Conservancy of the α4β7 integrin mimotope in the V2 domain of HIV type 1 CRF07_BC compared to subtype B' strains in China.

Abstract:

:HIV-1 is capable of mimicking the ligand of integrin α(4)β(7) by displaying a tripeptide mimotope on the V2 region. Through this mimicry HIV can bind the α(4)β(7) integrin and get carried through the lymphocyte proliferation signaling pathway, cell-to-cell adhesion and can migrate to gut-associated lymphoid tissues. The same tripeptide motif was suggested to be the epicenter of neutralization in laboratory strains of HIV-1. In this study, we compared the α(4)β(7) binding sites of two HIV-1 subtypes prevalent in China and found that the tripeptide binding domain of α(4)β(7) was more diverse in subtype B' strains than in CRF07_BC.

authors

He X,Mokili JL,Hong K,Chen J,Wei J,Xin R,Song YH,Feng Y,Jia M,Xing H,Shao Y

doi

10.1089/aid.2011.0007

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

1127-33

issue

10

eissn

0889-2229

issn

1931-8405

journal_volume

27

pub_type

杂志文章
  • Vitamin D Deficiency and Metabolism in HIV-Infected and HIV-Uninfected Men in the Multicenter AIDS Cohort Study.

    abstract::We evaluated associations of serum 25-hydroxyvitamin D (25[OH]D) and 1,25-dihydroxyvitamin D (1,25[OH]2D) levels in a cohort of HIV-infected and HIV-uninfected men at risk for infection in the United States. Stored samples collected between 1999 and 2008 were tested for vitamin D metabolites between 2014 and 2015. Vit...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章,多中心研究

    doi:10.1089/AID.2016.0144

    authors: Zhang L,Tin A,Brown TT,Margolick JB,Witt MD,Palella FJ Jr,Kingsley LA,Hoofnagle AN,Jacobson LP,Abraham AG

    更新日期:2017-03-01 00:00:00

  • Distinct populations of human immunodeficiency virus type 1 in blood and cerebrospinal fluid.

    abstract::The nucleotide sequence of the gp41 transmembrane protein coding region of human immunodeficiency virus type 1 (HIV-1) proviral DNA obtained from blood and cerebrospinal fluid (CSF) from 6 individuals was determined by direct sequencing of polymerase chain reaction (PCR)-amplified DNA. The direct sequencing approach w...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.1992.8.53

    authors: Steuler H,Storch-Hagenlocher B,Wildemann B

    更新日期:1992-01-01 00:00:00

  • Maternal proviral load and vertical transmission of human T cell lymphotropic virus type 1 in Guinea-Bissau.

    abstract::The relative importance of routes of transmission of human T cell lymphotropic virus type 1 (HTLV-1) in Guinea-Bissau is largely unknown; vertical transmission is thought to be important, but there are very few existing data. We aimed to examine factors associated with transmission in mothers and children in Guinea-Bi...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2011.0219

    authors: van Tienen C,McConkey SJ,de Silva TI,Cotten M,Kaye S,Sarge-Njie R,da Costa C,Gonçalves N,Parker J,Vincent T,Jaye A,Aaby P,Whittle H,Schim van der Loeff M

    更新日期:2012-06-01 00:00:00

  • Coordinate induction of interferon alpha and gamma by recombinant HIV-1 glycoprotein 120.

    abstract::Similarly to HIV-infected cells, recombinant HIV-1 glycoprotein 120 induces acid-labile interferon production in peripheral blood mononuclear cells from healthy donors. Acid lability of this interferon is due to the presence of both IFN-alpha and -gamma molecules. In fact, although not revealed by neutralization of an...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.1993.9.957

    authors: Capobianchi MR,Ameglio F,Cordiali Fei P,Castilletti C,Mercuri F,Fais S,Dianzani F

    更新日期:1993-10-01 00:00:00

  • Induction of potent humoral and cell-mediated immune responses following direct injection of DNA encoding the HIV type 1 env and rev gene products.

