Abstract:
:HIV prevalence in the Limpopo Province has increased rapidly within the past 10 years, as in other parts of South Africa. Little is known about the genetic and biological properties of HIV circulating in this region including the baseline drug resistance profiles. We therefore collected blood samples from 42 HIV-1-infected patients residing in this region for analysis. All samples were shown to belong to HIV-1 subtype C by env and gag heteroduplex mobility assay (HMA). Viral isolates from 14 of these patients were shown to use the CCR5 coreceptor exclusively and had gp120 V3 loop sequences consistent with this phenotype. Sequence analysis of both protease and reverse transcriptase genes showed that none of 13 isolates harbored primary resistance mutations. These data suggest that HIV-1 subtype C is the predominant subtype circulating in the Limpopo Province, and that viral strains from this region are indistinguishable from those found in other parts of South Africa.
journal_name
AIDS Res Hum Retrovirusesjournal_title
AIDS research and human retrovirusesauthors
Bessong PO,Larry Obi C,Cilliers T,Choge I,Phoswa M,Pillay C,Papathanasopoulos M,Morris Ldoi
10.1089/aid.2005.21.103subject
Has Abstractpub_date
2005-01-01 00:00:00pages
103-9issue
1eissn
0889-2229issn
1931-8405journal_volume
21pub_type
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journal_title:AIDS research and human retroviruses
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