Toward an endgame: finding and engaging people unaware of their HIV-1 infection in treatment and prevention.

abstract：:The tax gene of human T-lymphotropic virus type 1 (HTLV-1) diverges among isolates according to geographic regions and has been classified into two genotypes: taxA and taxB. In Brazil, taxA is the most prevalent genotype in symptomatic and asymptomatic carriers. Few studies have been conducted in HIV-infected patients...

journal_title：AIDS research and human retroviruses

authors： Magri MC,Brigido LF,Rodrigues R,Morimoto HK,Caterino-de-Araujo A

更新日期：2012-12-01 00:00:00

abstract：:To assess the impact of chronic viral liver disease (CVLD) on hospital admissions and death in HIV-infected patients since the introduction of highly active antiretroviral therapy, all hospital charts, from January 1996 to December 2000, in a large HIV/AIDS reference center in Madrid were reviewed. Discharge diagnosis...

journal_title：AIDS research and human retroviruses

authors： Martín-Carbonero L,Soriano V,Valencia E,García-Samaniego J,López M,González-Lahoz J

更新日期：2001-11-01 00:00:00

abstract：:The clinical significance of the reduced in vitro susceptibility of HIV to antiretroviral agents has been difficult to elucidate for nucleoside analogs such as zidovudine. However, the virological significance of resistance to nevirapine and other HIV-1-specific reverse transcriptase inhibitors has been established. W...

journal_title：AIDS research and human retroviruses

authors： Richman DD

更新日期：1994-08-01 00:00:00

abstract：:The gene encoding the major envelope glycoprotein of the HIV-SF2 isolate was engineered for the secretion of recombinant gp120 (rgp120SF2) from permanent Chinese hamster ovary (CHO) cell lines. Cellular production methods were scaled up and a method for purification of the secreted glycoprotein was devised. Mild purif...

journal_title：AIDS research and human retroviruses

authors： Scandella CJ,Kilpatrick J,Lidster W,Parker C,Moore JP,Moore GK,Mann KA,Brown P,Coates S,Chapman B

更新日期：1993-12-01 00:00:00

abstract：:Several regulatory sequences have been characterized in the HTLV-I promoter. We report here identification of a sequence element downstream of the transcriptional start site within the first 52 nucleotides of the 5' R region, which acts negatively on the activity of the HTLV-I promoter. Determination of the half-lives...

journal_title：AIDS research and human retroviruses

authors： Montagne J,Jalinot P

更新日期：1995-09-01 00:00:00

abstract：:Maraviroc (MVC) is licensed in clinical practice for patients with R5 virus and virological failure; however, in anecdotal reports, dual/mixed viruses were also inhibited. We retrospectively evaluated the evolution of HIV-1 coreceptor tropism in plasma and peripheral blood mononuclear cells (PBMCs) of an infected adol...

journal_title：AIDS research and human retroviruses

authors： Cavarelli M,Mainetti L,Pignataro AR,Bigoloni A,Tolazzi M,Galli A,Nozza S,Castagna A,Sampaolo M,Boeri E,Scarlatti G

更新日期：2014-12-01 00:00:00

abstract：:Recombination is one of several factors contributing to the genetic diversity of HIV-1, which is divided into group M (itself comprising 11 subtypes, A-K) and two other groups named O and N. In the present study, the full-length genome of an HIV-1 isolate obtained from a Greek subject (GR17) infected in the Democratic...

journal_title：AIDS research and human retroviruses

authors： Paraskevis D,Magiorkinis M,Paparizos V,Pavlakis GN,Hatzakis A

更新日期：2000-06-10 00:00:00

abstract：:In this study, HIV strains circulating among military personnel were characterized, in Malabo, the capital city of Equatorial Guinea. One sample was found to be HIV-2 group A while a high degree of genetic diversity was recorded in the pol region of 41 HIV-1-positive samples. CRF02_AG accounted for 53.7% of the strain...

