Covert vertical transmission of feline immunodeficiency virus.


:Covert vertical transmission of feline immunodeficiency virus (FIV), the feline counterpart of human immunodeficiency virus type 1 (HIV-1), was identified in kittens born to FIV-infected cats. DNA PCR detected FIV gag and env sequences in tissues from kittens nonviable at birth, and in viable kittens monitored postnatally and necropsied at either 11 weeks or 1 year of age. Although FIV DNA was detected in initial blood samples from all 16 viable kittens, viral DNA became increasingly difficult to detect over time and infectious virus could rarely be demonstrated. Only maternal FIV antibody was detected in kitten plasma during the entire postnatal observation period, and kittens remained healthy, with normal CD4:CD8 T cell ratios at >14 months of age. Thus, mother-to-offspring FIV exposure, occurring in utero and postnatally, can result in covert infection in kittens with virus sequestered and contained in tissue sites. These findings appear directly relevant to suspected transient HIV infections and reports of HIV-specific cellular immune responses in highly exposed seronegative adults and uninfected infants born to HIV-positive women.


Allison RW,Hoover EA




Has Abstract


2003-05-01 00:00:00












  • Viral genetic determinants of nonprogressive HIV type 1 subtype C infection in antiretroviral drug-naive children.

    abstract::Characterization of HIV-1 from slow progressors is important to facilitate vaccine and antiviral drug development. To identify virus attenuations that may contribute to slower rates of disease progression, the full-length viral genomes from primary isolates of six slow progressing HIV-positive children were sequenced....

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Tzitzivacos DB,Tiemessen CT,Stevens WS,Papathanasopoulos MA

    更新日期:2009-11-01 00:00:00

  • Genetic and Phenotypic Analysis of CRF01_AE HIV-1 env Clones from Patients Residing in Beijing, China.

    abstract::CRF01_AE is one of the four dominant HIV-1 strains circulating in China. In this study, we performed genetic and phenotypic analyses using a total of 60 full-length envelope gene clones from 14 HIV-1-infected individuals in the Beijing area. Among the 60 sequences analyzed, 32 have a complete open reading frame (ORF),...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Chen D,He X,Ye J,Zhao P,Zeng Y,Feng X

    更新日期:2016-10-01 00:00:00

  • Genetic Analyses of HIV-1 Strains Transmitted from Mother to Child in Northern Vietnam.

    abstract::We previously reported mother-to-child transmission of HIV-1 in nine (6.7%) of 135 children on nevirapine prophylaxis in Vietnam. In the current study, we investigated the appearance and profile of antiretroviral drug (ARV) resistance mutations, the predicted coreceptor usage, and the genetic diversity of HIV-1 strain...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Phan CT,Pham HV,Bi X,Ishizaki A,Saina M,Phung CD,Khu DT,Ichimura H

    更新日期:2015-08-01 00:00:00

  • Regression of feline immunodeficiency virus infection.

    abstract::Regression of feline immunodeficiency virus (FIV) infection was observed in seven of nine vertically infected kittens born to two chronically infected mother cats. Both provirus and nonmaternal FIV antibody were detected in all kittens by 4 weeks of age but only three of the seven kittens were positive by blood mononu...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: O'Neil LL,Burkhard MJ,Obert LA,Hoover EA

    更新日期:1997-05-20 00:00:00

  • Protease and reverse transcriptase mutation patterns in HIV type 1 isolates from heavily treated persons: comparison of isolates from Northern California with isolates from other regions.

    abstract::We compared HIV-1 subtype B reverse transcriptase (RT) and protease mutation patterns in isolates from heavily treated persons in Northern California with those from persons described in the published literature predominantly from other parts of the United States and Europe. There were few differences in the prevalenc...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Gonzales MJ,Belitskaya I,Dupnik KM,Rhee SY,Shafer RW

    更新日期:2003-10-01 00:00:00

  • Short communication: high prevalence of drug-resistant human immunodeficiency virus type 1 in treatment-naïve patients in Greenland.

    abstract::A molecular epidemiologic study of HIV-1 in Greenland showed distinct transmission clusters correlated with demographic and behavioral data. Resistance mutations were found in a majority of the pol sequences. The objective of the present study was to estimate prevalence of drug resistance in Greenland and identify tra...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Madsen TV,Lohse N,Jensen ES,Obel N,Ladefoged K,Gerstoft J,Petersen AB,Nielsen C,Jørgensen LB

    更新日期:2008-08-01 00:00:00

  • Simultaneous presence of endogenous retrovirus and herpes virus antigens has profound effect on cell-mediated immune responses: implications for multiple sclerosis.

