Molecular characterization of a recombinant HIV type 1 isolate (A/G/E/?): unidentified regions may be derived from parental subtype E sequences.

abstract：:The development of HIV vaccines is an urgent priority and there is need to generate reagents representing multiple subtypes that can be used to screen HIV-1-specific responses. We used Aldrithiol-2 (AT-2), a mild oxidizing reagent, to eliminate the infectivity of HIV while maintaining its structure and ability to be p...

journal_title：AIDS research and human retroviruses

authors： Rutebemberwa A,Bess JW Jr,Brown B,Arroyo M,Eller M,Slike B,Polonis V,McCutchan F,Currier JR,Birx D,Robb M,Marovich M,Lifson JD,Cox JH

更新日期：2007-04-01 00:00:00

abstract：:Although Cameroon, in west central Africa, has a relatively low HIV prevalence of 5-6%, all HIV-1 groups (M, N, O, and P), nearly all HIV-1 group M subtypes, and numerous intersubtype recombinant forms have been identified in Cameroon. In this report, we describe the near full-length sequence of 04CMU11421, an HIV-1 g...

journal_title：AIDS research and human retroviruses

authors： Yamaguchi J,Vallari A,Ngansop C,Makamche F,Ndembi N,Mbanya D,Kaptué L,Gürtler LG,Devare SG,Brennan CA

更新日期：2010-06-01 00:00:00

abstract：:We examined risk factors for avascular bone necrosis (AVN) particularly focusing o the question of whether antiretroviral treatment (ART) is associated with the emergence of osteonecrosis. After 11 years of following the entire cohort, 26 patients were found to have AVN. Compared to 260 concurrent HIV-infected control...

journal_title：AIDS research and human retroviruses

authors： Hasse B,Ledergerber B,Egger M,Flepp M,Bachmann S,Bernasconi E,Egger M,Guyot S,Hirschel B,Weber R,Günthard HF,Swiss HIV Cohort Study.

更新日期：2004-09-01 00:00:00

abstract：:Japan is one of the highest endemic areas of the world for human T cell leukemia-lymphoma virus type I (HTLV-I). To gain new insight as to the origin of this virus in Japan and especially in the southern islands of the archipelago, we investigated the long terminal repeat (LTR) of 67 newly isolated HTLV-I proviral DNA...

journal_title：AIDS research and human retroviruses

authors： Vidal AU,Gessain A,Yoshida M,Mahieux R,Nishioka K,Tekaia F,Rosen L,De Thé G

更新日期：1994-11-01 00:00:00

abstract：:Despite dramatic reduction of the levels of human immunodeficiency virus type I (HIV-1) virions in blood and seminal plasma of infected patients, highly active antiretroviral therapy (HAART) does not eradicate HIV-1. Three patients, with less than 50 copies/ml of plasma viral RNA, were enrolled in this eradication pro...

journal_title：AIDS research and human retroviruses

authors： Nunnari G,Leto D,Sullivan J,Xu Y,Mehlman KE,Kulkosky J,Pomerantz RJ

更新日期：2005-09-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) proviral DNA sequences in the 5' long terminal repeat (LTR) were examined among 28 drug-naive individuals. Twenty-four subjects had highly conserved LTR sequences, however, more significant changes were observed in the remaining four LTR sequences. These included a 9-bp dele...

journal_title：AIDS research and human retroviruses

authors： Copeland KF,Chen Z,Fiebig M,Ni L,Savoy S,Smaill FM,Rosenthal KL,Kim JE

更新日期：2004-09-01 00:00:00

abstract：:Previous studies have demonstrated that lopinavir/ritonavir monotherapy maintained plasma HIV-1 RNA suppression in a large proportion of antiretroviral naive subjects. However, more subjects receiving lopinavir/ritonavir monotherapy experienced confirmed virologic rebound >50 copies/ml compared to a standard three-dru...

journal_title：AIDS research and human retroviruses

authors： Campo RE,Da Silva BA,Cotte L,Gathe JC,Gazzard B,Hicks CB,Klein CE,Chiu YL,King MS,Bernstein BM