journal_title：AIDS research and human retroviruses

authors： Djoko CF,Wolfe ND,Vidal N,Tamoufe U,Montavon C,LeBreton M,Pike BL,Fair J,Mbacham WF,Benito A,Rimoin AW,Saylors K,Mpoudi-Ngole E,Grillo MP,Peeters M

更新日期：2010-09-01 00:00:00

abstract：:Epidemiological studies strongly suggest that a newly discovered herpesvirus, Kaposi's sarcoma associated-herpesvirus (KSHV/HHV8), is the likely infectious cause of Kaposi's sarcoma (KS). Identification of this agent suggests the possibility that existing anti-herpesvirus chemotherapeutics have activity against KSHV. ...

journal_title：AIDS research and human retroviruses

authors： Flore O,Gao SJ

更新日期：1997-09-20 00:00:00

abstract：:To investigate the origin and evolutionary history of the spread of HIV-1 subtype B in China, a total of 409 sequences of pol gene sampled from 1994 to 2012 in 29 provinces across China was subjected to phylogenetic and Bayesian molecular clock analyses. The study reveals that subtype B strains in China are geneticall...

journal_title：AIDS research and human retroviruses

authors： Ye J,Lu H,Su X,Xin R,Bai L,Xu K,Yu S,Feng X,Yan H,He X,Zeng Y

更新日期：2014-09-01 00:00:00

abstract：:The humoral immune response is a mechanism that potently suppresses or prevents viral infections. However, genetic diversity and resistance to antibody-mediated neutralization are serious obstacles in controlling HIV-1 infection. In this study, we isolated monoclonal antibodies from an SIV-infected macaque by using th...

journal_title：AIDS research and human retroviruses

authors： Kuwata T,Katsumata Y,Takaki K,Miura T,Igarashi T

更新日期：2011-05-01 00:00:00

abstract：:Population genotyping (PG) can underestimate resistance if resistance-containing low abundance variants go undetected. PG and clonal analysis (CA) results were compared in virologic failures (VFs) from a 48-week clinical trial that evaluated once-daily fosamprenavir/ritonavir (FPV/r) 1400 mg/100 mg or atazanavir/riton...

journal_title：AIDS research and human retroviruses

authors： Ross LL,Weinberg WG,DeJesus E,Fischl MA,Horton JH,Pappa KA,Lancaster CT,Pakes GE,Smith KY

更新日期：2010-04-01 00:00:00

abstract：:The human endogenous retrovirus, type K (HERV-K) represents the most biologically active form of known retroelements present in the human genome. Several HERV-K genomes have transcriptionally active open reading frames and encode their own protease (PR). The HERV-K PR has been shown to authentically cleave human immun...

journal_title：AIDS research and human retroviruses

authors： Padow M,Lai L,Fisher RJ,Zhou YC,Wu X,Kappes JC,Towler EM

更新日期：2000-12-10 00:00:00

abstract：:All-trans-retinoic acid (RA) has been shown either to activate or repress human immunodeficiency virus type 1 (HIV-1) replication in primary monocyte-derived-macrophages (MDMs). We systematically investigated the contribution that cell donor and virus differences make to this variability. We found that the effect of R...

journal_title：AIDS research and human retroviruses

authors： Brown XQ,Hanley TM,Viglianti GA

更新日期：2002-06-10 00:00:00

abstract：:Epstein-Barr virus (EBV) infection is associated with Burkitt's lymphoma (BL) in normal individuals and immunoblastic B cell lymphomas in immunosuppressed or HIV-infected individuals. SCID mice reconstituted with human peripheral blood leukocytes (hu-PBL-SCID) from EBV-seropositive donors also may develop spontaneous ...

journal_title：AIDS research and human retroviruses

authors： Mosier DE,Picchio GR,Kirven MB,Garnier JL,Torbett BE,Baird SM,Kobayashi R,Kipps TJ

