Lack of correlation between SIV-Nef evolution and rapid disease progression in morphine-dependent nonhuman primate model of AIDS.

abstract：:The aim of this study was to compare the extent of resistance to antiretroviral (ARV) drugs among the population in Mexico before and after 2005. The mutations and drug resistance database of Stanford University were used for analyzing drug resistance tests that had been performed on HIV treatment-naive patients. The ...

journal_title：AIDS research and human retroviruses

authors： Escoto-Delgadillo M,Torres-Mendoza BM,Flores-Soto M,Vazquez-Valls E

更新日期：2016-12-01 00:00:00

abstract：:In October of 2019, researchers and community members from around the world met at the NIH for the fifth annual International Workshop on Microbiome in HIV. New research was presented on the role of the microbiome on chronic inflammation and vaccine design, interactions of genetics, environment, sexual practice and HI...

journal_title：AIDS research and human retroviruses

authors： Sherrill-Mix S,Connors K,Aldrovandi GM,Brenchley JM,Boucher C,Bushman FD,Collman RG,Dandekar S,Klatt NR,Lagenaur LA,Paredes R,Tachedjian G,Turpin JA,Landay AL,Ghosh M

更新日期：2020-11-01 00:00:00

abstract：:In this study HIV-1 subtype C-infected adults demonstrated higher purifying selection on their viral populations in reverse transcriptase (RT) than infected children. This difference is likely explained by more mature cytotoxic T-lymphocyte responses in adults, which may have implications for the development of drug r...

journal_title：AIDS research and human retroviruses

authors： Saravanan S,Gomathi S,Kausalya B,Boobalan J,Murugavel KG,Balakrishnan P,Mothi SN,Solomon SS,Kumarasamy N,Selvamuthu P,Solomon S,Smith DM

更新日期：2015-06-01 00:00:00

abstract：:The molecular epidemiology of HIV-1 in Argentina is more complex than was previously appreciated. One circulating recombinant form, CRF12_BF, and many related BF recombinant forms predominate in the capital city, Buenos Aires. This study of HIV-1 subtypes acquired perinatally between 1984 and 2000 has permitted, for t...

journal_title：AIDS research and human retroviruses

authors： Gomez Carrillo M,Avila M,Hierholzer J,Pando M,Martinez PL,McCutchan FE,Carr JK

更新日期：2002-05-01 00:00:00

abstract：:The predictive value of virological response to lopinavir (LPV)/ritonavir (r) was assessed in 126 HIV-infected patients who failed antiretroviral therapy and had begun a rescue intervention based on LPV/r. At 3 months, subjects with < or =6 protease (PRO) resistance mutations showed a higher rate of virological respon...

journal_title：AIDS research and human retroviruses

authors： González de Requena D,Gallego O,Valer L,Jiménez-Nácher I,Soriano V

更新日期：2004-03-01 00:00:00

abstract：:The Tax protein encoded by HTLV-1 plays a key role in the development of ATL in infected individuals. Our previous studies showed that tax transgenic mice develop disease that is almost identical to human ATL, with widespread organ invasion by lymphomatous cells and the development of leukemia. The same pathology deve...

journal_title：AIDS research and human retroviruses

authors： Watters KM,Dean J,Hasegawa H,Sawa H,Hall W,Sheehy N

更新日期：2010-05-01 00:00:00

abstract：:A highly purified saponin from Q. saponaria (QS-21) was tested in juvenile rhesus macaques for adjuvant activity and toxicity. The QS-21 was tested alone or as part of an experimental subunit HIV-1 vaccine containing a truncated recombinant HIV-1 envelope protein (gp160D) adsorbed to alum. Antibody responses were meas...

journal_title：AIDS research and human retroviruses

authors： Newman MJ,Wu JY,Coughlin RT,Murphy CI,Seals JR,Wyand MS,Kensil CR

更新日期：1992-08-01 00:00:00

abstract：:An atypical HIV-1 strain (CAM001) was identified in a pregnant Cameroonian woman in 1995. HMA subtyping of the env region was unsuccessful, and sequence analyses were performed. Unique sequence motifs were found at the V3 tip (GAGRALHA and GAGRAWIHA), and phylogenetic studies showed that the env C2-V5 sequence branche...

