Short communication: benefits in the lipid profile after substitution of abacavir for Stavudine: a 48-week prospective study.

abstract：:The silent period that follows infection by the human immunodeficiency virus (HIV-1) and precedes seroconversion remains a problem for the screening of blood supply, and knowledge about the mechanism involved in the maintenance of latency is only fragmentary. Using purified nef recombinant protein and six synthetic ne...

journal_title：AIDS research and human retroviruses

authors： Ameisen JC,Guy B,Chamaret S,Loche M,Mouton Y,Neyrinck JL,Khalife J,Leprevost C,Beaucaire G,Boutillon C

更新日期：1989-06-01 00:00:00

abstract：:The long-term efficacy of once-daily (qd) fosamprenavir (FPV) 1400 mg boosted by ritonavir 100 mg (FPV/r100) has not been evaluated previously. A 96-week open-label, randomized, multicenter study compared the efficacy/safety of FPV/r100 with FPV 1400 mg boosted by ritonavir 200 mg qd (FPV/r200), plus abacavir/lamivudi...

journal_title：AIDS research and human retroviruses

authors： Hicks CB,DeJesus E,Sloan LM,Sension MG,Wohl DA,Liao Q,Ross LL,Pakes GE,Pappa KA,Lancaster CT,COL100758 Study Team.

更新日期：2009-04-01 00:00:00

abstract：:In Taiwan, sexual transmission is responsible for most HIV-1 infections with two dominant subtypes, subtype B and CRF01_AE, distributing among homosexual and heterosexual groups, respectively. Recently, intravenous drug use has become an emerging route of HIV-1 transmission and contributed to a significant increase of...

journal_title：AIDS research and human retroviruses

authors： Chang SY,Sheng WH,Lee CN,Sun HY,Kao CL,Chang SF,Liu WC,Yang JY,Wong WW,Hung CC,Chang SC

更新日期：2006-11-01 00:00:00

abstract：:Although Cameroon, in west central Africa, has a relatively low HIV prevalence of 5-6%, all HIV-1 groups (M, N, O, and P), nearly all HIV-1 group M subtypes, and numerous intersubtype recombinant forms have been identified in Cameroon. In this report, we describe the near full-length sequence of 04CMU11421, an HIV-1 g...

journal_title：AIDS research and human retroviruses

authors： Yamaguchi J,Vallari A,Ngansop C,Makamche F,Ndembi N,Mbanya D,Kaptué L,Gürtler LG,Devare SG,Brennan CA

更新日期：2010-06-01 00:00:00

abstract：:Patients with HIV-1 and human T-lymphotropic virus type 2 (HTLV-2) coinfections often exhibit a clinical course similar to that seen in HIV-1-infected individuals who are long-term nonprogressors. These findings have been attributed in part to the ability of HTLV-2 to activate production of antiviral chemokines and to...

journal_title：AIDS research and human retroviruses

authors： Barrios CS,Castillo L,Giam CZ,Wu L,Beilke MA

更新日期：2013-07-01 00:00:00

abstract：:Serum samples collected prospectively between 1982 and 1987 from a cohort of homosexual men were analyzed for HIV-1 neutralizing antibodies. Seven seroconverters who became infected between 1982 and 1984 and 12 seroprevalents who were already seropositive in 1982 remained free of AIDS. During the 6 year period, 1 sero...

journal_title：AIDS research and human retroviruses

authors： Robert-Guroff M,Goedert JJ,Naugle CJ,Jennings AM,Blattner WA,Gallo RC

更新日期：1988-10-01 00:00:00

abstract：:We investigated memory cytotoxic T lymphocyte (CTLm) responses to HIV-1 as a determinant of HIV-1 disease progression, in relation to plasma HIV-1 load and T lymphocyte numbers in a longitudinal study of 14 homosexual men with incident HIV-1 infection. Study participants were selected who exhibited failure of T cell h...

journal_title：AIDS research and human retroviruses

authors： Rinaldo CR Jr,Gupta P,Huang XL,Fan Z,Mullins JI,Gange S,Farzadegan H,Shankarappa R,Muñoz A,Margolick JB

