Spontaneous activation of human immunodeficiency virus type 1 in an immunotoxin-resistant variant T cell line.

abstract：:We previously reported a significant decrease in HIV-1 prevalence, with no increase in drug-resistant HIV-1 among injecting drug users (IDU), female sex workers (FSW), and blood donors (BD), in Haiphong, Vietnam, from 2007 to 2009. In 2012, 388 IDU, 51 FSW, and 200 BD were recruited for further analysis. None had a hi...

journal_title：AIDS research and human retroviruses

authors： Pham HV,Ishizaki A,Nguyen CH,Saina MC,Hoang HT,Tran VT,Bi X,Pham TV,Ichimura H

更新日期：2015-07-01 00:00:00

abstract：:Identifying and monitoring HIV clusters could be useful in tracking the leading edge of HIV transmission in epidemics. Currently, greater specificity in the definition of HIV clusters is needed to reduce confusion in the interpretation of HIV clustering results. We address sampling density as one of the key aspects of...

journal_title：AIDS research and human retroviruses

authors： Novitsky V,Moyo S,Lei Q,DeGruttola V,Essex M

更新日期：2014-12-01 00:00:00

abstract：:Despite the success of antiretroviral therapy (ART) in decreasing mortality for HIV-1-infected patients, ART has not cured the disease. A persistent viral reservoir in the T cells of HIV patients receiving potent ART is a significant barrier preventing eradication of HIV infection. We will briefly review what is known...

journal_title：AIDS research and human retroviruses

authors： Margolis DM

更新日期：2011-04-01 00:00:00

abstract：:Previous studies have suggested that the abilities of human immunodeficiency virus type 1 (HIV-1) to infect primary macrophages and transformed T cell lines are mutually exclusive and define an important biological distinction among HIV-1 strains. In a survey of eight macrophage-tropic HIV-1 strains and nine T cell li...

journal_title：AIDS research and human retroviruses

authors： Chowdhury IH,Potash MJ,Volsky DJ

更新日期：1995-12-01 00:00:00

abstract：:The retroviral integrase protein (IN) is essential for virus replication and, therefore, an attractive target for the development of inhibitors to treat human immunodeficiency virus (HIV) infection. Diverse classes of compounds that are active against this protein have been discovered using in vitro assays. Here we de...

journal_title：AIDS research and human retroviruses

authors： Daniel R,Myers CB,Kulkosky J,Taganov K,Greger JG,Merkel G,Weber IT,Harrison RW,Skalka AM

更新日期：2004-02-01 00:00:00

abstract：:Recombinant forms contribute significantly to the genetic diversity of HIV-1. Here we report a novel HIV-1 recombinant form (CRF01_AE/B'/C) detected from a comprehensive HIV-1 molecular epidemiologic study among heterosexuals in Jilin province of northeastern China. Recombinant analyses of the near full-length genome ...

journal_title：AIDS research and human retroviruses

authors： Li X,Ning C,Chen Y,Feng Y,Wei M,Xing H,Shao Y

更新日期：2014-07-01 00:00:00

abstract：:Endothelial progenitor cells (EPCs) repair damaged vascular endothelium, and low circulating EPC levels have been associated with cardiovascular disease (CVD). CD34+/KDR+ EPCs are commonly reported in the literature and CD34+/CD133+/KDR+ EPCs are rare in circulation but highly specific for endothelial lineage. HIV-inf...

journal_title：AIDS research and human retroviruses

authors： Seang S,Kelesidis T,Huynh D,Park S,Moe AA,Currier JS,Lake JE

更新日期：2018-01-01 00:00:00

abstract：:Phylogenetic analysis of partial env sequences of HIV-1 isolates from Cyprus and Greece suggested the existence of a distinct subtype of the virus, designated as I. We examined whether this subtype represents a distinct group, or a mosaic consisting of previously characterized subtypes. The full-length sequences under...

journal_title：AIDS research and human retroviruses

authors： Nasioulas G,Paraskevis D,Magiorkinis E,Theodoridou M,Hatzakis A

更新日期：1999-05-20 00:00:00

abstract：:Pathogenic microorganisms encode proteins that antagonize specific aspects of innate or adaptive immunity. Just as the study of the HIV-1 accessory protein Vif led to the identification of cellular cytidine deaminases as host defense proteins, the study of HIV-1 Vpu recently led to the discovery of the interferon-indu...

journal_title：AIDS research and human retroviruses

authors： Tokarev A,Skasko M,Fitzpatrick K,Guatelli J

更新日期：2009-12-01 00:00:00

abstract：:HIV patients beginning antiretroviral therapy (ART) with advanced immunodeficiency often retain low CD4+ T cell counts despite virological control. We examined proliferative responses and upregulation of costimulatory molecules, following anti-CD3 stimulation, in HIV patients with persistent CD4+ T cell deficiency on ...

