CD8+ T lymphocyte-mediated inhibition of HIV-1 long terminal repeat transcription: a novel antiviral mechanism.

abstract：:HIV patients beginning antiretroviral therapy (ART) with advanced immunodeficiency often retain low CD4+ T cell counts despite virological control. We examined proliferative responses and upregulation of costimulatory molecules, following anti-CD3 stimulation, in HIV patients with persistent CD4+ T cell deficiency on ...

journal_title：AIDS research and human retroviruses

authors： Tanaskovic S,Price P,French MA,Fernandez S

更新日期：2017-02-01 00:00:00

abstract：:Thymulin is a thymic peptide important for the maturation and differentiation of immature thymocytes, which have been found to be depressed in patients with low-level CD4(+) cell recovery despite viral control. Substance use is associated with faster progression of HIV disease, which has been ascribed to poor adherenc...

journal_title：AIDS research and human retroviruses

authors： Rafie C,Campa A,Smith S,Huffman F,Newman F,Baum MK

更新日期：2011-08-01 00:00:00

abstract：:Transmitted drug resistance (TDR) influencing nonnucleoside reverse transcriptase inhibitor (NNRTI) activity is increasing among new HIV-1 patients in several countries. As we recently observed an increase of K103N prevalence among new diagnoses in Belgium, we mined the Belgian national sequence database for homologou...

journal_title：AIDS research and human retroviruses

authors： Ruelle J,Ingels MG,Jnaoui K,Ausselet N,Vincent A,Sasse A,Verhofstede C,Goubau P

更新日期：2013-10-01 00:00:00

abstract：:Our goal has been to develop a safe and effective system that would allow us to explore the functions of the human immunodeficiency virus (HIV) envelope. We have generated a human lymphoid cell line (TF228.1.16) that stably expresses functional HIV envelope proteins on its cell surface, and therefore closely mimics th...

journal_title：AIDS research and human retroviruses

authors： Jonak ZL,Clark RK,Matour D,Trulli S,Craig R,Henri E,Lee EV,Greig R,Debouck C

更新日期：1993-01-01 00:00:00

abstract：:"Graying of HIV epidemic" is observed globally, as people living with HIV (PLWH) are aging, due to effectiveness of antiretrovirals. The normal aging processes and HIV-induced immune dysfunction, are potential mechanisms, driving multimorbidity (MM) in PLWH. MM is the concurrent presence of two or more diseases in a s...

journal_title：AIDS research and human retroviruses

authors： Obimakinde AM,Adebusoye L,Achenbach C,Ogunniyi A,Olaleye D

更新日期：2020-03-01 00:00:00

abstract：:The retroviral integrase protein (IN) is essential for virus replication and, therefore, an attractive target for the development of inhibitors to treat human immunodeficiency virus (HIV) infection. Diverse classes of compounds that are active against this protein have been discovered using in vitro assays. Here we de...

journal_title：AIDS research and human retroviruses

authors： Daniel R,Myers CB,Kulkosky J,Taganov K,Greger JG,Merkel G,Weber IT,Harrison RW,Skalka AM

更新日期：2004-02-01 00:00:00

abstract：:Simian species of Asian and African origin are naturally infected with the simian T cell leukemia virus type I (STLV-I). Like the closely related human T cell leukemia virus type I (HTLV-I), STLV-I is primarily cell associated, and typical infections exhibit low viral burdens. Four macaques experimentally inoculated w...

journal_title：AIDS research and human retroviruses

authors： Liska V,Fultz PN,Su L,Ruprecht RM

更新日期：1997-09-01 00:00:00

abstract：:In an effort to identify an immunological basis for natural resistance to HIV-1 infection, we have examined serum antibody responses to HLA class I antigens in female prostitutes of the Nairobi Sex Workers Study. Anti-HLA antibodies are known to block HIV infectivity in vitro and can be protective against SIV challeng...