    abstract::DNA vaccines have the potential of giving rise to a potent cell-mediated immune response by inducing intracellular synthesis and subsequent antigenic presentation of encoded antigens. We have tested a DNA vaccine specific for human immunodeficiency virus type 1 (HIV-1) by the injection of animals with expression plasm...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.1995.11.933

    authors: Okuda K,Bukawa H,Hamajima K,Kawamoto S,Sekigawa K,Yamada Y,Tanaka S,Ishi N,Aoki I,Nakamura M

    更新日期:1995-08-01 00:00:00

  • Identification of unusual and novel HIV type 1 spliced transcripts generated in vivo.

    abstract::HIV-1 transcripts are generated through a complex alternative splicing mechanism, resulting in the production of multiple RNAs coding for each viral protein. HIV-1 RNA splicing has been analyzed mostly in in vitro assays, and in vivo data are scarce. Here we analyze HIV-1 transcripts generated in peripheral blood mono...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.2010.0011

    authors: Carrera C,Pinilla M,Pérez-Alvarez L,Thomson MM

    更新日期:2010-07-01 00:00:00

  • Human T cell lymphotropic virus type I (HTLV-I) p12I is dispensable for HTLV-I transmission and maintenance of infection in vivo.

    abstract::The function of the p12(I) protein of human T cell lymphotropic virus type I (HTLV-I) has been under debate. p12K (lysine) and p12R (arginine) variants of this protein at amino acid 88 and a shorter life of p12K had been reported by another group. Because HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.2004.20.1092

    authors: Furukawa Y,Usuku K,Izumo S,Osame M

    更新日期:2004-10-01 00:00:00

  • HIV-1 envelope gp120 alters astrocytes in human brain cultures.

    abstract::The majority of AIDS patients will experience some degree of dementia induced by human immunodeficiency virus (HIV-1). In this study, we report that treatment of human brain tissue with envelope gp120 of HIV-1 did not cause neuronal death but did cause astrocyte alterations and/or death. Human astrocyte cultures showe...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.1993.9.439

    authors: Pulliam L,West D,Haigwood N,Swanson RA

    更新日期:1993-05-01 00:00:00

  • Near full-length genome characterization of HIV type 1 unique BC recombinant forms from Southern Brazil.

    abstract::Abstract In southern Brazil, CRF31_BC is the major HIV-1 recombinant form and URFs_BC occurs very infrequently. The near full-length genomes of four samples displaying a similar recombination profile in the integrase region and different profiles in the protease/reverse transcriptase regions were analyzed to elucidate...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.2009.0167

    authors: Passaes CP,Guimarães ML,Bello G,Morgado MG

    更新日期:2009-12-01 00:00:00

  • Helper and cytotoxic T cell responses of HIV type 1-infected individuals to synthetic peptides of HIV type 1 Rev.

    abstract::In cell-mediated immunity T cells recognize peptide fragments of the antigenic protein in association with major histocompatibility complex (MHC) proteins. Synthetic 9- to 16-mer peptides have been widely used to identify the region(s) of a protein that act as T cell epitope. Here, we report antigenic peptides identif...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.1995.11.1335

    authors: Blazevic V,Ranki A,Krohn KJ

    更新日期:1995-11-01 00:00:00

  • Simian Immunodeficiency Virus Infection Increases Blood Ethanol Concentration Duration After Both Acute and Chronic Administration.

    abstract::Alcohol use disorder (AUD) is a frequent comorbidity among people living with HIV/AIDS (PLWHA). Alcohol consumption is a significant predictor of nonadherence to antiretroviral therapy (ART), as well as worsening immunological and virological indicators among PLWHA. Clinical studies indicate that higher viral loads in...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2017.0195

    authors: Simon L,Siggins R,Winsauer P,Brashear M,Ferguson T,Mercante D,Song K,Vande Stouwe C,Nelson S,Bagby G,Amedee A,Molina PE