    abstract::Retroviruses have been suggested as possible pathogenic factors in multiple sclerosis (MS), supported by the observation that endogenous retroviruses are activated in MS patients. Different members of the herpes family of which several are neurotropic have also been suggested as factors in MS pathogenesis. Further, in...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Brudek T,Christensen T,Hansen HJ,Bobecka J,Møller-Larsen A

    更新日期:2004-04-01 00:00:00

  • Identification and characterization of CRF02_AG, CRF06_cpx, and CRF09_cpx recombinant subtypes in Mali, West Africa.

    abstract::Abstract Multiple HIV-1 subtypes and circulating recombinant forms (CRFs) are known to cocirculate in Africa. In West Africa, the high prevalence of CRF02_AG, and cocirculation of subtype A, CRF01_AE, CRF06_cpx, and other complex intersubtype recombinants has been well documented. Mali, situated in the heart of West A...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Imamichi H,Koita O,Dabitao D,Dao S,Ibrah M,Sogoba D,Dewar RL,Berg SC,Jiang MK,Parta M,Washington JA,Polis MA,Lane HC,Tounkara A

    更新日期:2009-01-01 00:00:00

  • Distinct populations of human immunodeficiency virus type 1 in blood and cerebrospinal fluid.

    abstract::The nucleotide sequence of the gp41 transmembrane protein coding region of human immunodeficiency virus type 1 (HIV-1) proviral DNA obtained from blood and cerebrospinal fluid (CSF) from 6 individuals was determined by direct sequencing of polymerase chain reaction (PCR)-amplified DNA. The direct sequencing approach w...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Steuler H,Storch-Hagenlocher B,Wildemann B

    更新日期:1992-01-01 00:00:00

  • Changes in nevirapine plasma concentrations over time and its relationship with liver enzyme elevations.

    abstract::Liver enzyme elevations are frequently seen in patients treated with nevirapine (NVP). Both elevated NVP plasma levels and hepatitis C virus (HCV) infection seem to favor the development of NVP-related liver toxicity. We have examined variation on NVP C(trough) over time, as well as the impact of NVP C(trough) concent...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: De Requena DG,Jiménez-Nácher I,Soriano V

    更新日期:2005-06-01 00:00:00

  • Short communication: persistence of high blood levels of the chemokines CCL2, CCL19, and CCL20 during the course of HIV infection.

    abstract::Dendritic cells (DCs) are important mediators of the immune response against HIV and yet blood DC numbers fall substantially during HIV infection. Here we report that blood levels of the DC-tissue tropic chemokines monocyte chemotactic protein (MCP-1/CCL2), macrophage inflammatory proteins (MIP-3α/CCL20), and MIP-3β/C...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Fontaine J,Poudrier J,Roger M

    更新日期:2011-06-01 00:00:00

  • Cocaine reduces thymic endocrine function: another mechanism for accelerated HIV disease progression.

    abstract::Thymulin is a thymic peptide important for the maturation and differentiation of immature thymocytes, which have been found to be depressed in patients with low-level CD4(+) cell recovery despite viral control. Substance use is associated with faster progression of HIV disease, which has been ascribed to poor adherenc...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Rafie C,Campa A,Smith S,Huffman F,Newman F,Baum MK

    更新日期:2011-08-01 00:00:00

  • Molecular differences between two immunologically related spumaretroviruses: the human prototype HSRV and the chimpanzee isolate SFV6.

    abstract::A comparative study at the genomic and protein level was performed between two immunologically related spumaretroviruses, the human HSRV and the simian SFV6. Cross immunoprecipitation analysis with specific polyclonal and monoclonal antisera indicates shared antigenic determinants. However, restriction analysis of the...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Tobaly-Tapiero J,Santillana-Hayat M,Giron ML,Guillemin MC,Rozain F,Périès J,Emanoil-Ravier R

    更新日期:1990-07-01 00:00:00

  • Longitudinal assessment of immune response and viral characteristics in HIV-infected patients with prolonged CD4(+)/viral load discordance.

    abstract::Although suppression of HIV-1 RNA below the limit of detection is associated with optimal outcomes, many patients can maintain or increase their CD4(+) count for prolonged time periods in the presence of persistent low-level viremia. We followed seven patients with prolonged (>5 years) discordant CD4(+)/viral load (VL...

    journal_title:AIDS research and human retroviruses

    pub_type: 临床试验,杂志文章


    authors: Kaplan SS,Ferrari G,Wrin T,Hellmann NS,Tomaras GD,Gryszowka VE,Fiscus SA,Weinhold KJ,Hicks CB

    更新日期:2005-01-01 00:00:00

  • Treatment outcomes of HIV-infected adolescents attending public-sector HIV clinics across Gauteng and Mpumalanga, South Africa.