更新日期：1998-11-01 00:00:00

abstract：:Simian AIDS-related lymphomas (sARL) of cynomolgus monkeys infected with a simian immunodeficiency virus (SIVsm) were studied in relation to growth in severe combined immunodeficient (SCID) mice, karyotype abnormalities, and DNA sequence of the first noncoding region of the Bcl-6 gene. The tumors were diffuse large B ...

journal_title：AIDS research and human retroviruses

authors： Castaños-Vélez E,Heiden T,Lindvall C,Capello D,Sandlund A,Imreh S,Blennow E,Andersson LC,Gaidano G,Nordenskjöld M,Biberfeld P

更新日期：2002-03-20 00:00:00

abstract：:Population genotyping (PG) can underestimate resistance if resistance-containing low abundance variants go undetected. PG and clonal analysis (CA) results were compared in virologic failures (VFs) from a 48-week clinical trial that evaluated once-daily fosamprenavir/ritonavir (FPV/r) 1400 mg/100 mg or atazanavir/riton...

journal_title：AIDS research and human retroviruses

authors： Ross LL,Weinberg WG,DeJesus E,Fischl MA,Horton JH,Pappa KA,Lancaster CT,Pakes GE,Smith KY

更新日期：2010-04-01 00:00:00

abstract：:HIV-1 Nef (Nef) is a myristoylated protein that contributes to HIV disease pathogenesis. Nef has a modulatory effect on T cell receptor (TCR) signaling, resulting in up-regulation of interleukin-2 (IL-2) production in stimulated T cells. Recent studies have shown that efficient TCR signaling requires enhanced associat...

journal_title：AIDS research and human retroviruses

authors： Djordjevic JT,Schibeci SD,Stewart GJ,Williamson P

更新日期：2004-05-01 00:00:00

abstract：:Jurkat cells stably expressing high levels of the HIV-1 Tat protein were generated after transfection with an Epstein-Barr virus-based episomal replicon and selection in hygromycin B. The Jurkat Tat transfectants exhibited a longer doubling time when compared to Jurkat cells or Jurkat cells transfected with the contro...

journal_title：AIDS research and human retroviruses

authors： Purvis SF,Jacobberger JW,Sramkoski RM,Patki AH,Lederman MM

更新日期：1995-04-01 00:00:00

abstract：:DC-SIGN, a C-type lection expressed on dendritic cells, enhances HIV-1 infection in cis and in trans. HIV-1 circulating recombinant form (CRF) 07_BC viruses have been the predominant strain found among injection drug users in southern China and Taiwan. The goal of this study was to map the DC-SIGN-interactive domain o...

journal_title：AIDS research and human retroviruses

authors： Liao CF,Wang SF,Lin YT,Ho DD,Chen YM

更新日期：2011-08-01 00:00:00

abstract：:A higher functionality of CD8(+) T cells might contribute to low-level HIV replication in long-term nonprogressors (LTNPs). However, the contrary could also be true, being the function of CD8(+) T cells modulated by HIV replication. We tested whether enhanced HIV replication following antiretroviral therapy interrupti...

journal_title：AIDS research and human retroviruses

authors： López M,Rallón N,Soriano V,Rodríguez I,Valencia E,Labarga P,Moreno V,Vispo E,Roncal F,González-Lahoz J,Benito JM

更新日期：2008-09-01 00:00:00

abstract：:The dichotomous effects of the protein kinase C (PKC) modulatory compounds 12-myristate 13-acetate (PMA), prostratin, and ingenol 3-angelate (I3A) on HIV-1 infection were investigated. PKC modulatory compounds were shown to be potent activators of cells latently infected with HIV-1 (I3A > prostratin). Conversely, PKC ...

journal_title：AIDS research and human retroviruses

authors： Warrilow D,Gardner J,Darnell GA,Suhrbier A,Harrich D

更新日期：2006-09-01 00:00:00

abstract：:Diversity of genotypes and prevalence of pretreatment drug resistance (PDR) are challenges for the epidemic control and vaccine development of HIV-1. However, little is known about the situation in Tianjin. Blood samples were collected from newly diagnosed, antiretroviral treatment (ART)-naive HIV/AIDS patients from J...