    更新日期:2018-02-01 00:00:00

  • Evidence of impact of maternal HIV infection on immunoglobulin levels in HIV-exposed uninfected children.

    abstract::HIV infection affects B cell function and is associated with increased immunoglobulin levels, including in HIV-infected pregnant women. It is unknown if maternal HIV infection affects immunoglobulins in their uninfected children. We investigated this using prospective longitudinal data from children born to HIV-infect...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.2009.0241

    authors: Bunders M,Pembrey L,Kuijpers T,Newell ML

    更新日期:2010-09-01 00:00:00

  • Virucidal efficacy of various lens cleaning and disinfecting solutions on HIV-I contaminated contact lenses.

    abstract::The virucidal efficacy of various commercially available contact lens care cleaning regimens on human immunodeficiency virus (HIV-1) contaminated contact lenses using either cursory or meticulous cleaning with a rubber policeman was evaluated. Levels of infectious HIV-1 remaining on individual contact lenses were dete...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.1991.7.403

    authors: Amin RM,Dean MT,Zaumetzer LE,Poiesz BJ

    更新日期:1991-04-01 00:00:00

  • Characterization of an HIV-1 group M variant that is distinct from the known subtypes.

    abstract::We identified an HIV-1 variant that belongs to the M group, with limited similarity of short genetic regions (100-200 nt) to subtype K, but the remainder of the genome is unrelated to any established HIV-1 subtype. The isolate was obtained from an HIV-1-positive male, living in the Netherlands, who encountered the vir...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.2006.0184

    authors: van der Hoek L,Pollakis G,Lukashov VV,Jebbink MF,Jeeninga RE,Bakker M,Dukers N,Jurriaans S,Paxton WA,Back NK,Berkhout B

    更新日期:2007-03-01 00:00:00

  • Seroprevalence and determinants of Kaposi sarcoma-associated human herpesvirus 8 in Indian HIV-infected males.

    abstract::In India Kaposi's sarcoma is rarely seen in AIDS patients. Hence the current belief is that the incidence of human herpesvirus-8 (HHV-8) is very low in this subcontinent, most probably due to the heterosexual route of HIV transmission. However, there is a scarcity of data on the prevalence of HHV-8 in India. In India ...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.2014.0184

    authors: Munawwar A,Sharma SK,Gupta S,Singh S

    更新日期:2014-12-01 00:00:00

  • Pharmacokinetics and pharmacodynamics in HIV prevention; current status and future directions: a summary of the DAIDS and BMGF sponsored think tank on pharmacokinetics (PK)/pharmacodynamics (PD) in HIV prevention.

    abstract::Thirty years after its beginning, the HIV/AIDS epidemic is still raging around the world. According to UNAIDS, in 2011 alone 1.7M deaths were attributable to AIDS, and 2.5M people were newly infected by the virus. Despite the success in treating HIV-infected people with potent antiretroviral drugs, preventing HIV infe...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章,评审

    doi:10.1089/aid.2013.0122

    authors: Romano J,Kashuba A,Becker S,Cummins J,Turpin J,Veronese F,Antiretroviral Pharmacology In HIV Prevention Think Tank Participants.

    更新日期:2013-11-01 00:00:00

  • Expression of HIV antigens at the surface of infected T4 cells: immunoelectron microscopic evidence of an immunogenic phase prior to the viral release.

    abstract::HIV antigens were detected by immunoelectron microscopy at the surface of human and simian T4 lymphocytes that had been infected in vitro. HIV antigens were detected at the surface of cells exhibiting viral particles but also at the surface of cells before the release of virions. The latter cells may be considered imm...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.1989.5.107

    authors: Desportes I,Bonnet D,Nicol I,Snart R,Sarin P

    更新日期:1989-02-01 00:00:00

  • Short communication: T cell activation in HIV-1/herpes simplex virus-2-coinfected Kenyan women receiving valacyclovir.

