Impact of HIV type 1 drug resistance mutations and phenotypic resistance profile on virologic response to salvage therapy.

abstract：:To eradicate human immunodeficiency virus type 1 (HIV-1) infection, a comprehensive strategy including preventive vaccine development is needed. Envelope glycoproteins (Env) play a central role in viral infection and are the major targets of humoral immune responses. Therefore, Env is a candidate vaccine antigen, and ...

journal_title：AIDS research and human retroviruses

authors： Sasaki M,Kotaki T,Khairunisa SQ,Tachibana S,Ophinni Y,Hayashi Y,Nasronudin,Kameoka M

更新日期：2020-03-01 00:00:00

abstract：:The combination of didanosine (ddI) and lamivudine (3TC) is attractive considering its low cost, potency, tolerability, and convenience (once daily administration), but it is not recommended as first-line therapy for HIV infection. A prospective, multicenter, open, comparative trial was conducted in HIV-infected, anti...

journal_title：AIDS research and human retroviruses

authors： Sánchez-Conde M,Palacios R,Sanz J,Rodríguez-Novoa S,Rivas P,Santos J,Sola J,Asensi V,de Mendoza C,Estrada V,Barreiro P,González-Lahoz J,Jiménez-Nacher I,Soriano V

更新日期：2007-10-01 00:00:00

abstract：:Six morphine-dependent and two control macaques were infected in an SIV/SHIV nonhuman primate model of AIDS. Three animals in the morphine group rapidly developed clinical disease and died within the timeframe of this study. The sequence evolution of nef in plasma virus was assessed at 4, 12, and 20 weeks postinfectio...

journal_title：AIDS research and human retroviruses

authors： Noel RJ,Toro-Bahamonde A,Marrero-Otero Z,Orsini S,Verma AS,Kumar R,Kumar A

更新日期：2006-08-01 00:00:00

abstract：:We sought to predict virus coreceptor utilization using a simple bioinformatics method based on genotypic analysis of human immunodeficiency virus types 1 (HIV-1) env V3 loop sequences of 28 infected but drug-naive women during pregnancy and their infected infants and to better understand coreceptor usage in vertical ...

journal_title：AIDS research and human retroviruses

authors： Duri K,Soko W,Gumbo F,Kristiansen K,Mapingure M,Stray-Pedersen B,Muller F,BHAMC Group.

更新日期：2011-04-01 00:00:00

abstract：:Il28B single nucleotide polymorphisms were found to influence interferon λ expression, resulting in changes in hepatitis C virus (HCV)-RNA serum levels as well as the HIV-RNA set point prior to combined antiretroviral therapy (cART). To date, there is limited information on the influence of this polymorphism on surviv...

journal_title：AIDS research and human retroviruses

authors： Parczewski M,Bander D,Leszczyszyn-Pynka M,Urbańska A,Socha Ł,Boroń-Kaczmarska A

更新日期：2012-12-01 00:00:00

abstract：:We aimed to determine the prevalence of a prolonged QTc interval in HIV-infected patients and its related factors through an observational study of a cohort of asymptomatic HIV-infected outpatients. All patients underwent a standard 12-lead electrocardiogram and a transthoracic echocardiogram. Prolonged QTc was consid...

journal_title：AIDS research and human retroviruses

authors： Moreno T,Pérez I,Isasti G,Cabrera F,Santos J,Palacios R

更新日期：2013-09-01 00:00:00

abstract：:Characterization of HIV-1 from slow progressors is important to facilitate vaccine and antiviral drug development. To identify virus attenuations that may contribute to slower rates of disease progression, the full-length viral genomes from primary isolates of six slow progressing HIV-positive children were sequenced....

journal_title：AIDS research and human retroviruses

authors： Tzitzivacos DB,Tiemessen CT,Stevens WS,Papathanasopoulos MA

更新日期：2009-11-01 00:00:00

abstract：:A primary concern of an antibody-based HIV-1 therapy is the virus' ability to rapidly escape antibody responses. Therefore, we investigated the relationships between antibody neutralization sensitivity, viral phenotype, and infectivity in 13 subtype C viruses using a HeLa transfectant-based assay. We observed that the...

