Understanding factors that modulate HIV infection at the female genital tract mucosae for the rationale design of microbicides.

abstract：:Two commercially available expression vectors were modified to generate plasmids pGEXcPk and pQ9cPk. Proteins expressed from pGEXcPk and pQ9cPk had a short oligopeptide tag termed Pk at their carboxy termini and either glutathione S-transferase (GST) or a small histidine (His) tag, respectively, at their N termini. GS...

journal_title：AIDS research and human retroviruses

authors： Hanke T,Botting C,Green EA,Szawlowski PW,Rud E,Randall RE

更新日期：1994-06-01 00:00:00

abstract：:As the number of women infected with HIV in the United States continues to increase, the medical community is faced with the challenge of providing adequate and appropriate care to them. This paper reviews key questions concerning the state of knowledge on the epidemiology, biology, and clinical care of women living w...

journal_title：AIDS research and human retroviruses

authors： Marlink R,Kao H,Hsieh E,\Giving Voice to a Silent Epidemic\ Working Group.

更新日期：2001-01-01 00:00:00

abstract：:We recently reported a novel adhesion pathway in lymphocytes that is mediated by cyclin-dependent kinase (Cdk) 4 activity and mediates lymphocyte interactions with endothelial matrix. We now demonstrate that HIV-infected lymphocytes also use Cdk4 to mediate spontaneous adhesion to fibronectin and endothelial matrix. W...

journal_title：AIDS research and human retroviruses

authors： Chow YH,Liu L,Schwartz B,Harlan JM,Schnapp LM

更新日期：2012-12-01 00:00:00

abstract：:There is an urgent need for a prophylactic vaccine to protect individuals from AIDS and to help abate the growing epidemic. In October 1993, the Conference on Advances in AIDS Vaccine Development reviewed the state-of-the-art in vaccine research and confirmed both the progress that has been made and the challenges tha...

journal_title：AIDS research and human retroviruses

authors： Johnston MI,Noe JS,Killen JY

更新日期：1994-01-01 00:00:00

abstract：:Coadministration of pVecB7, a replication-defective SIV DNA vaccine, with interleukin-12 and GM-CSF expression plasmids, induced markedly enhanced control of viral replication and disease-free survival in macaques challenged intrarectally with pathogenic SIVsmE660. Protective mechanisms correlated with broader cell-me...

journal_title：AIDS research and human retroviruses

authors： O'Neill E,Bostik V,Montefiori DC,Kraiselburd E,Villinger F

更新日期：2003-10-01 00:00:00

abstract：:In order to shed light on the nature of the persistent reservoir of human immunodeficiency virus type 1 (HIV-1), we investigated signs of recent evolution in the pool of proviral DNA in patients on successful HAART. Pro-viral DNA, corresponding to the C2-V3-C3 region of the HIV-1 env gene, was collected from PBMCs iso...

journal_title：AIDS research and human retroviruses

authors： Mens H,Pedersen AG,Jørgensen LB,Hue S,Yang Y,Gerstoft J,Katzenstein TL

更新日期：2007-01-01 00:00:00

abstract：:Serum samples collected prospectively between 1982 and 1987 from a cohort of homosexual men were analyzed for HIV-1 neutralizing antibodies. Seven seroconverters who became infected between 1982 and 1984 and 12 seroprevalents who were already seropositive in 1982 remained free of AIDS. During the 6 year period, 1 sero...

journal_title：AIDS research and human retroviruses

authors： Robert-Guroff M,Goedert JJ,Naugle CJ,Jennings AM,Blattner WA,Gallo RC

更新日期：1988-10-01 00:00:00

abstract：:Histone deacetylases (HDACs) act on histones within the nucleosome-bound promoter of human immunodeficiency virus type 1 (HIV-1) to maintain proviral latency. HDAC inhibition leads to promoter expression and the escape of HIV from latency. We evaluated the ability of the potent inhibitor recently licensed for use in o...

journal_title：AIDS research and human retroviruses

authors： Archin NM,Espeseth A,Parker D,Cheema M,Hazuda D,Margolis DM

更新日期：2009-02-01 00:00:00

abstract：:Partial sequences of HIV-1 polymerase from 185 patients, 141 ARV experienced and 44 naive, of gag (p24) and env (C2V3) from a subset of naive cases were evaluated in São Paulo, Brazil. Antiretroviral resistance mutations were detected in 4% of 26 recently (<2 years) infected patients. Polymorphisms at the protease gen...

journal_title：AIDS research and human retroviruses

authors： Brígido LF,Franco HM,Custódio RM,Oliveira CA,P Ferreira JL,Eira M,Bergel F,Araújo F,Carvalheiro JR,Rodrigues R

更新日期：2005-07-01 00:00:00

abstract：:Primary isolates of human immunodeficiency virus type 1 (HIV-1) were obtained by coculture of peripheral blood lymphocytes (PBLs) from HIV-1-infected people with PBLs from uninfected donors. These viral stocks tend to be resistant to neutralization/inactivation by soluble CD4 (sCD4). When these stocks were passed thro...