更新日期：2009-03-01 00:00:00

abstract：:The transmembrane envelope (TM) protein gp41 of HIV-1 is an attractive target when designing a vaccine to induce neutralizing antibodies. A few broadly neutralizing antibodies (2F5, 4E10, and 10E8) that target conserved epitopes in the membrane proximal external region (MPER) of gp41 have been isolated from infected i...

journal_title：AIDS research and human retroviruses

authors： Strasz N,Morozov VA,Kreutzberger J,Keller M,Eschricht M,Denner J

更新日期：2014-05-01 00:00:00

abstract：:The clinical significance of the reduced in vitro susceptibility of HIV to antiretroviral agents has been difficult to elucidate for nucleoside analogs such as zidovudine. However, the virological significance of resistance to nevirapine and other HIV-1-specific reverse transcriptase inhibitors has been established. W...

journal_title：AIDS research and human retroviruses

authors： Richman DD

更新日期：1994-08-01 00:00:00

abstract：:Eight HIV-2-infected Caucasian men living in the same geographical area in Gipuzkoa (northern Spain) have been identified in the last 5 years. HIV-2 infection in this area is uncommon, and no other cases of HIV-2 infection have been found after extensive testing for HIV-1/2 antibodies. Epidemiological data suggested a...

journal_title：AIDS research and human retroviruses

authors： Cilla G,Rodés B,Pérez-Trallero E,Arrizabalaga J,Soriano V

更新日期：2001-03-20 00:00:00

abstract：:Histone deacetylases (HDACs) act on histones within the nucleosome-bound promoter of human immunodeficiency virus type 1 (HIV-1) to maintain proviral latency. HDAC inhibition leads to promoter expression and the escape of HIV from latency. We evaluated the ability of the potent inhibitor recently licensed for use in o...

journal_title：AIDS research and human retroviruses

authors： Archin NM,Espeseth A,Parker D,Cheema M,Hazuda D,Margolis DM

更新日期：2009-02-01 00:00:00

abstract：:Analysis of reverse transcriptase (RT) sequences of 382 HIV-1 isolates from untreated and treated patients recruited in JJ Hospital (Mumbai, India) between 2002 and 2008 shows that subtype C is largely predominant (98%) and that non-C sequences cluster with A1, B, CRF01_AE, and CRF06_cpx. ...

journal_title：AIDS research and human retroviruses

authors： Deshpande A,Jauvin V,Pinson P,Jeannot AC,Fleury HJ

更新日期：2009-06-01 00:00:00

abstract：:HIV subtype characterization is an important tool to monitor the genetic variation of the HIV epidemic. This study investigated the current HIV subtype distribution and recombination among the northern Thai population. An in-house genotypic assay of HIV protease and reverse transcriptase genes was performed on 420 pla...

journal_title：AIDS research and human retroviruses

authors： Praparattanapan J,Tragoolpua Y,Pathom-aree W,Kotarathitithum W,Chaiwarith R,Nuntachit N,Sirisanthana T,Supparatpinyo K

更新日期：2011-11-01 00:00:00

abstract：:SIVsmmFGb is a lentivirus swarm that induces neuropathology in over 90% of infected pigtailed macaques and reliably models central nervous system HIV infection in people. We have previously studied SIVsmmFGb genetic diversity and compartmentalization during acute infection, but little is understood about diversity and...

journal_title：AIDS research and human retroviruses

authors： Reeve AB,Pearce NC,Patel K,Augustus KV,Novembre FJ

更新日期：2010-06-01 00:00:00

abstract：:Transmission of HIV-1 and drug resistance continue to occur at a considerable level in Italy, influenced mainly by changes in modality of infection. However, the long period of infectivity makes difficult the interpretation of epidemiological networks, based on epidemiological data only. We studied 510 naive HIV-1-inf...

journal_title：AIDS research and human retroviruses

authors： Lai A,Violin M,Ebranati E,Franzetti M,Micheli V,Gismondo MR,Capetti A,Meraviglia P,Simonetti FR,Bozzi G,Ciccozzi M,Galli M,Zehender G,Balotta C

