Correlates of antiretroviral utilization among hospitalized HIV-infected crack cocaine users.

abstract：:Our goal has been to develop a safe and effective system that would allow us to explore the functions of the human immunodeficiency virus (HIV) envelope. We have generated a human lymphoid cell line (TF228.1.16) that stably expresses functional HIV envelope proteins on its cell surface, and therefore closely mimics th...

journal_title：AIDS research and human retroviruses

authors： Jonak ZL,Clark RK,Matour D,Trulli S,Craig R,Henri E,Lee EV,Greig R,Debouck C

更新日期：1993-01-01 00:00:00

abstract：:The measurement of antiretroviral concentrations in hair is emerging as an important technology to objectively quantify adherence to combination antiretroviral therapy. Hair levels of antiretrovirals are the strongest independent predictor of virologic success in large prospective cohorts of HIV-infected patients and ...

journal_title：AIDS research and human retroviruses

authors： Gandhi M,Yang Q,Bacchetti P,Huang Y

更新日期：2014-01-01 00:00:00

abstract：:Differences in the extent of genetic diversity have been observed in human immunodeficiency virus type-1 (HIV-1) envelope sequences early in infection, and this has been linked to gender and to modifiable exogenous factors such as hormonal contraceptive use and genital tract infections. But it is unclear whether envel...

journal_title：AIDS research and human retroviruses

authors： Sagar M,Kirkegaard E,Lavreys L,Overbaugh J

更新日期：2006-05-01 00:00:00

abstract：:Patients with HIV-1 and human T-lymphotropic virus type 2 (HTLV-2) coinfections often exhibit a clinical course similar to that seen in HIV-1-infected individuals who are long-term nonprogressors. These findings have been attributed in part to the ability of HTLV-2 to activate production of antiviral chemokines and to...

journal_title：AIDS research and human retroviruses

authors： Barrios CS,Castillo L,Giam CZ,Wu L,Beilke MA

更新日期：2013-07-01 00:00:00

abstract：:HIV inhibitors targeted at the virus-associated reverse transcriptase (RT) can be divided into two groups, depending on whether they are targeted at the substrate or nonsubstrate binding site. To the first group belong the 2',3'-dideoxynucleosides (i.e., DDC, DDI), 3'-azido-2',3'-dideoxynucleosides (i.e., AZT), 3'-flu...

journal_title：AIDS research and human retroviruses

authors： De Clercq E

更新日期：1992-02-01 00:00:00

abstract：:DC-SIGN, a C-type lection expressed on dendritic cells, enhances HIV-1 infection in cis and in trans. HIV-1 circulating recombinant form (CRF) 07_BC viruses have been the predominant strain found among injection drug users in southern China and Taiwan. The goal of this study was to map the DC-SIGN-interactive domain o...

journal_title：AIDS research and human retroviruses

authors： Liao CF,Wang SF,Lin YT,Ho DD,Chen YM

更新日期：2011-08-01 00:00:00

abstract：:We compared HIV-1 subtype B reverse transcriptase (RT) and protease mutation patterns in isolates from heavily treated persons in Northern California with those from persons described in the published literature predominantly from other parts of the United States and Europe. There were few differences in the prevalenc...

journal_title：AIDS research and human retroviruses

authors： Gonzales MJ,Belitskaya I,Dupnik KM,Rhee SY,Shafer RW

更新日期：2003-10-01 00:00:00

abstract：:Non-B HIV-1 viruses are predominant in developing countries where access to antiretroviral drugs (ARVs) is progressively being intensified. It is important to obtain more data on the susceptibility of these viruses to available ARVs. CRF01_AE, CRF02_AG, and subtype C strains of HIV-1 obtained from untreated patients f...

journal_title：AIDS research and human retroviruses

authors： Fleury HJ,Toni T,Lan NT,Hung PV,Deshpande A,Recordon-Pinson P,Boucher S,Lazaro E,Jauvin V,Lavignolle-Aurillac V,Lebel-Binay S,Cheret A,Masquelier B

更新日期：2006-04-01 00:00:00

abstract：:An SV40-based expression vector was used to generate CD4-negative murine L cell lines which stably expressed the human immunodeficiency virus envelope glycoprotein (env). Despite the presence of abundant intracellular envelope glycoprotein, the expression of env gp120/41 was not detected on the cell surface. Pulse-cha...

journal_title：AIDS research and human retroviruses

authors： Bird C,Gleeson PA,Ramsay A,Li P,McCluskey J

更新日期：1992-12-01 00:00:00

abstract：:The predictive value of virological response to lopinavir (LPV)/ritonavir (r) was assessed in 126 HIV-infected patients who failed antiretroviral therapy and had begun a rescue intervention based on LPV/r. At 3 months, subjects with < or =6 protease (PRO) resistance mutations showed a higher rate of virological respon...

journal_title：AIDS research and human retroviruses

authors： González de Requena D,Gallego O,Valer L,Jiménez-Nácher I,Soriano V

更新日期：2004-03-01 00:00:00

abstract：:Gag-specific immune responses and changes in HIV-1 RNA levels were evaluated in eight HIV-1-infected persons, in order to assess the immunotherapeutic potential HIV-1 p17/p24: Ty virus-like particles (p24-VLP). All treated subjects showed transient and dose-dependent proliferative responses to the Ty-VLP carrier (stim...