journal_title：AIDS research and human retroviruses

authors： Moyo T,Guleid FH,Schomaker M,Williamson C,Dorfman JR

更新日期：2020-12-01 00:00:00

abstract：:Acquisition of cellular proteins by HIV-1 virions is known to alter the physiology of the virus in vitro. Reported studies of this aspect have been largely limited to transformed T cell lines. In this study, we investigated the incorporation of major histocompatibility antigens (HLAs) on a primary macrophage-tropic is...

journal_title：AIDS research and human retroviruses

authors： Tsai WP,Kung HF,Nara PL

更新日期：1999-01-01 00:00:00

abstract：:Abstract We assessed the viral envelope (V3-V5 region) sequence diversity from 13 HIV-1-infected Indian children from north India. All of the 13 children were found to be infected with subtype C viruses. One of the viral sequences exhibited usage of the CXCR4 coreceptor predicted by Web PSSM and Geno2pheno tools. Th...

journal_title：AIDS research and human retroviruses

authors： Prakash SS,Kalra R,Lodha R,Kabra SK,Luthra K

更新日期：2012-05-01 00:00:00

abstract：:Although Cameroon, in west central Africa, has a relatively low HIV prevalence of 5-6%, all HIV-1 groups (M, N, O, and P), nearly all HIV-1 group M subtypes, and numerous intersubtype recombinant forms have been identified in Cameroon. In this report, we describe the near full-length sequence of 04CMU11421, an HIV-1 g...

journal_title：AIDS research and human retroviruses

authors： Yamaguchi J,Vallari A,Ngansop C,Makamche F,Ndembi N,Mbanya D,Kaptué L,Gürtler LG,Devare SG,Brennan CA

更新日期：2010-06-01 00:00:00

abstract：:The feasibility and effectiveness of a hospital-based exercise-training program followed by a home-based program for improving fitness, strength, and changes in body composition in children and adolescents with HIV were evaluated. Subjects participated in nonrandomized 24-session, hospital supervised exercise training...

journal_title：AIDS research and human retroviruses

authors： Miller TL,Somarriba G,Kinnamon DD,Weinberg GA,Friedman LB,Scott GB

更新日期：2010-03-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) long terminal repeat (LTR) promoter-mediated gene expression is regulated by the viral Tat protein that relieves a block to viral transcription elongation after binding with a viral hairpin loop RNA structure called the trans-activation-responsive region (TAR). Tat protein significan...

journal_title：AIDS research and human retroviruses

authors： Chande AG,Baba M,Mukhopadhyaya R

更新日期：2012-08-01 00:00:00

abstract：:Endogenous retroviruses (ERVs) probably originate from ancient germ cell infections by exogenous retroviruses. A high expression of retroviruses in reproductive tissue increases the risk of viral transmission to germ line cells. We therefore investigated the expression of human ERVs (HERVs) in normal endometrium, endo...

journal_title：AIDS research and human retroviruses

authors： Hu L,Hornung D,Kurek R,Ostman H,Blomberg J,Bergqvist A

更新日期：2006-06-01 00:00:00

abstract：:The present study investigated the immunological pathogenesis of immune reconstitution inflammatory syndrome (IRIS) in acquired immunodeficiency syndrome (AIDS) patients undergoing highly active antiretroviral therapy (HAART). A total of 238 patients with AIDS who received initial HAART were included in this prospecti...

journal_title：AIDS research and human retroviruses

authors： Zheng Y,Zhou H,He Y,Chen Z,He B,He M

更新日期：2014-12-01 00:00:00

abstract：:We investigated a strategy for gene therapy, intracellular expression of anti-HIV-1 Rev single-chain variable fragments (SFvs), in promonocytic (U1) and T (ACH-2) cell lines latently infected with HIV-1. The cellular and molecular mechanisms leading to activation of latent integrated HIV-1 provirus in U1 and ACH-2 cel...

