Short communication: interactions between nevirapine plasma levels, chronic hepatitis C, and the development of liver toxicity in HIV-infected patients.

abstract：:The retroviral integrase protein (IN) is essential for virus replication and, therefore, an attractive target for the development of inhibitors to treat human immunodeficiency virus (HIV) infection. Diverse classes of compounds that are active against this protein have been discovered using in vitro assays. Here we de...

journal_title：AIDS research and human retroviruses

authors： Daniel R,Myers CB,Kulkosky J,Taganov K,Greger JG,Merkel G,Weber IT,Harrison RW,Skalka AM

更新日期：2004-02-01 00:00:00

abstract：:Myeloid dendritic cells (mDCs) are essential for initiation of adaptive immune responses but are depleted in HIV infection. Evidence suggests that apoptosis mediates loss, and to further understand the pathways involved, expression of caspases mediating apoptosis via the extrinsic and intrinsic pathways was analyzed. ...

journal_title：AIDS research and human retroviruses

authors： Chen J,Benlahrech A,Kelleher P,Patterson S

更新日期：2013-04-01 00:00:00

abstract：:A model system was established for studies of humoral and cellular immunity to human immunodeficiency virus (HIV) antigens after vaccination. Macaques (Macaca fascicularis) were immunized with purified HIV, an infected cell extract rich in gp120 or polypeptides of cloned genes representing parts of p24, gp41, and gp12...

journal_title：AIDS research and human retroviruses

authors： Wahren B,Chiodi F,Ljunggren K,Putney S,Kurth R,Gallo RC,Fenyö EM

更新日期：1988-06-01 00:00:00

abstract：:We previously reported that passive transfer of a murine V3-specific monoclonal antibody (BAT123) to hu-PBL-SCID mice challenged with HIV-1LAI confers postexposure protection from infection. The role of the Fc fragment of this antibody as well as the involvement of the complement system in protection were evaluated in...

journal_title：AIDS research and human retroviruses

authors： Gauduin MC,Weir R,Fung MS,Koup RA

更新日期：1998-02-10 00:00:00

abstract：:HIV-1 Vif, Vpr, and Vpu proteins have a profound effect on efficient viral replication and pathogenesis. This study describes the genotypic characterisation of vif , vpr and vpu from 20 South African HIV-1 subtype C primary isolates, and extensive analysis and comparison of known motifs. All HIV-1 subtype C Vif, Vpr a...

journal_title：AIDS research and human retroviruses

authors： Bell CM,Connell BJ,Capovilla A,Venter WD,Stevens WS,Papathanasopoulos MA

更新日期：2007-02-01 00:00:00

abstract：:Although the effect of highly active antiretroviral therapy (HAART) on HIV-1 replication has been established, the mechanisms involved in restoration of immune responses and reconstitution remain unknown. This study provides evidence of changes in expression of type 1 and type 2 cytokine-specific mRNA occurring during...

journal_title：AIDS research and human retroviruses

authors： Imami N,Antonopoulos C,Hardy GA,Gazzard B,Gotch FM

更新日期：1999-11-20 00:00:00

abstract：:In many countries, HIV testing among tuberculosis (TB) patients is recommended so that both infections are appropriately treated. Cross-reacting antibodies to HIV antigens have been reported for several conditions, including TB, leprosy, malaria, and rheumatoid arthritis. To study the pattern and prevalence of cross-r...

journal_title：AIDS research and human retroviruses

authors： Swaminathan S,Hanna LE,Sundaramurthi JC,Leonard A,Angayarkanni B,Francis AC,Lakshmi S,Nayak K

更新日期：2008-07-01 00:00:00

abstract：:Transmission of HIV-1 and drug resistance continue to occur at a considerable level in Italy, influenced mainly by changes in modality of infection. However, the long period of infectivity makes difficult the interpretation of epidemiological networks, based on epidemiological data only. We studied 510 naive HIV-1-inf...