    abstract::There is little evidence comparing treatment outcomes between adolescents and other age groups, particularly in resource-limited settings. A retrospective analysis of data from seven HIV clinics across urban Gauteng (n=5) and rural Mpumalanga (n=2), South Africa was conducted. The analysis compared HIV-positive antire...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Evans D,Menezes C,Mahomed K,Macdonald P,Untiedt S,Levin L,Jaffray I,Bhana N,Firnhaber C,Maskew M

    更新日期:2013-06-01 00:00:00

  • HIV type 1 antigen-responsive CD4+ T-lymphocytes in exposed yet HIV Type 1 seronegative Ugandans.

    abstract::CD4(+) T cell help is important for the functionality of CD8(+) cytotoxic T-lymphocytes (CTLs) in limiting viral replication and may contribute to mediation of apparent resistance to HIV-1 infection in exposed seronegative (ESN) individuals. Using five HIV-1 antigens in an intracellular cytokine assay, the presence of...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Kebba A,Kaleebu P,Serwanga J,Rowland S,Yirrell D,Downing R,Gilmour J,Imami N,Gotch F,Whitworth J

    更新日期:2004-01-01 00:00:00

  • HIV-1 Genetic Diversity and High Prevalence of Pretreatment Drug Resistance in Tianjin, China.

    abstract::Diversity of genotypes and prevalence of pretreatment drug resistance (PDR) are challenges for the epidemic control and vaccine development of HIV-1. However, little is known about the situation in Tianjin. Blood samples were collected from newly diagnosed, antiretroviral treatment (ART)-naive HIV/AIDS patients from J...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Zeng R,Ren D,Gong X,Wei M,Gao L,Yu A,Zhang D,Mi Y,Ma P

    更新日期:2020-10-01 00:00:00

  • HTLV type 1 molecular study in Brazilian villages with African characteristics giving support to the post-Columbian introduction hypothesis.

    abstract::We performed an HTLV epidemiological study of 986 individuals from 17 villages from the same state of Salvador, the city with the highest HTLV-1 prevalence in Brazil. The HTLV-1 prevalence was 3.85%, 1.56%, and 1.23% in three villages. Phylogenetic analysis of the LTR region demonstrated that all positive samples anal...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Rego FF,Alcantara LC,Moura Neto JP,Miranda AC,Pereira Ode S,Gonçalves Mde S,Galvão-Castro B

    更新日期:2008-05-01 00:00:00

  • Prediction of virological response to lopinavir/ritonavir using the genotypic inhibitory quotient.

    abstract::The predictive value of virological response to lopinavir (LPV)/ritonavir (r) was assessed in 126 HIV-infected patients who failed antiretroviral therapy and had begun a rescue intervention based on LPV/r. At 3 months, subjects with < or =6 protease (PRO) resistance mutations showed a higher rate of virological respon...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: González de Requena D,Gallego O,Valer L,Jiménez-Nácher I,Soriano V

    更新日期:2004-03-01 00:00:00

  • Isolation of potent neutralizing monoclonal antibodies from an SIV-Infected rhesus macaque by phage display.

    abstract::The humoral immune response is a mechanism that potently suppresses or prevents viral infections. However, genetic diversity and resistance to antibody-mediated neutralization are serious obstacles in controlling HIV-1 infection. In this study, we isolated monoclonal antibodies from an SIV-infected macaque by using th...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Kuwata T,Katsumata Y,Takaki K,Miura T,Igarashi T

    更新日期:2011-05-01 00:00:00

  • Elevated hepatic gamma-glutamylcysteine synthetase activity and abnormal sulfate levels in liver and muscle tissue may explain abnormal cysteine and glutathione levels in SIV-infected rhesus macaques.

    abstract::To establish whether the low cysteine and glutathione levels in HIV-infected patients and SIV-infected rhesus macaques may be consequences of an abnormal cysteine catabolism, we analyzed sulfate and glutathione levels in macaques. Muscle tissue (m. vastus lateralis and m. gastrocnemius) of SIV-infected macaques (n = 2...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Gross A,Hack V,Stahl-Hennig C,Dröge W

    更新日期:1996-11-20 00:00:00

  • Molecular and phylogenetic analysis of HIV type 1 vpr sequences of South African strains.

    abstract::HIV-1 subtype C is the prevalent subtype in South Africa, with non-C subtypes being sporadically detected. The accessory genes of subtype C have not been well studied in South Africa. In this study the HIV-1 vpr region of 58 strains was amplified, sequenced, and subtyped. Phylogenetic analysis characterized 54 strains...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Romani B,Glashoff R,Engelbrecht S

