Inhibition of HIV type 1 replication by human T lymphotropic virus types 1 and 2 Tax proteins in vitro.

abstract：:HIV-1 transcripts are generated through a complex alternative splicing mechanism, resulting in the production of multiple RNAs coding for each viral protein. HIV-1 RNA splicing has been analyzed mostly in in vitro assays, and in vivo data are scarce. Here we analyze HIV-1 transcripts generated in peripheral blood mono...

journal_title：AIDS research and human retroviruses

authors： Carrera C,Pinilla M,Pérez-Alvarez L,Thomson MM

更新日期：2010-07-01 00:00:00

abstract：:Perinatal antiretroviral (ARV) exposure has been related to hyperlactatemia and lactic acidosis in infants born to HIV-infected mothers. Our objective was to determine the incidence of these conditions during the first year of life in uninfected infants born to HIV-infected mothers and compare the data with infants bo...

journal_title：AIDS research and human retroviruses

authors： Soler-Palacín P,Martín-Nalda A,Martínez-Gómez X,Melendo S,Riudor E,Arranz JA,Espiau M,Figueras C

更新日期：2012-08-01 00:00:00

abstract：:With improved survival and aging, more persons living with HIV/AIDS (PLWHA) are at risk for colorectal cancer (CRC). This retrospective longitudinal study evaluated patient characteristics associated with CRC screening in our HIV cohort. Patients were followed beginning at age 50 years during a study period from Janua...

journal_title：AIDS research and human retroviruses

authors： Burkholder GA,Tamhane AR,Appell LE,Willig JH,Saag MS,Raper JL,Westfall AO,Mugavero MJ

更新日期：2015-05-01 00:00:00

abstract：:Simian AIDS-related lymphomas (sARL) of cynomolgus monkeys infected with a simian immunodeficiency virus (SIVsm) were studied in relation to growth in severe combined immunodeficient (SCID) mice, karyotype abnormalities, and DNA sequence of the first noncoding region of the Bcl-6 gene. The tumors were diffuse large B ...

journal_title：AIDS research and human retroviruses

authors： Castaños-Vélez E,Heiden T,Lindvall C,Capello D,Sandlund A,Imreh S,Blennow E,Andersson LC,Gaidano G,Nordenskjöld M,Biberfeld P

更新日期：2002-03-20 00:00:00

abstract：:We sought to determine the frequency and profile of HIV-1 BF recombinants in vitro and in vivo. Laboratory HIV-1 strains from subtypes B and F were cocultured and evaluated. Clinical samples from the city of Santos, Brazil, where the first HIV-1 B/F circulating recombinant forms (CRF) were described, were also assesse...

journal_title：AIDS research and human retroviruses

authors： Teixeira D,Munerato P,Komninakis SC,Fusuma EE,Janini LM,Sucupira MC,Diaz RS

更新日期：2010-09-01 00:00:00

abstract：:The aim of this study was to determine the patterns of change in body fat and metabolic parameters in a South African cohort on a first line ART regimen containing stavudine. Fasting lipogram, blood glucose and insulin levels, CD4 cell count, viral load, BMI, waist-to-hip ratio (WHR), and skinfold thickness at the tri...

journal_title：AIDS research and human retroviruses

authors： George JA,Venter WD,Van Deventer HE,Crowther NJ

更新日期：2009-08-01 00:00:00

abstract：:A murine monoclonal antibody (MoAb), VAK 4, has been known to specifically react with a major core protein (p24) as well as with its precursor (p55-57) and intermediate precursor (p40) of human immunodeficiency virus strain IIIB (HTLV-IIIB). Radioimmunoprecipitation assays revealed that VAK 4 MoAb precipitated a major...

