV-1 subtype B isolates from Russia. These full-length HIV-1 genomes were amplified by nested polymerase chain reaction and sequenced. The sequences obtained were subjected to neighbor-joining phylogenetic analysis using a Kimura two-parameter model and to detailed se...

journal_title：AIDS research and human retroviruses

authors： Galkin AN,Gagarina EY,Lukyanova NS,Danilova TV

更新日期：2006-11-01 00:00:00

abstract：:We examined risk factors for avascular bone necrosis (AVN) particularly focusing o the question of whether antiretroviral treatment (ART) is associated with the emergence of osteonecrosis. After 11 years of following the entire cohort, 26 patients were found to have AVN. Compared to 260 concurrent HIV-infected control...

journal_title：AIDS research and human retroviruses

authors： Hasse B,Ledergerber B,Egger M,Flepp M,Bachmann S,Bernasconi E,Egger M,Guyot S,Hirschel B,Weber R,Günthard HF,Swiss HIV Cohort Study.

更新日期：2004-09-01 00:00:00

abstract：:HIV infection is a risk factor for the tumorigenesis including non-AIDS-defining cancers such as those of the gastrointestinal tract. However, the mechanisms underlying such cancer outgrowth are still unknown. Furthermore, combined HIV/cancer studies are difficult to evaluate using primate models or in the clinical pa...

journal_title：AIDS research and human retroviruses

authors： Lu R,Wu S,Zhang Y,Xia Y,Huelsmann EJ,Lacek AT,Nabatiyan A,Richards MH,Narasipura SD,Lutgen V,Chen H,Kaufman HL,Chen D,Al-Harthi L,Zloza A,Sun J

更新日期：2014-07-01 00:00:00

abstract：:Many human immunodeficiency virus (HIV) proteins including Tat are produced by HIV-infected astrocytes and secreted into the brain resulting in extensive neuronal damage that contributes to the pathogenesis of HIV dementia. The neuroprotective hormone 17beta-estradiol (E2) is known to negatively regulate the HIV trans...

journal_title：AIDS research and human retroviruses

authors： Heron PM,Turchan-Cholewo J,Bruce-Keller AJ,Wilson ME

更新日期：2009-11-01 00:00:00

abstract：:We examined the sera from 14 HIV-1 seroconverters for the presence of autoantibodies against CD4. Anti-CD4 antibodies were detected in the serum of 11 of 13 HIV-1-infected persons at the time of HIV-1 seroconversion. In 6 of 14 persons from whom a serum was obtained prior to HIV-1 seroconversion, anti-CD4 antibodies w...

journal_title：AIDS research and human retroviruses

authors： Keiser P,Keay S,Wasserman S,Wecksler W

更新日期：1992-11-01 00:00:00

abstract：:Retroviruses have been suggested as possible pathogenic factors in multiple sclerosis (MS), supported by the observation that endogenous retroviruses are activated in MS patients. Different members of the herpes family of which several are neurotropic have also been suggested as factors in MS pathogenesis. Further, in...

journal_title：AIDS research and human retroviruses

authors： Brudek T,Christensen T,Hansen HJ,Bobecka J,Møller-Larsen A

更新日期：2004-04-01 00:00:00

abstract：:In recent years, increasing numbers of patients infected with HIV-1 non-B subtypes have been treated with modern antiretroviral regimens. Therefore, a better knowledge of HIV drug resistance in non-B strains is crucial. Thus, we compared the mutational pathways involved in drug resistance among the most common non-B s...

journal_title：AIDS research and human retroviruses

authors： Santoro MM,Alteri C,Ronga L,Flandre P,Fabeni L,Mercurio F,D'Arrigo R,Gori C,Palamara G,Bertoli A,Forbici F,Salpini R,Boumis E,Tozzi V,Visco-Comandini U,Zaccarelli M,Van Houtte M,Pattery T,Narciso P,Antinori A,Cecc

更新日期：2012-10-01 00:00:00

abstract：:Despite the success of antiretroviral therapy (ART) in decreasing mortality for HIV-1-infected patients, ART has not cured the disease. A persistent viral reservoir in the T cells of HIV patients receiving potent ART is a significant barrier preventing eradication of HIV infection. We will briefly review what is known...