journal_title：AIDS research and human retroviruses

authors： Luscher MA,Choy G,Njagi E,Bwayo JJ,Anzala AO,Ndinya-Achola JO,Ball TB,Wade JA,Plummer FA,Barber BH,MacDonald KS

更新日期：1998-01-20 00:00:00

abstract：:To determine the role that cellular immune responses play in the protection conferred by vaccination with attenuated SIVmac32H (pC8), we have attempted to deplete macaques of their CD8+ cells prior to challenge with wild-type SIVmac32H (pJ5). In two of four pC8-infected macaques, N109 and N112, a transient partial dep...

journal_title：AIDS research and human retroviruses

authors： Stebbings R,Stott J,Almond N,Hull R,Lines J,Silvera P,Sangster R,Corcoran T,Rose J,Cobbold S,Gotch F,McMichael A,Walker B

更新日期：1998-09-01 00:00:00

abstract：:Antigenic properties of the V3 region are reflected by HIV-1 serotypes. These may represent biological properties of the virus. We serotyped HIV-1 in 142 serum samples from participants in a rural Uganda cohort who seroconverted between August 1991 and December 2001. Clinical progression was assessed using Cox proport...

journal_title：AIDS research and human retroviruses

authors： Senkaali D,Muwonge R,Morgan D,Yirrell D,Whitworth J,Kaleebu P

更新日期：2004-09-01 00:00:00

abstract：:Although the effect of highly active antiretroviral therapy (HAART) on HIV-1 replication has been established, the mechanisms involved in restoration of immune responses and reconstitution remain unknown. This study provides evidence of changes in expression of type 1 and type 2 cytokine-specific mRNA occurring during...

journal_title：AIDS research and human retroviruses

authors： Imami N,Antonopoulos C,Hardy GA,Gazzard B,Gotch FM

更新日期：1999-11-20 00:00:00

abstract：:Laboratory tests that can distinguish recent from long-term HIV infection are used to estimate HIV incidence in a population, but can potentially misclassify a proportion of long-term HIV infections as recent. Correct application of an assay requires determination of the proportion false recents (PFRs) as part of the ...

journal_title：AIDS research and human retroviruses

authors： Shah NS,Duong YT,Le LV,Tuan NA,Parekh BS,Ha HTT,Pham QD,Cuc CTT,Dobbs T,Tram TH,Lien TTX,Wagar N,Yang C,Martin A,Wolfe M,Hien NT,Kim AA

更新日期：2017-06-01 00:00:00

abstract：:Non-B HIV-1 viruses are predominant in developing countries where access to antiretroviral drugs (ARVs) is progressively being intensified. It is important to obtain more data on the susceptibility of these viruses to available ARVs. CRF01_AE, CRF02_AG, and subtype C strains of HIV-1 obtained from untreated patients f...

journal_title：AIDS research and human retroviruses

authors： Fleury HJ,Toni T,Lan NT,Hung PV,Deshpande A,Recordon-Pinson P,Boucher S,Lazaro E,Jauvin V,Lavignolle-Aurillac V,Lebel-Binay S,Cheret A,Masquelier B

更新日期：2006-04-01 00:00:00

abstract：:We evaluated the performance of T-SPOT.TB (a commercial interferon gamma release assay) and its accuracy for the diagnosis of active tuberculosis (TB) among HIV-infected subjects with advanced immunodeficiency. In a clinical prospective study, we assessed the performance of T-SPOT.TB for the diagnosis of active TB in ...

journal_title：AIDS research and human retroviruses

authors： Chen J,Sun J,Zhang R,Liu L,Zheng Y,Shen Y,Wang Z,Sun F,Li L,Lu H

更新日期：2011-03-01 00:00:00

abstract：:Although suppression of HIV-1 RNA below the limit of detection is associated with optimal outcomes, many patients can maintain or increase their CD4(+) count for prolonged time periods in the presence of persistent low-level viremia. We followed seven patients with prolonged (>5 years) discordant CD4(+)/viral load (VL...