journal_title：AIDS research and human retroviruses

authors： Koito A,Hattori T,Matsushita S,Maeda Y,Nozaki C,Sagawa K,Takatsuki K

更新日期：1988-12-01 00:00:00

abstract：:We analyzed the HIV-1 pol gene from patients in Cape Town to determine the genetic diversity of HIV-1 in the region and to assess the baseline HIV-1 resistance level of treatment-naive patients. Plasma was collected prior to the national antiretroviral therapy (ART) program. RNA was extracted, followed by RT-PCR and a...

journal_title：AIDS research and human retroviruses

authors： Jacobs GB,Laten A,van Rensburg EJ,Bodem J,Weissbrich B,Rethwilm A,Preiser W,Engelbrecht S

更新日期：2008-07-01 00:00:00

abstract：:The Brazilian AIDS epidemic is characterized by significant geographic contrasts: a reduction in incidence and mortality in the epicenter (southeast) and an increase in the northeast. HIV-1-transmitted drug resistance (TDR) and genetic diversity were investigated among 106 antiretroviral (ARV)-naive patients from Mara...

journal_title：AIDS research and human retroviruses

authors： Moura ME,Reis MN,Lima YA,Eulálio KD,Cardoso LP,Stefani MM

更新日期：2015-02-01 00:00:00

abstract：:Multiple drug effect analyses with mismatched double-stranded RNA (mismatched dsRNA or Ampligen) as a core drug were performed to identify other agents and mechanisms through which mismatched dsRNA may potentiate effective therapeutic intervention in human immunodeficiency virus (HIV) infection. Antiviral activities w...

journal_title：AIDS research and human retroviruses

authors： Montefiori DC,Robinson WE Jr,Mitchell WM

更新日期：1989-04-01 00:00:00

abstract：:Downregulation of MHC class I expression following human immunodeficiency virus 1 (HIV-1) infection is thought to play an important role in viral escape from immune recognition by cytotoxic T-lymphocytes (CTLs). Since exogenous addition of HIV-1-derived peptides restores susceptibility of HIV-1-infected cells to CTL-m...

journal_title：AIDS research and human retroviruses

authors： Kutsch O,Vey T,Kerkau T,Hünig T,Schimpl A

更新日期：2002-11-20 00:00:00

abstract：:Propensity for developing coronary heart disease (CHD) is linked with Framingham-defined cardiovascular risk factors and elevated inflammatory biomarkers. Cardiovascular risk and inflammatory biomarkers were evaluated in ARIES, a Phase IIIb/IV clinical trial in which 515 antiretroviral-naive HIV-infected subjects init...

journal_title：AIDS research and human retroviruses

authors： Young B,Squires KE,Ross LL,Santiago L,Sloan LM,Zhao HH,Wine BC,Pakes GE,Margolis DA,Shaefer MS,Aries EPZ108859 Study Team.

更新日期：2013-02-01 00:00:00

abstract：:The gag-homologous region of the human endogenous retrovirus K10 (HERV-K10) was amplified by PCR from human genomic DNA and was analyzed by DNA cloning, sequencing, and expression of open reading frames in the prokaryotic pATH expression system. The analysis of genomic DNA of three donors provided evidence that HERV-K...

journal_title：AIDS research and human retroviruses

authors： Mueller-Lantzsch N,Sauter M,Weiskircher A,Kramer K,Best B,Buck M,Grässer F

更新日期：1993-04-01 00:00:00

abstract：:The HIV-1 Nef protein is known to be secreted, and our group has shown that Nef is secreted from nef-transfected and HIV-1-infected cells in small exosome-like vesicles (d. 40-100 nm). The role of secreted Nef remains to be fully characterized. Thus, it is important to characterize the nature of and the mechanisms reg...

journal_title：AIDS research and human retroviruses

authors： Ali SA,Huang MB,Campbell PE,Roth WW,Campbell T,Khan M,Newman G,Villinger F,Powell MD,Bond VC

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Immune activation, which is accompanied by the production of proinflammatory cytokines, is a strong predictor of disease progression in HIV infection. Inflammation is critical in neuronal damage linked to HIV-associated neurocognitive disorders. METHODS:We examined the relationship between plasma cytokine l...