更新日期：2012-08-01 00:00:00

abstract：:To examine the genetic features of the long terminal repeat (LTR) derived from six HIV-1-infected individuals enrolled in the Mexico City Cohort, we cloned and sequenced a 505-bp fragment of the proviral LTR from their peripheral blood mononuclear cells (PBMCs). All patients harbored HIV-1 LTR quasispecies correspondi...

journal_title：AIDS research and human retroviruses

authors： Gómez-Román VR,Vázquez JA,del Carmen Basualdo M,Estrada FJ,Ramos-Kuri M,Soler C

更新日期：2000-03-20 00:00:00

abstract：:Preexposure prophylaxis (PrEP) of HIV infection with tenofovir-containing regimens is effective, but plagued by poor adherence in some studies. Options for safe, effective, and acceptable PrEP products, especially for men and women at risk of HIV via receptive anal intercourse (RAI), are needed. We performed a randomi...

journal_title：AIDS research and human retroviruses

authors： Leyva F,Fuchs EJ,Bakshi R,Carballo-Dieguez A,Ventuneac A,Yue C,Caffo B,Du Y,Torbenson M,Li L,Mullin G,Lee L,Rohan L,Anton PA,Hendrix CW

更新日期：2015-11-01 00:00:00

abstract：:This randomized, open-labeled, multicenter study was designed to assess safety and pharmacokinetics of dronabinol (Marinol) tablets and megestrol acetate (Megace) micronized tablets, alone and in combination, for treatment of HIV wasting syndrome. Weight and quality of life data were also collected. Fifty-two patients...

journal_title：AIDS research and human retroviruses

authors： Timpone JG,Wright DJ,Li N,Egorin MJ,Enama ME,Mayers J,Galetto G

更新日期：1997-03-01 00:00:00

abstract：:Glutamine is a conditionally essential amino acid that is an important metabolic resource for proliferating tissues by acting as a proteinogenic amino acid, a nitrogen donor for biosynthetic reactions and as a substrate for the citric acid or tricarboxylic acid cycle. The human immunodeficiency virus type 1 (HIV-1) pr...

journal_title：AIDS research and human retroviruses

authors： Hegedus A,Kavanagh Williamson M,Khan MB,Dias Zeidler J,Da Poian AT,El-Bacha T,Struys EA,Huthoff H

更新日期：2017-12-01 00:00:00

abstract：:Six morphine-dependent and three control macaques were infected with a mixture of SIV/SHIV. Half of the animals in the morphine group developed accelerated disease (rapid progressor) and died within 20 weeks postinfection. The evolution of the envelope gene in the brain of the rapid progressor and morphine-dependent g...

journal_title：AIDS research and human retroviruses

authors： Rivera-Amill V,Noel RJ Jr,Román IR,Flores YG,Buch S,Kumar A

更新日期：2009-05-01 00:00:00

abstract：:Dendritic cells (DCs) are important mediators of the immune response against HIV and yet blood DC numbers fall substantially during HIV infection. Here we report that blood levels of the DC-tissue tropic chemokines monocyte chemotactic protein (MCP-1/CCL2), macrophage inflammatory proteins (MIP-3α/CCL20), and MIP-3β/C...

journal_title：AIDS research and human retroviruses

authors： Fontaine J,Poudrier J,Roger M

更新日期：2011-06-01 00:00:00

abstract：:Most viral vaccines currently in use in humans are live attenuated strains of virus that lack pathogenic potential. In general, such live attenuated vaccines induce the strongest longest-lasting immunity. Live attenuated strains of human immunodeficiency virus type 1 (HIV-1) have not been previously considered as vacc...

journal_title：AIDS research and human retroviruses

authors： Desrosiers RC

更新日期：1992-03-01 00:00:00

abstract：:The full-length RNA of human immunodeficiency virus type 1 (HIV-1) serves both as a messenger (mRNA) to direct the translation of Pr55(gag) proteins and as genomic or viral particle RNA (vpRNA) to be packaged into virions. In this study, we have assessed a putative cis-acting effect of Pr55(gag) translation on HIV-1 R...

