Susceptibility to antiretroviral drugs of CRF01_AE, CRF02_AG, and subtype C viruses from untreated patients of Africa and Asia: comparative genotypic and phenotypic data.

abstract：:Current methods to detect intraclade HIV dual infection are poorly suited for determining its prevalence in large cohorts. To investigate the potential of ultra-deep sequencing to screen for dual infection, we compared it to bulk sequence-based synonymous mixture index and the current standard of single genome sequenc...

journal_title：AIDS research and human retroviruses

authors： Pacold M,Smith D,Little S,Cheng PM,Jordan P,Ignacio C,Richman D,Pond SK

更新日期：2010-12-01 00:00:00

abstract：:Serum specimens (n = 1899) were assayed for infections with HTLV-I, HTLV-II, and HIV-1 in seven classified groups of normal healthy controls, children, pregnant women, prostitutes, intravenous drug abusers, patients under going hemodialysis, and hemophiliacs in South and North Vietnam. Surprisingly, 125 of 954 samples...

journal_title：AIDS research and human retroviruses

authors： Fukushima Y,Takahashi H,Hall WW,Nakasone T,Nakata S,Song P,Dinh Duc D,Hien B,Nguyen XQ,Ngoc Trinh T

更新日期：1995-05-01 00:00:00

abstract：:Intense research into fundamental processes of human immunodeficiency syndrome type 1 (HIV-1) replication has yielded knowledge that in many aspects equals or exceeds that of the oncogenic retroviruses. The availability of sensitive virus detection methods has allowed a more thorough characterization of the biology of...

journal_title：AIDS research and human retroviruses

authors： Stevenson M,Bukrinsky M,Haggerty S

更新日期：1992-02-01 00:00:00

abstract：:Epidemiological and experimental data suggest that both robust neutralizing antibodies and potent cellular responses play important roles in controlling primary HIV-1 infection. In this study we have investigated the induction of systemic and mucosal immune responses to HIV gp120 monomer immunogen administered intrana...

journal_title：AIDS research and human retroviruses

authors： Bielinska AU,Janczak KW,Landers JJ,Markovitz DM,Montefiori DC,Baker JR Jr

更新日期：2008-02-01 00:00:00

abstract：:Perinatal antiretroviral (ARV) exposure has been related to hyperlactatemia and lactic acidosis in infants born to HIV-infected mothers. Our objective was to determine the incidence of these conditions during the first year of life in uninfected infants born to HIV-infected mothers and compare the data with infants bo...

journal_title：AIDS research and human retroviruses

authors： Soler-Palacín P,Martín-Nalda A,Martínez-Gómez X,Melendo S,Riudor E,Arranz JA,Espiau M,Figueras C

更新日期：2012-08-01 00:00:00

abstract：:Serum samples collected prospectively between 1982 and 1987 from a cohort of homosexual men were analyzed for HIV-1 neutralizing antibodies. Seven seroconverters who became infected between 1982 and 1984 and 12 seroprevalents who were already seropositive in 1982 remained free of AIDS. During the 6 year period, 1 sero...

journal_title：AIDS research and human retroviruses

authors： Robert-Guroff M,Goedert JJ,Naugle CJ,Jennings AM,Blattner WA,Gallo RC

更新日期：1988-10-01 00:00:00

abstract：:An atypical HIV-1 strain (CAM001) was identified in a pregnant Cameroonian woman in 1995. HMA subtyping of the env region was unsuccessful, and sequence analyses were performed. Unique sequence motifs were found at the V3 tip (GAGRALHA and GAGRAWIHA), and phylogenetic studies showed that the env C2-V5 sequence branche...

journal_title：AIDS research and human retroviruses

authors： Roques P,Menu E,Narwa R,Scarlatti G,Tresoldi E,Damond F,Mauclère P,Dormont D,Chaouat G,Simon F,Barré-Sinoussi F

更新日期：1999-11-20 00:00:00

abstract：:HIV was first described in Kenya in 1984-1985. Currently, Kenya has an estimated HIV-1 prevalence of 6.2%. With the introduction of antiretroviral drugs, the survival of most HIV patients has been prolonged markedly. However, this is greatly threatened by increasing rates of antiretroviral dug resistance, which may ev...