journal_title：AIDS research and human retroviruses

authors： Kaplan SS,Ferrari G,Wrin T,Hellmann NS,Tomaras GD,Gryszowka VE,Fiscus SA,Weinhold KJ,Hicks CB

更新日期：2005-01-01 00:00:00

abstract：:Population genotyping (PG) can underestimate resistance if resistance-containing low abundance variants go undetected. PG and clonal analysis (CA) results were compared in virologic failures (VFs) from a 48-week clinical trial that evaluated once-daily fosamprenavir/ritonavir (FPV/r) 1400 mg/100 mg or atazanavir/riton...

journal_title：AIDS research and human retroviruses

authors： Ross LL,Weinberg WG,DeJesus E,Fischl MA,Horton JH,Pappa KA,Lancaster CT,Pakes GE,Smith KY

更新日期：2010-04-01 00:00:00

abstract：:To understand the evolution of HIV-1, the genetic and biological characteristics of viruses that infect persons living in regions in which the virus has been evolving for several decades must be studied. Thus, we investigated teh genetic subtypes, coreceptor usage, and syncytium-inducing ability of viruses in 47 HIV-1...

journal_title：AIDS research and human retroviruses

authors： Zhong P,BUrda S,Konings F,Urbanski M,Ma L,Zekeng L,Ewane L,Agyingi L,Agwara M,Saa,Afane ZE,Kinge T,Zolla-Pazner S,Nyambi P

更新日期：2003-12-01 00:00:00

abstract：:Human T cell leukemia virus protein induces T cells to permanent IL-2-dependent growth. These cells occasionally convert to factor independence. The viral oncoprotein Tax acts as an essential growth factor of transformed lymphocytes and stimulates the cell cycle in the G(1) phase. In T cells and fibroblasts Tax enhanc...

journal_title：AIDS research and human retroviruses

authors： Haller K,Ruckes T,Schmitt I,Saul D,Derow E,Grassmann R

更新日期：2000-11-01 00:00:00

abstract：:Monitoring HIV subtype distribution is important for understanding transmission dynamics. Subtype B has historically been dominant in Australia, but in recent years new clades have appeared. Since 2000, clade data have been collected as part of HIV surveillance in South Australia. The aim of this study was to evaluate...

journal_title：AIDS research and human retroviruses

authors： Hawke KG,Waddell RG,Gordon DL,Ratcliff RM,Ward PR,Kaldor JM

更新日期：2013-02-01 00:00:00

abstract：:HIV inhibitors targeted at the virus-associated reverse transcriptase (RT) can be divided into two groups, depending on whether they are targeted at the substrate or nonsubstrate binding site. To the first group belong the 2',3'-dideoxynucleosides (i.e., DDC, DDI), 3'-azido-2',3'-dideoxynucleosides (i.e., AZT), 3'-flu...

journal_title：AIDS research and human retroviruses

authors： De Clercq E

更新日期：1992-02-01 00:00:00

abstract：:HIV-infected patients are at increased risk of decreased bone mineral density. Some studies have implicated antiretroviral therapy as a contributor to the decreased bone mineral density seen in treated HIV-1 patients. In this study we explore the interactions between protease inhibitors (PI) and primary human osteobla...

journal_title：AIDS research and human retroviruses

authors： Malizia AP,Cotter E,Chew N,Powderly WG,Doran PP

更新日期：2007-02-01 00:00:00

abstract：:We describe four full-length genomic sequences of HIV-1 subtype B isolates from Russia. These full-length HIV-1 genomes were amplified by nested polymerase chain reaction and sequenced. The sequences obtained were subjected to neighbor-joining phylogenetic analysis using a Kimura two-parameter model and to detailed se...

journal_title：AIDS research and human retroviruses

authors： Galkin AN,Gagarina EY,Lukyanova NS,Danilova TV

更新日期：2006-11-01 00:00:00

abstract：:HIV-1 infection of tonsils takes place when virus spreads systemically, and may occur when tonsillar tissue serves as the initial portal of HIV-1 entry. The HIV replication cycle includes the production of regulatory and accessory gene mRNAs, produced by splicing of genomic mRNA, that are hallmarks of de novo virus pr...