journal_title：AIDS research and human retroviruses

authors： Margolis DM

更新日期：2011-04-01 00:00:00

abstract：:We investigated a strategy for gene therapy, intracellular expression of anti-HIV-1 Rev single-chain variable fragments (SFvs), in promonocytic (U1) and T (ACH-2) cell lines latently infected with HIV-1. The cellular and molecular mechanisms leading to activation of latent integrated HIV-1 provirus in U1 and ACH-2 cel...

journal_title：AIDS research and human retroviruses

authors： Ho WZ,Lai JP,Bouhamdan M,Duan L,Pomerantz RJ,Starr SE

更新日期：1998-11-20 00:00:00

abstract：:Lectins with specificity for terminal mannose residues and anti-mannan antibodies neutralize HIV-1 infection in vitro. This is assumed to be caused by binding of the agents to the viral glycoproteins. In this study we show that one such agent, the Galanthus nivalis lectin (GNA), also blocks infection at the target cel...

journal_title：AIDS research and human retroviruses

authors： Hammar L,Hirsch I,Machado AA,De Mareuil J,Baillon JG,Bolmont C,Chermann JC

更新日期：1995-01-01 00:00:00

abstract：:Information about the efficacy of antiretroviral drugs in HIV-1 group O strains as well on the virus evolution in terms of resistance development in vivo is very limited. We assessed the clinical, immunological, and virological response to antiretroviral therapy as well as the selection of drug resistance in six HIV-1...

journal_title：AIDS research and human retroviruses

authors： Rodes B,de Mendoza C,Rodgers M,Newell A,Jimenez V,Lopez-Brugada RM,Soriano V

更新日期：2005-07-01 00:00:00

abstract：:Similarly to HIV-infected cells, recombinant HIV-1 glycoprotein 120 induces acid-labile interferon production in peripheral blood mononuclear cells from healthy donors. Acid lability of this interferon is due to the presence of both IFN-alpha and -gamma molecules. In fact, although not revealed by neutralization of an...

journal_title：AIDS research and human retroviruses

authors： Capobianchi MR,Ameglio F,Cordiali Fei P,Castilletti C,Mercuri F,Fais S,Dianzani F

更新日期：1993-10-01 00:00:00

abstract：:Current methods to detect intraclade HIV dual infection are poorly suited for determining its prevalence in large cohorts. To investigate the potential of ultra-deep sequencing to screen for dual infection, we compared it to bulk sequence-based synonymous mixture index and the current standard of single genome sequenc...

journal_title：AIDS research and human retroviruses

authors： Pacold M,Smith D,Little S,Cheng PM,Jordan P,Ignacio C,Richman D,Pond SK

更新日期：2010-12-01 00:00:00

abstract：:It is known that the HTLV-I-transformed cell line MT4 releases chemotactic activity for monocytes spontaneously. The MT4 monocyte chemoattractant was purified to homogeneity and sequencing of 25 amino acids revealed identity with the C-C chemokine macrophage inflammatory protein-1 alpha (MIP-1 alpha/LD78). An anti-MIP...

journal_title：AIDS research and human retroviruses

authors： Bertini R,Luini W,Sozzani S,Bottazzi B,Ruggiero P,Boraschi D,Saggioro D,Chieco-Bianchi L,Proost P,van Damme J

更新日期：1995-01-01 00:00:00

abstract：:HIV prevalence in the Limpopo Province has increased rapidly within the past 10 years, as in other parts of South Africa. Little is known about the genetic and biological properties of HIV circulating in this region including the baseline drug resistance profiles. We therefore collected blood samples from 42 HIV-1-inf...

journal_title：AIDS research and human retroviruses

authors： Bessong PO,Larry Obi C,Cilliers T,Choge I,Phoswa M,Pillay C,Papathanasopoulos M,Morris L

更新日期：2005-01-01 00:00:00

abstract：:In order to investigate how human immunodeficiency virus (HIV) gains entry to the placenta, we have performed in vitro experiments in which highly purified trophoblast cells isolated from term human placentas were examined for their susceptibility to HIV infection. Trophoblast cells were exposed to cell-free HIV-1 for...

journal_title：AIDS research and human retroviruses

authors： Douglas GC,Fry GN,Thirkill T,Holmes E,Hakim H,Jennings M,King BF

更新日期：1991-09-01 00:00:00

abstract：:Eosinophils are granulocytic leukocytes that function in both protective and pathological immune responses. They can be infected by HIV-1, but characterization of the infection has been hindered by lack of a productive cell culture model. In the present study, the unique eosinophilic cell line AML14.3D10 was used as a...