journal_title：AIDS research and human retroviruses

authors： Tanaskovic S,Price P,French MA,Fernandez S

更新日期：2017-02-01 00:00:00

abstract：:Nucleoside analog-associated sensory neuropathy (NRTI-SN) attributed to stavudine, didanosine, or zalcitabine (the dNRTIs) and distal sensory polyneuropathy (DSP) attributed to HIV are clinically indistinguishable. As inflammatory cytokines are involved in DSP, we addressed a role for inflammation in NRTI-SN by determ...

journal_title：AIDS research and human retroviruses

authors： Cherry CL,Rosenow A,Affandi JS,McArthur JC,Wesselingh SL,Price P

更新日期：2008-02-01 00:00:00

abstract：:The feasibility and effectiveness of a hospital-based exercise-training program followed by a home-based program for improving fitness, strength, and changes in body composition in children and adolescents with HIV were evaluated. Subjects participated in nonrandomized 24-session, hospital supervised exercise training...

journal_title：AIDS research and human retroviruses

authors： Miller TL,Somarriba G,Kinnamon DD,Weinberg GA,Friedman LB,Scott GB

更新日期：2010-03-01 00:00:00

abstract：:Despite dramatic reduction of the levels of human immunodeficiency virus type I (HIV-1) virions in blood and seminal plasma of infected patients, highly active antiretroviral therapy (HAART) does not eradicate HIV-1. Three patients, with less than 50 copies/ml of plasma viral RNA, were enrolled in this eradication pro...

journal_title：AIDS research and human retroviruses

authors： Nunnari G,Leto D,Sullivan J,Xu Y,Mehlman KE,Kulkosky J,Pomerantz RJ

更新日期：2005-09-01 00:00:00

abstract：:The antiretroviral (ARV) service at Edendale Hospital in Pietermaritzburg, KwaZulu-Natal, South Africa has initiated more than 9,000 adults on therapy since 2004; however, virological outcomes among this patient cohort have not been systematically assessed. We conducted a retrospective chart review of patients initiat...

journal_title：AIDS research and human retroviruses

authors： Costiniuk CT,Sigal A,Jenabian MA,Nijs P,Wilson D

更新日期：2014-06-01 00:00:00

abstract：:HIV-1 and HTLV-1 infect CD4(+) T lymphocyte but little is known about the impact of coinfection on patient's immune response. In this study we have evaluated the spontaneous production of interleukin (IL)-2, IL-4, IL-6, and IL-10 and interferon (IFN)-γ by unstimulated peripheral blood mononuclear cell (PBMC) cultures ...

journal_title：AIDS research and human retroviruses

authors： Abrahão MH,Lima RG,Netto E,Brites C

更新日期：2012-08-01 00:00:00

abstract：:We sought to predict virus coreceptor utilization using a simple bioinformatics method based on genotypic analysis of human immunodeficiency virus types 1 (HIV-1) env V3 loop sequences of 28 infected but drug-naive women during pregnancy and their infected infants and to better understand coreceptor usage in vertical ...

journal_title：AIDS research and human retroviruses

authors： Duri K,Soko W,Gumbo F,Kristiansen K,Mapingure M,Stray-Pedersen B,Muller F,BHAMC Group.

更新日期：2011-04-01 00:00:00

abstract：:Women are now becoming the pivot of the epidemiological spread of HIV infection worldwide, especially in developing countries. Therefore, research to develop an efficient microbicide is now a priority for the prevention of HIV-1 acquisition in exposed women. However, recent disappointing failures in microbicide clinic...

journal_title：AIDS research and human retroviruses

authors： Saidi H,Jenabian MA,Belec L

更新日期：2012-11-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) infection has altered both the epidemiology and outcome of enteric opportunistic parasitic infections. This study was done to determine the prevalence and species/genotypes of intestinal coccidian and microsporidial infections among HIV/AIDS patients with diarrhea and/or a history of...

journal_title：AIDS research and human retroviruses

authors： Agholi M,Hatam GR,Motazedian MH

更新日期：2013-01-01 00:00:00

abstract：:A previously described self-complementary oligodeoxynucleotide termed triplex-forming oligodeoxynucleotide (TFO A), 54 bases in length, designed against the polypurine tract of HIV-1 RNA, inhibited viral replication at a 1 to 3 microM concentration in acutely infected cells, whereas antisense and scrambled sequence ol...

journal_title：AIDS research and human retroviruses

authors： Jendis J,Strack B,Volkmann S,Böni J,Mölling K

更新日期：1996-08-10 00:00:00

abstract：:Stavudine (d4T) has been associated with lipoatrophy and hyperlactatemia. In recent studies, d4T has also been related to both hypercholesterolemia and hypertriglyceridemia. Replacing d4T with another nucleoside analogue such as abacavir (ABC) may reduce lactate levels and improve lipoatrophy in the long term. However...

journal_title：AIDS research and human retroviruses

authors： García-Benayas T,Blanco F,Alcolea A,Cruz JJ,González-Lahoz J,Soriano V

更新日期：2004-12-01 00:00:00

abstract：:Diversity of genotypes and prevalence of pretreatment drug resistance (PDR) are challenges for the epidemic control and vaccine development of HIV-1. However, little is known about the situation in Tianjin. Blood samples were collected from newly diagnosed, antiretroviral treatment (ART)-naive HIV/AIDS patients from J...