journal_title：AIDS research and human retroviruses

authors： Roques P,Menu E,Narwa R,Scarlatti G,Tresoldi E,Damond F,Mauclère P,Dormont D,Chaouat G,Simon F,Barré-Sinoussi F

更新日期：1999-11-20 00:00:00

abstract：:Defining viral dynamics in natural infection is prognostic of disease progression and could prove to be important for vaccine trial design as viremia may be a likely secondary end point in phase III HIV efficacy trials. There are limited data available on the early course of plasma viral load in subtype C HIV-1 infect...

journal_title：AIDS research and human retroviruses

authors： Gray CM,Williamson C,Bredell H,Puren A,Xia X,Filter R,Zijenah L,Cao H,Morris L,Vardas E,Colvin M,Gray G,McIntyre J,Musonda R,Allen S,Katzenstein D,Mbizo M,Kumwenda N,Taha T,Karim SA,Flores J,Sheppard HW

更新日期：2005-04-01 00:00:00

abstract：:Characterization of HIV-1 from slow progressors is important to facilitate vaccine and antiviral drug development. To identify virus attenuations that may contribute to slower rates of disease progression, the full-length viral genomes from primary isolates of six slow progressing HIV-positive children were sequenced....

journal_title：AIDS research and human retroviruses

authors： Tzitzivacos DB,Tiemessen CT,Stevens WS,Papathanasopoulos MA

更新日期：2009-11-01 00:00:00

abstract：:In an attempt to develop an immunization strategy to induce mucosal and circulatory antibodies against SIV antigens, we have investigated the potential of attenuated recombinant vaccinia virus to deliver SIV antigens (gp160 of SIVmac239) to mucosal surfaces of mice. After systemic or mucosal (intragastric, intranasal,...

journal_title：AIDS research and human retroviruses

authors： Moldoveanu Z,Vzorov AN,Huang WQ,Mestecky J,Compans RW

更新日期：1999-11-01 00:00:00

abstract：:We studied plasma samples from 2082 Mataco Indians living in 22 different communities in the western part of Formosa Province, northern Argentina. Samples were screened for HTLV-I/II antibodies by particle agglutination assay. All positive or borderline samples were then tested by an immunofluorescence assay (IFA) on ...

journal_title：AIDS research and human retroviruses

authors： Biglione M,Vidan O,Mahieux R,de Colombo M,de los Angeles de Basualdo M,Bonnet M,Pankow G,De Efron MA,Zorrilla A,Tekaia F,Murphy E,de Thé G,Gessain A

更新日期：1999-03-20 00:00:00

abstract：:HIV-1 viremia has been shown to induce several phenotypic and functional abnormalities in natural killer (NK) cells. To assess immune defects associated with HIV viremia, we examined NK cell function, differentiation status, and phenotypic alterations based on expression of inhibitory and activating receptors on NK ce...

journal_title：AIDS research and human retroviruses

authors： Zulu MZ,Naidoo KK,Mncube Z,Jaggernath M,Goulder PJR,Ndung'u T,Altfeld M,Thobakgale CF

更新日期：2017-12-01 00:00:00

abstract：:Accurate methods for cross-sectional incidence estimation are needed for HIV prevention research. The Limiting Antigen Avidity (LAg-Avidity) assay has been marketed by two vendors, Maxim Biomedical and Sedia BioSciences Corporation. Performance differences between the two versions of the assay are unknown. We tested a...

journal_title：AIDS research and human retroviruses

authors： Schlusser KE,Konikoff J,Kirkpatrick AR,Morrison C,Chipato T,Chen PL,Munjoma M,Eshleman SH,Laeyendecker O

更新日期：2017-06-01 00:00:00

abstract：:The HIV epidemic in Russia, one of the world's fastest growing, has been concentrated mostly among people who inject drugs (PWID). We sought to explore the epidemiology of the epidemic in St. Petersburg by sampling from the highest risk groups of PWID and men who have sex with men (MSM) and use viral sequencing data t...