journal_title：AIDS research and human retroviruses

authors： Onsongo S,Abidi SH,Khamadi S,Shah R,Kageha S,Ojwang P,Ali S,Okinda N

更新日期：2016-03-01 00:00:00

abstract：:We studied plasma samples from 2082 Mataco Indians living in 22 different communities in the western part of Formosa Province, northern Argentina. Samples were screened for HTLV-I/II antibodies by particle agglutination assay. All positive or borderline samples were then tested by an immunofluorescence assay (IFA) on ...

journal_title：AIDS research and human retroviruses

authors： Biglione M,Vidan O,Mahieux R,de Colombo M,de los Angeles de Basualdo M,Bonnet M,Pankow G,De Efron MA,Zorrilla A,Tekaia F,Murphy E,de Thé G,Gessain A

更新日期：1999-03-20 00:00:00

abstract：:In HIV-infected persons, certain HLA class I alleles are associated with effective control of viremia, while others are associated with rapid disease progression. Among the most divergent clinical outcomes are the relatively good prognosis in HLA-B*5801 expressing persons and poor prognosis with HLA-B*5802. These two ...

journal_title：AIDS research and human retroviruses

authors： Ngumbela KC,Day CL,Mncube Z,Nair K,Ramduth D,Thobakgale C,Moodley E,Reddy S,de Pierres C,Mkhwanazi N,Bishop K,van der Stok M,Ismail N,Honeyborne I,Crawford H,Kavanagh DG,Rousseau C,Nickle D,Mullins J,Heckerman D,K

更新日期：2008-01-01 00:00:00

abstract：:CD8+ lymphocytes (CD8 cells) have been shown to inhibit replication of the human immunodeficiency virus (HIV) in vitro when cocultured with HIV-infected CD4+ lymphocytes (CD4 cells). This suppressive effect on HIV replication in experimentally infected CD4 cells has so far been demonstrated only for CD8 cells from HIV...

journal_title：AIDS research and human retroviruses

authors： Røsok B,Voltersvik P,Larsson BM,Albert J,Brinchmann JE,Asjö B

更新日期：1997-01-01 00:00:00

abstract：:Surveillance of drug resistance mutations in antiretroviral-experienced HIV(+) patients may provide useful information regarding options available for rescue interventions. All resistance tests performed from 1999 to 2005 on antiretroviral-experienced individuals at one reference laboratory in Madrid were examined. On...

journal_title：AIDS research and human retroviruses

authors： de Mendoza C,Garrido C,Corral A,Ramírez-Olivencia G,Jiménez-Nacher I,Zahonero N,Gonzalez-Lahoz J,Soriano V

更新日期：2007-07-01 00:00:00

abstract：:To investigate the origin and evolutionary history of the spread of HIV-1 subtype B in China, a total of 409 sequences of pol gene sampled from 1994 to 2012 in 29 provinces across China was subjected to phylogenetic and Bayesian molecular clock analyses. The study reveals that subtype B strains in China are geneticall...

journal_title：AIDS research and human retroviruses

authors： Ye J,Lu H,Su X,Xin R,Bai L,Xu K,Yu S,Feng X,Yan H,He X,Zeng Y

更新日期：2014-09-01 00:00:00

abstract：:Genetic polymorphisms within the MHC encoding region have the strongest impact on HIV disease progression of any in the human genome and provide important clues to the mechanisms of HIV immune control. Few analyses have been undertaken of HLA alleles associated with rapid disease progression. HLA-B*07:02 is an HLA cla...

journal_title：AIDS research and human retroviruses

authors： Kløverpris HN,Adland E,Koyanagi M,Stryhn A,Harndahl M,Matthews PC,Shapiro R,Walker BD,Ndung'u T,Brander C,Takiguchi M,Buus S,Goulder P

更新日期：2014-05-01 00:00:00

abstract：:Il28B single nucleotide polymorphisms were found to influence interferon λ expression, resulting in changes in hepatitis C virus (HCV)-RNA serum levels as well as the HIV-RNA set point prior to combined antiretroviral therapy (cART). To date, there is limited information on the influence of this polymorphism on surviv...