journal_title：AIDS research and human retroviruses

authors： Zeng R,Ren D,Gong X,Wei M,Gao L,Yu A,Zhang D,Mi Y,Ma P

更新日期：2020-10-01 00:00:00

abstract：:Maraviroc (MVC) is licensed in clinical practice for patients with R5 virus and virological failure; however, in anecdotal reports, dual/mixed viruses were also inhibited. We retrospectively evaluated the evolution of HIV-1 coreceptor tropism in plasma and peripheral blood mononuclear cells (PBMCs) of an infected adol...

journal_title：AIDS research and human retroviruses

authors： Cavarelli M,Mainetti L,Pignataro AR,Bigoloni A,Tolazzi M,Galli A,Nozza S,Castagna A,Sampaolo M,Boeri E,Scarlatti G

更新日期：2014-12-01 00:00:00

abstract：:Transcriptional regulation is critical for the human immunodeficiency virus 1 (HIV-1) life cycle and is the only step at which the virus amplifies the content of its genetic information. Numerous known and still unknown transcriptional factors, both host and viral, regulate HIV-1 gene expression and latency. This arti...

journal_title：AIDS research and human retroviruses

authors： Victoriano AF,Okamoto T

更新日期：2012-02-01 00:00:00

abstract：:New HIV infections among younger men who have sex with men (MSM) in the United States are escalating. Data on HIV infections in college students are limited. In 2010, three MSM college students presented to our clinic with primary HIV infection (PHI) in a single month. To determine the number of college students among...

journal_title：AIDS research and human retroviruses

authors： Chan PA,Kazi S,Rana A,Blazar I,Dejong CC,Mayer KH,Huard TK,Carleton K,Gillani F,Alexander N,Parillo Z,Flanigan TP,Kantor R

更新日期：2013-01-01 00:00:00

abstract：:The surface molecule CD4 plays a key role in initiating cellular entry by the human immunodeficiency virus type 1 (HIV-1), and it is now recognized as acting synergistically with select chemokine receptors (coreceptors) in the infection process. The present study was undertaken to determine whether the extracellular r...

journal_title：AIDS research and human retroviruses

authors： Esser U,Speck RF,Deen KC,Atchison RE,Sweet R,Goldsmith MA

更新日期：2000-11-20 00:00:00

abstract：:Currently, complex HIV-1 recombinations among the B', C, and CRF01_AE genotypes have frequently arisen in Yunnan, China. A novel HIV-1 complex circulating recombinant form (CRF) consisting of B', C, and CRF01_AE (CRF96_cpx) was recently characterized from three epidemiologically unlinked individuals. Two strains of th...

journal_title：AIDS research and human retroviruses

authors： Miao J,Ran J,Song Y,Liu Y,Gao L,Miao Z,Zhang C,Feng Y,Xia X

更新日期：2018-04-01 00:00:00

abstract：:Data reporting sexually transmitted infection (STI) incidence rates among HIV-negative U.S. men who have sex with men (MSM) are lacking. In addition, it is difficult to analyze the effect of STI on HIV acquisition given that sexual risk behaviors confound the relationship between bacterial STIs and incident HIV. The I...

journal_title：AIDS research and human retroviruses

authors： Kelley CF,Vaughan AS,Luisi N,Sanchez TH,Salazar LF,Frew PM,Cooper HL,Diclemente R,del Rio C,Sullivan PS,Rosenberg ES

更新日期：2015-06-01 00:00:00

abstract：:Both chronic hepatitis C and nevirapine (NVP) use are risk factors for transaminase elevation under highly active antiretroviral therapy. NVP is metabolized in the liver and its clearance could be altered in the presence of chronic hepatitis C virus (HCV) infection, enhancing the risk of liver toxicity. We examined NV...

journal_title：AIDS research and human retroviruses

authors： Núñez M,González-Requena D,González-Lahoz J,Soriano V

更新日期：2003-03-01 00:00:00

abstract：:A novel prophylactic AIDS vaccine candidate, consisting of single-stranded DNA for HIV-1 subtype C gag, protease, and part of reverse transcriptase genes, enclosed within a recombinant adeno-associated virus serotype-2 protein capsid (tgAAC09) induced T cell responses and antibodies in nonhuman primates. In this rando...