journal_title：AIDS research and human retroviruses

authors： Dukhovlinova E,Masharsky A,Toussova O,Verevochkin S,Solovyeva T,Meringof M,Paintsil E,White E,Barbour R,Heimer R,Kozlov A

更新日期：2015-06-01 00:00:00

abstract：:"Graying of HIV epidemic" is observed globally, as people living with HIV (PLWH) are aging, due to effectiveness of antiretrovirals. The normal aging processes and HIV-induced immune dysfunction, are potential mechanisms, driving multimorbidity (MM) in PLWH. MM is the concurrent presence of two or more diseases in a s...

journal_title：AIDS research and human retroviruses

authors： Obimakinde AM,Adebusoye L,Achenbach C,Ogunniyi A,Olaleye D

更新日期：2020-03-01 00:00:00

abstract：:Alcohol use disorder (AUD) is a frequent comorbidity among people living with HIV/AIDS (PLWHA). Alcohol consumption is a significant predictor of nonadherence to antiretroviral therapy (ART), as well as worsening immunological and virological indicators among PLWHA. Clinical studies indicate that higher viral loads in...

journal_title：AIDS research and human retroviruses

authors： Simon L,Siggins R,Winsauer P,Brashear M,Ferguson T,Mercante D,Song K,Vande Stouwe C,Nelson S,Bagby G,Amedee A,Molina PE

更新日期：2018-02-01 00:00:00

abstract：:Several regulatory sequences have been characterized in the HTLV-I promoter. We report here identification of a sequence element downstream of the transcriptional start site within the first 52 nucleotides of the 5' R region, which acts negatively on the activity of the HTLV-I promoter. Determination of the half-lives...

journal_title：AIDS research and human retroviruses

authors： Montagne J,Jalinot P

更新日期：1995-09-01 00:00:00

abstract：:To evaluate the course of liver fibrosis, 328 HIV-hepatitis C virus (HCV)-coinfected patients (210 HCV treated and 118 HCV untreated) were followed-up for 38-42 months. Liver fibrosis was assessed by biopsy or elastometry at baseline and by elastometry afterward, in addition to other noninvasive indexes. A combined li...

journal_title：AIDS research and human retroviruses

authors： Cartón JA,Collazos J,de la Fuente B,Asensi V

更新日期：2013-02-01 00:00:00

abstract：:A molecular epidemiologic study of HIV-1 in Greenland showed distinct transmission clusters correlated with demographic and behavioral data. Resistance mutations were found in a majority of the pol sequences. The objective of the present study was to estimate prevalence of drug resistance in Greenland and identify tra...

journal_title：AIDS research and human retroviruses

authors： Madsen TV,Lohse N,Jensen ES,Obel N,Ladefoged K,Gerstoft J,Petersen AB,Nielsen C,Jørgensen LB

更新日期：2008-08-01 00:00:00

abstract：:The presence of human immunodeficiency virus (HIV)-specific antibodies was examined in plasma and cervicovaginal (mucosal) samples of 24 HIV-exposed uninfected (EU) female sexual partners of HIV-infected men, and compared with findings in 18 HIV-infected and 15 low-risk HIV-uninfected women. Only HIV-infected women ha...

journal_title：AIDS research and human retroviruses

authors： Buchacz K,Parekh BS,Padian NS,van der Straten A,Phillips S,Jonte J,Holmberg SD

更新日期：2001-12-10 00:00:00

abstract：:The extraordinarily high mutation rate of HIV suggests that the viral population exists near the threshold for viral viability. An increase in mutation could mediate a lethal increase in the already high proportion of defective viruses. We initially tested this hypothesis by culturing HIV-infected cells in mutagenic d...

journal_title：AIDS research and human retroviruses

authors： Loeb LA,Mullins JI

更新日期：2000-01-01 00:00:00

abstract：:HIV-1 and HTLV-1 infect CD4(+) T lymphocyte but little is known about the impact of coinfection on patient's immune response. In this study we have evaluated the spontaneous production of interleukin (IL)-2, IL-4, IL-6, and IL-10 and interferon (IFN)-γ by unstimulated peripheral blood mononuclear cell (PBMC) cultures ...