更新日期：1992-05-01 00:00:00

abstract：:We have evaluated the genetic diversity of HIV-1 strains infecting injecting drug users (IDUs) in Lisbon, Portugal. Heteroduplex mobility assay and/or phylogenetic analysis revealed that env (C2V3C3 or gp41) subtype B is present in 63.7% of the 135 viral samples studied, followed by subtypes G (23.7%), A (6.7%), F (5....

journal_title：AIDS research and human retroviruses

authors： Esteves A,Parreira R,Piedade J,Venenno T,Franco M,Germano de Sousa J,Patrício L,Brum P,Costa A,Canas-Ferreira WF

更新日期：2003-06-01 00:00:00

abstract：:Little is known about the consequences of short cycles of structured treatment interruption or definitive interruption of HAART for both T cell subset dynamics and T lymphoproliferative responses (LPR). Immunological follow-up was performed in 45 early chronical HIV-1-infected patients during short STI cycles during t...

journal_title：AIDS research and human retroviruses

authors： Libois A,López A,Garcia F,Castro P,Maleno MJ,García A,Climent N,Arnedo M,Gallart T,Gatell JM,Plana M

更新日期：2006-07-01 00:00:00

abstract：:The predictive value of virological response to lopinavir (LPV)/ritonavir (r) was assessed in 126 HIV-infected patients who failed antiretroviral therapy and had begun a rescue intervention based on LPV/r. At 3 months, subjects with < or =6 protease (PRO) resistance mutations showed a higher rate of virological respon...

journal_title：AIDS research and human retroviruses

authors： González de Requena D,Gallego O,Valer L,Jiménez-Nácher I,Soriano V

更新日期：2004-03-01 00:00:00

abstract：:During HIV-1 infection, distinct biological phenotypes are observed between R5 and X4 HIV-1 strains with respect to pathogenicity and tropism. In this study, temporal changes of the expression levels of the complete human transcriptome, representing 47,000 well-characterized human transcripts, were monitored in the fi...

journal_title：AIDS research and human retroviruses

authors： Sirois M,Robitaille L,Sasik R,Estaquier J,Fortin J,Corbeil J

更新日期：2008-03-01 00:00:00

abstract：:Simian species of Asian and African origin are naturally infected with the simian T cell leukemia virus type I (STLV-I). Like the closely related human T cell leukemia virus type I (HTLV-I), STLV-I is primarily cell associated, and typical infections exhibit low viral burdens. Four macaques experimentally inoculated w...

journal_title：AIDS research and human retroviruses

authors： Liska V,Fultz PN,Su L,Ruprecht RM

更新日期：1997-09-01 00:00:00

abstract：:Thymulin is a thymic peptide important for the maturation and differentiation of immature thymocytes, which have been found to be depressed in patients with low-level CD4(+) cell recovery despite viral control. Substance use is associated with faster progression of HIV disease, which has been ascribed to poor adherenc...

journal_title：AIDS research and human retroviruses

authors： Rafie C,Campa A,Smith S,Huffman F,Newman F,Baum MK

更新日期：2011-08-01 00:00:00

abstract：:Some genomic elements of the multicopy HERV-W endogenous retroviral family have been previously identified in databases. One of them, located on chromosome 7, contains a single complete open reading frame (ORF) putatively encoding an envelope protein. We have experimentally investigated the genomic complexity and codi...

journal_title：AIDS research and human retroviruses

authors： Voisset C,Bouton O,Bedin F,Duret L,Mandrand B,Mallet F,Paranhos-Baccala G

更新日期：2000-05-20 00:00:00

abstract：:An EBV-transformed lymphoblastoid B cell clone (A12) derived from peripheral blood lymphocytes of an HIV-1-infected individual is described. The immunoglobulin isotype produced by this clone was IgM, and Southern blot analysis of immunoglobulin gene rearrangement showed a monoclonal pattern. The A12 monoclonal antibod...

journal_title：AIDS research and human retroviruses

authors： Amadori A,Ciminale V,Calabro ML,Tessarollo L,Francavilla E,Chieco-Bianchi L

