CD4 confers susceptibility to human immunodeficiency virus type 1 infection in a rat fibroblast cell line.

abstract：:Liver enzyme elevations are frequently seen in patients treated with nevirapine (NVP). Both elevated NVP plasma levels and hepatitis C virus (HCV) infection seem to favor the development of NVP-related liver toxicity. We have examined variation on NVP C(trough) over time, as well as the impact of NVP C(trough) concent...

journal_title：AIDS research and human retroviruses

authors： De Requena DG,Jiménez-Nácher I,Soriano V

更新日期：2005-06-01 00:00:00

abstract：:Aging with HIV poses unique and complex challenges, including avoidance of neurocognitive disorder. Our objective here is to identify the prevalence and predictors of successful cognitive aging (SCA) in a sample of older adults with HIV. One hundred three HIV-infected individuals aged 50 and older were recruited from ...

journal_title：AIDS research and human retroviruses

authors： Wallace LM,Ferrara M,Brothers TD,Garlassi S,Kirkland SA,Theou O,Zona S,Mussini C,Moore D,Rockwood K,Guaraldi G

更新日期：2017-02-01 00:00:00

abstract：:Stavudine (d4T) has been associated with lipoatrophy and hyperlactatemia. In recent studies, d4T has also been related to both hypercholesterolemia and hypertriglyceridemia. Replacing d4T with another nucleoside analogue such as abacavir (ABC) may reduce lactate levels and improve lipoatrophy in the long term. However...

journal_title：AIDS research and human retroviruses

authors： García-Benayas T,Blanco F,Alcolea A,Cruz JJ,González-Lahoz J,Soriano V

更新日期：2004-12-01 00:00:00

abstract：:To establish whether the low cysteine and glutathione levels in HIV-infected patients and SIV-infected rhesus macaques may be consequences of an abnormal cysteine catabolism, we analyzed sulfate and glutathione levels in macaques. Muscle tissue (m. vastus lateralis and m. gastrocnemius) of SIV-infected macaques (n = 2...

journal_title：AIDS research and human retroviruses

authors： Gross A,Hack V,Stahl-Hennig C,Dröge W

更新日期：1996-11-20 00:00:00

abstract：:HIV-1 protease activity is essential for viral replication. In spite of the high rates of HIV mutation, the active site of protease (residues 24-29) is a conserved site, where mutations have not been previously described. To determine the effect of mutations at positions T26 and A29 of the viral protease and its viabi...

journal_title：AIDS research and human retroviruses

authors： Melón S,Gil-Roda C,de Oña M,Erice A

更新日期：2004-11-01 00:00:00

abstract：:Population genotyping (PG) can underestimate resistance if resistance-containing low abundance variants go undetected. PG and clonal analysis (CA) results were compared in virologic failures (VFs) from a 48-week clinical trial that evaluated once-daily fosamprenavir/ritonavir (FPV/r) 1400 mg/100 mg or atazanavir/riton...

journal_title：AIDS research and human retroviruses

authors： Ross LL,Weinberg WG,DeJesus E,Fischl MA,Horton JH,Pappa KA,Lancaster CT,Pakes GE,Smith KY

更新日期：2010-04-01 00:00:00

abstract：:Cellular adhesion molecules, such as ICAM-1, -2, and -3; LFA-1; and HLA class I and II are incorporated into HIV-1 virions during budding from infected cells. These virion-associated molecules can be involved in the adsorption to susceptible cells displaying the corresponding counterligands. A number of cytokines have...

journal_title：AIDS research and human retroviruses

authors： Castilletti C,Capobianchi MR,Fais S,Abbate I,Ficociello B,Ameglio F,Cordiali Fei P,Santini SM,Dianzani F

更新日期：1995-05-01 00:00:00

abstract：:In this study HIV-1 subtype C-infected adults demonstrated higher purifying selection on their viral populations in reverse transcriptase (RT) than infected children. This difference is likely explained by more mature cytotoxic T-lymphocyte responses in adults, which may have implications for the development of drug r...