journal_title：AIDS research and human retroviruses

authors： Orloff SL,Bandea CI,Kennedy MS,Allaway GP,Maddon PJ,McDougal JS

更新日期：1995-03-01 00:00:00

abstract：:We evaluated the effect of drug alternation on human immunodeficiency virus type 1 (HIV-1) suppression and emergence of resistant virus strains in CEM cell cultures. Rapid, that is, twice weekly, alternation of lamivudine and nevirapine (at 0.1 microg/ml) at the time of each subcultivation resulted in a long-term supp...

journal_title：AIDS research and human retroviruses

authors： Balzarini J,De Clercq E

更新日期：2001-11-20 00:00:00

abstract：:A high incidence of decreased bone mineral density (BMD) has increasingly been associated with HIV infection. In this study mesenchymal stem cell (MSC) and human osteoblast (hOB) cell lines were treated with HIV tat, HIV rev, HIV p55-gag, HIV gp120 and HTLV env (100 ng/ml, 24 h). Cells were then analyzed for calcium d...

journal_title：AIDS research and human retroviruses

authors： Cotter EJ,Malizia AP,Chew N,Powderly WG,Doran PP

更新日期：2007-12-01 00:00:00

abstract：:We have previously shown that the cell line 6D5(451) chronically infected with the HIV-1 isolate HTLV-III(451), secretes the HIV-1 envelope glycoproteins gp120 and gp160 in the extracellular medium. The HTLV-III(451) gp120 and gp160 were purified by sequential affinity chromatographic steps using a monoclonal antibody...

journal_title：AIDS research and human retroviruses

authors： Kalyanaraman VS,Rodriguez V,Veronese F,Rahman R,Lusso P,DeVico AL,Copeland T,Oroszlan S,Gallo RC,Sarngadharan MG

更新日期：1990-03-01 00:00:00

abstract：:Epidemic modeling suggests that a major scale-up in HIV treatment could have a dramatic impact on HIV incidence. This has led both researchers and policymakers to set a goal of an "AIDS-Free Generation." One of the greatest obstacles to achieving this objective is the number of people with undiagnosed HIV infection. D...

journal_title：AIDS research and human retroviruses

authors： Burns DN,DeGruttola V,Pilcher CD,Kretzschmar M,Gordon CM,Flanagan EH,Duncombe C,Cohen MS

更新日期：2014-03-01 00:00:00

abstract：:GLQ223 is a formulated version of tricosanthin, a single-chain ribosome-inactivating protein that was shown in earlier studies to inhibit human immunodeficiency virus (HIV) replication in T-lymphoblastoid cells and to decrease HIV p24 levels in HIV-infected monocyte-derived macrophages as measured by flow cytometry. T...

journal_title：AIDS research and human retroviruses

authors： McGrath MS,Santulli S,Gaston I

更新日期：1990-08-01 00:00:00

abstract：:HIV-1 infection causes functional defects in T cells. It also leads to a progressive reduction in numbers of such cells and both CD4+ and CD8+ cells have been reported to undergo apoptosis in culture. A corresponding reduction in B cells has not been described, but these cells are also functionally altered, with repor...

journal_title：AIDS research and human retroviruses

authors： Samuelsson A,Sönnerborg A,Heuts N,Cöster J,Chiodi F

更新日期：1997-08-10 00:00:00

abstract：:Analyses of serum samples and blood cells have revealed a dysregulation of the Fas/Fas ligand (FasL) system during HIV infection, which may be related to disease progression. As Fas and FasL have been suggested to participate in brain injury in a variety of CNS disorders, the aim of this study was to determine (1) whe...

journal_title：AIDS research and human retroviruses

authors： Sporer B,Koedel U,Goebel FD,Pfister HW

更新日期：2000-02-10 00:00:00

abstract：:Data reporting sexually transmitted infection (STI) incidence rates among HIV-negative U.S. men who have sex with men (MSM) are lacking. In addition, it is difficult to analyze the effect of STI on HIV acquisition given that sexual risk behaviors confound the relationship between bacterial STIs and incident HIV. The I...

journal_title：AIDS research and human retroviruses

authors： Kelley CF,Vaughan AS,Luisi N,Sanchez TH,Salazar LF,Frew PM,Cooper HL,Diclemente R,del Rio C,Sullivan PS,Rosenberg ES

更新日期：2015-06-01 00:00:00

abstract：:Inhibitory factors to human immunodeficiency virus type 1 (HIV-1) in saliva may be responsible for the infrequent isolation of virus from saliva and also may account for the marked infrequency of salivary and/or oral transmission of HIV-1. Incubation of HIV-1 with human saliva followed by addition of the mixture to su...

journal_title：AIDS research and human retroviruses

authors： Archibald DW,Cole GA

更新日期：1990-12-01 00:00:00

abstract：:Cellular adhesion molecules, such as ICAM-1, -2, and -3; LFA-1; and HLA class I and II are incorporated into HIV-1 virions during budding from infected cells. These virion-associated molecules can be involved in the adsorption to susceptible cells displaying the corresponding counterligands. A number of cytokines have...