journal_title：AIDS research and human retroviruses

authors： Lai A,Violin M,Ebranati E,Franzetti M,Micheli V,Gismondo MR,Capetti A,Meraviglia P,Simonetti FR,Bozzi G,Ciccozzi M,Galli M,Zehender G,Balotta C

更新日期：2012-08-01 00:00:00

abstract：:Lymphoid tissues are the focus of critical events in HIV pathogenesis. Persistent and high levels of virus production, extensive trapping of virus particles in germinal centers, and progressive degenerative changes in lymph node architecture are characteristics of progressive HIV-1 infection. Infiltrates of granzyme B...

journal_title：AIDS research and human retroviruses

authors： Koopman G,Haaksma AG,ten Velden J,Hack CE,Heeney JL

更新日期：1999-03-01 00:00:00

abstract：:HIV-1 disease is associated with many infectious and neoplastic complications. This is particularly true of the genitourinary tract, where high rates of renal disease, neoplasms, voiding and erectile dysfunction, hematuria, opportunistic genitourinary infections, and epididymo-orchitis are found in HIV-1-infected indi...

journal_title：AIDS research and human retroviruses

authors： Coburn M

更新日期：1998-04-01 00:00:00

abstract：:In order to obtain more information about the presence of HIV-1 in mononuclear cells of colostrum, research was carried out on both the HIV-1 genome in the cellular fraction of colostrum and the viral antibody in cell-free colostrum of eight anti-HIV-1 seropositive asymptomatic mothers. In five cases cell fractions of...

journal_title：AIDS research and human retroviruses

authors： Vonesch N,Sturchio E,Humani AC,Cordiali Fei P,Cosenza D,Caprilli F,Pezzella M

更新日期：1992-07-01 00:00:00

abstract：:In a set of 42 antiretroviral naive HIV-1 infected persons who were treated with either Zidovudine (AZT) monotherapy, or a combination of AZT + ddC (Zalcitabine) or AZT + ddI (Didanosine), the HIV-1 DNA load was measured by competitive polymerase chain reaction (PCR) and related to the HIV-1 RNA load in plasma, the CD...

journal_title：AIDS research and human retroviruses

authors： Bruisten SM,Reiss P,Loeliger AE,van Swieten P,Schuurman R,Boucher CA,Weverling GJ,Huisman JG

更新日期：1998-08-10 00:00:00

abstract：:The presence of transmitted drug-resistant HIV-1 (TDR) at the time of antiretroviral therapy (ART) initiation is associated with failure to achieve viral load suppression. Rates of TDR in ART-naive patients have been reported from various parts of the world through ongoing national, regional, and global evaluations; h...

journal_title：AIDS research and human retroviruses

authors： MacVeigh MS,Kosmetatos MK,McDonald JE,Reeder JL,Parrish DA,Young TP

更新日期：2013-02-01 00:00:00

abstract：:Elite controllers or suppressors (ES) are HIV-1-infected patients who maintain viral loads of <50 copies/ml without antiretroviral therapy. While HLA-B*57 and B*5801 alleles are overrepresented in ES, many HLA-B*57/B*5801 patients become chronic progressors (CP). We show here that HIV-1 infection results in similar le...

journal_title：AIDS research and human retroviruses

authors： Sampah ME,Ceccato CM,Blankson JN

更新日期：2011-02-01 00:00:00

abstract：:HIV-1 transcripts are generated through a complex alternative splicing mechanism, resulting in the production of multiple RNAs coding for each viral protein. HIV-1 RNA splicing has been analyzed mostly in in vitro assays, and in vivo data are scarce. Here we analyze HIV-1 transcripts generated in peripheral blood mono...