journal_title：AIDS research and human retroviruses

authors： Parczewski M,Bander D,Leszczyszyn-Pynka M,Urbańska A,Socha Ł,Boroń-Kaczmarska A

更新日期：2012-12-01 00:00:00

abstract：:To design a vaccine that will remain potent against HIV-1, the immunogenic regions in the viral envelope that tend to change as well as those that remain constant over time must be identified. To determine the neutralization profiles of sequential viruses over time and study whether neutralization patterns correlate w...

journal_title：AIDS research and human retroviruses

authors： Nyambi P,Burda S,Urbanski M,Heyndrickx L,Janssens W,Vanham G,Nadas A

更新日期：2008-12-01 00:00:00

abstract：:Simian AIDS-related lymphomas (sARL) of cynomolgus monkeys infected with a simian immunodeficiency virus (SIVsm) were studied in relation to growth in severe combined immunodeficient (SCID) mice, karyotype abnormalities, and DNA sequence of the first noncoding region of the Bcl-6 gene. The tumors were diffuse large B ...

journal_title：AIDS research and human retroviruses

authors： Castaños-Vélez E,Heiden T,Lindvall C,Capello D,Sandlund A,Imreh S,Blennow E,Andersson LC,Gaidano G,Nordenskjöld M,Biberfeld P

更新日期：2002-03-20 00:00:00

abstract：:Using human macrophage hybridomas infected with HIV-1, we investigated monocyte function over a 5-week period after HIV-1 infection. Two clones, 63 and 30, were infected with HIV-1IIIB. Infection was documented by RT activity (15 x 10(6) cpm/ml), intracytoplasmic staining with an anti-p24 antibody, in situ hybridizati...

journal_title：AIDS research and human retroviruses

authors： Sperber K,Hamrang G,Louie MJ,Kalb T,Banerjee R,Choi HS,Paronetto F,Mayer L

更新日期：1993-07-01 00:00:00

abstract：:This study explores whether previous failures on antiretroviral drug regimens preclude the possibility of immune restoration. This was assessed by evaluating T cell subset changes in individuals who received a salvage regimen of highly active antiretroviral therapy (HAART) after initially failing protease inhibitor mo...

journal_title：AIDS research and human retroviruses

authors： Gray CM,Schapiro JM,Winters MA,Merigan TC

更新日期：1998-05-01 00:00:00

abstract：:The majority of AIDS patients will experience some degree of dementia induced by human immunodeficiency virus (HIV-1). In this study, we report that treatment of human brain tissue with envelope gp120 of HIV-1 did not cause neuronal death but did cause astrocyte alterations and/or death. Human astrocyte cultures showe...

journal_title：AIDS research and human retroviruses

authors： Pulliam L,West D,Haigwood N,Swanson RA

更新日期：1993-05-01 00:00:00

abstract：:Here we report the construction, sequencing, and biological characterization of a molecular clone of HIV-1(92UG001), a virus representative of subtype D strains circulating in Uganda. The virus produced by the clone has an aggressive syncytium-inducing phenotype, which matches that of the parental virus. This phenotyp...

journal_title：AIDS research and human retroviruses

authors： Novelli P,Vella C,Oxford J,Daniels RS

更新日期：2002-01-01 00:00:00

abstract：:Despite dramatic reduction of the levels of human immunodeficiency virus type I (HIV-1) virions in blood and seminal plasma of infected patients, highly active antiretroviral therapy (HAART) does not eradicate HIV-1. Three patients, with less than 50 copies/ml of plasma viral RNA, were enrolled in this eradication pro...

journal_title：AIDS research and human retroviruses

authors： Nunnari G,Leto D,Sullivan J,Xu Y,Mehlman KE,Kulkosky J,Pomerantz RJ

更新日期：2005-09-01 00:00:00

abstract：:In a set of 42 antiretroviral naive HIV-1 infected persons who were treated with either Zidovudine (AZT) monotherapy, or a combination of AZT + ddC (Zalcitabine) or AZT + ddI (Didanosine), the HIV-1 DNA load was measured by competitive polymerase chain reaction (PCR) and related to the HIV-1 RNA load in plasma, the CD...