journal_title：AIDS research and human retroviruses

authors： Zeng R,Ren D,Gong X,Wei M,Gao L,Yu A,Zhang D,Mi Y,Ma P

更新日期：2020-10-01 00:00:00

abstract：:During HIV-1 infection, distinct biological phenotypes are observed between R5 and X4 HIV-1 strains with respect to pathogenicity and tropism. In this study, temporal changes of the expression levels of the complete human transcriptome, representing 47,000 well-characterized human transcripts, were monitored in the fi...

journal_title：AIDS research and human retroviruses

authors： Sirois M,Robitaille L,Sasik R,Estaquier J,Fortin J,Corbeil J

更新日期：2008-03-01 00:00:00

abstract：:We have evaluated the genetic diversity of HIV-1 strains infecting injecting drug users (IDUs) in Lisbon, Portugal. Heteroduplex mobility assay and/or phylogenetic analysis revealed that env (C2V3C3 or gp41) subtype B is present in 63.7% of the 135 viral samples studied, followed by subtypes G (23.7%), A (6.7%), F (5....

journal_title：AIDS research and human retroviruses

authors： Esteves A,Parreira R,Piedade J,Venenno T,Franco M,Germano de Sousa J,Patrício L,Brum P,Costa A,Canas-Ferreira WF

更新日期：2003-06-01 00:00:00

abstract：:Changes in neutralizing antibody (NA) titers in stored sera collected over 5 years from 10 participants in the Multicenter AIDS Cohort Study (MACS) were evaluated. The participants were HIV-1 infected on enrollment in the MACS, and remained AIDS free during the 5-year study interval. Seven viruses derived from molecul...

journal_title：AIDS research and human retroviruses

authors： Quinnan GV Jr,Zhang PF,Fu DW,Dong M,Margolick JB

更新日期：1998-07-20 00:00:00

abstract：:Abstract Multiple HIV-1 subtypes and circulating recombinant forms (CRFs) are known to cocirculate in Africa. In West Africa, the high prevalence of CRF02_AG, and cocirculation of subtype A, CRF01_AE, CRF06_cpx, and other complex intersubtype recombinants has been well documented. Mali, situated in the heart of West A...

journal_title：AIDS research and human retroviruses

authors： Imamichi H,Koita O,Dabitao D,Dao S,Ibrah M,Sogoba D,Dewar RL,Berg SC,Jiang MK,Parta M,Washington JA,Polis MA,Lane HC,Tounkara A

更新日期：2009-01-01 00:00:00

abstract：:Cross-sectional estimation of HIV incidence could misclassify some established or chronic HIV infections as recent. Usually long-term nonprogressors, elite and viremic controllers, and individuals on ART contribute to misclassification. Local data on the false recent rate (FRR) could minimize misclassification during ...

journal_title：AIDS research and human retroviruses

authors： Moyo S,Kotokwe KP,Mohammed T,Boleo C,Mupfumi L,Chishala S,Tsalaile L,Bussmann H,Gaseitsiwe S,Musonda R,Makhema J,Baum M,Marlink R,Engelbrecht S,Essex M,Novitsky V

更新日期：2017-01-01 00:00:00

abstract：:Entry inhibitor is a new class of drugs that target the viral envelope protein. This region is variable; hence resistance to these drugs may be present before treatment. The aim of this study was to analyze the frequency of patients failing treatment with transcriptase reverse and protease inhibitors that would respon...

journal_title：AIDS research and human retroviruses

authors： Alencar CS,Nishiya AS,Ferreira S,Giret MT,Diaz RS,Sabino EC

更新日期：2010-12-01 00:00:00

abstract：:Liver enzyme elevations are frequently seen in patients treated with nevirapine (NVP). Both elevated NVP plasma levels and hepatitis C virus (HCV) infection seem to favor the development of NVP-related liver toxicity. We have examined variation on NVP C(trough) over time, as well as the impact of NVP C(trough) concent...

journal_title：AIDS research and human retroviruses

authors： De Requena DG,Jiménez-Nácher I,Soriano V

更新日期：2005-06-01 00:00:00

abstract：:Up to now, all known env subtype E viruses (CRF01-AE) have had the same mosaic structure with subtype A, and no other env subtype E HIV-1 viruses with non-A subtypes in their genomes have been described. In this report we describe the full-length genome sequence of an env subtype E isolate with a recombinant genome di...

journal_title：AIDS research and human retroviruses

authors： Vidal N,Mulanga-Kabeya C,Nzilambi N,Delaporte E,Peeters M

更新日期：2000-12-10 00:00:00

abstract：:Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) replicate during acute infection in lymphocytes of the gastrointestinal tract, before disseminating systemically. Localized replication and associated loss of gut-resident CD4+ T cells occur regardless of the portal of entry of the virus (e.g.,...

journal_title：AIDS research and human retroviruses

authors： Méndez-Lagares G,Lu D,Merriam D,Baker CA,Villinger F,Van Rompay KKA,McCune JM,Hartigan-O'Connor DJ

更新日期：2017-11-01 00:00:00