journal_title：AIDS research and human retroviruses

authors： Carrera C,Pinilla M,Pérez-Alvarez L,Thomson MM

更新日期：2010-07-01 00:00:00

abstract：:We investigated whether V3-binding assays might be useful to analyze human immunodeficiency virus type 1 (HIV-1) variants in different geographic regions. We showed that strong cross-reactivity between subtype-specific V3 peptides is almost inevitable in standard indirect enzyme-linked immunosorbent assays (EIA), impa...

journal_title：AIDS research and human retroviruses

authors： Barin F,Lahbabi Y,Buzelay L,Lejeune B,Baillou-Beaufils A,Denis F,Mathiot C,M'Boup S,Vithayasai V,Dietrich U,Goudeau A

更新日期：1996-09-01 00:00:00

abstract：:Extensive studies have been carried out on native Amerindian populations living in French Guiana in an attempt to detect human T cell leukemia virus type 2 (HTLV-2). However, the first strain of this virus identified in this region was not detected in these populations, but in a Brazilian woman of Amerindian origin. C...

journal_title：AIDS research and human retroviruses

authors： Kazanji M,Benoit B,Meddeb M,Meertens L,Marty C,Gessain A,Talarmin A

更新日期：2001-04-10 00:00:00

abstract：:The structure of the Vpu protein of human immunodeficiency virus type 1 (HIV-1) is composed of a short Nterminal domain (NTD), a transmembrane domain (TM), and a cytoplasmic domain (CD). Previous studies have shown that the Vpu protein from subtype B HIV-1 is transported predominantly to the rough endoplasmic reticulu...

journal_title：AIDS research and human retroviruses

authors： Pacyniak E,Gomez ML,Gomez LM,Mulcahy ER,Jackson M,Hout DR,Wisdom BJ,Stephens EB

更新日期：2005-05-01 00:00:00

abstract：:Infection with human T lymphotropic virus (HTLV), although asymptomatic in most cases, can lead to severe illnesses, such as adult T cell leukemia/lymphoma or myelopathy/tropical spastic paraparesis. HTLV can be transmitted by whole-blood (WB) transfusion. The prevalence of HTLV among blood donor populations has not b...

journal_title：AIDS research and human retroviruses

authors： Pham D,Nguyen D,Nguyen TA,Tran C,Tran L,Devare S,Tran A,Bhatnagar S

更新日期：2019-04-01 00:00:00

abstract：:The clinical significance of the reduced in vitro susceptibility of HIV to antiretroviral agents has been difficult to elucidate for nucleoside analogs such as zidovudine. However, the virological significance of resistance to nevirapine and other HIV-1-specific reverse transcriptase inhibitors has been established. W...

journal_title：AIDS research and human retroviruses

authors： Richman DD

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND:Immune activation, which is accompanied by the production of proinflammatory cytokines, is a strong predictor of disease progression in HIV infection. Inflammation is critical in neuronal damage linked to HIV-associated neurocognitive disorders. METHODS:We examined the relationship between plasma cytokine l...

journal_title：AIDS research and human retroviruses

authors： Ruhanya V,Jacobs GB,Naidoo S,Paul RH,Joska J,Seedat S,Nyandoro G,Engelbrecht S,Glashoff R

更新日期：2021-01-20 00:00:00

abstract：:The membrane glycolipids galactosylceramide (GalCer) and sulfatide (SGalCer) have been reported to act as receptors of human immunodeficiency virus (HIV) on CD4- cell lines. We show here that these glycolipids are present on CD4+ cells purified from human blood and on in vitro-differentiated monocyte-derived macrophag...

journal_title：AIDS research and human retroviruses

authors： Seddiki N,Ben Younes-Chennoufi A,Benjouad A,Saffar L,Baumann N,Gluckman JC,Gattegno L

更新日期：1996-05-20 00:00:00

abstract：:Previous studies have demonstrated that lopinavir/ritonavir monotherapy maintained plasma HIV-1 RNA suppression in a large proportion of antiretroviral naive subjects. However, more subjects receiving lopinavir/ritonavir monotherapy experienced confirmed virologic rebound >50 copies/ml compared to a standard three-dru...