journal_title：AIDS research and human retroviruses

authors： Ho WZ,Lai JP,Bouhamdan M,Duan L,Pomerantz RJ,Starr SE

更新日期：1998-11-20 00:00:00

abstract：:We have investigated in utero human immunodeficiency virus type 1 (HIV-1) transmission by analyzing human fetal tissues for the presence of viral DNA by means of the polymerase chain reaction (PCR). Thirty three fetal samples: thymus, spleen, and peripheral mononuclear blood cells (PMBC) were obtained at abortion (16 ...

journal_title：AIDS research and human retroviruses

authors： Courgnaud V,Lauré F,Brossard A,Bignozzi C,Goudeau A,Barin F,Bréchot C

更新日期：1991-03-01 00:00:00

abstract：:Cytotoxic T lymphocytes that specifically lyse HIV-1-infected cells occur at uncommonly high frequency in the blood of infected individuals. The CTL response is dominated by the recognition of a small number of peptides encoded by HIV-1 structural and regulatory genes. These two facts have enabled us to develop potent...

journal_title：AIDS research and human retroviruses

authors： Lieberman J,Fabry JA,Shankar P,Beckett L,Skolnik PR

更新日期：1995-02-01 00:00:00

abstract：:The human immunodeficiency virus 1 envelope glycoprotein is synthesized as a precursor, gp160, which is subsequently cleaved to generate the external gp120 and the transmembrane gp41. Both of these cleavage products are known to mediate critical functions of the virus. In order to define the best strategy for the deve...

journal_title：AIDS research and human retroviruses

authors： Pasquali JL,Kieny MP,Kolbe H,Christmann D,Knapp AM

更新日期：1990-09-01 00:00:00

abstract：:Maraviroc (MVC) is licensed in clinical practice for patients with R5 virus and virological failure; however, in anecdotal reports, dual/mixed viruses were also inhibited. We retrospectively evaluated the evolution of HIV-1 coreceptor tropism in plasma and peripheral blood mononuclear cells (PBMCs) of an infected adol...

journal_title：AIDS research and human retroviruses

authors： Cavarelli M,Mainetti L,Pignataro AR,Bigoloni A,Tolazzi M,Galli A,Nozza S,Castagna A,Sampaolo M,Boeri E,Scarlatti G

更新日期：2014-12-01 00:00:00

abstract：:The majority of early cases of HIV in Russia were among men who have sex with men (MSM). Despite this and the current resurgence of HIV among MSM globally, little systematic work has been done to assess current HIV risks. We conducted a rapid assessment of HIV and associated risk behaviors among MSM in Russia. An anon...

journal_title：AIDS research and human retroviruses

authors： Baral S,Sifakis F,Peryskina A,Mogilnii V,Masenior NF,Sergeyev B,Deobald I,Wirtz AL,Beyrer C

更新日期：2012-08-01 00:00:00

abstract：:The ability to trigger an innate immune response against opportunistic pathogens associated with HIV-1 infection is an important aspect of AIDS pathogenesis. Toll-like receptors (TLRs) play a critical role in innate immunity against pathogens, but in HIV-1 patients coinfected with opportunistic infections, the regulat...

journal_title：AIDS research and human retroviruses

authors： Hernández JC,Arteaga J,Paul S,Kumar A,Latz E,Urcuqui-Inchima S

更新日期：2011-10-01 00:00:00

abstract：:HIV subtype characterization is an important tool to monitor the genetic variation of the HIV epidemic. This study investigated the current HIV subtype distribution and recombination among the northern Thai population. An in-house genotypic assay of HIV protease and reverse transcriptase genes was performed on 420 pla...

journal_title：AIDS research and human retroviruses

authors： Praparattanapan J,Tragoolpua Y,Pathom-aree W,Kotarathitithum W,Chaiwarith R,Nuntachit N,Sirisanthana T,Supparatpinyo K

