Thrush and fever as markers of immune competence in the era of highly active antiretroviral therapy.

abstract：:The ability to trigger an innate immune response against opportunistic pathogens associated with HIV-1 infection is an important aspect of AIDS pathogenesis. Toll-like receptors (TLRs) play a critical role in innate immunity against pathogens, but in HIV-1 patients coinfected with opportunistic infections, the regulat...

journal_title：AIDS research and human retroviruses

authors： Hernández JC,Arteaga J,Paul S,Kumar A,Latz E,Urcuqui-Inchima S

更新日期：2011-10-01 00:00:00

abstract：:Epidemiological and experimental data suggest that both robust neutralizing antibodies and potent cellular responses play important roles in controlling primary HIV-1 infection. In this study we have investigated the induction of systemic and mucosal immune responses to HIV gp120 monomer immunogen administered intrana...

journal_title：AIDS research and human retroviruses

authors： Bielinska AU,Janczak KW,Landers JJ,Markovitz DM,Montefiori DC,Baker JR Jr

更新日期：2008-02-01 00:00:00

abstract：:Infection with the human immunodeficiency virus (HIV) leads to a progressive immunodeficiency characterized by decreasing levels of CD4+ T lymphocytes. VaxSyn, a vaccine based on the recombinant envelope glycoprotein subunit (rgp160) of HIV-1IIIB, was used to immunize HIV-infected patients to determine whether its adm...

journal_title：AIDS research and human retroviruses

authors： Tsoukas CM,Raboud J,Bernard NF,Montaner JS,Gill MJ,Rachlis A,Fong IW,Schlech W,Djurdjev O,Freedman J,Thomas R,Lafrenière R,Wainberg MA,Cassol S,O'Shaughnessy M,Todd J,Volvovitz F,Smith GE

更新日期：1998-04-10 00:00:00

abstract：:Transcriptional regulation is critical for the human immunodeficiency virus 1 (HIV-1) life cycle and is the only step at which the virus amplifies the content of its genetic information. Numerous known and still unknown transcriptional factors, both host and viral, regulate HIV-1 gene expression and latency. This arti...

journal_title：AIDS research and human retroviruses

authors： Victoriano AF,Okamoto T

更新日期：2012-02-01 00:00:00

abstract：:Serologic reactivities of serum or plasma from 55 HIV-1 subjects in four countries--Brazil, Rwanda, Thailand, and Uganda--were examined by V3 peptide immunoassay. Forty-seven (85.5%) of the 55 specimens tested positive to the homologous peptide. A strong correlation between serotype (i.e., pattern of serologic reactiv...

journal_title：AIDS research and human retroviruses

authors： Pau CP,Kai M,Holloman-Candal DL,Luo CC,Kalish ML,Schochetman G,Byers B,George JR

更新日期：1994-11-01 00:00:00

abstract：:Cytotoxic T lymphocytes that specifically lyse HIV-1-infected cells occur at uncommonly high frequency in the blood of infected individuals. The CTL response is dominated by the recognition of a small number of peptides encoded by HIV-1 structural and regulatory genes. These two facts have enabled us to develop potent...

journal_title：AIDS research and human retroviruses

authors： Lieberman J,Fabry JA,Shankar P,Beckett L,Skolnik PR

更新日期：1995-02-01 00:00:00

abstract：:Ascorbic acid (ascorbate or vitamin C) has been shown to suppress the induction of HIV in latently infected T lymphocytic cells following stimulation with a tumor promoter (PMA) and inflammatory cytokine (TNF-alpha). To assess whether this inhibition was mediated via modulation of the cellular transcription factor, NF...

journal_title：AIDS research and human retroviruses

authors： Harakeh S,Jariwalla RJ

更新日期：1997-02-10 00:00:00

abstract：:Some genomic elements of the multicopy HERV-W endogenous retroviral family have been previously identified in databases. One of them, located on chromosome 7, contains a single complete open reading frame (ORF) putatively encoding an envelope protein. We have experimentally investigated the genomic complexity and codi...

journal_title：AIDS research and human retroviruses

authors： Voisset C,Bouton O,Bedin F,Duret L,Mandrand B,Mallet F,Paranhos-Baccala G

更新日期：2000-05-20 00:00:00

abstract：:We studied the phylogeny of HIV-1 subtype F viruses from children and adults in Romania in order to (1) clarify whether the Romanian subtype F epidemic was caused by one or several virus introductions and (2) gain insight into the route of spread of the HIV-1 subtype F virus among children and adults in Romania. env (...

journal_title：AIDS research and human retroviruses

authors： Op De Coul E,van den Burg R,Asjö B,Goudsmit J,Cupsa A,Pascu R,Usein C,Cornelissen M

更新日期：2000-03-01 00:00:00

abstract：:An increasing number of circulating recombinant forms (CRFs) and unique recombinant forms (URFs) all over the world has necessitated being vigilant about new recombinants. Since the first report of a recombinant virus with an A1/C mosaic in 1998 more and more B/C and A/C recombinant viruses are being reported from Ind...