journal_title：AIDS research and human retroviruses

authors： Saravanan S,Gomathi S,Kausalya B,Boobalan J,Murugavel KG,Balakrishnan P,Mothi SN,Solomon SS,Kumarasamy N,Selvamuthu P,Solomon S,Smith DM

更新日期：2015-06-01 00:00:00

abstract：:Recombination contributes substantially to the genetic diversity of HIV-1, and mosaic strains arise frequently, especially in populations in which multiple subtypes circulate. Yunnan, which borders the "Golden triangle" region of Southeast Asia in the south, was considered as the epicenter of China. B, CRF01_AE, CRF07...

journal_title：AIDS research and human retroviruses

authors： Li L,Chen L,Yang S,Liu Y,Li H,Bao Z,Wang Z,Zhuang D,Liu S,Li J

更新日期：2010-06-01 00:00:00

abstract：:The purpose of this study was to investigate the mechanism of acquired cellular resistance to AZT, a mechanism that has been described as a potential source of drug resistance in addition to viral mutations. To study this phenomenon the kinetics parameters of thymidine kinase (TK) activity have been defined in CEMazt,...

journal_title：AIDS research and human retroviruses

authors： Antonelli G,Turriziani O,Verri A,Narciso P,Ferri F,D'Offizi G,Dianzani F

更新日期：1996-02-10 00:00:00

abstract：:Because mucosal inflammation contributes to colorectal carcinogenesis, we studied the impact of intestinal infections on risk of this malignancy among people with AIDS (PWA). Using the population-based HIV/AIDS Cancer Match, which includes approximately half of all PWA in the United States, the cancer registries ascer...

journal_title：AIDS research and human retroviruses

authors： Shebl FM,Engels EA,Goedert JJ

更新日期：2012-09-01 00:00:00

abstract：:The gag-homologous region of the human endogenous retrovirus K10 (HERV-K10) was amplified by PCR from human genomic DNA and was analyzed by DNA cloning, sequencing, and expression of open reading frames in the prokaryotic pATH expression system. The analysis of genomic DNA of three donors provided evidence that HERV-K...

journal_title：AIDS research and human retroviruses

authors： Mueller-Lantzsch N,Sauter M,Weiskircher A,Kramer K,Best B,Buck M,Grässer F

更新日期：1993-04-01 00:00:00

abstract：:The human endogenous retrovirus, type K (HERV-K) represents the most biologically active form of known retroelements present in the human genome. Several HERV-K genomes have transcriptionally active open reading frames and encode their own protease (PR). The HERV-K PR has been shown to authentically cleave human immun...

journal_title：AIDS research and human retroviruses

authors： Padow M,Lai L,Fisher RJ,Zhou YC,Wu X,Kappes JC,Towler EM

更新日期：2000-12-10 00:00:00

abstract：:In an attempt to develop an immunization strategy to induce mucosal and circulatory antibodies against SIV antigens, we have investigated the potential of attenuated recombinant vaccinia virus to deliver SIV antigens (gp160 of SIVmac239) to mucosal surfaces of mice. After systemic or mucosal (intragastric, intranasal,...

journal_title：AIDS research and human retroviruses

authors： Moldoveanu Z,Vzorov AN,Huang WQ,Mestecky J,Compans RW

更新日期：1999-11-01 00:00:00

abstract：:Retroviruses have been suggested as possible pathogenic factors in multiple sclerosis (MS), supported by the observation that endogenous retroviruses are activated in MS patients. Different members of the herpes family of which several are neurotropic have also been suggested as factors in MS pathogenesis. Further, in...

journal_title：AIDS research and human retroviruses

authors： Brudek T,Christensen T,Hansen HJ,Bobecka J,Møller-Larsen A

更新日期：2004-04-01 00:00:00

abstract：:Most HIV-1 transmissions occur at mucosae and involve exposure to semen. Semen contains immunomodulatory factors, which inhibit anti-HIV-1 natural killer cell and T cell responses. We demonstrate high concentrations (1:2 dilution) of seminal plasma (SP) inhibit monocyte phagocytosis and anti-HIV-1 Fc-dependent functio...