更新日期：2011-11-01 00:00:00

abstract：:The gag-homologous region of the human endogenous retrovirus K10 (HERV-K10) was amplified by PCR from human genomic DNA and was analyzed by DNA cloning, sequencing, and expression of open reading frames in the prokaryotic pATH expression system. The analysis of genomic DNA of three donors provided evidence that HERV-K...

journal_title：AIDS research and human retroviruses

authors： Mueller-Lantzsch N,Sauter M,Weiskircher A,Kramer K,Best B,Buck M,Grässer F

更新日期：1993-04-01 00:00:00

abstract：:This retrospective and longitudinal study evaluated the long-term hepatic tolerance of a nelfinavir (NFV)-antiretroviral combined regimen in 82 patients of the HCV-HIV Cohort of CISIH-Sud of Marseilles. Follow-up data (liver enzyme levels, CD4 cell count, HIV viral load, and metabolic parameters) of patients treated w...

journal_title：AIDS research and human retroviruses

authors： Poizot-Martin I,Marimoutou C,Drogoul-Vey MP,Vion-Dury F,Frixon-Marin V,Benhaim S,Poggi P,Gastaut JA

更新日期：2005-10-01 00:00:00

abstract：:A new HIV-1 circulating recombinant form (CRF), CRF33_01B, has been identified in Malaysia. Concurrently we found a unique recombinant form (URF), that is, the HIV-1 isolate 06MYKLD46, in Kuala Lumpur, Malaysia. It is composed of B or a Thai variant of the B subtype (B') and CRF01_AE. Here, we determined the near full...

journal_title：AIDS research and human retroviruses

authors： Lau KA,Wang B,Kamarulzaman A,Ng KP,Saksena NK

更新日期：2007-09-01 00:00:00

abstract：:Low albumin levels have been associated with HIV progression. The objective of this analysis was to confirm this association and to further examine the effect of albumin before and after HIV seroconversion on disease progression. The association was first examined among individuals already infected with HIV at entry i...

journal_title：AIDS research and human retroviruses

authors： Mehta SH,Astemborski J,Sterling TR,Thomas DL,Vlahov D

更新日期：2006-01-01 00:00:00

abstract：:Using human macrophage hybridomas infected with HIV-1, we investigated monocyte function over a 5-week period after HIV-1 infection. Two clones, 63 and 30, were infected with HIV-1IIIB. Infection was documented by RT activity (15 x 10(6) cpm/ml), intracytoplasmic staining with an anti-p24 antibody, in situ hybridizati...

journal_title：AIDS research and human retroviruses

authors： Sperber K,Hamrang G,Louie MJ,Kalb T,Banerjee R,Choi HS,Paronetto F,Mayer L

更新日期：1993-07-01 00:00:00

abstract：:Human T cell leukemia virus protein induces T cells to permanent IL-2-dependent growth. These cells occasionally convert to factor independence. The viral oncoprotein Tax acts as an essential growth factor of transformed lymphocytes and stimulates the cell cycle in the G(1) phase. In T cells and fibroblasts Tax enhanc...

journal_title：AIDS research and human retroviruses

authors： Haller K,Ruckes T,Schmitt I,Saul D,Derow E,Grassmann R

更新日期：2000-11-01 00:00:00

abstract：:We investigated whether V3-binding assays might be useful to analyze human immunodeficiency virus type 1 (HIV-1) variants in different geographic regions. We showed that strong cross-reactivity between subtype-specific V3 peptides is almost inevitable in standard indirect enzyme-linked immunosorbent assays (EIA), impa...

journal_title：AIDS research and human retroviruses

authors： Barin F,Lahbabi Y,Buzelay L,Lejeune B,Baillou-Beaufils A,Denis F,Mathiot C,M'Boup S,Vithayasai V,Dietrich U,Goudeau A

更新日期：1996-09-01 00:00:00