journal_title：AIDS research and human retroviruses

authors： Pandey S,Tripathy S,Paranjape R

更新日期：2013-09-01 00:00:00

abstract：:Defining viral dynamics in natural infection is prognostic of disease progression and could prove to be important for vaccine trial design as viremia may be a likely secondary end point in phase III HIV efficacy trials. There are limited data available on the early course of plasma viral load in subtype C HIV-1 infect...

journal_title：AIDS research and human retroviruses

authors： Gray CM,Williamson C,Bredell H,Puren A,Xia X,Filter R,Zijenah L,Cao H,Morris L,Vardas E,Colvin M,Gray G,McIntyre J,Musonda R,Allen S,Katzenstein D,Mbizo M,Kumwenda N,Taha T,Karim SA,Flores J,Sheppard HW

更新日期：2005-04-01 00:00:00

abstract：:HIV-1 viremia has been shown to induce several phenotypic and functional abnormalities in natural killer (NK) cells. To assess immune defects associated with HIV viremia, we examined NK cell function, differentiation status, and phenotypic alterations based on expression of inhibitory and activating receptors on NK ce...

journal_title：AIDS research and human retroviruses

authors： Zulu MZ,Naidoo KK,Mncube Z,Jaggernath M,Goulder PJR,Ndung'u T,Altfeld M,Thobakgale CF

更新日期：2017-12-01 00:00:00

abstract：:Previous studies have suggested that the abilities of human immunodeficiency virus type 1 (HIV-1) to infect primary macrophages and transformed T cell lines are mutually exclusive and define an important biological distinction among HIV-1 strains. In a survey of eight macrophage-tropic HIV-1 strains and nine T cell li...

journal_title：AIDS research and human retroviruses

authors： Chowdhury IH,Potash MJ,Volsky DJ

更新日期：1995-12-01 00:00:00

abstract：:HIV-1 and HTLV-1 infect CD4(+) T lymphocyte but little is known about the impact of coinfection on patient's immune response. In this study we have evaluated the spontaneous production of interleukin (IL)-2, IL-4, IL-6, and IL-10 and interferon (IFN)-γ by unstimulated peripheral blood mononuclear cell (PBMC) cultures ...

journal_title：AIDS research and human retroviruses

authors： Abrahão MH,Lima RG,Netto E,Brites C

更新日期：2012-08-01 00:00:00

abstract：:Human T-lymphotrophic virus type II (HTLV-II) has not yet been associated with any disease. Little is known about the proviral loads of HTLV-II in vivo and its relationship, if any, to lack of pathogenicity. We determined the HTLV-II proviral copy number in peripheral blood lymphocyte (PBL) samples from 49 HTLV-II-inf...

journal_title：AIDS research and human retroviruses

authors： Woods TC,Graber JM,Hershow RC,Khabbaz RF,Kaplan JE,Heneine W

更新日期：1995-10-01 00:00:00

abstract：:Downregulation of MHC class I expression following human immunodeficiency virus 1 (HIV-1) infection is thought to play an important role in viral escape from immune recognition by cytotoxic T-lymphocytes (CTLs). Since exogenous addition of HIV-1-derived peptides restores susceptibility of HIV-1-infected cells to CTL-m...

journal_title：AIDS research and human retroviruses

authors： Kutsch O,Vey T,Kerkau T,Hünig T,Schimpl A

更新日期：2002-11-20 00:00:00

abstract：:Women attending the Queen Elizabeth Central Hospital in Blantyre, Malawi, between November 1989 and October 1993 were studied as part of a longitudinal cohort study of mother-to-infant HIV transmission. 694 HIV-seropositive and 687 HIV-seronegative women were enrolled at delivery. In the follow-up phase, women attende...

journal_title：AIDS research and human retroviruses

authors： Miotti P,Canner J,Chiphangwi J,Liomba G,Saah A,Dallabetta G

更新日期：1994-01-01 00:00:00

abstract：:We evaluated the performance of T-SPOT.TB (a commercial interferon gamma release assay) and its accuracy for the diagnosis of active tuberculosis (TB) among HIV-infected subjects with advanced immunodeficiency. In a clinical prospective study, we assessed the performance of T-SPOT.TB for the diagnosis of active TB in ...

journal_title：AIDS research and human retroviruses

authors： Chen J,Sun J,Zhang R,Liu L,Zheng Y,Shen Y,Wang Z,Sun F,Li L,Lu H

更新日期：2011-03-01 00:00:00

abstract：:The gag-homologous region of the human endogenous retrovirus K10 (HERV-K10) was amplified by PCR from human genomic DNA and was analyzed by DNA cloning, sequencing, and expression of open reading frames in the prokaryotic pATH expression system. The analysis of genomic DNA of three donors provided evidence that HERV-K...

journal_title：AIDS research and human retroviruses

authors： Mueller-Lantzsch N,Sauter M,Weiskircher A,Kramer K,Best B,Buck M,Grässer F

更新日期：1993-04-01 00:00:00

abstract：:GLQ223 is a formulated version of tricosanthin, a single-chain ribosome-inactivating protein that was shown in earlier studies to inhibit human immunodeficiency virus (HIV) replication in T-lymphoblastoid cells and to decrease HIV p24 levels in HIV-infected monocyte-derived macrophages as measured by flow cytometry. T...