journal_title：AIDS research and human retroviruses

authors： Mehendale S,van Lunzen J,Clumeck N,Rockstroh J,Vets E,Johnson PR,Anklesaria P,Barin B,Boaz M,Kochhar S,Lehrman J,Schmidt C,Peeters M,Schwarze-Zander C,Kabamba K,Glaunsinger T,Sahay S,Thakar M,Paranjape R,Gilmour J,

更新日期：2008-06-01 00:00:00

abstract：:HIV-1 compartmentalization in the central nervous system (CNS) and its contribution to neurological disease have been well documented. Previous studies were conducted among people infected with subtypes B or C where CNS compartmentalization has been observed when comparing viral sequences in the blood to virus in cere...

journal_title：AIDS research and human retroviruses

authors： Adewumi OM,Dukhovlinova E,Shehu NY,Zhou S,Council OD,Akanbi MO,Taiwo B,Ogunniyi A,Robertson K,Kanyama C,Hosseinipour MC,Swanstrom R

更新日期：2020-06-01 00:00:00

abstract：:HIV patients beginning antiretroviral therapy (ART) with advanced immunodeficiency often retain low CD4+ T cell counts despite virological control. We examined proliferative responses and upregulation of costimulatory molecules, following anti-CD3 stimulation, in HIV patients with persistent CD4+ T cell deficiency on ...

journal_title：AIDS research and human retroviruses

authors： Tanaskovic S,Price P,French MA,Fernandez S

更新日期：2017-02-01 00:00:00

abstract：:Dendritic cells (DCs) are important mediators of the immune response against HIV and yet blood DC numbers fall substantially during HIV infection. Here we report that blood levels of the DC-tissue tropic chemokines monocyte chemotactic protein (MCP-1/CCL2), macrophage inflammatory proteins (MIP-3α/CCL20), and MIP-3β/C...

journal_title：AIDS research and human retroviruses

authors： Fontaine J,Poudrier J,Roger M

更新日期：2011-06-01 00:00:00

abstract：:HIV inhibitors targeted at the virus-associated reverse transcriptase (RT) can be divided into two groups, depending on whether they are targeted at the substrate or nonsubstrate binding site. To the first group belong the 2',3'-dideoxynucleosides (i.e., DDC, DDI), 3'-azido-2',3'-dideoxynucleosides (i.e., AZT), 3'-flu...

journal_title：AIDS research and human retroviruses

authors： De Clercq E

更新日期：1992-02-01 00:00:00

abstract：:We describe four full-length genomic sequences of HIV-1 subtype B isolates from Russia. These full-length HIV-1 genomes were amplified by nested polymerase chain reaction and sequenced. The sequences obtained were subjected to neighbor-joining phylogenetic analysis using a Kimura two-parameter model and to detailed se...

journal_title：AIDS research and human retroviruses

authors： Galkin AN,Gagarina EY,Lukyanova NS,Danilova TV

更新日期：2006-11-01 00:00:00

abstract：:Little is known about the consequences of short cycles of structured treatment interruption or definitive interruption of HAART for both T cell subset dynamics and T lymphoproliferative responses (LPR). Immunological follow-up was performed in 45 early chronical HIV-1-infected patients during short STI cycles during t...

journal_title：AIDS research and human retroviruses

authors： Libois A,López A,Garcia F,Castro P,Maleno MJ,García A,Climent N,Arnedo M,Gallart T,Gatell JM,Plana M

更新日期：2006-07-01 00:00:00

abstract：:Anti-HIV-1-specific T cell responses in early HIV-1 infection have been found to be important in deciding the course of disease progression. But there are few data concerning nonsubtype B HIV infection. HIV-1 subtype C is the most prevalent subtype in India. HIV-1 Gag-specific T cell responses in 12 Indian subjects wi...

journal_title：AIDS research and human retroviruses

authors： Thakar MR,Patke D,Lakhashe SK,Bhonge L,Kulkarni SV,Tripathy SP,Gupte N,Brookmeyer R,Quinn TC,Paranjape RS,Bollinger RC

更新日期：2002-12-10 00:00:00