journal_title：AIDS research and human retroviruses

authors： Ruhanya V,Jacobs GB,Naidoo S,Paul RH,Joska J,Seedat S,Nyandoro G,Engelbrecht S,Glashoff R

更新日期：2021-01-20 00:00:00

abstract：:The retroviral integrase protein (IN) is essential for virus replication and, therefore, an attractive target for the development of inhibitors to treat human immunodeficiency virus (HIV) infection. Diverse classes of compounds that are active against this protein have been discovered using in vitro assays. Here we de...

journal_title：AIDS research and human retroviruses

authors： Daniel R,Myers CB,Kulkosky J,Taganov K,Greger JG,Merkel G,Weber IT,Harrison RW,Skalka AM

更新日期：2004-02-01 00:00:00

abstract：:Enhancement of immunity in the setting of HIV infection is difficult owing to loss of functional CD4+ T cells. The MHC class II-deficient mouse (II-/-) environment simulates that of the immunocompromised HIV-infected individual, since these mice have low CD4+ T cell numbers, defective CD4-dependent responses, and are ...

journal_title：AIDS research and human retroviruses

authors： Scott DE,Golding H,Huang LY,Inman J,Golding B

更新日期：1998-09-20 00:00:00

abstract：:Myeloid dendritic cells (mDCs) are essential for initiation of adaptive immune responses but are depleted in HIV infection. Evidence suggests that apoptosis mediates loss, and to further understand the pathways involved, expression of caspases mediating apoptosis via the extrinsic and intrinsic pathways was analyzed. ...

journal_title：AIDS research and human retroviruses

authors： Chen J,Benlahrech A,Kelleher P,Patterson S

更新日期：2013-04-01 00:00:00

abstract：:HIV infection is associated with qualitative and functional immune deficiencies. It has been shown that the in vitro infection of CD4+ cells with HIV was associated with sustained elevation of cAMP and cGMP. In the present report the role of cAMP on HIV replication in MT-4 cells was investigated. The MT-4 cells were i...

journal_title：AIDS research and human retroviruses

authors： Nokta MA,Pollard RB

更新日期：1992-07-01 00:00:00

abstract：:HIV-1 subtype C is the prevalent subtype in South Africa, with non-C subtypes being sporadically detected. The accessory genes of subtype C have not been well studied in South Africa. In this study the HIV-1 vpr region of 58 strains was amplified, sequenced, and subtyped. Phylogenetic analysis characterized 54 strains...

journal_title：AIDS research and human retroviruses

authors： Romani B,Glashoff R,Engelbrecht S

更新日期：2009-03-01 00:00:00

abstract：:Changes in neutralizing antibody (NA) titers in stored sera collected over 5 years from 10 participants in the Multicenter AIDS Cohort Study (MACS) were evaluated. The participants were HIV-1 infected on enrollment in the MACS, and remained AIDS free during the 5-year study interval. Seven viruses derived from molecul...

journal_title：AIDS research and human retroviruses

authors： Quinnan GV Jr,Zhang PF,Fu DW,Dong M,Margolick JB

更新日期：1998-07-20 00:00:00

abstract：:This study examines the association between presence of drug resistance mutations and phenotypic resistance at baseline to virologic response to salvage therapy in a community setting. The study population consisted of 58 antiretroviral drug-experienced patients with HIV-1 infection who had recently switched therapy b...

journal_title：AIDS research and human retroviruses

authors： Ross L,Liao Q,Gao H,Pham S,Tolson J,Hertogs K,Larder B,Saag MS

更新日期：2001-10-10 00:00:00

abstract：:The first open reading frame of the HIV genome has been identified as the gag gene. The proteins encoded by this gene are p17 as the amino-terminal protein, p24 as the middle peptide, and p15 as the carboxyl-terminal end. A monoclonal antibody recognizing an antigenic determinant on a fragment of p15 has been develope...