journal_title：AIDS research and human retroviruses

authors： Campo RE,Da Silva BA,Cotte L,Gathe JC,Gazzard B,Hicks CB,Klein CE,Chiu YL,King MS,Bernstein BM

更新日期：2009-03-01 00:00:00

abstract：:The Brazilian AIDS epidemic is characterized by significant geographic contrasts: a reduction in incidence and mortality in the epicenter (southeast) and an increase in the northeast. HIV-1-transmitted drug resistance (TDR) and genetic diversity were investigated among 106 antiretroviral (ARV)-naive patients from Mara...

journal_title：AIDS research and human retroviruses

authors： Moura ME,Reis MN,Lima YA,Eulálio KD,Cardoso LP,Stefani MM

更新日期：2015-02-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNF-alpha) may be involved in the pathogenesis of metabolic and endocrine changes in HIV infection. Pentoxifylline (PTX) is able to suppress the production of TNF-alpha in vitro. The effect of two dosages of intravenously administered PTX on clinical symptoms and ex vivo LPS-stimulated TNF...

journal_title：AIDS research and human retroviruses

authors： Heijligenberg R,Romijn JA,Ackermans M,Endert E,Timmer JG,Sauerwein HP

更新日期：1998-03-01 00:00:00

abstract：:Entry inhibitor is a new class of drugs that target the viral envelope protein. This region is variable; hence resistance to these drugs may be present before treatment. The aim of this study was to analyze the frequency of patients failing treatment with transcriptase reverse and protease inhibitors that would respon...

journal_title：AIDS research and human retroviruses

authors： Alencar CS,Nishiya AS,Ferreira S,Giret MT,Diaz RS,Sabino EC

更新日期：2010-12-01 00:00:00

abstract：:HIV-1 protease activity is essential for viral replication. In spite of the high rates of HIV mutation, the active site of protease (residues 24-29) is a conserved site, where mutations have not been previously described. To determine the effect of mutations at positions T26 and A29 of the viral protease and its viabi...

journal_title：AIDS research and human retroviruses

authors： Melón S,Gil-Roda C,de Oña M,Erice A

更新日期：2004-11-01 00:00:00

abstract：:Lectins with specificity for terminal mannose residues and anti-mannan antibodies neutralize HIV-1 infection in vitro. This is assumed to be caused by binding of the agents to the viral glycoproteins. In this study we show that one such agent, the Galanthus nivalis lectin (GNA), also blocks infection at the target cel...

journal_title：AIDS research and human retroviruses

authors： Hammar L,Hirsch I,Machado AA,De Mareuil J,Baillon JG,Bolmont C,Chermann JC

更新日期：1995-01-01 00:00:00

abstract：:Aging with HIV poses unique and complex challenges, including avoidance of neurocognitive disorder. Our objective here is to identify the prevalence and predictors of successful cognitive aging (SCA) in a sample of older adults with HIV. One hundred three HIV-infected individuals aged 50 and older were recruited from ...

journal_title：AIDS research and human retroviruses

authors： Wallace LM,Ferrara M,Brothers TD,Garlassi S,Kirkland SA,Theou O,Zona S,Mussini C,Moore D,Rockwood K,Guaraldi G

更新日期：2017-02-01 00:00:00

abstract：:HIV-1 infection of tonsils takes place when virus spreads systemically, and may occur when tonsillar tissue serves as the initial portal of HIV-1 entry. The HIV replication cycle includes the production of regulatory and accessory gene mRNAs, produced by splicing of genomic mRNA, that are hallmarks of de novo virus pr...

journal_title：AIDS research and human retroviruses

authors： Brachtel EF,Mascola JR,Wear DJ,Ehrenberg PK,Dayhoff DE,Sanders-Buell E,Michael NL,Frankel SS

更新日期：2002-07-20 00:00:00