    abstract::Herpes simplex virus-2 (HSV-2) suppression with acyclovir or valacyclovir reduces HIV-1 viral RNA levels; one hypothesis is that HSV-2 suppression reduces immune activation. We measured T cell immune activation markers among women participating in a randomized placebo-controlled trial of valacyclovir to reduce HIV-1 R...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/AID.2012.0071

    authors: Roxby AC,Liu AY,Drake AL,Kiarie JN,Richardson B,Lohman-Payne BL,John-Stewart GC,Wald A,De Rosa S,Farquhar C

    更新日期:2013-01-01 00:00:00

  • Study of viral replication in HIV-1-infected CEM T-cell subclones which are reduced in their ability to form syncytia.

    abstract::The derivation of ethyl-methanesulfonate (EMS) mutagenized subclones from the CEM T-cell line has been described. These clones expressed CD4 and bound soluble gp120, however, two of the generated clones were markedly reduced in their ability to form syncytia after infection with either gp160-vaccinia vector or cell-fr...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.1992.8.1139

    authors: Gruber MF,Hewlett IK,Simms T,Vujcic L,Manischewitz J,Golding H

    更新日期:1992-06-01 00:00:00

  • Synthetic peptides allow discrimination of structural features of CD4(81-92) important for HIV-1 infection versus HIV-1-induced syncytium formation.

    abstract::Benzylated peptides with a primary amino acid sequence corresponding to either human CD4(81-92) (#18), or chimpanzee CD4(81-92) (#18C), were equipotent inhibitors of human immunodeficiency virus type 1 (HIV-1) infection of CD4+ cells and high-affinity binding of 125I-gp120 to CD4+ cells. The chimpanzee-based CD4(81-92...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.1991.7.521

    authors: Lifson JD,Rausch DM,Kalyanaraman VS,Hwang KM,Eiden LE

    更新日期:1991-06-01 00:00:00

  • Short communication: dynamic constraints on the second phase compartment of HIV-infected cells.

    abstract::The cells responsible for the second phase decay of HIV-1 viremia following the initiation of antiretroviral therapy have yet to be identified. A dynamic model that considers where drugs act in the virus life cycle places constraints on candidate cell types. In this regard, the rapid drop in viremia in patients starti...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2010.0199

    authors: Spivak AM,Rabi SA,McMahon MA,Shan L,Sedaghat AR,Wilke CO,Siliciano RF

    更新日期:2011-07-01 00:00:00

  • Postvaccination C-Reactive Protein and C5/gp41732-744 Antibody Level Fold-Changes Over Baseline Are Independent Predictors of Therapeutic HIV Vaccine Effect in a Phase 2 Clinical Study of Vacc-4x.

    abstract::Therapeutic vaccination has the potential to contribute to functional HIV cure strategies. However, to show functional HIV cure, study participants must be taken off combination antiretroviral therapy (cART). The availability of suitable biomarkers that can predict viral load (VL) or CD4 count outcomes following thera...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/AID.2017.0179

    authors: Huang Y,Zhang L,Jolliffe D,Sanchez B,Stjernholm G,Jelmert Ø,Ökvist M,Sommerfelt MA

    更新日期:2018-03-01 00:00:00

  • HIV/AIDS-associated opportunistic protozoal diarrhea.

    abstract::Human immunodeficiency virus (HIV) infection has altered both the epidemiology and outcome of enteric opportunistic parasitic infections. This study was done to determine the prevalence and species/genotypes of intestinal coccidian and microsporidial infections among HIV/AIDS patients with diarrhea and/or a history of...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/AID.2012.0119

    authors: Agholi M,Hatam GR,Motazedian MH

    更新日期:2013-01-01 00:00:00

  • Robust supervised and unsupervised statistical learning for HIV type 1 coreceptor usage analysis.