journal_title：AIDS research and human retroviruses

authors： Selva KJ,Juno JA,Worley MJ,Chung AW,Tachedjian G,Kent SJ,Parsons MS

更新日期：2019-06-01 00:00:00

abstract：:Inhibitory factors to human immunodeficiency virus type 1 (HIV-1) in saliva may be responsible for the infrequent isolation of virus from saliva and also may account for the marked infrequency of salivary and/or oral transmission of HIV-1. Incubation of HIV-1 with human saliva followed by addition of the mixture to su...

journal_title：AIDS research and human retroviruses

authors： Archibald DW,Cole GA

更新日期：1990-12-01 00:00:00

abstract：:This randomized, open-labeled, multicenter study was designed to assess safety and pharmacokinetics of dronabinol (Marinol) tablets and megestrol acetate (Megace) micronized tablets, alone and in combination, for treatment of HIV wasting syndrome. Weight and quality of life data were also collected. Fifty-two patients...

journal_title：AIDS research and human retroviruses

authors： Timpone JG,Wright DJ,Li N,Egorin MJ,Enama ME,Mayers J,Galetto G

更新日期：1997-03-01 00:00:00

abstract：:Genotropism was determined in 608 Brazilian samples collected in dried blood spots using Polyethersulfone collection cards. Patients were infected by subtype B (88.8%), F (5.6%), C (3.3%), A (1.8%), and G (0.5%). All patients were exposed to three classes of antiretrovirals, and 59.8% of the samples harbored R5 viruse...

journal_title：AIDS research and human retroviruses

authors： Lavigne S,Santos C,Arif MS,Reis A,Samer S,Dos Santos CV,Diaz RS

更新日期：2014-02-01 00:00:00

abstract：:The tax gene of human T-lymphotropic virus type 1 (HTLV-1) diverges among isolates according to geographic regions and has been classified into two genotypes: taxA and taxB. In Brazil, taxA is the most prevalent genotype in symptomatic and asymptomatic carriers. Few studies have been conducted in HIV-infected patients...

journal_title：AIDS research and human retroviruses

authors： Magri MC,Brigido LF,Rodrigues R,Morimoto HK,Caterino-de-Araujo A

更新日期：2012-12-01 00:00:00

abstract：:The chemokine polymorphisms CXCR6-3E/K, In1.1T/C, H7 haplotype, CX(3)CR1-V249I, and CX(3)CR1-T280M have been shown to affect the course of HIV infection. We studied their influence on immunologic and virologic response to HAART in a group of 143 HIV-1 patients. We performed Kaplan-Meier analysis using the following en...

journal_title：AIDS research and human retroviruses

authors： Passam AM,Sourvinos G,Krambovitis E,Miyakis S,Stavrianeas N,Zagoreos I,Spandidos DA

更新日期：2007-08-01 00:00:00

abstract：:With improved survival and aging, more persons living with HIV/AIDS (PLWHA) are at risk for colorectal cancer (CRC). This retrospective longitudinal study evaluated patient characteristics associated with CRC screening in our HIV cohort. Patients were followed beginning at age 50 years during a study period from Janua...

journal_title：AIDS research and human retroviruses

authors： Burkholder GA,Tamhane AR,Appell LE,Willig JH,Saag MS,Raper JL,Westfall AO,Mugavero MJ

更新日期：2015-05-01 00:00:00

abstract：:Pathogenic microorganisms encode proteins that antagonize specific aspects of innate or adaptive immunity. Just as the study of the HIV-1 accessory protein Vif led to the identification of cellular cytidine deaminases as host defense proteins, the study of HIV-1 Vpu recently led to the discovery of the interferon-indu...