journal_title：AIDS research and human retroviruses

authors： Bruisten SM,Reiss P,Loeliger AE,van Swieten P,Schuurman R,Boucher CA,Weverling GJ,Huisman JG

更新日期：1998-08-10 00:00:00

abstract：:We aimed to determine the prevalence of a prolonged QTc interval in HIV-infected patients and its related factors through an observational study of a cohort of asymptomatic HIV-infected outpatients. All patients underwent a standard 12-lead electrocardiogram and a transthoracic echocardiogram. Prolonged QTc was consid...

journal_title：AIDS research and human retroviruses

authors： Moreno T,Pérez I,Isasti G,Cabrera F,Santos J,Palacios R

更新日期：2013-09-01 00:00:00

abstract：:We performed an HTLV epidemiological study of 986 individuals from 17 villages from the same state of Salvador, the city with the highest HTLV-1 prevalence in Brazil. The HTLV-1 prevalence was 3.85%, 1.56%, and 1.23% in three villages. Phylogenetic analysis of the LTR region demonstrated that all positive samples anal...

journal_title：AIDS research and human retroviruses

authors： Rego FF,Alcantara LC,Moura Neto JP,Miranda AC,Pereira Ode S,Gonçalves Mde S,Galvão-Castro B

更新日期：2008-05-01 00:00:00

abstract：:Human T-lymphotrophic virus type II (HTLV-II) has not yet been associated with any disease. Little is known about the proviral loads of HTLV-II in vivo and its relationship, if any, to lack of pathogenicity. We determined the HTLV-II proviral copy number in peripheral blood lymphocyte (PBL) samples from 49 HTLV-II-inf...

journal_title：AIDS research and human retroviruses

authors： Woods TC,Graber JM,Hershow RC,Khabbaz RF,Kaplan JE,Heneine W

更新日期：1995-10-01 00:00:00

abstract：:Anemia, a common hematological abnormality in HIV, contributes to decreased quality of life (QOL). This study assessed once-every-2-week epoetin alfa on maintaining QOL and hemoglobin (Hb) in anemic HIV-infected patients in a 24-week, open-label, multicenter study. HIV-infected patients (Hb < or =12 g/dl) received epo...

journal_title：AIDS research and human retroviruses

authors： Levine AM,Salvato P,Leitz GJ,Champs 2 Study Group.

更新日期：2008-02-01 00:00:00

abstract：:Our goal has been to develop a safe and effective system that would allow us to explore the functions of the human immunodeficiency virus (HIV) envelope. We have generated a human lymphoid cell line (TF228.1.16) that stably expresses functional HIV envelope proteins on its cell surface, and therefore closely mimics th...

journal_title：AIDS research and human retroviruses

authors： Jonak ZL,Clark RK,Matour D,Trulli S,Craig R,Henri E,Lee EV,Greig R,Debouck C

更新日期：1993-01-01 00:00:00

abstract：:The aim of this study was to determine the patterns of change in body fat and metabolic parameters in a South African cohort on a first line ART regimen containing stavudine. Fasting lipogram, blood glucose and insulin levels, CD4 cell count, viral load, BMI, waist-to-hip ratio (WHR), and skinfold thickness at the tri...

journal_title：AIDS research and human retroviruses

authors： George JA,Venter WD,Van Deventer HE,Crowther NJ

更新日期：2009-08-01 00:00:00

abstract：:To examine the genetic features of the long terminal repeat (LTR) derived from six HIV-1-infected individuals enrolled in the Mexico City Cohort, we cloned and sequenced a 505-bp fragment of the proviral LTR from their peripheral blood mononuclear cells (PBMCs). All patients harbored HIV-1 LTR quasispecies correspondi...

journal_title：AIDS research and human retroviruses

authors： Gómez-Román VR,Vázquez JA,del Carmen Basualdo M,Estrada FJ,Ramos-Kuri M,Soler C

更新日期：2000-03-20 00:00:00