    abstract::Human immunodeficiency virus type 1 (HIV-1) isolates differ in their use of coreceptors to enter target cells. This has important implications for both viral pathogenicity and susceptibility to entry inhibitors, recently approved or under development. Predicting HIV-1 coreceptor usage on the basis of sequence informat...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.2008.0039

    authors: Prosperi MC,Fanti I,Ulivi G,Micarelli A,De Luca A,Zazzi M

    更新日期:2009-03-01 00:00:00

  • Identification and characterization of the Bel 3 protein of human foamy virus.

    abstract::The human foamy virus (HFV) is a complex retrovirus that contains several regulatory and auxiliary bel genes besides the gag, pol, and env genes. In contrast to the gene products of bel 1 and bel 2/bet that were identified previously, the Bel 3 protein has not been described to date. Here we report the identification ...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.1994.10.595

    authors: Weissenberger J,Flügel RM

    更新日期:1994-05-01 00:00:00

  • A high frequency of defective vif genes in peripheral blood mononuclear cells from HIV type 1-infected individuals.

    abstract::We studied the heterogeneity and intactness of the vif gene in six HIV-1-infected individuals at various clinical stages. The proviral vif sequences in peripheral blood mononuclear cells were amplified by PCR, followed by cloning and sequencing of 45 vif clones. The intraindividual diversity of the vif genes ranged fr...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.1996.12.1543

    authors: Tominaga K,Kato S,Negishi M,Takano T

    更新日期:1996-11-01 00:00:00

  • Progressive B cell apoptosis and expression of Fas ligand during human immunodeficiency virus type 1 infection.

    abstract::HIV-1 infection causes functional defects in T cells. It also leads to a progressive reduction in numbers of such cells and both CD4+ and CD8+ cells have been reported to undergo apoptosis in culture. A corresponding reduction in B cells has not been described, but these cells are also functionally altered, with repor...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.1997.13.1031

    authors: Samuelsson A,Sönnerborg A,Heuts N,Cöster J,Chiodi F

    更新日期:1997-08-10 00:00:00

  • Sequence variations in the amino- and carboxy-terminal parts of the surface envelope glycoprotein of HTLV type 1 induce specific neutralizing antibodies.

    abstract::The surface envelope glycoprotein gp46 of the human T cell leukemia virus type 1 elicits a strong immune response. Its protective role against HTLV-1 infection in animal models is well established, suggesting that recombinant envelope glycoproteins or synthetic peptides could be used as an effective vaccine. However, ...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/08892220150503708

    authors: Tallet B,Astier-Gin T,Moynet D,Londos-Gagliardi D,Guillemain B

    更新日期:2001-03-01 00:00:00

  • Antigenic variation and serotyping of HIV type 1 from four World Health Organization-sponsored HIV vaccine sites. WHO Network for HIV Isolation and Characterization.

    abstract::Serologic reactivities of serum or plasma from 55 HIV-1 subjects in four countries--Brazil, Rwanda, Thailand, and Uganda--were examined by V3 peptide immunoassay. Forty-seven (85.5%) of the 55 specimens tested positive to the homologous peptide. A strong correlation between serotype (i.e., pattern of serologic reactiv...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.1994.10.1369

    authors: Pau CP,Kai M,Holloman-Candal DL,Luo CC,Kalish ML,Schochetman G,Byers B,George JR

    更新日期:1994-11-01 00:00:00

  • Bacterial Vaginosis and Subclinical Markers of Genital Tract Inflammation and Mucosal Immunity.

    abstract::Bacterial vaginosis (BV) has been linked to an increased risk of human immunodeficiency virus (HIV) acquisition and transmission in observational studies, but the underlying biological mechanisms are unknown. We measured biomarkers of subclinical vaginal inflammation, endogenous antimicrobial activity, and vaginal flo...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章

    doi:10.1089/aid.2015.0006

    authors: Thurman AR,Kimble T,Herold B,Mesquita PM,Fichorova RN,Dawood HY,Fashemi T,Chandra N,Rabe L,Cunningham TD,Anderson S,Schwartz J,Doncel G

    更新日期:2015-11-01 00:00:00