journal_title：AIDS research and human retroviruses

authors： Wooley DP,Peterson KT,Taylor RJ,Paul CC,Baumann MA

更新日期：2000-09-20 00:00:00

abstract：:Endothelial progenitor cells (EPCs) repair damaged vascular endothelium, and low circulating EPC levels have been associated with cardiovascular disease (CVD). CD34+/KDR+ EPCs are commonly reported in the literature and CD34+/CD133+/KDR+ EPCs are rare in circulation but highly specific for endothelial lineage. HIV-inf...

journal_title：AIDS research and human retroviruses

authors： Seang S,Kelesidis T,Huynh D,Park S,Moe AA,Currier JS,Lake JE

更新日期：2018-01-01 00:00:00

abstract：:HIV-1 infection causes functional defects in T cells. It also leads to a progressive reduction in numbers of such cells and both CD4+ and CD8+ cells have been reported to undergo apoptosis in culture. A corresponding reduction in B cells has not been described, but these cells are also functionally altered, with repor...

journal_title：AIDS research and human retroviruses

authors： Samuelsson A,Sönnerborg A,Heuts N,Cöster J,Chiodi F

更新日期：1997-08-10 00:00:00

abstract：:We investigated whether V3-binding assays might be useful to analyze human immunodeficiency virus type 1 (HIV-1) variants in different geographic regions. We showed that strong cross-reactivity between subtype-specific V3 peptides is almost inevitable in standard indirect enzyme-linked immunosorbent assays (EIA), impa...

journal_title：AIDS research and human retroviruses

authors： Barin F,Lahbabi Y,Buzelay L,Lejeune B,Baillou-Beaufils A,Denis F,Mathiot C,M'Boup S,Vithayasai V,Dietrich U,Goudeau A

更新日期：1996-09-01 00:00:00

abstract：:Mycophenolate mofetil (MMF), the bioavailable form of mycophenolic acid (MPA), has been proposed as adjuvant therapy for human immunodeficiency virus type 1 (HIV-1) infection. MPA can inhibit viral replication and might blunt virus-induced immunopathology. However, other effects of this inhibitor might be detrimental ...

journal_title：AIDS research and human retroviruses

authors： Kaur R,Klichko V,Margolis D

更新日期：2005-02-01 00:00:00

abstract：:Our goal has been to develop a safe and effective system that would allow us to explore the functions of the human immunodeficiency virus (HIV) envelope. We have generated a human lymphoid cell line (TF228.1.16) that stably expresses functional HIV envelope proteins on its cell surface, and therefore closely mimics th...

journal_title：AIDS research and human retroviruses

authors： Jonak ZL,Clark RK,Matour D,Trulli S,Craig R,Henri E,Lee EV,Greig R,Debouck C

更新日期：1993-01-01 00:00:00

abstract：:Before the introduction of HAART, HIV-associated neurocognitive impairment (NCI) was recognized as an independent risk factor for death. Since 1996, we conducted a prospective study to assess whether NCI still represents a negative prognostic factor for mortality. Patients were administered measures of neurocognitive ...

journal_title：AIDS research and human retroviruses

authors： Tozzi V,Balestra P,Serraino D,Bellagamba R,Corpolongo A,Piselli P,Lorenzini P,Visco-Comandini U,Vlassi C,Quartuccio ME,Giulianelli M,Noto P,Galgani S,Ippolito G,Antinori A,Narciso P

更新日期：2005-08-01 00:00:00

abstract：:The dichotomous effects of the protein kinase C (PKC) modulatory compounds 12-myristate 13-acetate (PMA), prostratin, and ingenol 3-angelate (I3A) on HIV-1 infection were investigated. PKC modulatory compounds were shown to be potent activators of cells latently infected with HIV-1 (I3A > prostratin). Conversely, PKC ...

journal_title：AIDS research and human retroviruses

authors： Warrilow D,Gardner J,Darnell GA,Suhrbier A,Harrich D

更新日期：2006-09-01 00:00:00

abstract：:Dendritic cells (DCs) are important mediators of the immune response against HIV and yet blood DC numbers fall substantially during HIV infection. Here we report that blood levels of the DC-tissue tropic chemokines monocyte chemotactic protein (MCP-1/CCL2), macrophage inflammatory proteins (MIP-3α/CCL20), and MIP-3β/C...

journal_title：AIDS research and human retroviruses

authors： Fontaine J,Poudrier J,Roger M

更新日期：2011-06-01 00:00:00