journal_title：AIDS research and human retroviruses

authors： Klein MR,Veenstra J,Holwerda AM,Roos MT,Gow I,Patou G,Coutinho RA,De Wolf F,Miedema F

更新日期：1997-03-20 00:00:00

abstract：:Analysis of reverse transcriptase (RT) sequences of 382 HIV-1 isolates from untreated and treated patients recruited in JJ Hospital (Mumbai, India) between 2002 and 2008 shows that subtype C is largely predominant (98%) and that non-C sequences cluster with A1, B, CRF01_AE, and CRF06_cpx. ...

journal_title：AIDS research and human retroviruses

authors： Deshpande A,Jauvin V,Pinson P,Jeannot AC,Fleury HJ

更新日期：2009-06-01 00:00:00

abstract：:In vitro and in vivo studies have demonstrated that HIV can infect thymocytes at different maturational stages and lead to changes in the thymic microenvironment. To determine the effect of HIV on thymic stromal cells and the production of cytokines important in thymocyte development, three types of adherent thymic cu...

journal_title：AIDS research and human retroviruses

authors： Sandborg CI,Imfeld KL,Zaldivar F Jr,Berman MA

更新日期：1994-10-01 00:00:00

abstract：:Current methods to detect intraclade HIV dual infection are poorly suited for determining its prevalence in large cohorts. To investigate the potential of ultra-deep sequencing to screen for dual infection, we compared it to bulk sequence-based synonymous mixture index and the current standard of single genome sequenc...

journal_title：AIDS research and human retroviruses

authors： Pacold M,Smith D,Little S,Cheng PM,Jordan P,Ignacio C,Richman D,Pond SK

更新日期：2010-12-01 00:00:00

abstract：:To establish whether the low cysteine and glutathione levels in HIV-infected patients and SIV-infected rhesus macaques may be consequences of an abnormal cysteine catabolism, we analyzed sulfate and glutathione levels in macaques. Muscle tissue (m. vastus lateralis and m. gastrocnemius) of SIV-infected macaques (n = 2...

journal_title：AIDS research and human retroviruses

authors： Gross A,Hack V,Stahl-Hennig C,Dröge W

更新日期：1996-11-20 00:00:00

abstract：:Information about the efficacy of antiretroviral drugs in HIV-1 group O strains as well on the virus evolution in terms of resistance development in vivo is very limited. We assessed the clinical, immunological, and virological response to antiretroviral therapy as well as the selection of drug resistance in six HIV-1...

journal_title：AIDS research and human retroviruses

authors： Rodes B,de Mendoza C,Rodgers M,Newell A,Jimenez V,Lopez-Brugada RM,Soriano V

更新日期：2005-07-01 00:00:00

abstract：:Several reports have suggested an increased prevalence of osteopenia and osteoporosis in HIV-infected individuals. Vitamin D deficiency may be a risk factor for osteoporosis and bone fractures. We aimed to determine the prevalence of vitamin D insufficiency in an outpatient HIV clinic in Boston. We collected serum lev...

journal_title：AIDS research and human retroviruses

authors： Rodríguez M,Daniels B,Gunawardene S,Robbins GK

更新日期：2009-01-01 00:00:00

abstract：:To determine the role that cellular immune responses play in the protection conferred by vaccination with attenuated SIVmac32H (pC8), we have attempted to deplete macaques of their CD8+ cells prior to challenge with wild-type SIVmac32H (pJ5). In two of four pC8-infected macaques, N109 and N112, a transient partial dep...

journal_title：AIDS research and human retroviruses

authors： Stebbings R,Stott J,Almond N,Hull R,Lines J,Silvera P,Sangster R,Corcoran T,Rose J,Cobbold S,Gotch F,McMichael A,Walker B

更新日期：1998-09-01 00:00:00

abstract：:Nucleoside analog reverse transcriptase inhibitors (NRTIs) constitute the most commonly used drugs in antiretroviral therapy. NRTIs differ with respect to their host cell toxicity. We compared the in vitro effect of zidovudine (AZT; 2 μg/ml), lamivudine (3TC; 5 μg/ml), stavudine (d4T; 1 μg/ml), and tenofovir (TFV; 1 μ...

journal_title：AIDS research and human retroviruses

authors： Enomoto L,Anderson PL,Li S,Edelstein CL,Weinberg A

更新日期：2011-01-01 00:00:00

abstract：:We have previously shown that the cell line 6D5(451) chronically infected with the HIV-1 isolate HTLV-III(451), secretes the HIV-1 envelope glycoproteins gp120 and gp160 in the extracellular medium. The HTLV-III(451) gp120 and gp160 were purified by sequential affinity chromatographic steps using a monoclonal antibody...

journal_title：AIDS research and human retroviruses

authors： Kalyanaraman VS,Rodriguez V,Veronese F,Rahman R,Lusso P,DeVico AL,Copeland T,Oroszlan S,Gallo RC,Sarngadharan MG