    更新日期:2009-03-01 00:00:00

  • Phylogenetic analysis of HIV-1 reverse transcriptase sequences from 382 patients recruited in JJ Hospital of Mumbai, India, between 2002 and 2008.

    abstract::Analysis of reverse transcriptase (RT) sequences of 382 HIV-1 isolates from untreated and treated patients recruited in JJ Hospital (Mumbai, India) between 2002 and 2008 shows that subtype C is largely predominant (98%) and that non-C sequences cluster with A1, B, CRF01_AE, and CRF06_cpx. ...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Deshpande A,Jauvin V,Pinson P,Jeannot AC,Fleury HJ

    更新日期:2009-06-01 00:00:00

  • In vitro susceptibility of Macaca nemestrina to human herpesvirus 6: a potential animal model of coinfection with primate immunodeficiency viruses.

    abstract::Human herpesvirus 6 (HHV-6), a lymphotropic herpesvirus, has been suggested as a potential cofactor in the acquired immunodeficiency syndrome (AIDS). Previous studies indicate that HHV-6 has a restricted range of susceptible species. In this study, we tested the in vitro susceptibility to HHV-6 of Macaca nemestrina (p...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Lusso P,Secchiero P,Crowley RW

    更新日期:1994-02-01 00:00:00

  • Long-term exposure to zidovudine affects in vitro and in vivo the efficiency of phosphorylation of thymidine kinase.

    abstract::The purpose of this study was to investigate the mechanism of acquired cellular resistance to AZT, a mechanism that has been described as a potential source of drug resistance in addition to viral mutations. To study this phenomenon the kinetics parameters of thymidine kinase (TK) activity have been defined in CEMazt,...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Antonelli G,Turriziani O,Verri A,Narciso P,Ferri F,D'Offizi G,Dianzani F

    更新日期:1996-02-10 00:00:00

  • Changes in CD4+ and CD8+ T cell subsets in response to highly active antiretroviral therapy in HIV type 1-infected patients with prior protease inhibitor experience.

    abstract::This study explores whether previous failures on antiretroviral drug regimens preclude the possibility of immune restoration. This was assessed by evaluating T cell subset changes in individuals who received a salvage regimen of highly active antiretroviral therapy (HAART) after initially failing protease inhibitor mo...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Gray CM,Schapiro JM,Winters MA,Merigan TC

    更新日期:1998-05-01 00:00:00

  • Severe Kaposi Sarcoma in an Urban Public Hospital.

    abstract::The national incidence of epidemic Kaposi sarcoma (KS) has decreased dramatically since the availability of combined antiretroviral therapy. Despite national trends, we continue to see admissions for KS. Electronic medical records were queried to identify patients with HIV who were admitted with active KS between 2010...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Kasturia SE,Gunthel C,Zeng C,Nguyen ML

    更新日期:2017-06-01 00:00:00

  • Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis.

    abstract::The Human Immunodeficiency Virus (HIV), the causative agent of AIDS, is thought to bind to T4+ (CD4+) target cells through the heavily glycosylated gp120 envelope glycoprotein. Plant lectins bind glycoproteins through noncovalent interaction with specific hexose residues; therefore, lectins were evaluated for their ab...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Robinson WE Jr,Montefiori DC,Mitchell WM

    更新日期:1987-10-01 00:00:00

  • Spreading of HIV-1 subtype G and envB/gagG recombinant strains among injecting drug users in Lisbon, Portugal.

    abstract::We have evaluated the genetic diversity of HIV-1 strains infecting injecting drug users (IDUs) in Lisbon, Portugal. Heteroduplex mobility assay and/or phylogenetic analysis revealed that env (C2V3C3 or gp41) subtype B is present in 63.7% of the 135 viral samples studied, followed by subtypes G (23.7%), A (6.7%), F (5....

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Esteves A,Parreira R,Piedade J,Venenno T,Franco M,Germano de Sousa J,Patrício L,Brum P,Costa A,Canas-Ferreira WF

    更新日期:2003-06-01 00:00:00

  • Evolutionary repair of HIV type 1 gp41 with a kink in the N-terminal helix leads to restoration of the six-helix bundle structure.

    abstract::The HIV-1 envelope glycoprotein complex (Env) can be stabilized by the introduction of a disulfide bond between the gp120 and gp41 subunits. The resulting protein is monomeric, but trimerization can be improved by the introduction of a single helix-breaking residue at the conserved Ile559 site in the N-terminal heptad...

    journal_title:AIDS research and human retroviruses

    pub_type: 杂志文章


    authors: Sanders RW,Busser E,Moore JP,Lu M,Berkhout B

    更新日期:2004-07-01 00:00:00