journal_title：AIDS research and human retroviruses

authors： Brachtel EF,Mascola JR,Wear DJ,Ehrenberg PK,Dayhoff DE,Sanders-Buell E,Michael NL,Frankel SS

更新日期：2002-07-20 00:00:00

abstract：:Partial sequences of HIV-1 polymerase from 185 patients, 141 ARV experienced and 44 naive, of gag (p24) and env (C2V3) from a subset of naive cases were evaluated in São Paulo, Brazil. Antiretroviral resistance mutations were detected in 4% of 26 recently (<2 years) infected patients. Polymorphisms at the protease gen...

journal_title：AIDS research and human retroviruses

authors： Brígido LF,Franco HM,Custódio RM,Oliveira CA,P Ferreira JL,Eira M,Bergel F,Araújo F,Carvalheiro JR,Rodrigues R

更新日期：2005-07-01 00:00:00

abstract：:Iron is a key factor at various stages of HIV life cycle and determines the progression of HIV infection. Data about cellular labile iron pool (LIP) in the settings of contemporary antiretroviral therapy (cART) are lacking. Yet LIP is directly related to the generation of reactive oxygen species, and may contribute to...

journal_title：AIDS research and human retroviruses

authors： Emilova R,Manolov V,Todorova Y,Yancheva N,Alexiev I,Nikolova M

更新日期：2020-07-01 00:00:00

abstract：:We have previously used immunotoxins to select for HIV-1 variant cells that transcribe HIV at extremely low levels and fail to produce HIV proteins. Further observation of one of these variants (E9) demonstrated spontaneous in vitro activation of HIV production. The mechanism of activation is different from that of U1...

journal_title：AIDS research and human retroviruses

authors： Fang H,Pincus S

更新日期：1999-10-10 00:00:00

abstract：:We have shown that HIV budding occurs at cholesterol-rich membrane microdomains called lipid rafts (Nguyen and Hildreth, J Virol 2000;74:3264-3272). This observation prompted us to examine the role in HIV entry of cholesterol in the membrane of cells. We recently reported that host cell cholesterol is required for HIV...

journal_title：AIDS research and human retroviruses

authors： Liao Z,Graham DR,Hildreth JE

更新日期：2003-08-01 00:00:00

abstract：:A total of 110 HIV-1-positive samples obtained in 1997 (n = 44) and 2000 (n = 66) were genetically characterized in the V3-V5 envelope region and the p24 gag region. The majority of the strains were CRF02-AG (54.3%) or CRF06-cpx (18.1%) in env and gag. More than 9% of the samples were recombinants between CRF02 and CR...

journal_title：AIDS research and human retroviruses

authors： Mamadou S,Montavon C,Ben A,Djibo A,Rabiou S,Mboup S,Delaporte E,Peeters M

更新日期：2002-07-01 00:00:00

abstract：:The mechanisms responsible for the hematopoietic failure in human immunodeficiency virus type 1 (HIV-1)-infected patients are still unknown. Several findings indicate that the in vitro proliferative potential of precursor cells from AIDS patients is reduced. The changes seen in bone marrow (BM) morphology and the defe...

journal_title：AIDS research and human retroviruses

authors： Isgrò A,Mezzaroma I,Aiuti A,De Vita L,Franchi F,Pandolfi F,Alario C,Ficara F,Riva E,Antonelli G,Aiuti F

更新日期：2000-10-10 00:00:00

abstract：:The feasibility and effectiveness of a hospital-based exercise-training program followed by a home-based program for improving fitness, strength, and changes in body composition in children and adolescents with HIV were evaluated. Subjects participated in nonrandomized 24-session, hospital supervised exercise training...

journal_title：AIDS research and human retroviruses

authors： Miller TL,Somarriba G,Kinnamon DD,Weinberg GA,Friedman LB,Scott GB

更新日期：2010-03-01 00:00:00