journal_title：AIDS research and human retroviruses

authors： Tokarev A,Skasko M,Fitzpatrick K,Guatelli J

更新日期：2009-12-01 00:00:00

abstract：:Lymphoid tissues are the focus of critical events in HIV pathogenesis. Persistent and high levels of virus production, extensive trapping of virus particles in germinal centers, and progressive degenerative changes in lymph node architecture are characteristics of progressive HIV-1 infection. Infiltrates of granzyme B...

journal_title：AIDS research and human retroviruses

authors： Koopman G,Haaksma AG,ten Velden J,Hack CE,Heeney JL

更新日期：1999-03-01 00:00:00

abstract：:The prevalence of different HIV-1 subtypes in Spain varies by geographic region. In the present study isolates were collected from 72 newly diagnosed individuals in western Andalucia from 2004 to 2006. Viral sequences were amplified and the subtype diversity and prevalence of resistance mutations in the reverse transc...

journal_title：AIDS research and human retroviruses

authors： McConnell MJ,Docobo-Pérez F,Mata RC,Fernandez-Cuenca F,Viciana P,López-Cortés LF,Trastoy M,Pachón J,Pérez-Romero P

更新日期：2008-06-01 00:00:00

abstract：:The aim of this study was to evaluate the impact of HIV-1 very low-level viremia (<50 copies/ml) on the 2-year risk of virological failure. A retrospective analysis including HIV-positive patients presenting two consecutive HIV RNA below 50 copies/ml (outpatient clinic in Italy, first semester of 2010) was performed. ...

journal_title：AIDS research and human retroviruses

authors： Calcagno A,Motta I,Ghisetti V,Lo Re S,Allice T,Marinaro L,Milia MG,Tettoni MC,Trentini L,Orofino G,Salassa B,Di Perri G,Bonora S

更新日期：2015-10-01 00:00:00

abstract：:Surveillance of drug resistance mutations in antiretroviral-experienced HIV(+) patients may provide useful information regarding options available for rescue interventions. All resistance tests performed from 1999 to 2005 on antiretroviral-experienced individuals at one reference laboratory in Madrid were examined. On...

journal_title：AIDS research and human retroviruses

authors： de Mendoza C,Garrido C,Corral A,Ramírez-Olivencia G,Jiménez-Nacher I,Zahonero N,Gonzalez-Lahoz J,Soriano V

更新日期：2007-07-01 00:00:00

abstract：:In a set of 42 antiretroviral naive HIV-1 infected persons who were treated with either Zidovudine (AZT) monotherapy, or a combination of AZT + ddC (Zalcitabine) or AZT + ddI (Didanosine), the HIV-1 DNA load was measured by competitive polymerase chain reaction (PCR) and related to the HIV-1 RNA load in plasma, the CD...

journal_title：AIDS research and human retroviruses

authors： Bruisten SM,Reiss P,Loeliger AE,van Swieten P,Schuurman R,Boucher CA,Weverling GJ,Huisman JG

更新日期：1998-08-10 00:00:00

abstract：:A primary concern of an antibody-based HIV-1 therapy is the virus' ability to rapidly escape antibody responses. Therefore, we investigated the relationships between antibody neutralization sensitivity, viral phenotype, and infectivity in 13 subtype C viruses using a HeLa transfectant-based assay. We observed that the...

journal_title：AIDS research and human retroviruses

authors： Moyo T,Guleid FH,Schomaker M,Williamson C,Dorfman JR

更新日期：2020-12-01 00:00:00

abstract：:A new HIV-1 circulating recombinant form (CRF), CRF33_01B, has been identified in Malaysia. Concurrently we found a unique recombinant form (URF), that is, the HIV-1 isolate 06MYKLD46, in Kuala Lumpur, Malaysia. It is composed of B or a Thai variant of the B subtype (B') and CRF01_AE. Here, we determined the near full...

journal_title：AIDS research and human retroviruses

authors： Lau KA,Wang B,Kamarulzaman A,Ng KP,Saksena NK

更新日期：2007-09-01 00:00:00