更新日期：1990-03-01 00:00:00

abstract：:An EBV-transformed lymphoblastoid B cell clone (A12) derived from peripheral blood lymphocytes of an HIV-1-infected individual is described. The immunoglobulin isotype produced by this clone was IgM, and Southern blot analysis of immunoglobulin gene rearrangement showed a monoclonal pattern. The A12 monoclonal antibod...

journal_title：AIDS research and human retroviruses

authors： Amadori A,Ciminale V,Calabro ML,Tessarollo L,Francavilla E,Chieco-Bianchi L

更新日期：1989-02-01 00:00:00

abstract：:HIV infection is associated with qualitative and functional immune deficiencies. It has been shown that the in vitro infection of CD4+ cells with HIV was associated with sustained elevation of cAMP and cGMP. In the present report the role of cAMP on HIV replication in MT-4 cells was investigated. The MT-4 cells were i...

journal_title：AIDS research and human retroviruses

authors： Nokta MA,Pollard RB

更新日期：1992-07-01 00:00:00

abstract：:The prevalence of human immunodeficiency virus type 1 (HIV-1) is highest among men who have sex with men (MSM) in Jamaica but no genotypic data are available on the virus strains that are responsible for the epidemic among this key population. HIV-1 polymerase (pol) genes from 65 MSM were sequenced and used to predict...

journal_title：AIDS research and human retroviruses

authors： Collins-Fairclough AM,Dennis AM,Nelson JA,Weir SS,Figueroa JP

更新日期：2015-08-01 00:00:00

abstract：:We investigated whether V3-binding assays might be useful to analyze human immunodeficiency virus type 1 (HIV-1) variants in different geographic regions. We showed that strong cross-reactivity between subtype-specific V3 peptides is almost inevitable in standard indirect enzyme-linked immunosorbent assays (EIA), impa...

journal_title：AIDS research and human retroviruses

authors： Barin F,Lahbabi Y,Buzelay L,Lejeune B,Baillou-Beaufils A,Denis F,Mathiot C,M'Boup S,Vithayasai V,Dietrich U,Goudeau A

更新日期：1996-09-01 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiologic agent of COVID-19, a disease that as of July 10, 2020, has infected >12 million people and killed >500,000. COVID-19 infection leads to acute respiratory distress syndrome in a subset of patients and is a primary driver of acute morbidity in...

journal_title：AIDS research and human retroviruses

authors： Al-Harthi L,Campbell E,Schneider JA,Bennett DA

更新日期：2020-08-10 00:00:00

abstract：:Serological inspection of Simian T-lymphotropic Virus Type 1 was conducted for a wild colony of Macaca fuscata, which was captured in the middle Honshu, Japan. The increase of positive rate after the juvenile stage with the positive rate reaching 100% (or 35/35) in youngster and adult stages, was observed. This findin...

journal_title：AIDS research and human retroviruses

authors： Eguchi K,Ohsawa K,Fuse Kiyono M,Suzuki J,Kurokawa K,Yamamoto T

更新日期：2011-02-01 00:00:00

abstract：:The advent of antiretroviral treatment (ART) has resulted in a dramatic reduction in AIDS-related morbidity and mortality. However, the emergence and spread of antiretroviral drug resistance (DR) threaten to negatively impact treatment regimens and compromise efforts to control the epidemic. It is recommended that sur...

journal_title：AIDS research and human retroviruses

authors： Cheriro W,Kiptoo M,Kikuvi G,Mining S,Emonyi W,Songok E

更新日期：2015-12-01 00:00:00

abstract：:We have previously used immunotoxins to select for HIV-1 variant cells that transcribe HIV at extremely low levels and fail to produce HIV proteins. Further observation of one of these variants (E9) demonstrated spontaneous in vitro activation of HIV production. The mechanism of activation is different from that of U1...

journal_title：AIDS research and human retroviruses

authors： Fang H,Pincus S

更新日期：1999-10-10 00:00:00

abstract：:To investigate the origin and evolutionary history of the spread of HIV-1 subtype B in China, a total of 409 sequences of pol gene sampled from 1994 to 2012 in 29 provinces across China was subjected to phylogenetic and Bayesian molecular clock analyses. The study reveals that subtype B strains in China are geneticall...

journal_title：AIDS research and human retroviruses

authors： Ye J,Lu H,Su X,Xin R,Bai L,Xu K,Yu S,Feng X,Yan H,He X,Zeng Y

更新日期：2014-09-01 00:00:00

abstract：:Similarly to HIV-infected cells, recombinant HIV-1 glycoprotein 120 induces acid-labile interferon production in peripheral blood mononuclear cells from healthy donors. Acid lability of this interferon is due to the presence of both IFN-alpha and -gamma molecules. In fact, although not revealed by neutralization of an...

journal_title：AIDS research and human retroviruses

authors： Capobianchi MR,Ameglio F,Cordiali Fei P,Castilletti C,Mercuri F,Fais S,Dianzani F

更新日期：1993-10-01 00:00:00