journal_title：AIDS research and human retroviruses

authors： Veronese FD,Rahman R,Copeland TD,Oroszlan S,Gallo RC,Sarngadharan MG

更新日期：1987-10-01 00:00:00

abstract：:A new HIV-1 circulating recombinant form (CRF), CRF33_01B, has been identified in Malaysia. Concurrently we found a unique recombinant form (URF), that is, the HIV-1 isolate 06MYKLD46, in Kuala Lumpur, Malaysia. It is composed of B or a Thai variant of the B subtype (B') and CRF01_AE. Here, we determined the near full...

journal_title：AIDS research and human retroviruses

authors： Lau KA,Wang B,Kamarulzaman A,Ng KP,Saksena NK

更新日期：2007-09-01 00:00:00

abstract：:Cell activation is essential for HIV infection. CD4+ T lymphocyte activation allows virus replication and CD8+ T lymphocyte activation may contribute to pathogenesis. We combined hydroxyurea, a cytostatic drug that inhibits cell activation and proliferation, with two drugs that inhibit HIV (didanosine and indinavir), ...

journal_title：AIDS research and human retroviruses

authors： Lori F,Jessen H,Lieberman J,Clerici M,Tinelli C,Lisziewicz J

更新日期：1999-05-01 00:00:00

abstract：:In a set of 42 antiretroviral naive HIV-1 infected persons who were treated with either Zidovudine (AZT) monotherapy, or a combination of AZT + ddC (Zalcitabine) or AZT + ddI (Didanosine), the HIV-1 DNA load was measured by competitive polymerase chain reaction (PCR) and related to the HIV-1 RNA load in plasma, the CD...

journal_title：AIDS research and human retroviruses

authors： Bruisten SM,Reiss P,Loeliger AE,van Swieten P,Schuurman R,Boucher CA,Weverling GJ,Huisman JG

更新日期：1998-08-10 00:00:00

abstract：:Eight fragments derived from the HIV-1 pol gene were expressed as recombinant polypeptides in Escherichia coli. The fragments were from the portion of the pol gene that encodes the reverse transcriptase. The expressed peptides were analyzed immunologically with sera from HIV-1-infected individuals. Three distinct immu...

journal_title：AIDS research and human retroviruses

authors： Padberg C,Nowlan S,Mermer B

更新日期：1989-02-01 00:00:00

abstract：:Human T lymphotropic virus type I trans-activator Tax protein regulates expression of several cellular genes that are involved in cellular activation, proliferation, and transformation. Tax mediates its regulatory activity through interaction with cellular transcription factors such as members of the cAMP-responsive e...

journal_title：AIDS research and human retroviruses

authors： Moriuchi M,Moriuchi H,Fauci AS

更新日期：1999-06-10 00:00:00

abstract：:Cellular adhesion molecules, such as ICAM-1, -2, and -3; LFA-1; and HLA class I and II are incorporated into HIV-1 virions during budding from infected cells. These virion-associated molecules can be involved in the adsorption to susceptible cells displaying the corresponding counterligands. A number of cytokines have...

journal_title：AIDS research and human retroviruses

authors： Castilletti C,Capobianchi MR,Fais S,Abbate I,Ficociello B,Ameglio F,Cordiali Fei P,Santini SM,Dianzani F

更新日期：1995-05-01 00:00:00

abstract：:Investigations into the use of baboons as organ donors for human transplant recipients, a procedure called xenotransplantation, have raised the specter of transmitting baboon viruses to humans and possibly establishing new human infectious diseases. Retrospective analysis of tissues from two human transplant recipient...

journal_title：AIDS research and human retroviruses

authors： Allan JS,Broussard SR,Michaels MG,Starzl TE,Leighton KL,Whitehead EM,Comuzzie AG,Lanford RE,Leland MM,Switzer WM,Heneine W

更新日期：1998-07-01 00:00:00