更新日期：1989-02-01 00:00:00

abstract：:The HIV epidemic in Russia, one of the world's fastest growing, has been concentrated mostly among people who inject drugs (PWID). We sought to explore the epidemiology of the epidemic in St. Petersburg by sampling from the highest risk groups of PWID and men who have sex with men (MSM) and use viral sequencing data t...

journal_title：AIDS research and human retroviruses

authors： Dukhovlinova E,Masharsky A,Toussova O,Verevochkin S,Solovyeva T,Meringof M,Paintsil E,White E,Barbour R,Heimer R,Kozlov A

更新日期：2015-06-01 00:00:00

abstract：:The efficacy, safety, and pharmacokinetics of three doses of tipranavir/ritonavir (TPV/r) in highly treatment-experienced human immunodeficiency virus (HIV)-1-infected patients with protease inhibitor (PI)-resistant isolates were evaluated. A 24-week multicenter, double-blind, randomized, dose-finding trial was conduc...

journal_title：AIDS research and human retroviruses

authors： Gathe JC Jr,Pierone G,Piliero P,Arasteh K,Rubio R,Lalonde RG,Cooper D,Lazzarin A,Kohlbrenner VM,Dohnanyi C,Sabo J,Mayers D

更新日期：2007-02-01 00:00:00

abstract：:We examined the sera from 14 HIV-1 seroconverters for the presence of autoantibodies against CD4. Anti-CD4 antibodies were detected in the serum of 11 of 13 HIV-1-infected persons at the time of HIV-1 seroconversion. In 6 of 14 persons from whom a serum was obtained prior to HIV-1 seroconversion, anti-CD4 antibodies w...

journal_title：AIDS research and human retroviruses

authors： Keiser P,Keay S,Wasserman S,Wecksler W

更新日期：1992-11-01 00:00:00

abstract：:Non-B HIV-1 viruses are predominant in developing countries where access to antiretroviral drugs (ARVs) is progressively being intensified. It is important to obtain more data on the susceptibility of these viruses to available ARVs. CRF01_AE, CRF02_AG, and subtype C strains of HIV-1 obtained from untreated patients f...

journal_title：AIDS research and human retroviruses

authors： Fleury HJ,Toni T,Lan NT,Hung PV,Deshpande A,Recordon-Pinson P,Boucher S,Lazaro E,Jauvin V,Lavignolle-Aurillac V,Lebel-Binay S,Cheret A,Masquelier B

更新日期：2006-04-01 00:00:00

abstract：:We report here a novel HIV-1 second-generation recombinant form (CRF01_AE/CRF07_BC) composed of CRF01_AE and CRF07_BC, identified among men who have sex with men (MSM) in Jilin, with four breakpoints observed in the pol, vif, and vpr genes. The CRF01_AE regions of the recombinant were clustered with the CRF01_AE linea...

journal_title：AIDS research and human retroviruses

authors： Li X,Ning C,He X,Yang Y,Xing H,Hong K,Shao Y,Yang R

更新日期：2013-12-01 00:00:00

abstract：:Differences in emergence of HIV resistance between subtypes B and C in vitro and potential implications on tenofovir alafenamide efficacy in vivo were evaluated. Dose escalation resistance selections showed K65R emerging earlier for subtype C viruses in vitro, as previously reported. Viral breakthrough experiments at ...

journal_title：AIDS research and human retroviruses

authors： Cox S,Margot N,Miller M,Callebaut C

更新日期：2018-05-01 00:00:00

abstract：:HIV-1 outbreaks in Guangxi Province, southern China were initiated from two separate border cities in 1996 and 1997. Drug users in Pingxiang City, which borders Vietnam, were infected with CRF01_AE HIV-1, and drug users in Baise City, which borders Yunan Province, were infected with a novel B/C recombinant HIV-1. Sinc...

journal_title：AIDS research and human retroviruses

authors： Yu XF,Liu W,Chen J,Kong W,Liu B,Zhu Q,Liang F,McCutchan F,Piyasirisilp S,Lai S

更新日期：2002-01-20 00:00:00