journal_title：AIDS research and human retroviruses

authors： Liang C,Hu J,Russell RS,Wainberg MA

更新日期：2002-10-10 00:00:00

abstract：:Several reports have suggested an increased prevalence of osteopenia and osteoporosis in HIV-infected individuals. Vitamin D deficiency may be a risk factor for osteoporosis and bone fractures. We aimed to determine the prevalence of vitamin D insufficiency in an outpatient HIV clinic in Boston. We collected serum lev...

journal_title：AIDS research and human retroviruses

authors： Rodríguez M,Daniels B,Gunawardene S,Robbins GK

更新日期：2009-01-01 00:00:00

abstract：:A workshop entitled "Regulatory T cells (T(reg)) and HIV/AIDS" was held in Cincinnati, OH, September 7-8, 2006. This workshop was the first completely dedicated to T(reg) in HIV infection, and gathered investigators working on different aspects of T(reg) biology, and on HIV pathogenesis. We report here the major topic...

journal_title：AIDS research and human retroviruses

authors： Chougnet CA,Shearer GM

更新日期：2007-07-01 00:00:00

abstract：:We performed an HTLV epidemiological study of 986 individuals from 17 villages from the same state of Salvador, the city with the highest HTLV-1 prevalence in Brazil. The HTLV-1 prevalence was 3.85%, 1.56%, and 1.23% in three villages. Phylogenetic analysis of the LTR region demonstrated that all positive samples anal...

journal_title：AIDS research and human retroviruses

authors： Rego FF,Alcantara LC,Moura Neto JP,Miranda AC,Pereira Ode S,Gonçalves Mde S,Galvão-Castro B

更新日期：2008-05-01 00:00:00

abstract：:Some genomic elements of the multicopy HERV-W endogenous retroviral family have been previously identified in databases. One of them, located on chromosome 7, contains a single complete open reading frame (ORF) putatively encoding an envelope protein. We have experimentally investigated the genomic complexity and codi...

journal_title：AIDS research and human retroviruses

authors： Voisset C,Bouton O,Bedin F,Duret L,Mandrand B,Mallet F,Paranhos-Baccala G

更新日期：2000-05-20 00:00:00

abstract：:In order to investigate how human immunodeficiency virus (HIV) gains entry to the placenta, we have performed in vitro experiments in which highly purified trophoblast cells isolated from term human placentas were examined for their susceptibility to HIV infection. Trophoblast cells were exposed to cell-free HIV-1 for...

journal_title：AIDS research and human retroviruses

authors： Douglas GC,Fry GN,Thirkill T,Holmes E,Hakim H,Jennings M,King BF

更新日期：1991-09-01 00:00:00

abstract：:Persons living with HIV (PLWH) with substance use disorders (SUD) remain a population difficult to engage in HIV care. Project HOPE (Hospital Visits as an Opportunity for Prevention and Engagement), a randomized controlled trial testing patient navigation with/without contingency management for PLWH with SUD, aimed to...

journal_title：AIDS research and human retroviruses

authors： Summers NA,Colasanti JA,Feaster DJ,Armstrong WS,Rodriguez A,Jain MK,Jacobs P,Metsch LR,Del Rio C

更新日期：2020-05-01 00:00:00

abstract：:Partial sequences of HIV-1 polymerase from 185 patients, 141 ARV experienced and 44 naive, of gag (p24) and env (C2V3) from a subset of naive cases were evaluated in São Paulo, Brazil. Antiretroviral resistance mutations were detected in 4% of 26 recently (<2 years) infected patients. Polymorphisms at the protease gen...

journal_title：AIDS research and human retroviruses

authors： Brígido LF,Franco HM,Custódio RM,Oliveira CA,P Ferreira JL,Eira M,Bergel F,Araújo F,Carvalheiro JR,Rodrigues R

更新日期：2005-07-01 00:00:00