journal_title：AIDS research and human retroviruses

authors： McGrath MS,Santulli S,Gaston I

更新日期：1990-08-01 00:00:00

abstract：:Antibodies (Abs) against HLA and other cell surface molecules, which HIV-1 acquires during the budding process at the host cell surface, neutralize HIV-1 in vitro. Macaques were protected against infection by SIV grown in human cells after xenoimmunization with human MHC molecules. Besides the immune responses arising...

journal_title：AIDS research and human retroviruses

authors： Spruth M,Stoiber H,Kacani L,Schönitzer D,Dierich MP

更新日期：1999-04-10 00:00:00

abstract：:The Tax protein encoded by HTLV-1 plays a key role in the development of ATL in infected individuals. Our previous studies showed that tax transgenic mice develop disease that is almost identical to human ATL, with widespread organ invasion by lymphomatous cells and the development of leukemia. The same pathology deve...

journal_title：AIDS research and human retroviruses

authors： Watters KM,Dean J,Hasegawa H,Sawa H,Hall W,Sheehy N

更新日期：2010-05-01 00:00:00

abstract：:In the context of an emerging aging epidemic affecting people living with HIV (PLWH), we critically discuss existing data regarding two different conceptual models of aging-frailty and intrinsic capacity, respectively, both in a clinical and public health perspective. These constructs have not yet been integrated in t...

journal_title：AIDS research and human retroviruses

authors： Guaraldi G,Milic J

更新日期：2019-11-01 00:00:00

abstract：:HTLV-II-specific antibodies, with patterns similar to those in the Americas, were present in sera collected about 1970 from Bambuti pygmies in Zaire (14/102; 14%) and from pygmies in Cameroon (5/214; 2.3%), and were more prevalent than HTLV-I. In the Central African Republic, 504 pygmies were HTLV negative. After find...

journal_title：AIDS research and human retroviruses

authors： Goubau P,Liu HF,De Lange GG,Vandamme AM,Desmyter J

更新日期：1993-08-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) replicate during acute infection in lymphocytes of the gastrointestinal tract, before disseminating systemically. Localized replication and associated loss of gut-resident CD4+ T cells occur regardless of the portal of entry of the virus (e.g.,...

journal_title：AIDS research and human retroviruses

authors： Méndez-Lagares G,Lu D,Merriam D,Baker CA,Villinger F,Van Rompay KKA,McCune JM,Hartigan-O'Connor DJ

更新日期：2017-11-01 00:00:00

abstract：:Lectins with specificity for terminal mannose residues and anti-mannan antibodies neutralize HIV-1 infection in vitro. This is assumed to be caused by binding of the agents to the viral glycoproteins. In this study we show that one such agent, the Galanthus nivalis lectin (GNA), also blocks infection at the target cel...

journal_title：AIDS research and human retroviruses

authors： Hammar L,Hirsch I,Machado AA,De Mareuil J,Baillon JG,Bolmont C,Chermann JC

更新日期：1995-01-01 00:00:00

abstract：:To evaluate the course of liver fibrosis, 328 HIV-hepatitis C virus (HCV)-coinfected patients (210 HCV treated and 118 HCV untreated) were followed-up for 38-42 months. Liver fibrosis was assessed by biopsy or elastometry at baseline and by elastometry afterward, in addition to other noninvasive indexes. A combined li...

journal_title：AIDS research and human retroviruses

authors： Cartón JA,Collazos J,de la Fuente B,Asensi V

更新日期：2013-02-01 00:00:00

abstract：:Data indicate the presence in the Seychelles Islands of a high level of human T cell leukemia/lymphoma virus type I (HTLV-I) endemicity as well as the presence of tropical spastic paraparesis/HTLV-I-associated myelopathy (TSP/HAM). We present here the results of an hospital survey performed since 1988 in La Réunion Is...

journal_title：AIDS research and human retroviruses

authors： Mahieux R,Gessain A,Truffert A,Vitrac D,Hubert A,Dandelot J,Montchamp-Moreau C,Cnudde F,Tekaia F,De Thé G

更新日期：1994-06-01 00:00:00

abstract：:Patients with HIV-1 and human T-lymphotropic virus type 2 (HTLV-2) coinfections often exhibit a clinical course similar to that seen in HIV-1-infected individuals who are long-term nonprogressors. These findings have been attributed in part to the ability of HTLV-2 to activate production of antiviral chemokines and to...

journal_title：AIDS research and human retroviruses

authors： Barrios CS,Castillo L,Giam CZ,Wu L,Beilke MA

更新日期：2013-07-01 00:00:00

abstract：:Mutant HIV virions, encoding C-terminally truncated Env proteins, exhibit a cell-specific replication defect, i.e., they can replicate in a few T cell lines (termed permissive cells) but not in the majority of T cell lines (termed nonpermissive cells). We have studied the properties of two mutant virions (pNL-Tr712 an...

journal_title：AIDS research and human retroviruses

authors： Holtkotte D,Pfeiffer T,Bosch V

更新日期：2007-05-01 00:00:00