journal_title：AIDS research and human retroviruses

authors： Abrahão MH,Lima RG,Netto E,Brites C

更新日期：2012-08-01 00:00:00

abstract：:We used enzyme-linked immunosorbant assay (ELISA) and Western blotting, with "purified" human T-cell leukemia virus I (HTLV-I), to test for HTLV-I antibodies in 2583 plasma samples from 1053 leukemia/lymphoma patients treated at Roswell Park Memorial Institute, mostly between 1972 and 1984, and in 110 sera samples fro...

journal_title：AIDS research and human retroviruses

authors： Srivastava BI,Gonzales C,Loftus R,Fitzpatrick JE,Saxinger CW

更新日期：1990-05-01 00:00:00

abstract：:Serological inspection of Simian T-lymphotropic Virus Type 1 was conducted for a wild colony of Macaca fuscata, which was captured in the middle Honshu, Japan. The increase of positive rate after the juvenile stage with the positive rate reaching 100% (or 35/35) in youngster and adult stages, was observed. This findin...

journal_title：AIDS research and human retroviruses

authors： Eguchi K,Ohsawa K,Fuse Kiyono M,Suzuki J,Kurokawa K,Yamamoto T

更新日期：2011-02-01 00:00:00

abstract：:HIV type 1 (HIV-1) envelope glycoproteins (Env) mediate virus entry and are the target of neutralizing antibodies. Binding of the metastable HIV-1 Env trimer to the CD4 receptor triggers structural rearrangements that mediate Env conformational transitions from a closed conformation to a more open state through an int...

journal_title：AIDS research and human retroviruses

authors： Flemming J,Wiesen L,Herschhorn A

更新日期：2018-09-01 00:00:00

abstract：:Am important aspect of human immunodeficiency virus (HIV-1) infection is the regulation of its expression by nuclear factor kappa B (NF-kappa B) by redox-controlled signal transduction pathways. In this study, we demonstrate that selenium supplementation can effectively increase glutathione peroxidase (GPx) activity i...

journal_title：AIDS research and human retroviruses

authors： Sappey C,Legrand-Poels S,Best-Belpomme M,Favier A,Rentier B,Piette J

更新日期：1994-11-01 00:00:00

abstract：:Anemia, a common hematological abnormality in HIV, contributes to decreased quality of life (QOL). This study assessed once-every-2-week epoetin alfa on maintaining QOL and hemoglobin (Hb) in anemic HIV-infected patients in a 24-week, open-label, multicenter study. HIV-infected patients (Hb < or =12 g/dl) received epo...

journal_title：AIDS research and human retroviruses

authors： Levine AM,Salvato P,Leitz GJ,Champs 2 Study Group.

更新日期：2008-02-01 00:00:00

abstract：:The World Health Organizations HIV Drug Resistance (WHO HIVDR) Threshold survey method was used to assess transmitted HIVDR in newly diagnosed HIV-1-infected primigravida women attending the Prevention of Parent to Child Transmission (PPTCT) centers in Kakinada, in whom it is likely that the infection had recently occ...

journal_title：AIDS research and human retroviruses

authors： Thorat SR,Chaturbhuj DN,Hingankar NK,Chandrasekhar V,Koppada R,Datkar SR,Srikantiah P,Garg R,Kabra S,Haldar P,Reddy DC,Bachani D,Tripathy SP,Paranjape RS

更新日期：2011-12-01 00:00:00

abstract：:Recombination is one of several factors contributing to the genetic diversity of HIV-1, which is divided into group M (itself comprising 11 subtypes, A-K) and two other groups named O and N. In the present study, the full-length genome of an HIV-1 isolate obtained from a Greek subject (GR17) infected in the Democratic...

journal_title：AIDS research and human retroviruses

authors： Paraskevis D,Magiorkinis M,Paparizos V,Pavlakis GN,Hatzakis A

更新日期：2000-06-10 00:00:00