journal_title：AIDS research and human retroviruses

authors： Castilletti C,Capobianchi MR,Fais S,Abbate I,Ficociello B,Ameglio F,Cordiali Fei P,Santini SM,Dianzani F

更新日期：1995-05-01 00:00:00

abstract：:Human T cell leukemia virus protein induces T cells to permanent IL-2-dependent growth. These cells occasionally convert to factor independence. The viral oncoprotein Tax acts as an essential growth factor of transformed lymphocytes and stimulates the cell cycle in the G(1) phase. In T cells and fibroblasts Tax enhanc...

journal_title：AIDS research and human retroviruses

authors： Haller K,Ruckes T,Schmitt I,Saul D,Derow E,Grassmann R

更新日期：2000-11-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) long terminal repeat (LTR) promoter-mediated gene expression is regulated by the viral Tat protein that relieves a block to viral transcription elongation after binding with a viral hairpin loop RNA structure called the trans-activation-responsive region (TAR). Tat protein significan...

journal_title：AIDS research and human retroviruses

authors： Chande AG,Baba M,Mukhopadhyaya R

更新日期：2012-08-01 00:00:00

abstract：:Understanding factors that affect heterosexual transmission of HIV in women is of great importance. Lactobacilli in the lower genital tract of women utilize glycogen in vaginal epithelial cells as an energy source and produce lactic acid. The resultant vaginal acidity is believed to provide protection against HIV infe...

journal_title：AIDS research and human retroviruses

authors： Mirmonsef P,Gilbert D,Veazey RS,Wang J,Kendrick SR,Spear GT

更新日期：2012-01-01 00:00:00

abstract：:A sequence of four amino acid residues amino-terminal to the only intramolecular disulphide bond of the human immunodeficiency virus type 1 (HIV-1) transmembrane protein gp41 is recognized by an anti-idiotypic antibody (9G5A) raised against another monoclonal antibody (M38), which recognizes the C5 region of gp120. 9G...

journal_title：AIDS research and human retroviruses

authors： Lopalco L,Longhi R,Ciccomascolo F,De Rossi A,Pelagi M,Andronico F,Moore JP,Schulz T,Beretta A,Siccardi AG

更新日期：1993-01-01 00:00:00

abstract：:Antibodies (Abs) against HLA and other cell surface molecules, which HIV-1 acquires during the budding process at the host cell surface, neutralize HIV-1 in vitro. Macaques were protected against infection by SIV grown in human cells after xenoimmunization with human MHC molecules. Besides the immune responses arising...

journal_title：AIDS research and human retroviruses

authors： Spruth M,Stoiber H,Kacani L,Schönitzer D,Dierich MP

更新日期：1999-04-10 00:00:00

abstract：:HIV-1 is capable of mimicking the ligand of integrin α(4)β(7) by displaying a tripeptide mimotope on the V2 region. Through this mimicry HIV can bind the α(4)β(7) integrin and get carried through the lymphocyte proliferation signaling pathway, cell-to-cell adhesion and can migrate to gut-associated lymphoid tissues. T...

journal_title：AIDS research and human retroviruses

authors： He X,Mokili JL,Hong K,Chen J,Wei J,Xin R,Song YH,Feng Y,Jia M,Xing H,Shao Y

更新日期：2011-10-01 00:00:00

abstract：:Cytotoxic T lymphocytes that specifically lyse HIV-1-infected cells occur at uncommonly high frequency in the blood of infected individuals. The CTL response is dominated by the recognition of a small number of peptides encoded by HIV-1 structural and regulatory genes. These two facts have enabled us to develop potent...

journal_title：AIDS research and human retroviruses

authors： Lieberman J,Fabry JA,Shankar P,Beckett L,Skolnik PR

更新日期：1995-02-01 00:00:00

abstract：:Lentivirus infections are characterized by a dramatic loss of mucosal CD4(+) T cells, breakdown of the gut mucosa, and subsequent chronic immune activation. Residual immune activation persists even in patients controlling virus replication and remains a significant source of ongoing disease morbidities, but the causes...

journal_title：AIDS research and human retroviruses

authors： Li H,Goepfert P,Reeves RK

更新日期：2014-12-01 00:00:00

abstract：:Multiple drug effect analyses with mismatched double-stranded RNA (mismatched dsRNA or Ampligen) as a core drug were performed to identify other agents and mechanisms through which mismatched dsRNA may potentiate effective therapeutic intervention in human immunodeficiency virus (HIV) infection. Antiviral activities w...

journal_title：AIDS research and human retroviruses

authors： Montefiori DC,Robinson WE Jr,Mitchell WM

更新日期：1989-04-01 00:00:00

abstract：:Monoclonal antibodies (mAbs) specific for CD4 are potent inhibitors of HIV replication in vitro. These agents may be useful prophylactically or in chronic HIV infection if they can be administered without inducing immunosuppression. In the present study, we explored the safety of a CD4-specific murine mAb in rhesus mo...

journal_title：AIDS research and human retroviruses

authors： Reimann KA,Burkly LC,Burrus B,Waite BC,Lord CI,Letvin NL

更新日期：1993-03-01 00:00:00